FollowMyHealth Patient Portal

William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Serum alpha-fetoprotein level per total tumor volume as a predictor of recurrence of hepatocellular carcinoma after resection.
Sharma Y, Weaver MJ, Ludwig DR, Fowler K, Vachharajani N, Chapman WC, Crippin JS
Surgery. 2017 Dec 25; pii: S0039-6060(17)30804-8. doi: 10.1016/j.surg.2017.10.063.

PMID:
    29284589
    [PubMed - as supplied by publisher]
Related citations


Adjuvant therapy is associated with improved survival after curative resection for hilar cholangiocarcinoma: A multi-institution analysis from the U.S. extrahepatic biliary malignancy consortium.
Krasnick BA, Jin LX, Davidson JT 4th, Sanford DE, Ethun CG, Pawlik TM, Poultsides GA, Tran T, Idrees K, Hawkins WG, Chapman WC, Doyle MBM, Weber SM, Strasberg SM, Salem A, Martin RCG, Isom CA, Scoggins C, Schmidt CR, Shen P, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
J Surg Oncol. 2017 Dec 28; doi: 10.1002/jso.24836.

PMID:
    29284072
    [PubMed - as supplied by publisher]
Related citations


Outcomes after vascular resection during curative-intent resection for hilar cholangiocarcinoma: a multi-institution study from the US extrahepatic biliary malignancy consortium.
Schimizzi GV, Jin LX, Davidson JT 4th, Krasnick BA, Ethun CG, Pawlik TM, Poultsides G, Tran T, Idrees K, Isom CA, Weber SM, Salem A, Hawkins WG, Strasberg SM, Doyle MB, Chapman WC, Martin RCG, Scoggins C, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Maithel SK, Fields RC
HPB (Oxford). 2017 Nov 20; pii: S1365-182X(17)31090-0. doi: 10.1016/j.hpb.2017.10.003.

PMID:
    29169904
    [PubMed - as supplied by publisher]
Related citations


Prospective Evaluation of Pasireotide in Patients Undergoing Pancreaticoduodenectomy: The Washington University Experience.
Dominguez-Rosado I, Fields RC, Woolsey CA, Williams G, Horwedel TA, Rose JB, Hammill CW, Doyle MB, Chapman WC, Strasberg SM, Hawkins WG, Sanford DE
J Am Coll Surg. 2017 Nov 11; pii: S1072-7515(17)32066-5. doi: 10.1016/j.jamcollsurg.2017.10.021.

PMID:
    29133263
    [PubMed - as supplied by publisher]
Related citations


Anti-CD47 monoclonal antibody therapy reduces ischemia-reperfusion injury of renal allografts in a porcine model of donation after cardiac death.
Xu M, Wang X, Banan B, Chirumbole DL, Garcia-Aroz S, Balakrishnan A, Nayak DK, Zhang Z, Jia J, Upadhya GA, Gaut JP, Hiebsch R, Manning PT, Wu N, Lin Y, Chapman WC
Am J Transplant. 2017 Oct 31; doi: 10.1111/ajt.14567.

PMID:
    29087049
    [PubMed - as supplied by publisher]
Related citations


Response: "Which is the True Role of Bridging Therapies for HCC Patients Waiting for Liver Transplantation?"
Agopian VG, Chapman WC, Busuttil RW, United States Multicenter Hepatocellular Carcinoma Transplant Consortium (UMHTC).
Ann Surg. 2017 Oct 23; doi: 10.1097/SLA.0000000000002577.

PMID:
    29064906
    [PubMed - as supplied by publisher]
Related citations


Transplantation Versus Resection for Hilar Cholangiocarcinoma: An Argument for Shifting Treatment Paradigms for Resectable Disease.
Ethun CG, Lopez-Aguiar AG, Anderson DJ, Adams AB, Fields RC, Doyle MB, Chapman WC, Krasnick BA, Weber SM, Mezrich JD, Salem A, Pawlik TM, Poultsides G, Tran TB, Idrees K, Isom CA, Martin RCG, Scoggins CR, Shen P, Mogal HD, Schmidt C, Beal E, Hatzaras I, Shenoy R, Cardona K, Maithel SK
Ann Surg. 2017 Oct 23; doi: 10.1097/SLA.0000000000002574.

PMID:
    29064885
    [PubMed - as supplied by publisher]
Related citations


Surgeon Variation in Intraoperative Supply Cost for Pancreaticoduodenectomy: Is Intraoperative Supply Cost Associated with Outcomes?
Brauer DG, Ohman KA, Jaques DP, Woolsey CA, Wu N, Liu J, Doyle MBM, Fields RC, Chapman WC, Strasberg SM, Hawkins WG
J Am Coll Surg. 2018 Jan; 226(1)37-45.e1. doi: 10.1016/j.jamcollsurg.2017.10.007.

PMID:
    29056314
    [PubMed - in process]
Related citations


CD47 blockade reduces ischemia/reperfusion injury in donation after cardiac death rat kidney transplantation.
Wang X, Xu M, Jia J, Zhang Z, Gaut JP, Upadhya GA, Manning PT, Lin Y, Chapman WC
Am J Transplant. 2017 Oct 4; doi: 10.1111/ajt.14523.

PMID:
    28975767
    [PubMed - as supplied by publisher]
Related citations


Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Quantitative Image Analysis.
Zheng J, Chakraborty J, Chapman WC, Gerst S, Gonen M, Pak LM, Jarnagin WR, DeMatteo RP, Do RKG, Simpson AL, Hepatopancreatobiliary Service in the Department of Surgery of the Memorial Sloan Kettering Cancer Center., Research Staff in the Department of Surgery at Washington University School of Medicine.
J Am Coll Surg. 2017 Dec; 225(6)778-788.e1. doi: 10.1016/j.jamcollsurg.2017.09.003.

PMID:
    28941728
    [PubMed - indexed for MEDLINE]
Related citations


Defining Benchmarks in Liver Transplantation: A Multicenter Outcome Analysis Determining Best Achievable Results.
Muller X, Marcon F, Sapisochin G, Marquez M, Dondero F, Rayar M, Doyle MMB, Callans L, Li J, Nowak G, Allard MA, Jochmans I, Jacskon K, Beltrame MC, van Reeven M, Iesari S, Cucchetti A, Sharma H, Staiger RD, Raptis DA, Petrowsky H, de Oliveira M, Hernandez-Alejandro R, Pinna AD, Lerut J, Polak WG, de Santibañes E, de Santibañes M, Cameron AM, Pirenne J, Cherqui D, Adam RA, Ericzon BG, Nashan B, Olthoff K, Shaked A, Chapman WC, Boudjema K, Soubrane O, Paugam-Burtz C, Greig PD, Grant DR, Carvalheiro A, Muiesan P, Dutkowski P, Puhan M, Clavien PA
Ann Surg. 2017 Sep 6; doi: 10.1097/SLA.0000000000002477.

PMID:
    28885508
    [PubMed - as supplied by publisher]
Related citations


Challenges in patient selection for liver resection or transplantation in patients with hepatocellular carcinoma beyond Milan criteria.
Zaydfudim VM, Chapman WC, Nagorney DM
Hepatobiliary Surg Nutr. 2017 Aug; 6(4)287-289. doi: 10.21037/hbsn.2017.07.04.

PMID:
    28848757
    [PubMed]
Related citations


Reexamining the Association of Body Mass Index With Overall Survival Outcomes After Liver Transplantation.
Chang SH, Liu X, Carlsson NP, Park Y, Colditz GA, Garonzik-Wang JM, Chapman WC, Wellen JR, Doyle MB, Alhamad T
Transplant Direct. 2017 Jul; 3(7)e172. doi: 10.1097/TXD.0000000000000681.

PMID:
    28706975
    [PubMed]
Related citations


Impact of Pretransplant Bridging Locoregional Therapy for Patients With Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients From the US Multicenter HCC Transplant Consortium.
Agopian VG, Harlander-Locke MP, Ruiz RM, Klintmalm GB, Senguttuvan S, Florman SS, Haydel B, Hoteit M, Levine MH, Lee DD, Taner CB, Verna EC, Halazun KJ, Abdelmessih R, Tevar AD, Humar A, Aucejo F, Chapman WC, Vachharajani N, Nguyen MH, Melcher ML, Nydam TL, Mobley C, Ghobrial RM, Amundsen B, Markmann JF, Langnas AN, Carney CA, Berumen J, Hemming AW, Sudan DL, Hong JC, Kim J, Zimmerman MA, Rana A, Kueht ML, Jones CM, Fishbein TM, Busuttil RW
Ann Surg. 2017 Sep; 266(3)525-535. doi: 10.1097/SLA.0000000000002381.

PMID:
    28654545
    [PubMed - indexed for MEDLINE]
Related citations


Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection: Validation of a Clinical Risk Score in an International Cohort.
Zheng J, Chou JF, Gönen M, Vachharajani N, Chapman WC, Majella Doyle MB, Turcotte S, Vandenbroucke-Menu F, Lapointe R, Buettner S, Groot Koerkamp B, Ijzermans JNM, Chan CY, Goh BKP, Teo JY, Kam JH, Jeyaraj PR, Cheow PC, Chung AYF, Chow PKH, Ooi LLPJ, Balachandran VP, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Jarnagin WR, Lee SY
Ann Surg. 2017 Oct; 266(4)693-701. doi: 10.1097/SLA.0000000000002360.

PMID:
    28650354
    [PubMed - indexed for MEDLINE]
Related citations


Development of immune response to tissue-restricted self-antigens in simultaneous kidney-pancreas transplant recipients with acute rejection.
Gunasekaran M, Vachharajani N, Gaut JP, Maw TT, Delos Santos R, Shenoy S, Chapman WC, Wellen J, Mohanakumar T
Clin Transplant. 2017 Aug; 31(8)doi: 10.1111/ctr.13009.

PMID:
    28639386
    [PubMed - in process]
Related citations


LI-RADS and transplantation for hepatocellular carcinoma.
Tang A, Fowler KJ, Chernyak V, Chapman WC, Sirlin CB
Abdom Radiol (NY). 2018 Jan; 43(1)193-202. doi: 10.1007/s00261-017-1210-8.

PMID:
    28612162
    [PubMed - in process]
Related citations


Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.
Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA
Sci Immunol. 2017 Apr 21; 2(10)pii: eaai7616. doi: 10.1126/sciimmunol.aai7616.

PMID:
    28567448
    [PubMed]
Related citations


Neoadjuvant Locoregional Therapy and Recurrent Hepatocellular Carcinoma after Liver Transplantation.
Xu M, Doyle MM, Banan B, Vachharajani N, Wang X, Saad N, Fowler K, Brunt EM, Lin Y, Chapman WC
J Am Coll Surg. 2017 Jul; 225(1)28-40. doi: 10.1016/j.jamcollsurg.2017.03.015.

PMID:
    28400300
    [PubMed - indexed for MEDLINE]
Related citations


Liver Transplantation for Malignant Primary Pediatric Hepatic Tumors.
Khan AS, Brecklin B, Vachharajani N, Subramanian V, Nadler M, Stoll J, Turmelle Y, Lowell JA, Chapman WC, Doyle MM
J Am Coll Surg. 2017 Jul; 225(1)103-113. doi: 10.1016/j.jamcollsurg.2017.02.006.

PMID:
    28232059
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2017

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention