Patient Portal

Timothy J. Ley, MD

Lewis T. and Rosalind B. Apple Chair in Oncology
Professor of Medicine and Genetics
Division of Oncology
Director, Section of Stem Cell Biology
Associate Director, Cancer Genomics, The Genome Institute

Specialty Areas

Bone Marrow Transplant
Hematology
Oncology
Hematologic Malignancies
Leukemia

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Hemoglobinopathies, acute and chronic myeloid leukemias, cancer genomis, cytotoxic lymphocytes

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-9337
Fax: 314-362-9333

Education

Education

Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, MO 1984
Residency: Medicine, Massachusetts General Hospital, Boston, MO 1980
Medical School: Washington University School of Medicine, St. Louis, MO 1978
B.A.: Drake University, Des Moines, IA 1974

Publication & Research

Publication & Research

Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies studies and correlation with flt3 mutations and polyunsaturated fatty acid metabolism.
Mazzarella L, Botteri E, Matthews A, Gatti E, Di Salvatore D, Bagnardi V, Breccia M, Montesinos P, Bernal T, Gil C, Ley TJ, Sanz M, Bhaskaran K, Lo Coco F, Pelicci PG
Haematologica. 2019 Sep 12; pii: haematol.2019.223925. doi: 10.3324/haematol.2019.223925.

PMID:
    31515354
    [PubMed - as supplied by publisher]
Related citations


A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.
Petti AA, Williams SR, Miller CA, Fiddes IT, Srivatsan SN, Chen DY, Fronick CC, Fulton RS, Church DM, Ley TJ
Nat Commun. 2019 Aug 14; 10(1)3660. doi: 10.1038/s41467-019-11591-1.

PMID:
    31413257
    [PubMed - in process]
Related citations


Immune Escape of AML Cells after Transplantation. Reply.
Christopher M, DiPersio JF, Ley TJ
N Engl J Med. 2019 Mar 28; 380(13)1290. doi: 10.1056/NEJMc1900424.

PMID:
    30917273
    [PubMed - indexed for MEDLINE]
Related citations


Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.
Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, Baty JD, Payton JE, Graubert TA, Link DC, Walter MJ, Westervelt P, Ley TJ, DiPersio JF
N Engl J Med. 2018 Dec 13; 379(24)2330-2341. doi: 10.1056/NEJMoa1808777.

PMID:
    30380364
    [PubMed - indexed for MEDLINE]
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Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
N Engl J Med. 2018 Sep 13; 379(11)1028-1041. doi: 10.1056/NEJMoa1804714.

PMID:
    30207916
    [PubMed - indexed for MEDLINE]
Related citations


<i>MIR142</i> Loss-of-Function Mutations Derepress ASH1L to Increase <i>HOXA</i> Gene Expression and Promote Leukemogenesis.
Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty J, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy PR, Link DC
Cancer Res. 2018 Jul 1; 78(13)3510-3521. doi: 10.1158/0008-5472.CAN-17-3592.

PMID:
    29724719
    [PubMed - indexed for MEDLINE]
Related citations


Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.
Spencer DH, Ley TJ
JAMA. 2018 Apr 10; 319(14)1497-1498. doi: 10.1001/jama.2018.2281.

PMID:
    29634818
    [PubMed - indexed for MEDLINE]
Related citations


DNMT3A<sup>R882</sup>-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A<sup>R882C</sup> OCI-AML3 leukemia cell line.
Chen D, Christopher M, Helton NM, Ferguson I, Ley TJ, Spencer DH
Blood Cancer J. 2018 Apr 4; 8(4)38. doi: 10.1038/s41408-018-0072-9.

PMID:
    29618788
    [PubMed - indexed for MEDLINE]
Related citations


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight. 2018 Mar 8; 3(5)pii: 98962. doi: 10.1172/jci.insight.98962.

PMID:
    29515031
    [PubMed - in process]
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Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
Nat Commun. 2018 Jan 31; 9(1)455. doi: 10.1038/s41467-018-02858-0.

PMID:
    29386642
    [PubMed - indexed for MEDLINE]
Related citations


Expression profiling of snoRNAs in normal hematopoiesis and AML.
Warner WA, Spencer DH, Trissal M, White BS, Helton N, Ley TJ, Link DC
Blood Adv. 2018 Jan 23; 2(2)151-163. doi: 10.1182/bloodadvances.2017006668.

PMID:
    29365324
    [PubMed - indexed for MEDLINE]
Related citations


Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Cole CB, Russler-Germain DA, Ketkar S, Verdoni AM, Smith AM, Bangert CV, Helton NM, Guo M, Klco JM, O'Laughlin S, Fronick C, Fulton R, Chang GS, Petti AA, Miller CA, Ley TJ
J Clin Invest. 2017 Oct 2; 127(10)3657-3674. doi: 10.1172/JCI93041.

PMID:
    28872462
    [PubMed - indexed for MEDLINE]
Related citations


Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.
Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Klco JM, Mardis ER, Ley TJ, Wilson RK, Maher CA
Exp Hematol. 2017 Nov; 5519-33. doi: 10.1016/j.exphem.2017.07.008.

PMID:
    28760689
    [PubMed - indexed for MEDLINE]
Related citations


Decitabine in TP53-Mutated AML.
Welch JS, Petti AA, Ley TJ
N Engl J Med. 2017 Feb 23; 376(8)797-8. doi: 10.1056/NEJMc1616062.

PMID:
    28225682
    [PubMed - indexed for MEDLINE]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - indexed for MEDLINE]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - indexed for MEDLINE]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Visualizing tumor evolution with the fishplot package for R.
Miller CA, McMichael J, Dang HX, Maher CA, Ding L, Ley TJ, Mardis ER, Wilson RK
BMC Genomics. 2016 Nov 7; 17(1)880.

PMID:
    27821060
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - indexed for MEDLINE]
Related citations


Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia. 2016 Dec; 30(12)2422-2426. doi: 10.1038/leu.2016.247.

PMID:
    27573557
    [PubMed - indexed for MEDLINE]
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