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Todd E. Druley, MD, PhD

Assistant Professor, Pediatrics
Division of Hematology and Oncology

Specialty Areas

Pediatric Oncology
Brain Tumors - Pediatric
Pediatric Hematology

Board Certifications

Pediatrics
Pediatric Hematology
Pediatric Oncology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric cancer, pediatric blood disorders, pediatric brain tumor, pediatric oncology, pediatrics; cancer predisposition

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6018
Fax: 314-454-2780

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: 2E
Office Phone: 314-454-6018
Fax: 314-454-2780

Education

Education

Ph.D.: University of Illinois at Chicago, Chicago, Illinois 2002
Residency: Pediatrics, St. Louis Children's Hospital at Washington University School of Medicine, St. Louis, Missouri 2005
B.S.: Cell and Structural Biology, University of Illinois at Urbana-Champaign, Chicago, Illinois 1994
Medical Degree: University of Illinois at Chicago, Chicago, Illinois 2002
Fellowship: Pediatric Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri 2008

Publication & Research

Publication & Research

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults.
Young AL, Challen GA, Birmann BM, Druley TE
Nat Commun. 2016 Aug 22; 712484. doi: 10.1038/ncomms12484.

PMID:
    27546487
    [PubMed - in process]
Related citations


Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.
Druley TE, Wang L, Lin SJ, Lee JH, Zhang Q, Daw EW, Abel HJ, Chasnoff SE, Ramos EI, Levinson BT, Thyagarajan B, Newman AB, Christensen K, Mayeux R, Province MA
BMC Geriatr. 2016 Apr 9; 1680. doi: 10.1186/s12877-016-0253-y.

PMID:
    27060904
    [PubMed - in process]
Related citations


Pooled Sequencing of Candidate Genes Implicates Rare Variants in the Development of Asthma Following Severe RSV Bronchiolitis in Infancy.
Torgerson DG, Giri T, Druley TE, Zheng J, Huntsman S, Seibold MA, Young AL, Schweiger T, Yin-Declue H, Sajol GD, Schechtman KB, Hernandez RD, Randolph AG, Bacharier LB, Castro M
PLoS One. 2015; 10(11)e0142649. doi: 10.1371/journal.pone.0142649.

PMID:
    26587832
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
Leukemia. 2015 Jul; 29(7)1608-11. doi: 10.1038/leu.2015.17.

PMID:
    25644247
    [PubMed - indexed for MEDLINE]
Related citations


Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature. 2015 Feb 26; 518(7540)552-5. doi: 10.1038/nature13968.

PMID:
    25487151
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children.
Madden LM, Ngwube AI, Shenoy S, Druley TE, Hayashi RJ
J Pediatr Hematol Oncol. 2015 Mar; 37(2)e94-e101. doi: 10.1097/MPH.0000000000000272.

PMID:
    25333837
    [PubMed - indexed for MEDLINE]
Related citations


Multiplexed direct genomic selection (MDiGS): a pooled BAC capture approach for highly accurate CNV and SNP/INDEL detection.
Alvarado DM, Yang P, Druley TE, Lovett M, Gurnett CA
Nucleic Acids Res. 2014 Jun; 42(10)e82. doi: 10.1093/nar/gku218.

PMID:
    24682816
    [PubMed - indexed for MEDLINE]
Related citations


Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome.
Wambach JA, Wegner DJ, Heins HB, Druley TE, Mitra RD, Hamvas A, Cole FS
J Pediatr. 2014 Jun; 164(6)1316-21.e3. doi: 10.1016/j.jpeds.2014.02.021.

PMID:
    24657120
    [PubMed - indexed for MEDLINE]
Related citations


Integrated analysis of germline and somatic variants in ovarian cancer.
Kanchi KL, Johnson KJ, Lu C, McLellan MD, Leiserson MD, Wendl MC, Zhang Q, Koboldt DC, Xie M, Kandoth C, McMichael JF, Wyczalkowski MA, Larson DE, Schmidt HK, Miller CA, Fulton RS, Spellman PT, Mardis ER, Druley TE, Graubert TA, Goodfellow PJ, Raphael BJ, Wilson RK, Ding L
Nat Commun. 2014; 53156. doi: 10.1038/ncomms4156.

PMID:
    24448499
    [PubMed - indexed for MEDLINE]
Related citations


Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.
Valentine MC, Linabery AM, Chasnoff S, Hughes AE, Mallaney C, Sanchez N, Giacalone J, Heerema NA, Hilden JM, Spector LG, Ross JA, Druley TE
Leukemia. 2014 Jun; 28(6)1235-41. doi: 10.1038/leu.2013.367.

PMID:
    24301523
    [PubMed - indexed for MEDLINE]
Related citations


Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly.
Ramos EI, Bien-Willner GA, Li J, Hughes AE, Giacalone J, Chasnoff S, Kulkarni S, Parmacek M, Cole FS, Druley TE
Clin Genet. 2014 May; 85(5)423-32. doi: 10.1111/cge.12197.

PMID:
    23692340
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Druley TE
Clin Chem. 2013 Jan; 59(1)50-1. doi: 10.1373/clinchem.2012.192310.

PMID:
    23284014
    [PubMed - indexed for MEDLINE]
Related citations


Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing.
Ramos E, Levinson BT, Chasnoff S, Hughes A, Young AL, Thornton K, Li A, Vallania FL, Province M, Druley TE
BMC Genomics. 2012 Dec 6; 13683. doi: 10.1186/1471-2164-13-683.

PMID:
    23216810
    [PubMed - indexed for MEDLINE]
Related citations


Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome.
Wambach JA, Wegner DJ, Depass K, Heins H, Druley TE, Mitra RD, An P, Zhang Q, Nogee LM, Cole FS, Hamvas A
Pediatrics. 2012 Dec; 130(6)e1575-82. doi: 10.1542/peds.2012-0918.

PMID:
    23166334
    [PubMed - indexed for MEDLINE]
Related citations


Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.
Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, Knowles MR, Brody SL, Dutcher SK, Ferkol TW
Am J Hum Genet. 2012 Oct 5; 91(4)685-93. doi: 10.1016/j.ajhg.2012.08.022.

PMID:
    23040496
    [PubMed - indexed for MEDLINE]
Related citations


Detection of rare genomic variants from pooled sequencing using SPLINTER.
Vallania F, Ramos E, Cresci S, Mitra RD, Druley TE
J Vis Exp. 2012 Jun 23; (64)pii: 3943. doi: 10.3791/3943.

PMID:
    22760212
    [PubMed - indexed for MEDLINE]
Related citations


High-throughput discovery of rare insertions and deletions in large cohorts.
Vallania FL, Druley TE, Ramos E, Wang J, Borecki I, Province M, Mitra RD
Genome Res. 2010 Dec; 20(12)1711-8. doi: 10.1101/gr.109157.110.

PMID:
    21041413
    [PubMed - indexed for MEDLINE]
Related citations


Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1.
Gurnett CA, Desruisseau DM, McCall K, Choi R, Meyer ZI, Talerico M, Miller SE, Ju JS, Pestronk A, Connolly AM, Druley TE, Weihl CC, Dobbs MB
Hum Mol Genet. 2010 Apr 1; 19(7)1165-73. doi: 10.1093/hmg/ddp587.

PMID:
    20045868
    [PubMed - indexed for MEDLINE]
Related citations


Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.
Matkovich SJ, Van Booven DJ, Hindes A, Kang MY, Druley TE, Vallania FL, Mitra RD, Reilly MP, Cappola TP, Dorn GW 2nd
J Clin Invest. 2010 Jan; 120(1)280-9. doi: 10.1172/JCI39085.

PMID:
    20038796
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Developing targeted high throughput pooled sample DNA sequencing, designed to detect rare germline variants in specific genes involved in pediatric carcinogenesis, as well as the general population.