Patient Portal

Todd E. Druley, MD, PhD

Assistant Professor, Pediatrics
Division of Hematology and Oncology

Specialty Areas

Pediatric Oncology
Brain Tumors - Pediatric
Pediatric Hematology

Board Certifications

Pediatrics
Pediatric Hematology
Pediatric Oncology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric cancer, pediatric blood disorders, pediatric brain tumor, pediatric oncology, pediatrics; cancer predisposition

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6018
Fax: 314-454-2780

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

Ph.D.: University of Illinois at Chicago, Chicago, Illinois 2002
Residency: Pediatrics, St. Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2005
B.S.: Cell and Structural Biology, University of Illinois at Urbana-Champaign, Chicago, Illinois 1994
Medical Degree: University of Illinois at Chicago, Chicago, Illinois 2002
Fellowship: Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri 2008

Publication & Research

Publication & Research

Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples.
Barwe SP, Gopalakrisnapillai A, Mahajan N, Druley TE, Kolb EA, Crowgey EL
Genomics Inform. 2020 Mar; 18(1)e6. doi: 10.5808/GI.2020.18.1.e6.

PMID:
    32224839
    [PubMed]
Related citations


The evolutionary dynamics and fitness landscape of clonal hematopoiesis.
Watson CJ, Papula AL, Poon GYP, Wong WH, Young AL, Druley TE, Fisher DS, Blundell JR
Science. 2020 Mar 27; 367(6485)1449-1454. doi: 10.1126/science.aay9333.

PMID:
    32217721
    [PubMed - indexed for MEDLINE]
Related citations


Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.
Crowgey EL, Mahajan N, Wong WH, Gopalakrishnapillai A, Barwe SP, Kolb EA, Druley TE
BMC Med Genomics. 2020 Mar 4; 13(1)32. doi: 10.1186/s12920-020-0671-8.

PMID:
    32131829
    [PubMed - in process]
Related citations


Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation.
Wong WH, Bhatt S, Trinkaus K, Pusic I, Elliott K, Mahajan N, Wan F, Switzer GE, Confer DL, DiPersio J, Pulsipher MA, Shah NN, Sees J, Bystry A, Blundell JR, Shaw BE, Druley TE
Sci Transl Med. 2020 Jan 15; 12(526)pii: eaax6249. doi: 10.1126/scitranslmed.aax6249.

PMID:
    31941826
    [PubMed - in process]
Related citations


The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases.
Pringle ES, Wertman J, Melong N, Coombs AJ, Young AL, O'Leary D, Veinotte C, Robinson CA, Ha MN, Dellaire G, Druley TE, McCormick C, Berman JN
Viruses. 2019 Dec 20; 12(1)pii: E12. doi: 10.3390/v12010012.

PMID:
    31861850
    [PubMed - in process]
Related citations


NF1 glioblastoma clonal profiling reveals <i>KMT2B</i> mutations as potential somatic oncogenic events.
Wong WH, Junck L, Druley TE, Gutmann DH
Neurology. 2019 Dec 10; 93(24)1067-1069. doi: 10.1212/WNL.0000000000008623.

PMID:
    31690684
    [PubMed - indexed for MEDLINE]
Related citations


Novel mutation in AIRE gene with autoimmune polyendocrine syndrome type 1.
Fardi Golyan F, Ghaemi N, Abbaszadegan MR, Dehghan Manshadi SH, Vakili R, Druley TE, Rahimi HR, Ghahraman M
Immunobiology. 2019 Nov; 224(6)728-733. doi: 10.1016/j.imbio.2019.09.004.

PMID:
    31526676
    [PubMed - indexed for MEDLINE]
Related citations


Whole-exome sequencing of familial esophageal squamous cell carcinoma identified rare pathogenic variants in new predisposition genes.
Golyan FF, Druley TE, Abbaszadegan MR
Clin Transl Oncol. 2020 May; 22(5)681-693. doi: 10.1007/s12094-019-02174-z.

PMID:
    31321674
    [PubMed - in process]
Related citations


Clonal hematopoiesis and risk of acute myeloid leukemia.
Young AL, Tong RS, Birmann BM, Druley TE
Haematologica. 2019 Dec; 104(12)2410-2417. doi: 10.3324/haematol.2018.215269.

PMID:
    31004019
    [PubMed - in process]
Related citations


Distal chromosome 16p11.2 duplications containing <i>SH2B1</i> in patients with scoliosis.
Sadler B, Haller G, Antunes L, Bledsoe X, Morcuende J, Giampietro P, Raggio C, Miller N, Kidane Y, Wise CA, Amarillo I, Walton N, Seeley M, Johnson D, Jenkins C, Jenkins T, Oetjens M, Tong RS, Druley TE, Dobbs MB, Gurnett CA
J Med Genet. 2019 Jul; 56(7)427-433. doi: 10.1136/jmedgenet-2018-105877.

