Patient Portal

Wayland Wing-Lun Cheng, MD, PhD

Assistant Professor, Anesthesiology
Division of Cardiothoracic Anesthesiology

Specialty Areas

Anesthesiology
Cardiothoracic Anesthesiology

Board Certifications

Anesthesiology
Advanced Perioperative Transesophageal Echocardiography

Hospital Affiliations

Barnes-Jewish Hospital

Languages

Chinese

Areas of Clinical Interest

Coronary artery bypass grafting, prosthetic valve repair/replacement, heart transplant, lung transplant.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Education

Education

Fellowship, Cardiothoracic Anesthesiology: Washington University School of Medicine, St. Louis, MO 2017
Residency, Anesthesiology: Barnes-Jewish Hospital, St. Louis, MO 2016
Medical Degree: Washington University School of Medicine, St. Louis, MO 2012
PhD, Biochemistry: Washington University School of Medicine, St. Louis, MO 2012
BSc, Chemistry: Wheaton College, Wheaton, IL 2005

Publication & Research

Publication & Research

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel.
Tong A, Petroff JT, Hsu FF, Schmidpeter PA, Nimigean CM, Sharp L, Brannigan G, Cheng WW
Elife. 2019 Nov 14; 8pii: e50766. doi: 10.7554/eLife.50766.

PMID:
    31724949
    [PubMed - in process]
Related citations


Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct; 1864(10)1269-1279. doi: 10.1016/j.bbalip.2019.06.004.

PMID:
    31176038
    [PubMed - in process]
Related citations


The molecular determinants of neurosteroid binding in the GABA(A) receptor.
Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL
J Steroid Biochem Mol Biol. 2019 Sep; 192105383. doi: 10.1016/j.jsbmb.2019.105383.

PMID:
    31150831
    [PubMed - in process]
Related citations


Multiple functional neurosteroid binding sites on GABAA receptors.
Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS
PLoS Biol. 2019 Mar; 17(3)e3000157. doi: 10.1371/journal.pbio.3000157.

PMID:
    30845142
    [PubMed - in process]
Related citations


Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.
Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Krishnan K, Mydock-McGrane L, Covey DF, Evers AS
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb; 1864(2)128-136. doi: 10.1016/j.bbalip.2018.11.005.

PMID:
    30471426
    [PubMed - indexed for MEDLINE]
Related citations


Mechanically Enhancing Planar Lipid Bilayers with a Minimal Actin Cortex.
Burden DL, Kim D, Cheng W, Chandler Lawler E, Dreyer DR, Keranen Burden LM
Langmuir. 2018 Sep 18; 34(37)10847-10855. doi: 10.1021/acs.langmuir.8b01847.

PMID:
    30149716
    [PubMed - indexed for MEDLINE]
Related citations


Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.
Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS
J Biol Chem. 2018 Feb 23; 293(8)3013-3027. doi: 10.1074/jbc.RA117.000359.

PMID:
    29301936
    [PubMed - indexed for MEDLINE]
Related citations


Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.
Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS
J Biol Chem. 2017 Jun 2; 292(22)9294-9304. doi: 10.1074/jbc.M116.773069.

PMID:
    28396346
    [PubMed - indexed for MEDLINE]
Related citations


Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS
Anal Chem. 2017 Feb 21; 89(4)2636-2644. doi: 10.1021/acs.analchem.6b05003.

PMID:
    28194953
    [PubMed - indexed for MEDLINE]
Related citations


Energetics and location of phosphoinositide binding in human Kir2.1 channels.
D'Avanzo N, Lee SJ, Cheng WW, Nichols CG
J Biol Chem. 2013 Jun 7; 288(23)16726-37. doi: 10.1074/jbc.M113.452540.

PMID:
    23564459
    [PubMed - indexed for MEDLINE]
Related citations


Mechanism for selectivity-inactivation coupling in KcsA potassium channels.
Cheng WW, McCoy JG, Thompson AN, Nichols CG, Nimigean CM
Proc Natl Acad Sci U S A. 2011 Mar 29; 108(13)5272-7. doi: 10.1073/pnas.1014186108.

PMID:
    21402935
    [PubMed - indexed for MEDLINE]
Related citations


Polyamine block of inwardly rectifying potassium channels.
Kurata HT, Cheng WW, Nichols CG
Methods Mol Biol. 2011; 720113-26. doi: 10.1007/978-1-61779-034-8_6.

PMID:
    21318869
    [PubMed - indexed for MEDLINE]
Related citations


Dual-mode phospholipid regulation of human inward rectifying potassium channels.
Cheng WWL, D'Avanzo N, Doyle DA, Nichols CG
Biophys J. 2011 Feb 2; 100(3)620-628. doi: 10.1016/j.bpj.2010.12.3724.

PMID:
    21281576
    [PubMed - indexed for MEDLINE]
Related citations


Lipids driving protein structure? Evolutionary adaptations in Kir channels.
D'Avanzo N, Cheng WW, Wang S, Enkvetchakul D, Nichols CG
Channels (Austin). 2010 May-Jun; 4(3)139-41.

PMID:
    21150302
    [PubMed - indexed for MEDLINE]
Related citations


Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate.
D'Avanzo N, Cheng WW, Doyle DA, Nichols CG
J Biol Chem. 2010 Nov 26; 285(48)37129-32. doi: 10.1074/jbc.C110.186692.

PMID:
    20921230
    [PubMed - indexed for MEDLINE]
Related citations


Functional complementation and genetic deletion studies of KirBac channels: activatory mutations highlight gating-sensitive domains.
Paynter JJ, Andres-Enguix I, Fowler PW, Tottey S, Cheng W, Enkvetchakul D, Bavro VN, Kusakabe Y, Sansom MS, Robinson NJ, Nichols CG, Tucker SJ
J Biol Chem. 2010 Dec 24; 285(52)40754-61. doi: 10.1074/jbc.M110.175687.

PMID:
    20876570
    [PubMed - indexed for MEDLINE]
Related citations


Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae.
D'Avanzo N, Cheng WW, Xia X, Dong L, Savitsky P, Nichols CG, Doyle DA
Protein Expr Purif. 2010 May; 71(1)115-21. doi: 10.1016/j.pep.2010.01.010.

PMID:
    20064617
    [PubMed - indexed for MEDLINE]
Related citations


KirBac1.1: it's an inward rectifying potassium channel.
Cheng WW, Enkvetchakul D, Nichols CG
J Gen Physiol. 2009 Mar; 133(3)295-305. doi: 10.1085/jgp.200810125.

PMID:
    19204189
    [PubMed - indexed for MEDLINE]
Related citations


Random assembly of SUR subunits in K(ATP) channel complexes.
Cheng WW, Tong A, Flagg TP, Nichols CG
Channels (Austin). 2008 Jan-Feb; 2(1)34-8.

PMID:
    18690055
    [PubMed - indexed for MEDLINE]
Related citations


The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.
Kurata HT, Cheng WW, Arrabit C, Slesinger PA, Nichols CG
J Gen Physiol. 2007 Aug; 130(2)145-55.

PMID:
    17635958
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Molecular mechanisms of anesthetic action.