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Todd E. Druley, MD, PhD

Assistant Professor, Pediatrics
Division of Hematology and Oncology

Specialty Areas

Pediatric Oncology
Brain Tumors - Pediatric
Pediatric Hematology

Board Certifications

Pediatrics
Pediatric Hematology
Pediatric Oncology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric cancer, pediatric blood disorders, pediatric brain tumor, pediatric oncology, pediatrics; cancer predisposition

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6018
Fax: 314-454-2780

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

Ph.D.: University of Illinois at Chicago, Chicago, Illinois 2002
Residency: Pediatrics, St. Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2005
B.S.: Cell and Structural Biology, University of Illinois at Urbana-Champaign, Chicago, Illinois 1994
Medical Degree: University of Illinois at Chicago, Chicago, Illinois 2002
Fellowship: Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri 2008

Publication & Research

Publication & Research

Parental Age and Risk of Infant Leukaemia: A Pooled Analysis.
Marcotte EL, Druley TE, Johnson KJ, Richardson M, von Behren J, Mueller BA, Carozza S, McLaughlin C, Chow EJ, Reynolds P, Spector LG
Paediatr Perinat Epidemiol. 2017 Nov; 31(6)563-572. doi: 10.1111/ppe.12412.

PMID:
    28940632
    [PubMed - in process]
Related citations


Congenital neurodevelopmental anomalies in pediatric and young adult cancer.
Wong-Siegel JR, Johnson KJ, Gettinger K, Cousins N, McAmis N, Zamarione A, Druley TE
Am J Med Genet A. 2017 Oct; 173(10)2670-2679. doi: 10.1002/ajmg.a.38387.

PMID:
    28851129
    [PubMed - in process]
Related citations


Pediatric cancer risk in association with birth defects: A systematic review.
Johnson KJ, Lee JM, Ahsan K, Padda H, Feng Q, Partap S, Fowler SA, Druley TE
PLoS One. 2017; 12(7)e0181246. doi: 10.1371/journal.pone.0181246.

PMID:
    28749971
    [PubMed - indexed for MEDLINE]
Related citations


Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.
Kalish JM, Doros L, Helman LJ, Hennekam RC, Kuiper RP, Maas SM, Maher ER, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz KAP, States LJ, Tomlinson GE, Zelley K, Druley TE
Clin Cancer Res. 2017 Jul 1; 23(13)e115-e122. doi: 10.1158/1078-0432.CCR-17-0710.

PMID:
    28674120
    [PubMed - in process]
Related citations


Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions.
Porter CC, Druley TE, Erez A, Kuiper RP, Onel K, Schiffman JD, Wolfe Schneider K, Scollon SR, Scott HS, Strong LC, Walsh MF, Nichols KE
Clin Cancer Res. 2017 Jun 1; 23(11)e14-e22. doi: 10.1158/1078-0432.CCR-17-0428.

PMID:
    28572263
    [PubMed - in process]
Related citations


Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4.
Creamer JP, Dege C, Ren Q, Ho JTK, Valentine MC, Druley TE, Sturgeon CM
Blood. 2017 Jun 1; 129(22)2988-2992. doi: 10.1182/blood-2016-11-749382.

PMID:
    28408465
    [PubMed - indexed for MEDLINE]
Related citations


Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Kramer AC, Kothari A, Wilson WC, Celik H, Nikitas J, Mallaney C, Ostrander EL, Eultgen E, Martens A, Valentine MC, Young AL, Druley TE, Figueroa ME, Zhang B, Challen GA
Leukemia. 2017 Nov; 31(11)2479-2490. doi: 10.1038/leu.2017.89.

PMID:
    28321121
    [PubMed - in process]
Related citations


Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults.
Young AL, Challen GA, Birmann BM, Druley TE
Nat Commun. 2016 Aug 22; 712484. doi: 10.1038/ncomms12484.

PMID:
    27546487
    [PubMed - in process]
Related citations


Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.
Druley TE, Wang L, Lin SJ, Lee JH, Zhang Q, Daw EW, Abel HJ, Chasnoff SE, Ramos EI, Levinson BT, Thyagarajan B, Newman AB, Christensen K, Mayeux R, Province MA
BMC Geriatr. 2016 Apr 9; 1680. doi: 10.1186/s12877-016-0253-y.

PMID:
    27060904
    [PubMed - indexed for MEDLINE]
Related citations


Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.
Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M
PLoS One. 2015; 10(11)e0142649. doi: 10.1371/journal.pone.0142649.

PMID:
    26587832
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
Leukemia. 2015 Jul; 29(7)1608-11. doi: 10.1038/leu.2015.17.

PMID:
    25644247
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children.
Madden LM, Ngwube AI, Shenoy S, Druley TE, Hayashi RJ
J Pediatr Hematol Oncol. 2015 Mar; 37(2)e94-e101. doi: 10.1097/MPH.0000000000000272.

PMID:
    25333837
    [PubMed - indexed for MEDLINE]
Related citations


Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.
Alvarado DM, Yang P, Druley TE, Lovett M, Gurnett CA
Nucleic Acids Res. 2014 Jun; 42(10)e82. doi: 10.1093/nar/gku218.

PMID:
    24682816
    [PubMed - indexed for MEDLINE]
Related citations


Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome.
Wambach JA, Wegner DJ, Heins HB, Druley TE, Mitra RD, Hamvas A, Cole FS
J Pediatr. 2014 Jun; 164(6)1316-21.e3. doi: 10.1016/j.jpeds.2014.02.021.

PMID:
    24657120
    [PubMed - indexed for MEDLINE]
Related citations


Integrated analysis of germline and somatic variants in ovarian cancer.
Kanchi KL, Johnson KJ, Lu C, McLellan MD, Leiserson MD, Wendl MC, Zhang Q, Koboldt DC, Xie M, Kandoth C, McMichael JF, Wyczalkowski MA, Larson DE, Schmidt HK, Miller CA, Fulton RS, Spellman PT, Mardis ER, Druley TE, Graubert TA, Goodfellow PJ, Raphael BJ, Wilson RK, Ding L
Nat Commun. 2014; 53156. doi: 10.1038/ncomms4156.

PMID:
    24448499
    [PubMed - indexed for MEDLINE]
Related citations


Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.
Valentine MC, Linabery AM, Chasnoff S, Hughes AE, Mallaney C, Sanchez N, Giacalone J, Heerema NA, Hilden JM, Spector LG, Ross JA, Druley TE
Leukemia. 2014 Jun; 28(6)1235-41. doi: 10.1038/leu.2013.367.

PMID:
    24301523
    [PubMed - indexed for MEDLINE]
Related citations


Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly.
Ramos EI, Bien-Willner GA, Li J, Hughes AE, Giacalone J, Chasnoff S, Kulkarni S, Parmacek M, Cole FS, Druley TE
Clin Genet. 2014 May; 85(5)423-32. doi: 10.1111/cge.12197.

PMID:
    23692340
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Druley TE
Clin Chem. 2013 Jan; 59(1)50-1. doi: 10.1373/clinchem.2012.192310.

PMID:
    23284014
    [PubMed - indexed for MEDLINE]
Related citations


Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing.
Ramos E, Levinson BT, Chasnoff S, Hughes A, Young AL, Thornton K, Li A, Vallania FL, Province M, Druley TE
BMC Genomics. 2012 Dec 6; 13683. doi: 10.1186/1471-2164-13-683.

PMID:
    23216810
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Developing targeted high throughput pooled sample DNA sequencing, designed to detect rare germline variants in specific genes involved in pediatric carcinogenesis, as well as the general population.