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Todd A. Fehniger, MD, PhD

Associate Professor, Medicine
Division of Oncology
Section, Bone Marrow Transplant

Specialty Areas

Oncology
Lymphoma
Bone Marrow Transplant

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lymphoma, cellular therapy and bone marrow transplantation

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

PhD: Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, College of Medicine and Public Health Columbus, Ohio 2000
BS: Biological Sciences, SUNY, Buffalo, New York 1994
Fellowship: Hematology and Oncology, Washington University School of Medicine, St. Louis, Missouri 2008
Residency: Internal Medicine, Barnes-Jewish Hospital, Washington University School of Medicine, St. Louis, Missouri 2004
Medical Degree: The Ohio State University, College of Medicine and Public Health, Columbus, Ohio 2002

Publication & Research

Publication & Research

Lenalidomide consolidation benefits patients with CLL receiving chemoimmunotherapy: results for CALGB 10404 (Alliance).
Byrd JC, Ruppert AS, Heerema NA, Halvorson AE, Hoke E, Smith MR, Godwin JE, Couban S, Fehniger TA, Thirman MJ, Tallman MS, Appelbaum FR, Stone RM, Robinson S, Chang JE, Mandrekar SJ, Larson RA
Blood Adv. 2018 Jul 24; 2(14)1705-1718. doi: 10.1182/bloodadvances.2017015396.

PMID:
    30030269
    [PubMed - in process]
Related citations


Comment on: Evidence of innate lymphoid cell redundancy in humans.
Orange JS, Mace EM, French AR, Yokoyama WM, Fehniger TA, Cooper MA
Nat Immunol. 2018 Aug; 19(8)788-789. doi: 10.1038/s41590-018-0164-5.

PMID:
    30026477
    [PubMed - in process]
Related citations


<i>MIR142</i> Loss-of-Function Mutations Derepress ASH1L to Increase <i>HOXA</i> Gene Expression and Promote Leukemogenesis.
Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC
Cancer Res. 2018 Jul 1; 78(13)3510-3521. doi: 10.1158/0008-5472.CAN-17-3592.

PMID:
    29724719
    [PubMed - in process]
Related citations


A Phase 1 Trial of CNDO-109-Activated Natural Killer Cells in Patients with High-Risk Acute Myeloid Leukemia.
Fehniger TA, Miller JS, Stuart RK, Cooley S, Salhotra A, Curtsinger J, Westervelt P, DiPersio JF, Hillman TM, Silver N, Szarek M, Gorelik L, Lowdell MW, Rowinsky E
Biol Blood Marrow Transplant. 2018 Aug; 24(8)1581-1589. doi: 10.1016/j.bbmt.2018.03.019.

PMID:
    29597002
    [PubMed - in process]
Related citations


Lenalidomide results in a durable complete remission in acute myeloid leukemia accompanied by persistence of somatic mutations and a T-cell infiltrate in the bone marrow.
Bansal D, Vij K, Chang GS, Miller CA, DiPersio JF, Vij R, Heath SE, Westervelt P, Welch JS, Fehniger TA
Haematologica. 2018 Jun; 103(6)e270-e273. doi: 10.3324/haematol.2017.184168.

PMID:
    29567774
    [PubMed - in process]
Related citations


First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation.
Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE, Vivek S, Peck L, DiPersio JF, Cashen AF, Kyllo R, Musiek A, Schaffer A, Anadkat MJ, Rosman I, Miller D, Egan JO, Jeng EK, Rock A, Wong HC, Fehniger TA, Miller JS
Blood. 2018 Jun 7; 131(23)2515-2527. doi: 10.1182/blood-2017-12-823757.

PMID:
    29463563
    [PubMed - in process]
Related citations


Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? Vaccination Strategies Based on NK Cell and ILC Memory.
Cooper MA, Fehniger TA, Colonna M
Cold Spring Harb Perspect Biol. 2017 Dec 18; pii: a029512. doi: 10.1101/cshperspect.a029512.

PMID:
    29254976
    [PubMed - as supplied by publisher]
Related citations


Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control.
Mah AY, Rashidi A, Keppel MP, Saucier N, Moore EK, Alinger JB, Tripathy SK, Agarwal SK, Jeng EK, Wong HC, Miller JS, Fehniger TA, Mace EM, French AR, Cooper MA
JCI Insight. 2017 Dec 7; 2(23)pii: 95128. doi: 10.1172/jci.insight.95128.

