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Faculty Physicians

William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Surgical treatment of hepatocellular carcinoma in North America: can hepatic resection still be justified?
Chapman WC, Klintmalm G, Hemming A, Vachharajani N, Majella Doyle MB, DeMatteo R, Zaydfudim V, Chung H, Cavaness K, Goldstein R, Zendajas I, Melstrom LG, Nagorney D, Jarnagin W
J Am Coll Surg. 2015 Apr; 220(4)628-37. doi: 10.1016/j.jamcollsurg.2014.12.030.

PMID:
    25728142
    [PubMed - indexed for MEDLINE]
Related citations


Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma.
Xiao Z, Chung H, Banan B, Manning PT, Ott KC, Lin S, Capoccia BJ, Subramanian V, Hiebsch RR, Upadhya GA, Mohanakumar T, Frazier WA, Lin Y, Chapman WC
Cancer Lett. 2015 May 1; 360(2)302-9. doi: 10.1016/j.canlet.2015.02.036.

PMID:
    25721088
    [PubMed - indexed for MEDLINE]
Related citations


Standardizing a control group for comparing open with laparoscopic major liver resection in observational studies: reducing the need for correction of clinical heterogeneity.
Panni RZ, Hall BL, Chapman WC, Strasberg SM
J Am Coll Surg. 2014 Dec; 219(6)1124-33. doi: 10.1016/j.jamcollsurg.2014.08.010.

PMID:
    25442067
    [PubMed - indexed for MEDLINE]
Related citations


Comparison of the transcriptional landscapes between human and mouse tissues.
Lin S, Lin Y, Nery JR, Urich MA, Breschi A, Davis CA, Dobin A, Zaleski C, Beer MA, Chapman WC, Gingeras TR, Ecker JR, Snyder MP
Proc Natl Acad Sci U S A. 2014 Dec 2; 111(48)17224-9. doi: 10.1073/pnas.1413624111.

PMID:
    25413365
    [PubMed - indexed for MEDLINE]
Related citations


Current surgical treatment strategies for hepatocellular carcinoma in North America.
Khan AS, Fowler KJ, Chapman WC
World J Gastroenterol. 2014 Nov 7; 20(41)15007-17. doi: 10.3748/wjg.v20.i41.15007.

PMID:
    25386049
    [PubMed - indexed for MEDLINE]
Related citations


Early survival and safety of ALPPS: first report of the International ALPPS Registry.
Schadde E, Ardiles V, Robles-Campos R, Malago M, Machado M, Hernandez-Alejandro R, Soubrane O, Schnitzbauer AA, Raptis D, Tschuor C, Petrowsky H, De Santibanes E, Clavien PA, ALPPS Registry Group
Ann Surg. 2014 Nov; 260(5)829-36; discussion 836-8. doi: 10.1097/SLA.0000000000000947.

PMID:
    25379854
    [PubMed - indexed for MEDLINE]
Related citations


Liver transplantation for metastatic neuroendocrine tumors.
Chung H, Chapman WC
Adv Surg. 2014; 48235-52.

PMID:
    25293619
    [PubMed - indexed for MEDLINE]
Related citations


Characterization of inflammatory (lymphoepithelioma-like) hepatocellular carcinoma: a study of 8 cases.
Patel KR, Liu TC, Vaccharajani N, Chapman WC, Brunt EM
Arch Pathol Lab Med. 2014 Sep; 138(9)1193-202. doi: 10.5858/arpa.2013-0371-OA.

PMID:
    25171701
    [PubMed - indexed for MEDLINE]
Related citations


Hepatic venous outflow obstruction in pediatric liver transplantation: technical considerations in prevention, diagnosis, and management.
Sommovilla J, Doyle MM, Vachharajani N, Saad N, Nadler M, Turmelle YP, Weymann A, Chapman WC, Lowell JA
Pediatr Transplant. 2014 Aug; 18(5)497-502. doi: 10.1111/petr.12277.

PMID:
    24815309
    [PubMed - indexed for MEDLINE]
Related citations


SALL4 immunoreactivity predicts prognosis in Western hepatocellular carcinoma patients but is a rare event: a study of 236 cases.
Liu TC, Vachharajani N, Chapman WC, Brunt EM
Am J Surg Pathol. 2014 Jul; 38(7)966-72. doi: 10.1097/PAS.0000000000000218.

PMID:
    24805857
    [PubMed - indexed for MEDLINE]
Related citations


A novel organ donor facility: a decade of experience with liver donors.
Doyle MB, Vachharajani N, Wellen JR, Lowell JA, Shenoy S, Ridolfi G, Jendrisak MD, Coleman J, Maher M, Brockmeier D, Kappel D, Chapman WC
Am J Transplant. 2014 Mar; 14(3)615-20.

PMID:
    24612713
    [PubMed - indexed for MEDLINE]
Related citations


Effect of donor body mass index on the outcome of donation after cardiac death kidneys: how big is too big?
Jin LX, Pitt SC, Doyle MB, Klein C, Shenoy S, Lowell JA, Chapman WC, Wellen JR
Transplant Proc. 2014 Jan-Feb; 46(1)46-9. doi: 10.1016/j.transproceed.2013.07.068.

PMID:
    24507024
    [PubMed - indexed for MEDLINE]
Related citations


Liver volume in the cirrhotic patient: does size matter?
Hagan MT, Sayuk GS, Lisker-Melman M, Korenblat KM, Kerr TA, Chapman WC, Crippin JS
Dig Dis Sci. 2014 Apr; 59(4)886-91. doi: 10.1007/s10620-014-3038-1.

PMID:
    24504591
    [PubMed - indexed for MEDLINE]
Related citations


Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis.
Sarma NJ, Tiriveedhi V, Crippin JS, Chapman WC, Mohanakumar T
J Virol. 2014 Apr; 88(7)3733-43. doi: 10.1128/JVI.03060-13.

PMID:
    24429361
    [PubMed - indexed for MEDLINE]
Related citations


Immune responses to collagen-IV and fibronectin in renal transplant recipients with transplant glomerulopathy.
Angaswamy N, Klein C, Tiriveedhi V, Gaut J, Anwar S, Rossi A, Phelan D, Wellen JR, Shenoy S, Chapman WC, Mohanakumar T
Am J Transplant. 2014 Mar; 14(3)685-93. doi: 10.1111/ajt.12592.

PMID:
    24410875
    [PubMed - indexed for MEDLINE]
Related citations


Organ allocation in pediatric renal transplants: is there an optimal donor?
Pitt SC, Vachharajani N, Doyle MB, Lowell JA, Chapman WC, Anderson CD, Shenoy S, Wellen JR
Clin Transplant. 2013 Nov-Dec; 27(6)938-44. doi: 10.1111/ctr.12272.

PMID:
    24224847
    [PubMed - indexed for MEDLINE]
Related citations


Noncirrhotic hepatocellular carcinoma: derivation from hepatocellular adenoma? Clinicopathologic analysis.
Liu TC, Vachharajani N, Chapman WC, Brunt EM
Mod Pathol. 2014 Mar; 27(3)420-32. doi: 10.1038/modpathol.2013.148.

PMID:
    24051694
    [PubMed - indexed for MEDLINE]
Related citations


Bouveret's syndrome complicated by classic gallstone ileus: progression of disease or iatrogenic?
Reinhardt SW, Jin LX, Pitt SC, Earl TM, Chapman WC, Doyle MB
J Gastrointest Surg. 2013 Nov; 17(11)2020-4. doi: 10.1007/s11605-013-2301-7.

PMID:
    24018589
    [PubMed - indexed for MEDLINE]
Related citations


Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis.
Ramachandran S, Ilias Basha H, Sarma NJ, Lin Y, Crippin JS, Chapman WC, Mohanakumar T
PLoS One. 2013; 8(8)e70744. doi: 10.1371/journal.pone.0070744.

PMID:
    23950995
    [PubMed - indexed for MEDLINE]
Related citations


Hepatocellular carcinoma: resection versus transplantation.
Earl TM, Chapman WC
Semin Liver Dis. 2013 Aug; 33(3)282-92. doi: 10.1055/s-0033-1351783.

PMID:
    23943108
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention