Patient Portal

Yo-El S Ju, MD

Associate Professor, Neurology

Specialty Areas

Sleep Medicine
Neurology - Adult

Board Certifications

Sleep Medicine
Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Evaluation and treatment of patients with sleep disorders, including parasomnias, narcolepsy, restless legs syndrome, and obstructive sleep apnea. Polysomnograms (sleep studies) are frequently part of this evaluation.

Learn More About the Sleep Medicine Center.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center 40 Building

1600 S. Brentwood Blvd.
Suite 600
St. Louis, MO 63144

Office Phone: (314) 362-4342
Fax: (314) 747-3813
Email: juy@neuro.wustl.edu

Education

Education

MD: Columbia University, College of Physicians and Surgeons. New York, NY. 2005
AB: Harvard College. Cambridge, MA. 2001
Residency: Washington University School of Medicine, Barnes Jewish Hospital, St. Louis, MO 2006
Clinical Fellowship: Washington University School of Medicine; Washington University Multidisciplinary Sleep Medicine Center, St. Louis, MO 2010
Research Fellowship: Washington University School of Medicine; Washington University Multidisciplinary Sleep Medicine Center, St. Louis, MO 2011

Publication & Research

Publication & Research

Clinical trials in REM sleep behavioural disorder: challenges and opportunities.
Videnovic A, Ju YS, Arnulf I, Cochen-De Cock V, Högl B, Kunz D, Provini F, Ratti PL, Schiess MC, Schenck CH, Trenkwalder C, Treatment and Trials Working Group of the International RBD Study Group.
J Neurol Neurosurg Psychiatry. 2020 May 13; pii: jnnp-2020-322875. doi: 10.1136/jnnp-2020-322875.

PMID:
    32404379
    [PubMed - as supplied by publisher]
Related citations


Proteomic biomarkers of sleep apnea.
Ambati A, Ju YE, Lin L, Olesen AN, Koch H, Hedou JJ, Leary EB, Sempere VP, Mignot E, Taheri S
Sleep. 2020 May 5; pii: zsaa086. doi: 10.1093/sleep/zsaa086.

PMID:
    32369590
    [PubMed - as supplied by publisher]
Related citations


Association Between Preoperative Obstructive Sleep Apnea and Preoperative Positive Airway Pressure With Postoperative Intensive Care Unit Delirium.
King CR, Fritz BA, Escallier K, Ju YS, Lin N, McKinnon S, Avidan MS, Palanca BJ
JAMA Netw Open. 2020 Apr 1; 3(4)e203125. doi: 10.1001/jamanetworkopen.2020.3125.

PMID:
    32310284
    [PubMed - in process]
Related citations


Obstructive sleep apnoea, positive airway pressure treatment and postoperative delirium: protocol for a retrospective observational study.
King CR, Escallier KE, Ju YS, Lin N, Palanca BJ, McKinnon SL, Avidan MS
BMJ Open. 2019 Aug 26; 9(8)e026649. doi: 10.1136/bmjopen-2018-026649.

PMID:
    31455698
    [PubMed - in process]
Related citations


Reply to "obstructive sleep apnea treatment and amyloid-β in cerebrospinal fluid".
Ju YS, Holtzman DM
Ann Neurol. 2019 Mar; 85(3)460-461. doi: 10.1002/ana.25424.

PMID:
    30706528
    [PubMed - indexed for MEDLINE]
Related citations


Obstructive sleep apnea treatment, slow wave activity, and amyloid-β.
Ju YS, Zangrilli MA, Finn MB, Fagan AM, Holtzman DM
Ann Neurol. 2019 Feb; 85(2)291-295. doi: 10.1002/ana.25408.

PMID:
    30597615
    [PubMed - indexed for MEDLINE]
Related citations


Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels.
Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM
Brain. 2017 Aug 1; 140(8)2104-2111. doi: 10.1093/brain/awx148.

PMID:
    28899014
    [PubMed - indexed for MEDLINE]
Related citations


Comorbid Sleep Disturbances in Neurologic Disorders.
Ju YS, Videnovic A, Vaughn BV
Continuum (Minneap Minn). 2017 Aug; 23(4, Sleep Neurology)1117-1131. doi: 10.1212/CON.0000000000000501.

PMID:
    28777179
    [PubMed - indexed for MEDLINE]
Related citations


Self-reported sleep and Alzheimer disease CSF biomarkers: A wake-up call.
Spira AP, Ju YS
Neurology. 2017 Aug 1; 89(5)419-420. doi: 10.1212/WNL.0000000000004189.

