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William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Locoregional Therapy and Recurrent Hepatocellular Carcinoma after Liver Transplantation.
Xu M, Doyle M, Banan B, Vachharajani N, Wang X, Saad N, Fowler K, Brunt EM, Lin Y, Chapman WC
J Am Coll Surg. 2017 Apr 8; pii: S1072-7515(17)30350-2. doi: 10.1016/j.jamcollsurg.2017.03.015.

PMID:
    28400300
    [PubMed - as supplied by publisher]
Related citations


Liver Transplantation for Malignant Primary Pediatric Hepatic Tumors.
Khan AS, Brecklin B, Vachharajani N, Subramanian V, Nadler M, Stoll J, Turmelle Y, Lowell JA, Chapman WC, Doyle MM
J Am Coll Surg. 2017 Feb 20; pii: S1072-7515(17)30183-7. doi: 10.1016/j.jamcollsurg.2017.02.006.

PMID:
    28232059
    [PubMed - as supplied by publisher]
Related citations


Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.
Chapman WC, Brown RS Jr, Chavin KD, Sudan D, Koneru B, Junge G, Dong G, Patel D, Teperman L, Fung JJ
Transplantation. 2017 Feb; 101(2)341-349. doi: 10.1097/TP.0000000000001524.

PMID:
    28121741
    [PubMed - in process]
Related citations


Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
Aw Yeang HX, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C, Krupnick AS, Chapman WC, Yokoyama WM
J Immunol. 2017 Feb 15; 198(4)1417-1422. doi: 10.4049/jimmunol.1601818.

PMID:
    28093522
    [PubMed - in process]
Related citations


Liver Transplantation for Advanced Hepatocellular Carcinoma after Downstaging Without Up-Front Stage Restrictions.
Chapman WC, Garcia-Aroz S, Vachharajani N, Fowler K, Saad N, Lin Y, Wellen J, Tan B, Khan AS, Doyle MB
J Am Coll Surg. 2017 Apr; 224(4)610-621. doi: 10.1016/j.jamcollsurg.2016.12.020.

PMID:
    28069527
    [PubMed - in process]
Related citations


Liver transplantation for hepatocellular carcinoma: current update on treatment and allocation.
Dageforde LA, Fowler KJ, Chapman WC
Curr Opin Organ Transplant. 2017 Apr; 22(2)128-134. doi: 10.1097/MOT.0000000000000385.

PMID:
    27926548
    [PubMed - in process]
Related citations


Physician-Patient Communication is Associated With Hepatocellular Carcinoma Screening in Chronic Liver Disease Patients.
Li DJ, Park Y, Vachharajani N, Aung WY, Garonzik-Wang J, Chapman WC
J Clin Gastroenterol. 2016 Dec 1;

PMID:
    27918312
    [PubMed - as supplied by publisher]
Related citations


Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study.
Brauer DG, Strand MS, Sanford DE, Kushnir VM, Lim KH, Mullady DK, Tan BR Jr, Wang-Gillam A, Morton AE, Ruzinova MB, Parikh PJ, Narra VR, Fowler KJ, Doyle MB, Chapman WC, Strasberg SS, Hawkins WG, Fields RC
HPB (Oxford). 2017 Feb; 19(2)133-139. doi: 10.1016/j.hpb.2016.11.002.

PMID:
    27916436
    [PubMed - in process]
Related citations


Operative Site Drainage after Hepatectomy: A Propensity Score Matched Analysis Using the American College of Surgeons NSQIP Targeted Hepatectomy Database.
Brauer DG, Nywening TM, Jaques DP, Doyle MB, Chapman WC, Fields RC, Hawkins WG
J Am Coll Surg. 2016 Dec; 223(6)774-783.e2. doi: 10.1016/j.jamcollsurg.2016.09.004.

PMID:
    27793459
    [PubMed - in process]
Related citations


Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.
Santos CA, Hotchkiss RS, Chapman WC, Olsen MA
Transplant Direct. 2016 Mar; 2(3)e67. doi: 10.1097/TXD.0000000000000573.

