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William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.
Santos CA, Hotchkiss RS, Chapman WC, Olsen MA
Transplant Direct. 2016 Mar; 2(3)e67. doi: 10.1097/TXD.0000000000000573.

PMID:
    27458606
    [PubMed]
Related citations


Liver Resection and Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria.
Zaydfudim VM, Vachharajani N, Klintmalm GB, Jarnagin WR, Hemming AW, Doyle MB, Cavaness KM, Chapman WC, Nagorney DM
Ann Surg. 2016 Oct; 264(4)650-8. doi: 10.1097/SLA.0000000000001866.

PMID:
    27433910
    [PubMed - in process]
Related citations


Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody.
Xiao Z, Banan B, Xu M, Jia J, Manning PT, Hiebsch RR, Gunasekaran M, Upadhya GA, Frazier WA, Mohanakumar T, Lin Y, Chapman WC
Transplantation. 2016 Jul; 100(7)1480-9. doi: 10.1097/TP.0000000000001186.

PMID:
    27331362
    [PubMed - in process]
Related citations


HPB Surgery: The Specialty is Here to Stay, but the Training is in Evolution.
D'Angelica MI, Chapman WC
Ann Surg Oncol. 2016 Jul; 23(7)2123-5. doi: 10.1245/s10434-016-5230-3.

PMID:
    27138384
    [PubMed - in process]
Related citations


Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation.
Leal JN, Bressan AK, Vachharajani N, Gonen M, Kingham TP, D'Angelica MI, Allen PJ, DeMatteo RP, Doyle MB, Bathe OF, Greig PD, Wei A, Chapman WC, Dixon E, Jarnagin WR
J Am Coll Surg. 2016 May; 222(5)766-79. doi: 10.1016/j.jamcollsurg.2016.01.046.

PMID:
    27113514
    [PubMed - in process]
Related citations


Results of Simultaneous Liver and Kidney Transplantation: A Single-Center Review.
Doyle MB, Subramanian V, Vachharajani N, Maynard E, Shenoy S, Wellen JR, Lin Y, Chapman WC
J Am Coll Surg. 2016 Jul; 223(1)193-201. doi: 10.1016/j.jamcollsurg.2016.04.005.

PMID:
    27103549
    [PubMed - in process]
Related citations


Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging.
Owen JW, Fowler KJ, Doyle MB, Saad NE, Linehan DC, Chapman WC
HPB (Oxford). 2016 Mar; 18(3)296-303. doi: 10.1016/j.hpb.2015.10.009.

PMID:
    27017170
    [PubMed - in process]
Related citations


Surgical Training in the United States: Is It Time for a Paradigm Shift?
Chapman WC
J Am Coll Surg. 2016 Jul; 223(1)1-7. doi: 10.1016/j.jamcollsurg.2016.01.055.

PMID:
    27012839
    [PubMed - in process]
Related citations


Organ Donor Recovery Performed at an Organ Procurement Organization-Based Facility Is an Effective Way to Minimize Organ Recovery Costs and Increase Organ Yield.
Doyle M, Subramanian V, Vachharajani N, Collins K, Wellen JR, Stahlschmidt E, Brockmeier D, Coleman J, Kappel D, Chapman WC
J Am Coll Surg. 2016 Apr; 222(4)591-600. doi: 10.1016/j.jamcollsurg.2015.12.032.

PMID:
    26947113
    [PubMed - indexed for MEDLINE]
Related citations


The new lottery ticket: Share 35.
Chapman WC
Liver Transpl. 2016 Apr; 22(4)393-5. doi: 10.1002/lt.24420.

PMID:
    26915465
    [PubMed - indexed for MEDLINE]
Related citations


Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial.
Genyk Y, Kato T, Pomposelli JJ, Wright JK Jr, Sher LS, Tetens V, Chapman WC
J Am Coll Surg. 2016 Mar; 222(3)261-8. doi: 10.1016/j.jamcollsurg.2015.12.007.

PMID:
    26776356
    [PubMed - indexed for MEDLINE]
Related citations


A quantitative model to predict blood use in adult orthotopic liver transplantation.
Liu C, Vachharajani N, Song S, Cooke R, Kangrga I, Chapman WC, Grossman BJ
Transfus Apher Sci. 2015 Dec; 53(3)386-92. doi: 10.1016/j.transci.2015.07.008.

PMID:
    26297190
    [PubMed - in process]
Related citations


Liver Transplantation and Donor Age: In Reply to Detry.
Majella Doyle MB, Chapman WC
J Am Coll Surg. 2015 Sep; 221(3)780. doi: 10.1016/j.jamcollsurg.2015.06.002.

PMID:
    26296684
    [PubMed - indexed for MEDLINE]
Related citations


Normothermic extracorporeal liver perfusion for donation after cardiac death (DCD) livers.
Banan B, Chung H, Xiao Z, Tarabishy Y, Jia J, Manning P, Upadhya GA, Mohanakumar T, Lin Y, Chapman WC
Surgery. 2015 Dec; 158(6)1642-50. doi: 10.1016/j.surg.2015.07.016.

PMID:
    26294088
    [PubMed - indexed for MEDLINE]
Related citations


Biphenotypic Primary Liver Carcinomas: Assessing Outcomes of Hepatic Directed Therapy.
Fowler K, Saad NE, Brunt E, Doyle MB, Amin M, Vachharajani N, Tan B, Chapman WC
Ann Surg Oncol. 2015 Dec; 22(13)4130-7. doi: 10.1245/s10434-015-4774-y.

PMID:
    26293835
    [PubMed - indexed for MEDLINE]
Related citations


Equalizing MELD Scores Over Broad Geographies Is Not the Most Efficacious Way to Allocate a Scarce Resource in a Value-based Environment.
Reed A, Chapman WC, Knechtle S, Chavin K, Gilroy R, Klintmalm GB
Ann Surg. 2015 Aug; 262(2)220-3. doi: 10.1097/SLA.0000000000001331.

PMID:
    26164428
    [PubMed - indexed for MEDLINE]
Related citations


Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study.
Fischer L, Saliba F, Kaiser GM, De Carlis L, Metselaar HJ, De Simone P, Duvoux C, Nevens F, Fung JJ, Dong G, Rauer B, Junge G, H2304 Study Group
Transplantation. 2015 Jul; 99(7)1455-62. doi: 10.1097/TP.0000000000000555.

PMID:
    26151607
    [PubMed - indexed for MEDLINE]
Related citations


Organ Procurement Organization Liver Acquisition Costs Could More Than Double With Proposed Redistricts.
Kappel DF, Chapman WC, Conrad S, Reed A, Linderer R, Dunn S, Niles P, Levy MF, Cawiezell T
Am J Transplant. 2015 Aug; 15(8)2269-70. doi: 10.1111/ajt.13346.

PMID:
    26096181
    [PubMed - indexed for MEDLINE]
Related citations


Outcomes Using Grafts from Donors after Cardiac Death.
Doyle MB, Collins K, Vachharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC
J Am Coll Surg. 2015 Jul; 221(1)142-52. doi: 10.1016/j.jamcollsurg.2015.03.053.

PMID:
    26095563
    [PubMed - indexed for MEDLINE]
Related citations


The hepatic buttress: A novel surgical technique to treat an intrapericardial diaphragmatic defect after hybrid myocardial ablation.
Chapman WC Jr, Sosin M, Salameh JR, Espinel CF
J Thorac Cardiovasc Surg. 2015 Jul; 150(1)e5-7. doi: 10.1016/j.jtcvs.2015.03.065.

PMID:
    25957456
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention