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Faculty Physicians

Wayne M. Yokoyama, MD

Professor, Medicine
Division of Rheumatology
Professor, Pathology and Immunology
Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis
Investigator, Howard Hughes Medical Institute
Director, Medical Scientist Training Program

Specialty Areas

Rheumatology
Internal Medicine

Board Certifications

Internal Medicine
Rheumatology

Areas of Clinical Interest

Human immunology, natural killer cells







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  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-286-2635
Fax: 314-362-9257

Education

Education

Fellowship: Research, Immunology, NIAID, NIH, Bethesda, Maryland 1989
Fellowship: Research, Rheumatology, University of Iowa Hospitals, Iowa City, Iowa 1985
Fellowship: Clinical, Rheumatology, University of Iowa Hopsitals, Iowa City, Iowa 1982
Residency: Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa 1981
Medical Degree: University Of Hawaii at Manoa, Honolulu, Hawaii 1978
B.A.: University of Rochester, Rochester, New York 1974

Publication & Research

Publication & Research

Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.
Miner JJ, Aw Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AH, Diamond MS, Lenschow DJ, Yokoyama WM
Arthritis Rheumatol. 2015 May; 67(5)1214-20. doi: 10.1002/art.39027.

PMID:
    25605621
    [PubMed - indexed for MEDLINE]
Related citations


Chronic allergic contact dermatitis promotes skin cancer.
Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM
J Clin Invest. 2014 Nov; 124(11)5037-41. doi: 10.1172/JCI77843.

PMID:
    25295539
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-resident natural killer cells.
Yokoyama WM, Sojka DK, Peng H, Tian Z
Cold Spring Harb Symp Quant Biol. 2013; 78149-56. doi: 10.1101/sqb.2013.78.020354.

PMID:
    24584057
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-resident natural killer cells and their potential diversity.
Sojka DK, Tian Z, Yokoyama WM
Semin Immunol. 2014 Apr; 26(2)127-31. doi: 10.1016/j.smim.2014.01.010.

PMID:
    24548893
    [PubMed - indexed for MEDLINE]
Related citations


Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.
McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH
Mol Immunol. 2013 Sep; 55(2)156-8. doi: 10.1016/j.molimm.2012.11.011.

PMID:
    23312338
    [PubMed - indexed for MEDLINE]
Related citations


Cryopreservation and thawing of cells.
Yokoyama WM, Thompson ML, Ehrhardt RO
Curr Protoc Immunol. 2012 Nov; Appendix 33G. doi: 10.1002/0471142735.ima03gs99.

PMID:
    23129152
    [PubMed - indexed for MEDLINE]
Related citations


Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer.
Kreisel D, Gelman AE, Higashikubo R, Lin X, Vikis HG, White JM, Toth KA, Deshpande C, Carreno BM, You M, Taffner SM, Yokoyama WM, Bui JD, Schreiber RD, Krupnick AS
Cancer Res. 2012 Sep 1; 72(17)4311-7.

PMID:
    22751136
    [PubMed - indexed for MEDLINE]
Related citations


Unifying concepts of MHC-dependent natural killer cell education.
Elliott JM, Yokoyama WM
Trends Immunol. 2011 Aug; 32(8)364-72. doi: 10.1016/j.it.2011.06.001.

PMID:
    21752715
    [PubMed - indexed for MEDLINE]
Related citations


Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane.
Keyel PA, Loultcheva L, Roth R, Salter RD, Watkins SC, Yokoyama WM, Heuser JE
J Cell Sci. 2011 Jul 15; 124(Pt 14)2414-23. doi: 10.1242/jcs.076182.

PMID:
    21693578
    [PubMed - indexed for MEDLINE]
Related citations


Innate or adaptive immunity? The example of natural killer cells.
Vivier E, Raulet DH, Moretta A, Caligiuri MA, Zitvogel L, Lanier LL, Yokoyama WM, Ugolini S
Science. 2011 Jan 7; 331(6013)44-9. doi: 10.1126/science.1198687.

PMID:
    21212348
    [PubMed - indexed for MEDLINE]
Related citations


Memory-like responses of natural killer cells.
Cooper MA, Yokoyama WM
Immunol Rev. 2010 May; 235(1)297-305. doi: 10.1111/j.0105-2896.2010.00891.x.

PMID:
    20536571
    [PubMed - indexed for MEDLINE]
Related citations


Stability of murine cytomegalovirus genome after in vitro and in vivo passage.
Cheng TP, Valentine MC, Gao J, Pingel JT, Yokoyama WM
J Virol. 2010 Mar; 84(5)2623-8. doi: 10.1128/JVI.02142-09.

PMID:
    20015993
    [PubMed - indexed for MEDLINE]
Related citations


Natural killer cells: tolerance to self and innate immunity to viral infection and malignancy.
Yokoyama WM, Altfeld M, Hsu KC
Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl)S97-S105. doi: 10.1016/j.bbmt.2009.10.009.

PMID:
    19835969
    [PubMed - indexed for MEDLINE]
Related citations


Hidden talents of natural killers: NK cells in innate and adaptive immunity.
Cooper MA, Colonna M, Yokoyama WM
EMBO Rep. 2009 Oct; 10(10)1103-10. doi: 10.1038/embor.2009.203.

PMID:
    19730434
    [PubMed - indexed for MEDLINE]
Related citations


Natural killer cell tolerance licensing and other mechanisms.
Jonsson AH, Yokoyama WM
Adv Immunol. 2009; 10127-79. doi: 10.1016/S0065-2776(08)01002-X.

PMID:
    19231592
    [PubMed - indexed for MEDLINE]
Related citations


Inhibitory receptors signal activation.
Yokoyama WM
Immunity. 2008 Oct 17; 29(4)515-7. doi: 10.1016/j.immuni.2008.09.009.

PMID:
    18957262
    [PubMed - indexed for MEDLINE]
Related citations


Mistaken notions about natural killer cells.
Yokoyama WM
Nat Immunol. 2008 May; 9(5)481-5. doi: 10.1038/ni1583.

PMID:
    18425104
    [PubMed - indexed for MEDLINE]
Related citations


NK cell tolerance and the maternal-fetal interface.
Riley JK, Yokoyama WM
Am J Reprod Immunol. 2008 May; 59(5)371-87. doi: 10.1111/j.1600-0897.2008.00593.x.

PMID:
    18405308
    [PubMed - indexed for MEDLINE]
Related citations


HLA alleles determine differences in human natural killer cell responsiveness and potency.
Kim S, Sunwoo JB, Yang L, Choi T, Song YJ, French AR, Vlahiotis A, Piccirillo JF, Cella M, Colonna M, Mohanakumar T, Hsu KC, Dupont B, Yokoyama WM
Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8)3053-8. doi: 10.1073/pnas.0712229105.

PMID:
    18287063
    [PubMed - indexed for MEDLINE]
Related citations


Innate immunity to pathogens.
Yokoyama WM, Colonna M
Curr Opin Immunol. 2008 Feb; 20(1)1-2. doi: 10.1016/j.coi.2008.01.004.

PMID:
    18262400
    [PubMed - indexed for MEDLINE]
Related citations