PMID:
    28679599
    [PubMed - indexed for MEDLINE]
Related citations


Automated selective disruption of slow wave sleep.
Ooms SJ, Zempel JM, Holtzman DM, Ju YS
J Neurosci Methods. 2017 Apr 1; 28133-39. doi: 10.1016/j.jneumeth.2017.02.008.

PMID:
    28238859
    [PubMed - indexed for MEDLINE]
Related citations


The interaction of sleep and amyloid deposition on cognitive performance.
Molano JRV, Roe CM, Ju YS
J Sleep Res. 2017 Jun; 26(3)288-292. doi: 10.1111/jsr.12474.

PMID:
    27905159
    [PubMed - indexed for MEDLINE]
Related citations


Treatment of Sleep Disorders in Dementia.
Ooms S, Ju YE
Curr Treat Options Neurol. 2016 Sep; 18(9)40. doi: 10.1007/s11940-016-0424-3.

PMID:
    27476067
    [PubMed]
Related citations


Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.
Ju YE, Finn MB, Sutphen CL, Herries EM, Jerome GM, Ladenson JH, Crimmins DL, Fagan AM, Holtzman DM
Ann Neurol. 2016 Jul; 80(1)154-9. doi: 10.1002/ana.24672.

PMID:
    27129429
    [PubMed - indexed for MEDLINE]
Related citations


Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study.
Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, Miyamoto T, Oertel W, Dauvilliers Y, Ju YE, Puligheddu M, Sonka K, Pelletier A, Santamaria J, Frauscher B, Leu-Semenescu S, Zucconi M, Terzaghi M, Miyamoto M, Unger MM, Carlander B, Fantini ML, Montplaisir JY
Ann Neurol. 2015 May; 77(5)830-9. doi: 10.1002/ana.24385.

PMID:
    25767079
    [PubMed - indexed for MEDLINE]
Related citations


Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle.
Larson-Prior LJ, Ju YE, Galvin JE
Front Neurol. 2014; 5165. doi: 10.3389/fneur.2014.00165.

PMID:
    25309500
    [PubMed]
Related citations


Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study.
Frauscher B, Jennum P, Ju YE, Postuma RB, Arnulf I, Cochen De Cock V, Dauvilliers Y, Fantini ML, Ferini-Strambi L, Gabelia D, Iranzo A, Leu-Semenescu S, Mitterling T, Miyamoto M, Miyamoto T, Montplaisir JY, Oertel W, Pelletier A, Prunetti P, Puligheddu M, Santamaria J, Sonka K, Unger M, Wolfson C, Zucconi M, Terzaghi M, Högl B, Mayer G, Manni R
Neurology. 2014 Mar 25; 82(12)1076-9. doi: 10.1212/WNL.0000000000000247.

PMID:
    24553425
    [PubMed - indexed for MEDLINE]
Related citations


Sleep and Alzheimer disease pathology--a bidirectional relationship.
Ju YE, Lucey BP, Holtzman DM
Nat Rev Neurol. 2014 Feb; 10(2)115-9. doi: 10.1038/nrneurol.2013.269.

PMID:
    24366271
    [PubMed - indexed for MEDLINE]
Related citations


Sleep evaluation by actigraphy for patients with Alzheimer disease--reply.
Ju YE, Holtzman DM
JAMA Neurol. 2013 Aug; 70(8)1074-5. doi: 10.1001/jamaneurol.2013.3490.

PMID:
    23939592
    [PubMed - indexed for MEDLINE]
Related citations


Sleep quality and preclinical Alzheimer disease.
Ju YE, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Morris JC, Holtzman DM
JAMA Neurol. 2013 May; 70(5)587-93. doi: 10.1001/jamaneurol.2013.2334.

PMID:
    23479184
    [PubMed - indexed for MEDLINE]
Related citations


Morbidities in rapid eye movement sleep behavior disorder.
Jennum P, Mayer G, Ju YE, Postuma R
Sleep Med. 2013 Aug; 14(8)782-7. doi: 10.1016/j.sleep.2012.11.002.

PMID:
    23375425
    [PubMed - indexed for MEDLINE]
Related citations

Notes

Learn more about the study of sleep and neurological diseases in Dr. Ju's lab

Areas of Research Interest

Interaction of sleep and neurodegenerative diseases. Specific interests include REM sleep behavior disorder (RBD), relationship of sleep and risk of Alzheimer’s Disease, and functional neuroimaging of sleep disorders.