PMID:
    29212951
    [PubMed - as supplied by publisher]
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Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial.
Bartlett NL, Costello BA, LaPlant BR, Ansell SM, Kuruvilla JG, Reeder CB, Thye LS, Anderson DM, Krysiak K, Ramirez C, Qi J, Siegel BA, Griffith M, Griffith OL, Gomez F, Fehniger TA
Blood. 2018 Jan 11; 131(2)182-190. doi: 10.1182/blood-2017-09-804641.

PMID:
    29074501
    [PubMed - in process]
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Patterns of infectious complications in acute myeloid leukemia and myelodysplastic syndromes patients treated with 10-day decitabine regimen.
Ali AM, Weisel D, Gao F, Uy GL, Cashen AF, Jacoby MA, Wartman LD, Ghobadi A, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Schroeder MA, Westervelt P, DiPersio JF, Welch JS
Cancer Med. 2017 Dec; 6(12)2814-2821. doi: 10.1002/cam4.1231.

PMID:
    29058375
    [PubMed - indexed for MEDLINE]
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Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J
Eur J Immunol. 2017 Oct; 47(10)1584-1797. doi: 10.1002/eji.201646632.

PMID:
    29023707
    [PubMed - indexed for MEDLINE]
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CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.
Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA, Becker-Hapak M, Schappe T, Abdel-Latif S, Ireland AR, Jaishankar D, King JA, Vij R, Clement D, Goodridge J, Malmberg KJ, Wong HC, Fehniger TA
J Clin Invest. 2017 Nov 1; 127(11)4042-4058. doi: 10.1172/JCI90387.

PMID:
    28972539
    [PubMed - indexed for MEDLINE]
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CD70 turns on NK cells to attack lymphoma.
Fehniger TA
Blood. 2017 Jul 20; 130(3)238-239. doi: 10.1182/blood-2017-06-786244.

PMID:
    28729334
    [PubMed - indexed for MEDLINE]
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A Phase I/II Trial of Panobinostat in Combination With Lenalidomide in Patients With Relapsed or Refractory Hodgkin Lymphoma.
Maly JJ, Christian BA, Zhu X, Wei L, Sexton JL, Jaglowski SM, Devine SM, Fehniger TA, Wagner-Johnston ND, Phelps MA, Bartlett NL, Blum KA
Clin Lymphoma Myeloma Leuk. 2017 Jun; 17(6)347-353. doi: 10.1016/j.clml.2017.05.008.

PMID:
    28622959
    [PubMed - indexed for MEDLINE]
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T Cell-Replete Peripheral Blood Haploidentical Hematopoietic Cell Transplantation with Post-Transplantation Cyclophosphamide Results in Outcomes Similar to Transplantation from Traditionally Matched Donors in Active Disease Acute Myeloid Leukemia.
How J, Slade M, Vu K, DiPersio JF, Westervelt P, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Romee R
Biol Blood Marrow Transplant. 2017 Apr; 23(4)648-653. doi: 10.1016/j.bbmt.2017.01.068.

PMID:
    28087457
    [PubMed - indexed for MEDLINE]
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Single institution experience with G-CSF mobilized T-cell replete haploidentical hematopoietic cell transplantation.
Huselton E, Slade M, DiPersio JF, Westervelt P, Vij R, Uy GL, Fehniger TA, Abboud CN, Gao F, Schroeder MA, Romee R
Bone Marrow Transplant. 2017 May; 52(5)769-771. doi: 10.1038/bmt.2016.354.

PMID:
    28067881
    [PubMed - indexed for MEDLINE]
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Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma.
Krysiak K, Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC, Fulton RS, Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL, Griffith M, Griffith OL, Fehniger TA
Blood. 2017 Jan 26; 129(4)473-483. doi: 10.1182/blood-2016-07-729954.

PMID:
    28064239
    [PubMed - indexed for MEDLINE]
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TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
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Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses.
Wagner JA, Berrien-Elliott MM, Rosario M, Leong JW, Jewell BA, Schappe T, Abdel-Latif S, Fehniger TA
Biol Blood Marrow Transplant. 2017 Mar; 23(3)398-404. doi: 10.1016/j.bbmt.2016.11.018.

PMID:
    27894857
    [PubMed - indexed for MEDLINE]
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Cytomegalovirus viremia, disease, and impact on relapse in T-cell replete peripheral blood haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide.
Goldsmith SR, Slade M, DiPersio JF, Westervelt P, Lawrence SJ, Uy GL, Abboud CN, Vij R, Schroeder MA, Fehniger TA, Dubberke ER, Trinkaus K, Romee R
Haematologica. 2016 Nov; 101(11)e465-e468.

PMID:
    27443287
    [PubMed - indexed for MEDLINE]
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