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Wayne M. Yokoyama, MD

Professor, Medicine
Division of Rheumatology
Professor, Pathology and Immunology
Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis
Investigator, Howard Hughes Medical Institute
Director, Medical Scientist Training Program

Specialty Areas

Rheumatology
Internal Medicine

Board Certifications

Internal Medicine
Rheumatology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Human immunology, natural killer cells







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  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-286-2635
Fax: 314-362-9257

Education

Education

Fellowship: Research, Immunology, NIAID, NIH, Bethesda, Maryland 1989
Fellowship: Research, Rheumatology, University of Iowa Hospitals, Iowa City, Iowa 1985
Fellowship: Clinical, Rheumatology, University of Iowa Hopsitals, Iowa City, Iowa 1982
Residency: Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa 1981
Medical Degree: University Of Hawaii at Manoa, Honolulu, Hawaii 1978
B.A.: University of Rochester, Rochester, New York 1974

Publication & Research

Publication & Research

CD8<sup>+</sup> T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection.
Patel SJ, Yokoyama WM
J Immunol. 2017 Nov 1; 199(9)3212-3221. doi: 10.4049/jimmunol.1700982.

PMID:
    28972091
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG
Immunity. 2017 Sep 19; 47(3)597. doi: 10.1016/j.immuni.2017.08.018.

PMID:
    28930665
    [PubMed - in process]
Related citations


Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.
Bern MD, Beckman DL, Ebihara T, Taffner SM, Poursine-Laurent J, White JM, Yokoyama WM
Proc Natl Acad Sci U S A. 2017 Oct 3; 114(40)E8440-E8447. doi: 10.1073/pnas.1713064114.

PMID:
    28923946
    [PubMed - in process]
Related citations


Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice.
Almishaal AA, Mathur PD, Hillas E, Chen L, Zhang A, Yang J, Wang Y, Yokoyama WM, Firpo MA, Park AH
PLoS Pathog. 2017 Aug; 13(8)e1006599. doi: 10.1371/journal.ppat.1006599.

PMID:
    28859161
    [PubMed - indexed for MEDLINE]
Related citations


Reply to "Murine Roseolovirus, Historically Known as Murine Thymic Lymphotropic Virus".
Patel SJ, Yokoyama WM
J Virol. 2017 Sep 15; 91(18)pii: e00956-17. doi: 10.1128/JVI.00956-17.

PMID:
    28839089
    [PubMed - in process]
Related citations


Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression.
Zhu Y, Herndon JM, Sojka DK, Kim KW, Knolhoff BL, Zuo C, Cullinan DR, Luo J, Bearden AR, Lavine KJ, Yokoyama WM, Hawkins WG, Fields RC, Randolph GJ, DeNardo DG
Immunity. 2017 Aug 15; 47(2)323-338.e6. doi: 10.1016/j.immuni.2017.07.014.

PMID:
    28813661
    [PubMed - indexed for MEDLINE]
Related citations


Contribution of inhibitory receptor TIGIT to NK cell education.
He Y, Peng H, Sun R, Wei H, Ljunggren HG, Yokoyama WM, Tian Z
J Autoimmun. 2017 Jul; 811-12. doi: 10.1016/j.jaut.2017.04.001.

PMID:
    28438433
    [PubMed - in process]
Related citations


A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.
Patel SJ, Zhao G, Penna VR, Park E, Lauron EJ, Harvey IB, Beatty WL, Plougastel-Douglas B, Poursine-Laurent J, Fremont DH, Wang D, Yokoyama WM
J Virol. 2017 May 1; 91(9)pii: e02463-16. doi: 10.1128/JVI.02463-16.

PMID:
    28179532
    [PubMed - indexed for MEDLINE]
Related citations


Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
Aw Yeang HX, Piersma SJ, Lin Y, Yang L, Malkova ON, Miner C, Krupnick AS, Chapman WC, Yokoyama WM
J Immunol. 2017 Feb 15; 198(4)1417-1422. doi: 10.4049/jimmunol.1601818.

PMID:
    28093522
    [PubMed - indexed for MEDLINE]
Related citations


Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis.
Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM
J Clin Invest. 2016 Apr 1; 126(4)1458-70. doi: 10.1172/JCI83724.

PMID:
    26927668
    [PubMed - indexed for MEDLINE]
Related citations


Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.
Parikh BA, Piersma SJ, Pak-Wittel MA, Yang L, Schreiber RD, Yokoyama WM
PLoS Pathog. 2015 Dec; 11(12)e1005323. doi: 10.1371/journal.ppat.1005323.

PMID:
    26720279
    [PubMed - indexed for MEDLINE]
Related citations


The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M
Immunity. 2015 Dec 15; 43(6)1112-24. doi: 10.1016/j.immuni.2015.11.005.

PMID:
    26680205
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.
Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D, Yokoyama WM, Eltzschig HK, Clambey ET
J Immunol. 2015 Nov 15; 195(10)4973-85. doi: 10.4049/jimmunol.1500651.

PMID:
    26453755
    [PubMed - indexed for MEDLINE]
Related citations


Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s.
Tang L, Peng H, Zhou J, Chen Y, Wei H, Sun R, Yokoyama WM, Tian Z
J Autoimmun. 2016 Feb; 6729-35. doi: 10.1016/j.jaut.2015.09.004.

PMID:
    26422992
    [PubMed - indexed for MEDLINE]
Related citations


Runx3 specifies lineage commitment of innate lymphoid cells.
Ebihara T, Song C, Ryu SH, Plougastel-Douglas B, Yang L, Levanon D, Groner Y, Bern MD, Stappenbeck TS, Colonna M, Egawa T, Yokoyama WM
Nat Immunol. 2015 Nov; 16(11)1124-33. doi: 10.1038/ni.3272.

PMID:
    26414766
    [PubMed - indexed for MEDLINE]
Related citations


The pancreas anatomy conditions the origin and properties of resident macrophages.
Calderon B, Carrero JA, Ferris ST, Sojka DK, Moore L, Epelman S, Murphy KM, Yokoyama WM, Randolph GJ, Unanue ER
J Exp Med. 2015 Sep 21; 212(10)1497-512. doi: 10.1084/jem.20150496.

PMID:
    26347472
    [PubMed - indexed for MEDLINE]
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Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM
Nature. 2015 Sep 3; 525(7567)144. doi: 10.1038/nature14555.

PMID:
    26153856
    [PubMed]
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PTEN regulates natural killer cell trafficking in vivo.
Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA
Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7)E700-9. doi: 10.1073/pnas.1413886112.

PMID:
    25646418
    [PubMed - indexed for MEDLINE]
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Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.
Miner JJ, Aw-Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AHJ, Diamond MS, Lenschow DJ, Yokoyama WM
Arthritis Rheumatol. 2015 May; 67(5)1214-1220. doi: 10.1002/art.39027.

PMID:
    25605621
    [PubMed - indexed for MEDLINE]
Related citations


Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing.
Parikh BA, Beckman DL, Patel SJ, White JM, Yokoyama WM
PLoS One. 2015; 10(1)e0116484. doi: 10.1371/journal.pone.0116484.

PMID:
    25587897
    [PubMed - indexed for MEDLINE]
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