PMID:
    30803986
    [PubMed - indexed for MEDLINE]
Related citations


Age-specific changes in genome-wide methylation enrich for Foxa2 and estrogen receptor alpha binding sites.
Uli N, Michelen-Gomez E, Ramos EI, Druley TE
PLoS One. 2018; 13(9)e0203147. doi: 10.1371/journal.pone.0203147.

PMID:
    30256791
    [PubMed - indexed for MEDLINE]
Related citations


Rare Event Detection Using Error-corrected DNA and RNA Sequencing.
Wong WH, Tong RS, Young AL, Druley TE
J Vis Exp. 2018 Aug 3; (138)doi: 10.3791/57509.

PMID:
    30124656
    [PubMed - indexed for MEDLINE]
Related citations


Special Therapy and Psychosocial Needs Identified in a Multidisciplinary Cancer Predisposition Syndrome Clinic.
Groves AP, Gettinger K, Druley TE, Kozel BA, Shinawi M, Mohrmann C, Henry J, Jacobi C, Trinkaus K, Hayashi RJ
J Pediatr Hematol Oncol. 2019 Mar; 41(2)133-136. doi: 10.1097/MPH.0000000000001251.

PMID:
    30028825
    [PubMed - indexed for MEDLINE]
Related citations


Parental Age and Risk of Infant Leukaemia: A Pooled Analysis.
Marcotte EL, Druley TE, Johnson KJ, Richardson M, von Behren J, Mueller BA, Carozza S, McLaughlin C, Chow EJ, Reynolds P, Spector LG
Paediatr Perinat Epidemiol. 2017 Nov; 31(6)563-572. doi: 10.1111/ppe.12412.

PMID:
    28940632
    [PubMed - indexed for MEDLINE]
Related citations


Congenital neurodevelopmental anomalies in pediatric and young adult cancer.
Wong-Siegel JR, Johnson KJ, Gettinger K, Cousins N, McAmis N, Zamarione A, Druley TE
Am J Med Genet A. 2017 Oct; 173(10)2670-2679. doi: 10.1002/ajmg.a.38387.

PMID:
    28851129
    [PubMed - indexed for MEDLINE]
Related citations


Pediatric cancer risk in association with birth defects: A systematic review.
Johnson KJ, Lee JM, Ahsan K, Padda H, Feng Q, Partap S, Fowler SA, Druley TE
PLoS One. 2017; 12(7)e0181246. doi: 10.1371/journal.pone.0181246.

PMID:
    28749971
    [PubMed - indexed for MEDLINE]
Related citations


Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma.
Kalish JM, Doros L, Helman LJ, Hennekam RC, Kuiper RP, Maas SM, Maher ER, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz KAP, States LJ, Tomlinson GE, Zelley K, Druley TE
Clin Cancer Res. 2017 Jul 1; 23(13)e115-e122. doi: 10.1158/1078-0432.CCR-17-0710.

PMID:
    28674120
    [PubMed - indexed for MEDLINE]
Related citations


Recommendations for Surveillance for Children with Leukemia-Predisposing Conditions.
Porter CC, Druley TE, Erez A, Kuiper RP, Onel K, Schiffman JD, Wolfe Schneider K, Scollon SR, Scott HS, Strong LC, Walsh MF, Nichols KE
Clin Cancer Res. 2017 Jun 1; 23(11)e14-e22. doi: 10.1158/1078-0432.CCR-17-0428.

PMID:
    28572263
    [PubMed - indexed for MEDLINE]
Related citations


Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4.
Creamer JP, Dege C, Ren Q, Ho JTK, Valentine MC, Druley TE, Sturgeon CM
Blood. 2017 Jun 1; 129(22)2988-2992. doi: 10.1182/blood-2016-11-749382.

PMID:
    28408465
    [PubMed - indexed for MEDLINE]
Related citations


Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
Kramer AC, Kothari A, Wilson WC, Celik H, Nikitas J, Mallaney C, Ostrander EL, Eultgen E, Martens A, Valentine MC, Young AL, Druley TE, Figueroa ME, Zhang B, Challen GA
Leukemia. 2017 Nov; 31(11)2479-2490. doi: 10.1038/leu.2017.89.

PMID:
    28321121
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2019:

Company Name: ArcherDX, Inc.,

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2020

Areas of Research Interest

Developing targeted high throughput pooled sample DNA sequencing, designed to detect rare germline variants in specific genes involved in pediatric carcinogenesis, as well as the general population.