FollowMyHealth Patient Portal

Faculty Physicians

William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial.
Genyk Y, Kato T, Pomposelli JJ, Wright JK Jr, Sher LS, Tetens V, Chapman WC
J Am Coll Surg. 2015 Dec 18; pii: S1072-7515(15)01777-9. doi: 10.1016/j.jamcollsurg.2015.12.007.

PMID:
    26776356
    [PubMed - as supplied by publisher]
Related citations


A quantitative model to predict blood use in adult orthotopic liver transplantation.
Liu C, Vachharajani N, Song S, Cooke R, Kangrga I, Chapman WC, Grossman BJ
Transfus Apher Sci. 2015 Dec; 53(3)386-92. doi: 10.1016/j.transci.2015.07.008.

PMID:
    26297190
    [PubMed - in process]
Related citations


Liver Transplantation and Donor Age: In Reply to Detry.
Majella Doyle MB, Chapman WC
J Am Coll Surg. 2015 Sep; 221(3)780. doi: 10.1016/j.jamcollsurg.2015.06.002.

PMID:
    26296684
    [PubMed - indexed for MEDLINE]
Related citations


Normothermic extracorporeal liver perfusion for donation after cardiac death (DCD) livers.
Banan B, Chung H, Xiao Z, Tarabishy Y, Jia J, Manning P, Upadhya GA, Mohanakumar T, Lin Y, Chapman WC
Surgery. 2015 Dec; 158(6)1642-50. doi: 10.1016/j.surg.2015.07.016.

PMID:
    26294088
    [PubMed - in process]
Related citations


Biphenotypic Primary Liver Carcinomas: Assessing Outcomes of Hepatic Directed Therapy.
Fowler K, Saad NE, Brunt E, Doyle MB, Amin M, Vachharajani N, Tan B, Chapman WC
Ann Surg Oncol. 2015 Dec; 22(13)4130-7. doi: 10.1245/s10434-015-4774-y.

PMID:
    26293835
    [PubMed - in process]
Related citations


Equalizing MELD Scores Over Broad Geographies Is Not the Most Efficacious Way to Allocate a Scarce Resource in a Value-based Environment.
Reed A, Chapman WC, Knechtle S, Chavin K, Gilroy R, Klintmalm GB
Ann Surg. 2015 Aug; 262(2)220-3. doi: 10.1097/SLA.0000000000001331.

PMID:
    26164428
    [PubMed - indexed for MEDLINE]
Related citations


Three-year Outcomes in De Novo Liver Transplant Patients Receiving Everolimus With Reduced Tacrolimus: Follow-Up Results From a Randomized, Multicenter Study.
Fischer L, Saliba F, Kaiser GM, De Carlis L, Metselaar HJ, De Simone P, Duvoux C, Nevens F, Fung JJ, Dong G, Rauer B, Junge G, H2304 Study Group
Transplantation. 2015 Jul; 99(7)1455-62. doi: 10.1097/TP.0000000000000555.

PMID:
    26151607
    [PubMed - in process]
Related citations


Organ Procurement Organization Liver Acquisition Costs Could More Than Double With Proposed Redistricts.
Kappel DF, Chapman WC, Conrad S, Reed A, Linderer R, Dunn S, Niles P, Levy MF, Cawiezell T
Am J Transplant. 2015 Aug; 15(8)2269-70. doi: 10.1111/ajt.13346.

PMID:
    26096181
    [PubMed - in process]
Related citations


Outcomes Using Grafts from Donors after Cardiac Death.
Doyle MB, Collins K, Vachharajani N, Lowell JA, Shenoy S, Nalbantoglu I, Byrnes K, Garonzik-Wang J, Wellen J, Lin Y, Chapman WC
J Am Coll Surg. 2015 Jul; 221(1)142-52. doi: 10.1016/j.jamcollsurg.2015.03.053.

PMID:
    26095563
    [PubMed - indexed for MEDLINE]
Related citations


The hepatic buttress: A novel surgical technique to treat an intrapericardial diaphragmatic defect after hybrid myocardial ablation.
Chapman WC Jr, Sosin M, Salameh JR, Espinel CF
J Thorac Cardiovasc Surg. 2015 Jul; 150(1)e5-7. doi: 10.1016/j.jtcvs.2015.03.065.

PMID:
    25957456
    [PubMed - indexed for MEDLINE]
Related citations


Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families.
Lin Y, Lin S, Baxter MD, Lin L, Kennedy SM, Zhang Z, Goodfellow PJ, Chapman WC, Davidson NO
Genome Med. 2015; 7(1)42. doi: 10.1186/s13073-015-0148-0.

PMID:
    25941542
    [PubMed]
Related citations


Donor Age-Based Analysis of Liver Transplantation Outcomes: Short- and Long-Term Outcomes Are Similar Regardless of Donor Age.
Chapman WC, Vachharajani N, Collins KM, Garonzik-Wang J, Park Y, Wellen JR, Lin Y, Shenoy S, Lowell JA, Doyle MB
J Am Coll Surg. 2015 Jul; 221(1)59-69. doi: 10.1016/j.jamcollsurg.2015.01.061.

PMID:
    25872684
    [PubMed - indexed for MEDLINE]
Related citations


High-risk liver transplant candidates: An ethical proposal on where to draw the line.
Collins KM, Chapman WC
Liver Transpl. 2015 May; 21(5)567-9. doi: 10.1002/lt.24127.

PMID:
    25825867
    [PubMed - in process]
Related citations


Surgical treatment of hepatocellular carcinoma in North America: can hepatic resection still be justified?
Chapman WC, Klintmalm G, Hemming A, Vachharajani N, Majella Doyle MB, DeMatteo R, Zaydfudim V, Chung H, Cavaness K, Goldstein R, Zendajas I, Melstrom LG, Nagorney D, Jarnagin W
J Am Coll Surg. 2015 Apr; 220(4)628-37. doi: 10.1016/j.jamcollsurg.2014.12.030.

PMID:
    25728142
    [PubMed - indexed for MEDLINE]
Related citations


Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma.
Xiao Z, Chung H, Banan B, Manning PT, Ott KC, Lin S, Capoccia BJ, Subramanian V, Hiebsch RR, Upadhya GA, Mohanakumar T, Frazier WA, Lin Y, Chapman WC
Cancer Lett. 2015 May 1; 360(2)302-9. doi: 10.1016/j.canlet.2015.02.036.

PMID:
    25721088
    [PubMed - indexed for MEDLINE]
Related citations


Delayed-onset cytomegalovirus disease coded during hospital readmission in a multicenter, retrospective cohort of liver transplant recipients.
Santos CA, Brennan DC, Chapman WC, Fraser VJ, Olsen MA
Liver Transpl. 2015 May; 21(5)581-90. doi: 10.1002/lt.24089.

PMID:
    25678072
    [PubMed - in process]
Related citations


Ischemia-reperfusion injury in kidney transplantation.
Chen CC, Chapman WC, Hanto DW
Front Biosci (Elite Ed). 2015 Jan 1; 7117-34.

PMID:
    25553368
    [PubMed - indexed for MEDLINE]
Related citations


BH3-only proteins contribute to steatotic liver ischemia-reperfusion injury.
DuBray BJ Jr, Conzen KD, Upadhya GA, Gunter KL, Jia J, Knolhoff BL, Mohanakumar T, Chapman WC, Anderson CD
J Surg Res. 2015 Apr; 194(2)653-8. doi: 10.1016/j.jss.2014.10.024.

PMID:
    25483735
    [PubMed - indexed for MEDLINE]
Related citations


CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.
Xiao ZY, Banan B, Jia J, Manning PT, Hiebsch RR, Gunasekaran M, Upadhya GA, Frazier WA, Mohanakumar T, Lin Y, Chapman WC
Liver Transpl. 2015 Apr; 21(4)468-77. doi: 10.1002/lt.24059.

PMID:
    25482981
    [PubMed - indexed for MEDLINE]
Related citations


Standardizing a control group for comparing open with laparoscopic major liver resection in observational studies: reducing the need for correction of clinical heterogeneity.
Panni RZ, Hall BL, Chapman WC, Strasberg SM
J Am Coll Surg. 2014 Dec; 219(6)1124-33. doi: 10.1016/j.jamcollsurg.2014.08.010.

PMID:
    25442067
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention