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Faculty Physicians

Wayne M. Yokoyama, MD

Professor, Medicine
Division of Rheumatology
Professor, Pathology and Immunology
Sam J. Levin and Audrey Loew Levin Chair for Research on Arthritis
Investigator, Howard Hughes Medical Institute
Director, Medical Scientist Training Program

Specialty Areas

Rheumatology
Internal Medicine

Board Certifications

Internal Medicine
Rheumatology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Human immunology, natural killer cells







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  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-286-2635
Fax: 314-362-9257

Education

Education

Fellowship: Research, Immunology, NIAID, NIH, Bethesda, Maryland 1989
Fellowship: Research, Rheumatology, University of Iowa Hospitals, Iowa City, Iowa 1985
Fellowship: Clinical, Rheumatology, University of Iowa Hopsitals, Iowa City, Iowa 1982
Residency: Internal Medicine, University of Iowa Hospitals, Iowa City, Iowa 1981
Medical Degree: University Of Hawaii at Manoa, Honolulu, Hawaii 1978
B.A.: University of Rochester, Rochester, New York 1974

Publication & Research

Publication & Research

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis.
Demehri S, Cunningham TJ, Manivasagam S, Ngo KH, Moradi Tuchayi S, Reddy R, Meyers MA, DeNardo DG, Yokoyama WM
J Clin Invest. 2016 Apr 1; 126(4)1458-70. doi: 10.1172/JCI83724.

PMID:
    26927668
    [PubMed - in process]
Related citations


Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.
Parikh BA, Piersma SJ, Pak-Wittel MA, Yang L, Schreiber RD, Yokoyama WM
PLoS Pathog. 2015 Dec; 11(12)e1005323. doi: 10.1371/journal.ppat.1005323.

PMID:
    26720279
    [PubMed - in process]
Related citations


The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.
Rapaport AS, Schriewer J, Gilfillan S, Hembrador E, Crump R, Plougastel BF, Wang Y, Le Friec G, Gao J, Cella M, Pircher H, Yokoyama WM, Buller RM, Colonna M
Immunity. 2015 Dec 15; 43(6)1112-24. doi: 10.1016/j.immuni.2015.11.005.

PMID:
    26680205
    [PubMed - in process]
Related citations


Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.
Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D, Yokoyama WM, Eltzschig HK, Clambey ET
J Immunol. 2015 Nov 15; 195(10)4973-85. doi: 10.4049/jimmunol.1500651.

PMID:
    26453755
    [PubMed - indexed for MEDLINE]
Related citations


Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s.
Tang L, Peng H, Zhou J, Chen Y, Wei H, Sun R, Yokoyama WM, Tian Z
J Autoimmun. 2016 Feb; 6729-35. doi: 10.1016/j.jaut.2015.09.004.

PMID:
    26422992
    [PubMed - in process]
Related citations


Runx3 specifies lineage commitment of innate lymphoid cells.
Ebihara T, Song C, Ryu SH, Plougastel-Douglas B, Yang L, Levanon D, Groner Y, Bern MD, Stappenbeck TS, Colonna M, Egawa T, Yokoyama WM
Nat Immunol. 2015 Nov; 16(11)1124-33. doi: 10.1038/ni.3272.

PMID:
    26414766
    [PubMed - indexed for MEDLINE]
Related citations


The pancreas anatomy conditions the origin and properties of resident macrophages.
Calderon B, Carrero JA, Ferris ST, Sojka DK, Moore L, Epelman S, Murphy KM, Yokoyama WM, Randolph GJ, Unanue ER
J Exp Med. 2015 Sep 21; 212(10)1497-512. doi: 10.1084/jem.20150496.

PMID:
    26347472
    [PubMed - indexed for MEDLINE]
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Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM
Nature. 2015 Sep 3; 525(7567)144. doi: 10.1038/nature14555.

PMID:
    26153856
    [PubMed]
Related citations


PTEN regulates natural killer cell trafficking in vivo.
Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA
Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7)E700-9. doi: 10.1073/pnas.1413886112.

PMID:
    25646418
    [PubMed - indexed for MEDLINE]
Related citations


Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis.
Miner JJ, Aw Yeang HX, Fox JM, Taffner S, Malkova ON, Oh ST, Kim AH, Diamond MS, Lenschow DJ, Yokoyama WM
Arthritis Rheumatol. 2015 May; 67(5)1214-20. doi: 10.1002/art.39027.

PMID:
    25605621
    [PubMed - indexed for MEDLINE]
Related citations


Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing.
Parikh BA, Beckman DL, Patel SJ, White JM, Yokoyama WM
PLoS One. 2015; 10(1)e0116484. doi: 10.1371/journal.pone.0116484.

PMID:
    25587897
    [PubMed - indexed for MEDLINE]
Related citations


Chronic allergic contact dermatitis promotes skin cancer.
Demehri S, Cunningham TJ, Hurst EA, Schaffer A, Sheinbein DM, Yokoyama WM
J Clin Invest. 2014 Nov; 124(11)5037-41. doi: 10.1172/JCI77843.

PMID:
    25295539
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
Sojka DK, Plougastel-Douglas B, Yang L, Pak-Wittel MA, Artyomov MN, Ivanova Y, Zhong C, Chase JM, Rothman PB, Yu J, Riley JK, Zhu J, Tian Z, Yokoyama WM
Elife. 2014 Jan 1; 3e01659. doi: 10.7554/eLife.01659.

PMID:
    24714492
    [PubMed - indexed for MEDLINE]
Related citations


Isolation of murine natural killer cells.
Pak-Wittel MA, Piersma SJ, Plougastel BF, Poursine-Laurent J, Yokoyama WM
Curr Protoc Immunol. 2014 Apr 2; 1053.22.1-9. doi: 10.1002/0471142735.im0322s105.

PMID:
    24700324
    [PubMed - in process]
Related citations


Tissue-resident natural killer cells.
Yokoyama WM, Sojka DK, Peng H, Tian Z
Cold Spring Harb Symp Quant Biol. 2013; 78149-56. doi: 10.1101/sqb.2013.78.020354.

PMID:
    24584057
    [PubMed - indexed for MEDLINE]
Related citations


Tissue-resident natural killer cells and their potential diversity.
Sojka DK, Tian Z, Yokoyama WM
Semin Immunol. 2014 Apr; 26(2)127-31. doi: 10.1016/j.smim.2014.01.010.

PMID:
    24548893
    [PubMed - indexed for MEDLINE]
Related citations


Production of monoclonal antibodies.
Yokoyama WM, Christensen M, Dos Santos G, Miller D, Ho J, Wu T, Dziegelewski M, Neethling FA
Curr Protoc Immunol. 2013 Oct 1; 102Unit 2.5.. doi: 10.1002/0471142735.im0205s102.

PMID:
    24510488
    [PubMed - indexed for MEDLINE]
Related citations


Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsberg EC, Yokoyama WM, Unanue ER, Colonna M, Randolph GJ, Mann DL
Immunity. 2014 Jan 16; 40(1)91-104. doi: 10.1016/j.immuni.2013.11.019.

PMID:
    24439267
    [PubMed - indexed for MEDLINE]
Related citations


Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM
Nature. 2014 Jan 30; 505(7485)691-5. doi: 10.1038/nature12862.

PMID:
    24284630
    [PubMed - indexed for MEDLINE]
Related citations


Natural killer cell licensing in mice with inducible expression of MHC class I.
Ebihara T, Jonsson AH, Yokoyama WM
Proc Natl Acad Sci U S A. 2013 Nov 5; 110(45)E4232-7. doi: 10.1073/pnas.1318255110.

PMID:
    24145414
    [PubMed - indexed for MEDLINE]
Related citations