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Timothy J. Ley, MD

Lewis T. and Rosalind B. Apple Chair in Oncology
Professor of Medicine and Genetics
Division of Oncology
Director, Section of Stem Cell Biology
Associate Director, Cancer Genomics, The Genome Institute

Specialty Areas

Bone Marrow Transplant
Hematology
Oncology
Hematologic Malignancies
Leukemia

Board Certifications

Hematology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Hemoglobinopathies, acute and chronic myeloid leukemias, cancer genomis, cytotoxic lymphocytes

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-362-9337
Fax: 314-362-9333

Education

Education

Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, MO 1984
Residency: Medicine, Massachusetts General Hospital, Boston, MO 1980
Medical School: Washington University School of Medicine, St. Louis, MO 1978
B.A.: Drake University, Des Moines, IA 1974

Publication & Research

Publication & Research

Decitabine in TP53-Mutated AML.
Welch JS, Petti AA, Ley TJ
N Engl J Med. 2017 Feb 23; 376(8)797-8. doi: 10.1056/NEJMc1616062.

PMID:
    28225682
    [PubMed - indexed for MEDLINE]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - in process]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - in process]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Visualizing tumor evolution with the fishplot package for R.
Miller CA, McMichael J, Dang HX, Maher CA, Ding L, Ley TJ, Mardis ER, Wilson RK
BMC Genomics. 2016 Nov 7; 17(1)880.

PMID:
    27821060
    [PubMed - in process]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - in process]
Related citations


Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia. 2016 Dec; 30(12)2422-2426. doi: 10.1038/leu.2016.247.

PMID:
    27573557
    [PubMed - in process]
Related citations


Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 Jul; 44(7)603-13. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - in process]
Related citations


Patterns and functional implications of rare germline variants across 12 cancer types.
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
Nat Commun. 2015 Dec 22; 610086. doi: 10.1038/ncomms10086.

PMID:
    26689913
    [PubMed - indexed for MEDLINE]
Related citations


Optimizing cancer genome sequencing and analysis.
Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, Walker JR, Dang HX, Trani L, Larson DE, Demeter RT, Wendl MC, McMichael JF, Austin RE, Magrini V, McGrath SD, Ly A, Kulkarni S, Cordes MG, Fronick CC, Fulton RS, Maher CA, Ding L, Klco JM, Mardis ER, Ley TJ, Wilson RK
Cell Syst. 2015 Sep 23; 1(3)210-223.

PMID:
    26645048
    [PubMed]
Related citations


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood. 2016 Feb 18; 127(7)893-7. doi: 10.1182/blood-2015-10-677021.

PMID:
    26631115
    [PubMed - indexed for MEDLINE]
Related citations


PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Cole CB, Verdoni AM, Ketkar S, Leight ER, Russler-Germain DA, Lamprecht TL, Demeter RT, Magrini V, Ley TJ
J Clin Invest. 2016 Jan; 126(1)85-98. doi: 10.1172/JCI82897.

PMID:
    26595813
    [PubMed - indexed for MEDLINE]
Related citations


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
Related citations


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
Related citations


Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH
Clin Cancer Res. 2015 Sep 15; 21(18)4201-11. doi: 10.1158/1078-0432.CCR-14-3049.

PMID:
    25925892
    [PubMed - indexed for MEDLINE]
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Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.
Li C, Klco JM, Helton NM, George DR, Mudd JL, Miller CA, Lu C, Fulton R, O'Laughlin M, Fronick C, Wilson RK, Ley TJ
PLoS One. 2015; 10(3)e0120585. doi: 10.1371/journal.pone.0120585.

PMID:
    25799070
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing.
Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE
Leukemia. 2015 Jul; 29(7)1608-11. doi: 10.1038/leu.2015.17.

PMID:
    25644247
    [PubMed - indexed for MEDLINE]
Related citations


Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.
Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ
Leukemia. 2015 Jun; 29(6)1279-89. doi: 10.1038/leu.2015.6.

PMID:
    25600023
    [PubMed - indexed for MEDLINE]
Related citations


Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Graubert TA, Ley TJ, Druley TE, Link DC, Wilson RK
Nature. 2015 Feb 26; 518(7540)552-5. doi: 10.1038/nature13968.

PMID:
    25487151
    [PubMed - indexed for MEDLINE]
Related citations


Clonal architectures and driver mutations in metastatic melanomas.
Ding L, Kim M, Kanchi KL, Dees ND, Lu C, Griffith M, Fenstermacher D, Sung H, Miller CA, Goetz B, Wendl MC, Griffith O, Cornelius LA, Linette GP, McMichael JF, Sondak VK, Fields RC, Ley TJ, Mulé JJ, Wilson RK, Weber JS
PLoS One. 2014; 9(11)e111153. doi: 10.1371/journal.pone.0111153.

PMID:
    25393105
    [PubMed - indexed for MEDLINE]
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