PMID:
    27458606
    [PubMed]
Related citations


Liver Resection and Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria.
Zaydfudim VM, Vachharajani N, Klintmalm GB, Jarnagin WR, Hemming AW, Doyle MB, Cavaness KM, Chapman WC, Nagorney DM
Ann Surg. 2016 Oct; 264(4)650-8. doi: 10.1097/SLA.0000000000001866.

PMID:
    27433910
    [PubMed - in process]
Related citations


Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody.
Xiao Z, Banan B, Xu M, Jia J, Manning PT, Hiebsch RR, Gunasekaran M, Upadhya GA, Frazier WA, Mohanakumar T, Lin Y, Chapman WC
Transplantation. 2016 Jul; 100(7)1480-9. doi: 10.1097/TP.0000000000001186.

PMID:
    27331362
    [PubMed - in process]
Related citations


HPB Surgery: The Specialty is Here to Stay, but the Training is in Evolution.
D'Angelica MI, Chapman WC
Ann Surg Oncol. 2016 Jul; 23(7)2123-5. doi: 10.1245/s10434-016-5230-3.

PMID:
    27138384
    [PubMed - in process]
Related citations


Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation.
Leal JN, Bressan AK, Vachharajani N, Gonen M, Kingham TP, D'Angelica MI, Allen PJ, DeMatteo RP, Doyle MB, Bathe OF, Greig PD, Wei A, Chapman WC, Dixon E, Jarnagin WR
J Am Coll Surg. 2016 May; 222(5)766-79. doi: 10.1016/j.jamcollsurg.2016.01.046.

PMID:
    27113514
    [PubMed - in process]
Related citations


Results of Simultaneous Liver and Kidney Transplantation: A Single-Center Review.
Doyle MB, Subramanian V, Vachharajani N, Maynard E, Shenoy S, Wellen JR, Lin Y, Chapman WC
J Am Coll Surg. 2016 Jul; 223(1)193-201. doi: 10.1016/j.jamcollsurg.2016.04.005.

PMID:
    27103549
    [PubMed - in process]
Related citations


Colorectal liver metastases: disappearing lesions in the era of Eovist hepatobiliary magnetic resonance imaging.
Owen JW, Fowler KJ, Doyle MB, Saad NE, Linehan DC, Chapman WC
HPB (Oxford). 2016 Mar; 18(3)296-303. doi: 10.1016/j.hpb.2015.10.009.

PMID:
    27017170
    [PubMed - indexed for MEDLINE]
Related citations


Surgical Training in the United States: Is It Time for a Paradigm Shift?
Chapman WC
J Am Coll Surg. 2016 Jul; 223(1)1-7. doi: 10.1016/j.jamcollsurg.2016.01.055.

PMID:
    27012839
    [PubMed - in process]
Related citations


Organ Donor Recovery Performed at an Organ Procurement Organization-Based Facility Is an Effective Way to Minimize Organ Recovery Costs and Increase Organ Yield.
Doyle M, Subramanian V, Vachharajani N, Collins K, Wellen JR, Stahlschmidt E, Brockmeier D, Coleman J, Kappel D, Chapman WC
J Am Coll Surg. 2016 Apr; 222(4)591-600. doi: 10.1016/j.jamcollsurg.2015.12.032.

PMID:
    26947113
    [PubMed - indexed for MEDLINE]
Related citations


The new lottery ticket: Share 35.
Chapman WC
Liver Transpl. 2016 Apr; 22(4)393-5. doi: 10.1002/lt.24420.

PMID:
    26915465
    [PubMed - indexed for MEDLINE]
Related citations


Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial.
Genyk Y, Kato T, Pomposelli JJ, Wright JK Jr, Sher LS, Tetens V, Chapman WC
J Am Coll Surg. 2016 Mar; 222(3)261-8. doi: 10.1016/j.jamcollsurg.2015.12.007.

PMID:
    26776356
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention