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William C. Chapman, MD, FACS

Professor, Surgery
Eugene M. Bricker Chair of Surgery
Chief, Division of General Surgery
Chief, Abdominal Transplantation Section

Specialty Areas

Liver Surgery
Transplantation Surgery
Hepatobiliary Surgery
Liver Diseases
Pediatric Liver Transplantation
Liver Transplantation

Board Certifications

Critical Care
General Surgery

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital
VA Medical Center - St. Louis

Areas of Clinical Interest

Surgical treatment of complex hepatobiliary conditions, image-guided liver surgery, gallstone pathogenesis and prevention, hepatic transplant immunosuppression, hepatic surgery, bile duct surgery, liver surgery, bile duct surgery, surgery for portal hypertension, radiofrequency ablation (RFA) of liver tumors, cryoablation, hepatic artery infusion (HAI) pumps, liver transplant in adults, liver transplant in children, living donor, living adult related donor, adult to adult liver doner, live doner transplant

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Gastrointestinal Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 8
Office Phone: (314) 362-2538
Additional Phone: 314-362-7792.
Fax: 314-361-4197

Education

Education

Fellowship: Hepatobiliary Surgery and Liver Transplantation, Kings College Hospital, London, England 1992
Chief Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1991
Fellowship: Hepatobiliary Research, Vanderbilt University Medical Center, Nashville, Tennesee 1989
Residency: General Surgery, Vanderbilt University Hospital, Nashville, Tennessee 1987
Medical Degree: Medical University of South Carolina, Charleston, South Carolina 1984
B.A.: Chemistry, University of North Carolina, Chapel Hill, North Carolina 1980

Publication & Research

Publication & Research

Reexamining the Association of Body Mass Index With Overall Survival Outcomes After Liver Transplantation.
Chang SH, Liu X, Carlsson NP, Park Y, Colditz GA, Garonzik-Wang JM, Chapman WC, Wellen JR, Doyle MB, Alhamad T
Transplant Direct. 2017 Jul; 3(7)e172. doi: 10.1097/TXD.0000000000000681.

PMID:
    28706975
    [PubMed]
Related citations


Impact of Pretransplant Bridging Locoregional Therapy for Patients With Hepatocellular Carcinoma Within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients from the US Multicenter HCC Transplant Consortium.
Agopian VG, Harlander-Locke MP, Ruiz RM, Klintmalm GB, Senguttuvan S, Florman SS, Haydel B, Hoteit M, Levine MH, Lee DD, Taner CB, Verna EC, Halazun KJ, Abdelmessih R, Tevar AD, Humar A, Aucejo F, Chapman WC, Vachharajani N, Nguyen MH, Melcher ML, Nydam TL, Mobley C, Ghobrial RM, Amundsen B, Markmann JF, Langnas AN, Carney CA, Berumen J, Hemming AW, Sudan DL, Hong JC, Kim J, Zimmerman MA, Rana A, Kueht ML, Jones CM, Fishbein TM, Busuttil RW
Ann Surg. 2017 Jun 26; doi: 10.1097/SLA.0000000000002381.

PMID:
    28654545
    [PubMed - as supplied by publisher]
Related citations


Prediction of Hepatocellular Carcinoma Recurrence Beyond Milan Criteria After Resection: Validation of a Clinical Risk Score in an International Cohort.
Zheng J, Chou JF, Gönen M, Vachharajani N, Chapman WC, Majella Doyle MB, Turcotte S, Vandenbroucke-Menu F, Lapointe R, Buettner S, Groot Koerkamp B, Ijzermans JNM, Chan CY, Goh BKP, Teo JY, Kam JH, Jeyaraj PR, Cheow PC, Chung AYF, Chow PKH, Ooi LLPJ, Balachandran VP, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Jarnagin WR, Lee SY
Ann Surg. 2017 Jul 22; doi: 10.1097/SLA.0000000000002360.

PMID:
    28650354
    [PubMed - as supplied by publisher]
Related citations


Development of immune response to tissue-restricted self-antigens in simultaneous kidney-pancreas transplant recipients with acute rejection.
Gunasekaran M, Vachharajani N, Gaut JP, Maw TT, Delos Santos R, Shenoy S, Chapman WC, Wellen J, Mohanakumar T
Clin Transplant. 2017 Jun 21; doi: 10.1111/ctr.13009.

PMID:
    28639386
    [PubMed - as supplied by publisher]
Related citations


LI-RADS and transplantation for hepatocellular carcinoma.
Tang A, Fowler KJ, Chernyak V, Chapman WC, Sirlin CB
Abdom Radiol (NY). 2017 Jun 13; doi: 10.1007/s00261-017-1210-8.

PMID:
    28612162
    [PubMed - as supplied by publisher]
Related citations


Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.
Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA
Sci Immunol. 2017 Apr 21; 2(10)pii: eaai7616. doi: 10.1126/sciimmunol.aai7616.

PMID:
    28567448
    [PubMed - in process]
Related citations


Neoadjuvant Locoregional Therapy and Recurrent Hepatocellular Carcinoma after Liver Transplantation.
Xu M, Doyle MM, Banan B, Vachharajani N, Wang X, Saad N, Fowler K, Brunt EM, Lin Y, Chapman WC
J Am Coll Surg. 2017 Jul; 225(1)28-40. doi: 10.1016/j.jamcollsurg.2017.03.015.

PMID:
    28400300
    [PubMed - in process]
Related citations


Liver Transplantation for Malignant Primary Pediatric Hepatic Tumors.
Khan AS, Brecklin B, Vachharajani N, Subramanian V, Nadler M, Stoll J, Turmelle Y, Lowell JA, Chapman WC, Doyle MM
J Am Coll Surg. 2017 Jul; 225(1)103-113. doi: 10.1016/j.jamcollsurg.2017.02.006.

