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William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Utility of Endoscopic Ultrasound in Evaluating Local Recurrence After Surgery for Pancreatic Cancer.
Lang GD, Mullady DK, Early DS, Hollander T, Edmundowicz SA, Murad FM, Strasberg SM, Fields RC, Hawkins WG, Doyle MB, Chapman WC, Wang-Gillam A, Kushnir VM
Clin Gastroenterol Hepatol. 2018 Mar 2; pii: S1542-3565(18)30219-2. doi: 10.1016/j.cgh.2018.02.031.

PMID:
    29505906
    [PubMed - as supplied by publisher]
Related citations


A Cost Evaluation of a Donation after Cardiac Death Program: How Cost per Organ Compares to Other Donor Types.
Lindemann J, Dageforde LA, Vachharajani N, Stahlschmidt E, Brockmeier D, Wellen JR, Khan A, Chapman WC, Doyle M
J Am Coll Surg. 2018 Mar 2; pii: S1072-7515(18)30159-5. doi: 10.1016/j.jamcollsurg.2018.02.005.

PMID:
    29505825
    [PubMed - as supplied by publisher]
Related citations


Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort.
Pak LM, Chakraborty J, Gonen M, Chapman WC, Do RKG, Groot Koerkamp B, Verhoef K, Lee SY, Massani M, van der Stok EP, Simpson AL, Memorial Sloan Kettering Cancer Center Hepatopancreatobiliary Service.
J Am Coll Surg. 2018 Feb 15; pii: S1072-7515(18)30122-4. doi: 10.1016/j.jamcollsurg.2018.02.001.

PMID:
    29454098
    [PubMed - as supplied by publisher]
Related citations


Assessment and optimization of liver volume before major hepatic resection: Current guidelines and a narrative review.
Khan AS, Garcia-Aroz S, Ansari MA, Atiq SM, Senter-Zapata M, Fowler K, Doyle MB, Chapman WC
Int J Surg. 2018 Apr; 5274-81. doi: 10.1016/j.ijsu.2018.01.042.

PMID:
    29425829
    [PubMed - in process]
Related citations


Proposed standards for reporting outcomes of treating biliary injuries.
Cho JY, Baron TH, Carr-Locke DL, Chapman WC, Costamagna G, de Santibanes E, Dominguez Rosado I, Garden OJ, Gouma D, Lillemoe KD, Angel Mercado M, Mullady DK, Padbury R, Picus D, Pitt HA, Sherman S, Shlansky-Goldberg R, Tornqvist B, Strasberg SM
HPB (Oxford). 2018 Apr; 20(4)370-378. doi: 10.1016/j.hpb.2017.10.012.

PMID:
    29397335
    [PubMed - in process]
Related citations


Optimal extent of surgical and pathologic lymph node evaluation for resected intrahepatic cholangiocarcinoma.
Brauer DG, Fields RC, Tan BR Jr., Doyle MBM, Hammill CW, Hawkins WG, Colditz GA, Chapman WC
HPB (Oxford). 2018 Jan 19; pii: S1365-182X(17)31164-4. doi: 10.1016/j.hpb.2017.11.010.

PMID:
    29370972
    [PubMed - as supplied by publisher]
Related citations


Patient and Graft Survival: Biliary Complications after Liver Transplantation.
Senter-Zapata M, Khan AS, Subramanian T, Vachharajani N, Dageforde LA, Wellen JR, Shenoy S, Majella Doyle MB, Chapman WC
J Am Coll Surg. 2018 Apr; 226(4)484-494. doi: 10.1016/j.jamcollsurg.2017.12.039.

PMID:
    29360615
    [PubMed - in process]
Related citations


Serum alpha-fetoprotein level per total tumor volume as a predictor of recurrence of hepatocellular carcinoma after resection.
Sharma Y, Weaver MJ, Ludwig DR, Fowler K, Vachharajani N, Chapman WC, Crippin JS
Surgery. 2017 Dec 25; pii: S0039-6060(17)30804-8. doi: 10.1016/j.surg.2017.10.063.

PMID:
    29284589
    [PubMed - as supplied by publisher]
Related citations


Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi-institution analysis from the U.S. extrahepatic biliary malignancy consortium.
Krasnick BA, Jin LX, Davidson JT 4th, Sanford DE, Ethun CG, Pawlik TM, Poultsides GA, Tran T, Idrees K, Hawkins WG, Chapman WC, Doyle MBM, Weber SM, Strasberg SM, Salem A, Martin RCG, Isom CA, Scoggins C, Schmidt CR, Shen P, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
J Surg Oncol. 2018 Mar; 117(3)363-371. doi: 10.1002/jso.24836.

PMID:
    29284072
    [PubMed - indexed for MEDLINE]
Related citations


Outcomes after vascular resection during curative-intent resection for hilar cholangiocarcinoma: a multi-institution study from the US extrahepatic biliary malignancy consortium.
Schimizzi GV, Jin LX, Davidson JT 4th, Krasnick BA, Ethun CG, Pawlik TM, Poultsides G, Tran T, Idrees K, Isom CA, Weber SM, Salem A, Hawkins WG, Strasberg SM, Doyle MB, Chapman WC, Martin RCG, Scoggins C, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
HPB (Oxford). 2018 Apr; 20(4)332-339. doi: 10.1016/j.hpb.2017.10.003.

PMID:
    29169904
    [PubMed - in process]
Related citations


Prospective Evaluation of Pasireotide in Patients Undergoing Pancreaticoduodenectomy: The Washington University Experience.
Dominguez-Rosado I, Fields RC, Woolsey CA, Williams G, Horwedel TA, Rose JB, Hammill CW, Doyle MB, Chapman WC, Strasberg SM, Hawkins WG, Sanford DE
J Am Coll Surg. 2018 Feb; 226(2)147-154.e1. doi: 10.1016/j.jamcollsurg.2017.10.021.

PMID:
    29133263
    [PubMed - in process]
Related citations


Anti-CD47 monoclonal antibody therapy reduces ischemia-reperfusion injury of renal allografts in a porcine model of donation after cardiac death.
Xu M, Wang X, Banan B, Chirumbole DL, Garcia-Aroz S, Balakrishnan A, Nayak DK, Zhang Z, Jia J, Upadhya GA, Gaut JP, Hiebsch R, Manning PT, Wu N, Lin Y, Chapman WC
Am J Transplant. 2018 Apr; 18(4)855-867. doi: 10.1111/ajt.14567.

PMID:
    29087049
    [PubMed - in process]
Related citations


Response: "Which is the True Role of Bridging Therapies for HCC Patients Waiting for Liver Transplantation?"
Agopian VG, Chapman WC, Busuttil RW, United States Multicenter Hepatocellular Carcinoma Transplant Consortium (UMHTC).
Ann Surg. 2017 Oct 23; doi: 10.1097/SLA.0000000000002577.

PMID:
    29064906
    [PubMed - as supplied by publisher]
Related citations


Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease.
Ethun CG, Lopez-Aguiar AG, Anderson DJ, Adams AB, Fields RC, Doyle MB, Chapman WC, Krasnick BA, Weber SM, Mezrich JD, Salem A, Pawlik TM, Poultsides G, Tran TB, Idrees K, Isom CA, Martin RCG, Scoggins CR, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Cardona K, Maithel SK
Ann Surg. 2018 May; 267(5)797-805. doi: 10.1097/SLA.0000000000002574.

PMID:
    29064885
    [PubMed - in process]
Related citations


Surgeon Variation in Intraoperative Supply Cost for Pancreaticoduodenectomy: Is Intraoperative Supply Cost Associated with Outcomes?
Brauer DG, Ohman KA, Jaques DP, Woolsey CA, Wu N, Liu J, Doyle MBM, Fields RC, Chapman WC, Strasberg SM, Hawkins WG
J Am Coll Surg. 2018 Jan; 226(1)37-45.e1. doi: 10.1016/j.jamcollsurg.2017.10.007.

PMID:
    29056314
    [PubMed - in process]
Related citations


CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation.
Wang X, Xu M, Jia J, Zhang Z, Gaut JP, Upadhya GA, Manning PT, Lin Y, Chapman WC
Am J Transplant. 2018 Apr; 18(4)843-854. doi: 10.1111/ajt.14523.

PMID:
    28975767
    [PubMed - in process]
Related citations


Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Quantitative Image Analysis.
Zheng J, Chakraborty J, Chapman WC, Gerst S, Gonen M, Pak LM, Jarnagin WR, DeMatteo RP, Do RKG, Simpson AL, Hepatopancreatobiliary Service in the Department of Surgery of the Memorial Sloan Kettering Cancer Center., Research Staff in the Department of Surgery at Washington University School of Medicine.
J Am Coll Surg. 2017 Dec; 225(6)778-788.e1. doi: 10.1016/j.jamcollsurg.2017.09.003.

PMID:
    28941728
    [PubMed - indexed for MEDLINE]
Related citations


Defining Benchmarks in Liver Transplantation: A Multicenter Outcome Analysis Determining Best Achievable Results.
Muller X, Marcon F, Sapisochin G, Marquez M, Dondero F, Rayar M, Doyle MMB, Callans L, Li J, Nowak G, Allard MA, Jochmans I, Jacskon K, Beltrame MC, van Reeven M, Iesari S, Cucchetti A, Sharma H, Staiger RD, Raptis DA, Petrowsky H, de Oliveira M, Hernandez-Alejandro R, Pinna AD, Lerut J, Polak WG, de Santibañes E, de Santibañes M, Cameron AM, Pirenne J, Cherqui D, Adam RA, Ericzon BG, Nashan B, Olthoff K, Shaked A, Chapman WC, Boudjema K, Soubrane O, Paugam-Burtz C, Greig PD, Grant DR, Carvalheiro A, Muiesan P, Dutkowski P, Puhan M, Clavien PA
Ann Surg. 2018 Mar; 267(3)419-425. doi: 10.1097/SLA.0000000000002477.

PMID:
    28885508
    [PubMed - in process]
Related citations


Challenges in patient selection for liver resection or transplantation in patients with hepatocellular carcinoma beyond Milan criteria.
Zaydfudim VM, Chapman WC, Nagorney DM
Hepatobiliary Surg Nutr. 2017 Aug; 6(4)287-289. doi: 10.21037/hbsn.2017.07.04.

PMID:
    28848757
    [PubMed]
Related citations


Reexamining the Association of Body Mass Index With Overall Survival Outcomes After Liver Transplantation.
Chang SH, Liu X, Carlsson NP, Park Y, Colditz GA, Garonzik-Wang JM, Chapman WC, Wellen JR, Doyle MB, Alhamad T
Transplant Direct. 2017 Jul; 3(7)e172. doi: 10.1097/TXD.0000000000000681.

PMID:
    28706975
    [PubMed]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2017

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention