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William Hawkins, MD

Neidorff Family and Robert C. Packman Professor, Surgery
Division of General Surgery
Chief, Hepatobiliary-Pancreatic and Gastrointestinal Surgery Section

Specialty Areas

Hepatobiliary Pancreatic (HPB) Surgery
Biliary Surgery
Gallbladder Surgery
Hepatobiliary Pancreatic Cancer
Gastrointestinal Oncology
Sarcoma
Liver Surgery
Pancreatic Surgery

Board Certifications

Surgery

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Minimally invasive foregut and solid organ surgery, pancreatic cancer, liver cancer, sarcoma, abdominal wall hernia, and biliary tract disease, hepatocellular cancer, hepatoma, gastric cancer, revision surgery

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: 314-362-7046
Fax: 314-222-6255

Siteman Cancer Center - South County

5225 MidAmerica Plaza
St. Louis, MO 63129
Phone: 314-747-7222

Office Phone: 314-362-7046

Education

Education

Fellowship: Surgical Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 2004
Chief Residency: Surgery, Massachusetts General Hospital, Boston, Massachusetts 2002
Residency: Surgery, Massachusetts General Hospital, Boston, Massachusetts 2001
Research Fellowship: Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 2000
Residency: Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 1998
Medical Degree: State University of New York at Stony Brook, School of Medicine, Stony Brook, New York 1995
B.S.: Biology, State University of New York at Stony Brook, Stony Brook, New York 1991

Publication & Research

Publication & Research

The diagnosis of pancreatic mucinous cystic neoplasm and associated adenocarcinoma in males: An eight-institution study of 349 patients over 15 years.
Ethun CG, Postlewait LM, McInnis MR, Merchant N, Parikh A, Idrees K, Isom CA, Hawkins W, Fields RC, Strand M, Weber SM, Cho CS, Salem A, Martin RC, Scoggins CR, Bentrem D, Kim HJ, Carr J, Ahmad SA, Abbott DE, Wilson G, Kooby DA, Maithel SK
J Surg Oncol. 2017 Feb 17; doi: 10.1002/jso.24582.

PMID:
    28211072
    [PubMed - as supplied by publisher]
Related citations


Interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: long-term follow-up.
Ohman KA, Liu J, Linehan DC, Tan MC, Tan BR, Fields RC, Strasberg SM, Hawkins WG
HPB (Oxford). 2017 Feb 2; pii: S1365-182X(17)30042-4. doi: 10.1016/j.hpb.2017.01.012.

PMID:
    28162923
    [PubMed - as supplied by publisher]
Related citations


The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer.
Hashim YM, Vangveravong S, Sankpal NV, Binder PS, Liu J, Goedegebuure SP, Mach RH, Spitzer D, Hawkins WG
J Exp Clin Cancer Res. 2017 Jan 17; 36(1)14. doi: 10.1186/s13046-016-0470-4.

PMID:
    28095907
    [PubMed - in process]
Related citations


Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
Pati ML, Hornick JR, Niso M, Berardi F, Spitzer D, Abate C, Hawkins W
BMC Cancer. 2017 Jan 13; 17(1)51. doi: 10.1186/s12885-016-3040-4.

PMID:
    28086830
    [PubMed - in process]
Related citations


Whipple-specific complications result in prolonged length of stay not accounted for in ACS-NSQIP Surgical Risk Calculator.
Cusworth BM, Krasnick BA, Nywening TM, Woolsey CA, Fields RC, Doyle MM, Liu J, Hawkins WG
HPB (Oxford). 2017 Feb; 19(2)147-153. doi: 10.1016/j.hpb.2016.10.015.

PMID:
    27939807
    [PubMed - in process]
Related citations


Pattern of Venous Collateral Development after Splenic Vein Occlusion in an Extended Whipple Procedure (Whipple at the Splenic Artery) and Long-Term Results.
Rosado ID, Bhalla S, Sanchez LA, Fields RC, Hawkins WG, Strasberg SM
J Gastrointest Surg. 2017 Mar; 21(3)516-526. doi: 10.1007/s11605-016-3325-6.

PMID:
    27921207
    [PubMed - in process]
Related citations


Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study.
Brauer DG, Strand MS, Sanford DE, Kushnir VM, Lim KH, Mullady DK, Tan BR Jr, Wang-Gillam A, Morton AE, Ruzinova MB, Parikh PJ, Narra VR, Fowler KJ, Doyle MB, Chapman WC, Strasberg SS, Hawkins WG, Fields RC
HPB (Oxford). 2017 Feb; 19(2)133-139. doi: 10.1016/j.hpb.2016.11.002.

PMID:
    27916436
    [PubMed - in process]
Related citations


Analysis of Pesticides and Toxic Heavy Metals Contained in Mosquito Coils.
Kasumba J, Hettick B, French A, Wickliffe JK, Lichtveld MY, Hawkins WB, van Sauers-Muller A, Klein D
Bull Environ Contam Toxicol. 2016 Nov; 97(5)614-618.

PMID:
    27699449
    [PubMed - indexed for MEDLINE]
Related citations


Operative Site Drainage after Hepatectomy: A Propensity Score Matched Analysis Using the American College of Surgeons NSQIP Targeted Hepatectomy Database.
Brauer DG, Nywening TM, Jaques DP, Doyle MB, Chapman WC, Fields RC, Hawkins WG
J Am Coll Surg. 2016 Dec; 223(6)774-783.e2. doi: 10.1016/j.jamcollsurg.2016.09.004.

PMID:
    27793459
    [PubMed - in process]
Related citations


Association of Preoperative Risk Factors With Malignancy in Pancreatic Mucinous Cystic Neoplasms: A Multicenter Study.
Postlewait LM, Ethun CG, McInnis MR, Merchant N, Parikh A, Idrees K, Isom CA, Hawkins W, Fields RC, Strand M, Weber SM, Cho CS, Salem A, Martin RC, Scoggins C, Bentrem D, Kim HJ, Carr J, Ahmad S, Abbott DE, Wilson GC, Kooby DA, Maithel SK
JAMA Surg. 2017 Jan 1; 152(1)19-25. doi: 10.1001/jamasurg.2016.3598.

PMID:
    27760255
    [PubMed - in process]
Related citations


Timing of Surgical Repair After Bile Duct Injury Impacts Postoperative Complications but Not Anastomotic Patency.
Dominguez-Rosado I, Sanford DE, Liu J, Hawkins WG, Mercado MA
Ann Surg. 2016 Sep; 264(3)544-53. doi: 10.1097/SLA.0000000000001868.

PMID:
    27433902
    [PubMed - in process]
Related citations


Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Jiang H, Hegde S, Knolhoff BL, Zhu Y, Herndon JM, Meyer MA, Nywening TM, Hawkins WG, Shapiro IM, Weaver DT, Pachter JA, Wang-Gillam A, DeNardo DG
Nat Med. 2016 Aug; 22(8)851-60. doi: 10.1038/nm.4123.

PMID:
    27376576
    [PubMed - in process]
Related citations


Necessary but not sufficient? Engaging young people in the development of an avatar-based online intervention designed to provide psychosocial support to young people affected by their own or a family member's cancer diagnosis.
Phelps C, Minou M, Baker A, Hughes C, French H, Hawkins W, Leeuwenberg A, Crabtree R, Hutchings PB
Health Expect. 2016 Jun 12; doi: 10.1111/hex.12473.

PMID:
    27292018
    [PubMed - as supplied by publisher]
Related citations


Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic.
Ohman KA, Hashim YM, Vangveravong S, Nywening TM, Cullinan DR, Goedegebuure SP, Liu J, Van Tine BA, Tiriac H, Tuveson DA, DeNardo DG, Spitzer D, Mach RH, Hawkins WG
Oncotarget. 2016 Jun 7; 7(23)33529-41. doi: 10.18632/oncotarget.9551.

PMID:
    27244881
    [PubMed - in process]
Related citations


Single institution results of radical antegrade modular pancreatosplenectomy for adenocarcinoma of the body and tail of pancreas in 78 patients.
Grossman JG, Fields RC, Hawkins WG, Strasberg SM
J Hepatobiliary Pancreat Sci. 2016 Jul; 23(7)432-41. doi: 10.1002/jhbp.362.

PMID:
    27207482
    [PubMed - in process]
Related citations


Perception Is Reality: quality metrics in pancreas surgery - a Central Pancreas Consortium (CPC) analysis of 1399 patients.
Abbott DE, Martin G, Kooby DA, Merchant NB, Squires MH, Maithel SK, Weber SM, Winslow ER, Cho CS, Bentrem DJ, Kim HJ, Scoggins CR, Martin RC, Parikh AA, Hawkins WG, Ahmad SA
HPB (Oxford). 2016 May; 18(5)462-9. doi: 10.1016/j.hpb.2015.11.006.

PMID:
    27154811
    [PubMed - in process]
Related citations


Mortality of emergency abdominal surgery in high-, middle- and low-income countries.
GlobalSurg Collaborative.
Br J Surg. 2016 Jul; 103(8)971-88. doi: 10.1002/bjs.10151.

PMID:
    27145169
    [PubMed - indexed for MEDLINE]
Related citations


Erratum: Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Tatzel K, Kuroki L, Dmitriev I, Kashentseva E, Curiel DT, Goedegebuure SP, Powell MA, Mutch DG, Hawkins WG, Spitzer D
Sci Rep. 2016 May 4; 625217. doi: 10.1038/srep25217.

PMID:
    27142169
    [PubMed]
Related citations


Mesothelin's minimal MUC16 binding moiety converts TR3 into a potent cancer therapeutic via hierarchical binding events at the plasma membrane.
Su Y, Tatzel K, Wang X, Belt B, Binder P, Kuroki L, Powell MA, Mutch DG, Hawkins WG, Spitzer D
Oncotarget. 2016 May 24; 7(21)31534-49. doi: 10.18632/oncotarget.8925.

PMID:
    27120790
    [PubMed - in process]
Related citations


Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.
Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan DC
Lancet Oncol. 2016 May; 17(5)651-62. doi: 10.1016/S1470-2045(16)00078-4.

PMID:
    27055731
    [PubMed - in process]
Related citations

Areas of Research Interest

Tumor immunology