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Timothy J. Ley, MD

Lewis T. and Rosalind B. Apple Chair in Oncology
Professor of Medicine and Genetics
Division of Oncology
Director, Section of Stem Cell Biology
Associate Director, Cancer Genomics, The Genome Institute

Specialty Areas

Bone Marrow Transplant
Hematology
Oncology
Hematologic Malignancies
Leukemia

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Hemoglobinopathies, acute and chronic myeloid leukemias, cancer genomis, cytotoxic lymphocytes

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-9337
Fax: 314-362-9333

Education

Education

Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, MO 1984
Residency: Medicine, Massachusetts General Hospital, Boston, MO 1980
Medical School: Washington University School of Medicine, St. Louis, MO 1978
B.A.: Drake University, Des Moines, IA 1974

Publication & Research

Publication & Research

Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton R, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 May 12; pii: S0301-472X(16)30115-1. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - as supplied by publisher]
Related citations


Patterns and functional implications of rare germline variants across 12 cancer types.
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
Nat Commun. 2015 Dec 22; 610086. doi: 10.1038/ncomms10086.

PMID:
    26689913
    [PubMed - indexed for MEDLINE]
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Optimizing cancer genome sequencing and analysis.
Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK
Cell Syst. 2015 Sep 23; 1(3)210-223.

PMID:
    26645048
    [PubMed]
Related citations


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood. 2016 Feb 18; 127(7)893-7. doi: 10.1182/blood-2015-10-677021.

PMID:
    26631115
    [PubMed - in process]
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PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ
J Clin Invest. 2016 Jan; 126(1)85-98. doi: 10.1172/JCI82897.

PMID:
    26595813
    [PubMed - in process]
Related citations


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
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Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
Clin Cancer Res. 2015 Sep 15; 21(18)4201-11. doi: 10.1158/1078-0432.CCR-14-3049.

PMID:
    25925892
    [PubMed - in process]
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Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.
Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ
PLoS One. 2015; 10(3)e0120585. doi: 10.1371/journal.pone.0120585.

PMID:
    25799070
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
Leukemia. 2015 Jul; 29(7)1608-11. doi: 10.1038/leu.2015.17.

PMID:
    25644247
    [PubMed - indexed for MEDLINE]
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Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ
Leukemia. 2015 Jun; 29(6)1279-89. doi: 10.1038/leu.2015.6.

PMID:
    25600023
    [PubMed - indexed for MEDLINE]
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Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature. 2015 Feb 26; 518(7540)552-5. doi: 10.1038/nature13968.

PMID:
    25487151
    [PubMed - indexed for MEDLINE]
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Clonal architectures and driver mutations in metastatic melanomas.
Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mulé JJ, Wilson RK, Weber JS
PLoS One. 2014; 9(11)e111153. doi: 10.1371/journal.pone.0111153.

PMID:
    25393105
    [PubMed - indexed for MEDLINE]
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Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA
Blood. 2014 Dec 18; 124(26)3887-95. doi: 10.1182/blood-2014-06-582551.

PMID:
    25349173
    [PubMed - indexed for MEDLINE]
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Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, Dipersio JF, Chen F, Wilson RK, Ley TJ, Ding L
Nat Med. 2014 Dec; 20(12)1472-8. doi: 10.1038/nm.3733.

PMID:
    25326804
    [PubMed - indexed for MEDLINE]
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U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing.
Okeyo-Owuor T, White BS, Chatrikhi R, Mohan DR, Kim S, Griffith M, Ding L, Ketkar-Kulkarni S, Hundal J, Laird KM, Kielkopf CL, Ley TJ, Walter MJ, Graubert TA
Leukemia. 2015 Apr; 29(4)909-17. doi: 10.1038/leu.2014.303.

PMID:
    25311244
    [PubMed - indexed for MEDLINE]
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Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.
Engle EK, Fisher DA, Miller CA, McLellan MD, Fulton RS, Moore DM, Wilson RK, Ley TJ, Oh ST
Leukemia. 2015 Apr; 29(4)869-76. doi: 10.1038/leu.2014.289.

PMID:
    25252869
    [PubMed - indexed for MEDLINE]
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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.
Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MD, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van't Veer LJ, Lopez-Bigas N, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA, Cancer Genome Atlas Research Network, Benz CC, Perou CM, Stuart JM
Cell. 2014 Aug 14; 158(4)929-44. doi: 10.1016/j.cell.2014.06.049.

PMID:
    25109877
    [PubMed - indexed for MEDLINE]
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SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution.
Miller CA, White BS, Dees ND, Griffith M, Welch JS, Griffith OL, Vij R, Tomasson MH, Graubert TA, Walter MJ, Ellis MJ, Schierding W, DiPersio JF, Ley TJ, Mardis ER, Wilson RK, Ding L
PLoS Comput Biol. 2014 Aug; 10(8)e1003665. doi: 10.1371/journal.pcbi.1003665.

PMID:
    25102416
    [PubMed - indexed for MEDLINE]
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Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro.
Sarkaria SM, Christopher MJ, Klco JM, Ley TJ
Leukemia. 2014 Dec; 28(12)2403-6. doi: 10.1038/leu.2014.235.

PMID:
    25092143
    [PubMed - indexed for MEDLINE]
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