PMID:
    28232059
    [PubMed - in process]
Related citations


Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.
Chapman WC, Brown RS Jr, Chavin KD, Sudan D, Koneru B, Junge G, Dong G, Patel D, Teperman L, Fung JJ
Transplantation. 2017 Feb; 101(2)341-349. doi: 10.1097/TP.0000000000001524.

PMID:
    28121741
    [PubMed - indexed for MEDLINE]
Related citations


Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
Aw Yeang HX, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C, Krupnick AS, Chapman WC, Yokoyama WM
J Immunol. 2017 Feb 15; 198(4)1417-1422. doi: 10.4049/jimmunol.1601818.

PMID:
    28093522
    [PubMed - in process]
Related citations


Liver Transplantation for Advanced Hepatocellular Carcinoma after Downstaging Without Up-Front Stage Restrictions.
Chapman WC, Garcia-Aroz S, Vachharajani N, Fowler K, Saad N, Lin Y, Wellen J, Tan B, Khan AS, Doyle MB
J Am Coll Surg. 2017 Apr; 224(4)610-621. doi: 10.1016/j.jamcollsurg.2016.12.020.

PMID:
    28069527
    [PubMed - in process]
Related citations


Liver transplantation for hepatocellular carcinoma: current update on treatment and allocation.
Dageforde LA, Fowler KJ, Chapman WC
Curr Opin Organ Transplant. 2017 Apr; 22(2)128-134. doi: 10.1097/MOT.0000000000000385.

PMID:
    27926548
    [PubMed - in process]
Related citations


Physician-Patient Communication is Associated With Hepatocellular Carcinoma Screening in Chronic Liver Disease Patients.
Li DJ, Park Y, Vachharajani N, Aung WY, Garonzik-Wang J, Chapman WC
J Clin Gastroenterol. 2016 Dec 1;

PMID:
    27918312
    [PubMed - as supplied by publisher]
Related citations


Utility of a multidisciplinary tumor board in the management of pancreatic and upper gastrointestinal diseases: an observational study.
Brauer DG, Strand MS, Sanford DE, Kushnir VM, Lim KH, Mullady DK, Tan BR Jr, Wang-Gillam A, Morton AE, Ruzinova MB, Parikh PJ, Narra VR, Fowler KJ, Doyle MB, Chapman WC, Strasberg SS, Hawkins WG, Fields RC
HPB (Oxford). 2017 Feb; 19(2)133-139. doi: 10.1016/j.hpb.2016.11.002.

PMID:
    27916436
    [PubMed - in process]
Related citations


Operative Site Drainage after Hepatectomy: A Propensity Score Matched Analysis Using the American College of Surgeons NSQIP Targeted Hepatectomy Database.
Brauer DG, Nywening TM, Jaques DP, Doyle MB, Chapman WC, Fields RC, Hawkins WG
J Am Coll Surg. 2016 Dec; 223(6)774-783.e2. doi: 10.1016/j.jamcollsurg.2016.09.004.

PMID:
    27793459
    [PubMed - in process]
Related citations


Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.
Santos CA, Hotchkiss RS, Chapman WC, Olsen MA
Transplant Direct. 2016 Mar; 2(3)e67. doi: 10.1097/TXD.0000000000000573.

PMID:
    27458606
    [PubMed]
Related citations


Liver Resection and Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria.
Zaydfudim VM, Vachharajani N, Klintmalm GB, Jarnagin WR, Hemming AW, Doyle MB, Cavaness KM, Chapman WC, Nagorney DM
Ann Surg. 2016 Oct; 264(4)650-8. doi: 10.1097/SLA.0000000000001866.

PMID:
    27433910
    [PubMed - indexed for MEDLINE]
Related citations


Attenuation of Ischemia-Reperfusion Injury and Improvement of Survival in Recipients of Steatotic Rat Livers Using CD47 Monoclonal Antibody.
Xiao Z, Banan B, Xu M, Jia J, Manning PT, Hiebsch RR, Gunasekaran M, Upadhya GA, Frazier WA, Mohanakumar T, Lin Y, Chapman WC
Transplantation. 2016 Jul; 100(7)1480-9. doi: 10.1097/TP.0000000000001186.

PMID:
    27331362
    [PubMed - indexed for MEDLINE]
Related citations


HPB Surgery: The Specialty is Here to Stay, but the Training is in Evolution.
D'Angelica MI, Chapman WC
Ann Surg Oncol. 2016 Jul; 23(7)2123-5. doi: 10.1245/s10434-016-5230-3.

PMID:
    27138384
    [PubMed - in process]
Related citations


Time-to-Surgery and Survival Outcomes in Resectable Colorectal Liver Metastases: A Multi-Institutional Evaluation.
Leal JN, Bressan AK, Vachharajani N, Gonen M, Kingham TP, D'Angelica MI, Allen PJ, DeMatteo RP, Doyle MB, Bathe OF, Greig PD, Wei A, Chapman WC, Dixon E, Jarnagin WR
J Am Coll Surg. 2016 May; 222(5)766-79. doi: 10.1016/j.jamcollsurg.2016.01.046.

PMID:
    27113514
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Novartis

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2017

Areas of Research Interest

Liver-lung interactions following liver injury, Image-guided liver surgery, Transcriptional regulation of hepatocellular carcinoma, Surgical Treatment of complex hepatobiliary problems, Hepatic transplant immunosuppression, Gallstone pathogenesis and prevention