Patient Portal

William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research
  • Videos

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

First, Do No Harm: Rethinking Routine Diversion in Sphincter-Preserving Rectal Cancer Resection.
Chapman WC Jr, Subramanian M, Jayarajan S, Makhdoom B, Mutch MG, Hunt S, Silviera ML, Glasgow S, Olsen MA, Wise PE
J Am Coll Surg. 2019 Jan 9; pii: S1072-7515(19)30009-2. doi: 10.1016/j.jamcollsurg.2018.12.012.

PMID:
    30639302
    [PubMed - as supplied by publisher]
Related citations


Hepatocellular carcinoma: Where are we in 2018?
Chapman WC, Korenblat KM, Fowler KJ, Saad N, Khan AS, Subramanian V, Doyle MBM, Dageforde LA, Tan B, Grierson P, Lin Y, Xu M, Brunt EM
Curr Probl Surg. 2018 Nov; 55(11)450-503. doi: 10.1067/j.cpsurg.2018.10.002.

PMID:
    30526875
    [PubMed - in process]
Related citations


Accounting for proximal variants improves neoantigen prediction.
Hundal J, Kiwala S, Feng YY, Liu CJ, Govindan R, Chapman WC, Uppaluri R, Swamidass SJ, Griffith OL, Mardis ER, Griffith M
Nat Genet. 2019 Jan; 51(1)175-179. doi: 10.1038/s41588-018-0283-9.

PMID:
    30510237
    [PubMed - in process]
Related citations


Systemic Therapy for Combined Hepatocellular-Cholangiocarcinoma: A Single-Institution Experience.
Trikalinos NA, Zhou A, Doyle MBM, Fowler KJ, Morton A, Vachharajani N, Amin M, Keller JW, Chapman WC, Brunt EM, Tan BR
J Natl Compr Canc Netw. 2018 Oct; 16(10)1193-1199. doi: 10.6004/jnccn.2018.7053.

PMID:
    30323089
    [PubMed - in process]
Related citations


Thoracic Epidural Analgesia: Does It Enhance Recovery?
Rosen DR, Wolfe RC, Damle A, Atallah C, Chapman WC Jr, Vetter JM, Mutch MG, Hunt SR, Glasgow SC, Wise PE, Smith RK, Silviera ML
Dis Colon Rectum. 2018 Dec; 61(12)1403-1409. doi: 10.1097/DCR.0000000000001226.

PMID:
    30308525
    [PubMed - indexed for MEDLINE]
Related citations


Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function in a Murine Deceased Criteria Donor Model.
Vemuri C, Upadhya GA, Arif B, Jia J, Lin Y, Gaut JP, Fazal J, Pan H, Wickline SA, Chapman WC
Transplant Direct. 2018 Sep; 4(9)e384. doi: 10.1097/TXD.0000000000000817.

PMID:
    30234153
    [PubMed]
Related citations


Enhanced immunosuppression improves early allograft function in a porcine kidney transplant model of donation after circulatory death.
Xu M, Garcia-Aroz S, Banan B, Wang X, Rabe BJ, Zhou F, Nayak DK, Zhang Z, Jia J, Upadhya GA, Manning PT, Gaut JP, Lin Y, Chapman WC
Am J Transplant. 2018 Aug 27; doi: 10.1111/ajt.15098.

PMID:
    30152136
    [PubMed - as supplied by publisher]
Related citations


"Response to Letter to the Editor: Impact of Recurrence Surveillance on Recurrence Patterns After Resection of Hepatocellular Carcinoma".
Zheng J, Chapman WC, Turcotte S, Koerkamp BG, Lee SY, Jarnagin WR
Ann Surg. 2018 Jun 28; doi: 10.1097/SLA.0000000000002871.

PMID:
    29958228
    [PubMed - as supplied by publisher]
Related citations


The importance of early recognition in management of ERCP-related perforations.
Bill JG, Smith Z, Brancheck J, Elsner J, Hobbs P, Lang GD, Early DS, Das K, Hollander T, Doyle MBM, Fields RC, Hawkins WG, Strasberg SM, Hammill C, Chapman WC, Edmundowicz S, Mullady DK, Kushnir VM
Surg Endosc. 2018 May 16; doi: 10.1007/s00464-018-6235-8.

PMID:
    29770887
    [PubMed - as supplied by publisher]
Related citations


Benchmarking rectal cancer care: institutional compliance with a longitudinal checklist.
Chapman WC Jr, Choi P, Hawkins AT, Hunt SR, Silviera ML, Wise PE, Mutch MG, Glasgow SC
J Surg Res. 2018 May; 225142-147. doi: 10.1016/j.jss.2018.01.006.

PMID:
    29605024
    [PubMed - in process]
Related citations


Utility of Endoscopic Ultrasound in Evaluating Local Recurrence After Surgery for Pancreatic Cancer.
Lang GD, Mullady DK, Early DS, Hollander T, Edmundowicz SA, Murad FM, Strasberg SM, Fields RC, Hawkins WG, Doyle MB, Chapman WC, Wang-Gillam A, Kushnir VM
Clin Gastroenterol Hepatol. 2018 Nov; 16(11)1834-1835. doi: 10.1016/j.cgh.2018.02.031.

PMID:
    29505906
    [PubMed - in process]
Related citations


Cost Evaluation of a Donation after Cardiac Death Program: How Cost per Organ Compares to Other Donor Types.
Lindemann J, Dageforde LA, Vachharajani N, Stahlschmidt E, Brockmeier D, Wellen JR, Khan A, Chapman WC, Doyle MM
J Am Coll Surg. 2018 May; 226(5)909-916. doi: 10.1016/j.jamcollsurg.2018.02.005.

PMID:
    29505825
    [PubMed - in process]
Related citations


Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort.
Pak LM, Chakraborty J, Gonen M, Chapman WC, Do RKG, Groot Koerkamp B, Verhoef K, Lee SY, Massani M, van der Stok EP, Simpson AL, Memorial Sloan Kettering Cancer Center Hepatopancreatobiliary Service.
J Am Coll Surg. 2018 May; 226(5)835-843. doi: 10.1016/j.jamcollsurg.2018.02.001.

PMID:
    29454098
    [PubMed - in process]
Related citations


Assessment and optimization of liver volume before major hepatic resection: Current guidelines and a narrative review.
Khan AS, Garcia-Aroz S, Ansari MA, Atiq SM, Senter-Zapata M, Fowler K, Doyle MB, Chapman WC
Int J Surg. 2018 Apr; 5274-81. doi: 10.1016/j.ijsu.2018.01.042.

PMID:
    29425829
    [PubMed - indexed for MEDLINE]
Related citations


Proposed standards for reporting outcomes of treating biliary injuries.
Cho JY, Baron TH, Carr-Locke DL, Chapman WC, Costamagna G, de Santibanes E, Dominguez Rosado I, Garden OJ, Gouma D, Lillemoe KD, Angel Mercado M, Mullady DK, Padbury R, Picus D, Pitt HA, Sherman S, Shlansky-Goldberg R, Tornqvist B, Strasberg SM
HPB (Oxford). 2018 Apr; 20(4)370-378. doi: 10.1016/j.hpb.2017.10.012.

PMID:
    29397335
    [PubMed - in process]
Related citations


Optimal extent of surgical and pathologic lymph node evaluation for resected intrahepatic cholangiocarcinoma.
Brauer DG, Fields RC, Tan BR Jr, Doyle MBM, Hammill CW, Hawkins WG, Colditz GA, Chapman WC
HPB (Oxford). 2018 May; 20(5)470-476. doi: 10.1016/j.hpb.2017.11.010.

PMID:
    29370972
    [PubMed - in process]
Related citations


Patient and Graft Survival: Biliary Complications after Liver Transplantation.
Senter-Zapata M, Khan AS, Subramanian T, Vachharajani N, Dageforde LA, Wellen JR, Shenoy S, Majella Doyle MB, Chapman WC
J Am Coll Surg. 2018 Apr; 226(4)484-494. doi: 10.1016/j.jamcollsurg.2017.12.039.

PMID:
    29360615
    [PubMed - in process]
Related citations


Serum alpha-fetoprotein level per total tumor volume as a predictor of recurrence of hepatocellular carcinoma after resection.
Sharma Y, Weaver MJ, Ludwig DR, Fowler K, Vachharajani N, Chapman WC, Crippin JS
Surgery. 2018 May; 163(5)1002-1007. doi: 10.1016/j.surg.2017.10.063.

PMID:
    29284589
    [PubMed - indexed for MEDLINE]
Related citations


Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi-institution analysis from the U.S. extrahepatic biliary malignancy consortium.
Krasnick BA, Jin LX, Davidson JT 4th, Sanford DE, Ethun CG, Pawlik TM, Poultsides GA, Tran T, Idrees K, Hawkins WG, Chapman WC, Doyle MBM, Weber SM, Strasberg SM, Salem A, Martin RCG, Isom CA, Scoggins C, Schmidt CR, Shen P, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
J Surg Oncol. 2018 Mar; 117(3)363-371. doi: 10.1002/jso.24836.

PMID:
    29284072
    [PubMed - indexed for MEDLINE]
Related citations


Outcomes after vascular resection during curative-intent resection for hilar cholangiocarcinoma: a multi-institution study from the US extrahepatic biliary malignancy consortium.
Schimizzi GV, Jin LX, Davidson JT 4th, Krasnick BA, Ethun CG, Pawlik TM, Poultsides G, Tran T, Idrees K, Isom CA, Weber SM, Salem A, Hawkins WG, Strasberg SM, Doyle MB, Chapman WC, Martin RCG, Scoggins C, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
HPB (Oxford). 2018 Apr; 20(4)332-339. doi: 10.1016/j.hpb.2017.10.003.

PMID:
    29169904
    [PubMed - in process]
Related citations

Videos

Videos

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention