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Faculty Physicians

Tiffany M. Osborn, MD MPH, FACEP

Associate Professor, Surgery
Acute and Critical Care Surgery

Specialty Areas

Acute and Critical Care Surgery
Trauma Surgery
Burn/Trauma/Surgical Critical Care

Board Certifications

Critical Care ( European Society of Intensive Care Medicine)
Emergency Medicine

Areas of Clinical Interest

Emergency medicine, critical care, trauma

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Center for Outpatient Health

4901 Forest Park Avenue
St. Louis, MO 63108

Office Phone: 314-362-1272
Fax: 314-362-5743

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Office Phone: 314-362-1272
Fax: 314-362-5743

Education

Education

Masters Degree: (Public Health Research), London School of Hygiene and Tropical Medicine, London, England 2009
Medical School: University of Texas Health Sciences Center, San Antonio TX 1997
Residency: Emergency Medicine, University of Maryland Medical System, Baltimore, MD 2000
Fellowship: Trauma and Surgical Critical Care, R Adams Cowley Shock Trauma Center, Baltimore, MD, 2002

Publication & Research

Publication & Research

Trial of early, goal-directed resuscitation for septic shock.
Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, Rowan KM, ProMISe Trial Investigators
N Engl J Med. 2015 Apr 2; 372(14)1301-11. doi: 10.1056/NEJMoa1500896.

PMID:
    25776532
    [PubMed - indexed for MEDLINE]
Related citations


Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database.
Casserly B, Phillips GS, Schorr C, Dellinger RP, Townsend SR, Osborn TM, Reinhart K, Selvakumar N, Levy MM
Crit Care Med. 2015 Mar; 43(3)567-73. doi: 10.1097/CCM.0000000000000742.

PMID:
    25479113
    [PubMed - indexed for MEDLINE]
Related citations


Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis.
Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI
Shock. 2014 Aug; 42(2)99-107. doi: 10.1097/SHK.0000000000000182.

PMID:
    24978893
    [PubMed - indexed for MEDLINE]
Related citations


Sepsis severity score: an internationally derived scoring system from the surviving sepsis campaign database*.
Osborn TM, Phillips G, Lemeshow S, Townsend S, Schorr CA, Levy MM, Dellinger RP
Crit Care Med. 2014 Sep; 42(9)1969-76. doi: 10.1097/CCM.0000000000000416.

PMID:
    24919160
    [PubMed - indexed for MEDLINE]
Related citations


ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.
McLean JR, Smith GA, Rocha EM, Osborn TM, Dib S, Hayes MA, Beagan JA, Brown TB, Lawson TF, Hallett PJ, Robertson J, Isacson O
Exp Neurol. 2014 Nov; 261217-29. doi: 10.1016/j.expneurol.2014.05.024.

PMID:
    24907400
    [PubMed - indexed for MEDLINE]
Related citations


The Protocolised Management in Sepsis (ProMISe) trial statistical analysis plan.
Power GS, Harrison DA, Mouncey PR, Osborn TM, Harvey SE, Rowan KM
Crit Care Resusc. 2013 Dec; 15(4)311-7.

PMID:
    24289513
    [PubMed - indexed for MEDLINE]
Related citations


The authors reply.
Osborn TM, Levy M, Dellinger RP, Annane D
Crit Care Med. 2013 Oct; 41(10)e293-4. doi: 10.1097/CCM.0b013e3182a51d07.

PMID:
    24060795
    [PubMed - indexed for MEDLINE]
Related citations


Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe.
ProCESS/ARISE/ProMISe Methodology Writing Committee, Huang DT, Angus DC, Barnato A, Gunn SR, Kellum JA, Stapleton DK, Weissfeld LA, Yealy DM, Peake SL, Delaney A, Bellomo R, Cameron P, Higgins A, Holdgate A, Howe B, Webb SA, Williams P, Osborn TM, Mouncey PR, Harrison DA, Harvey SE, Rowan KM
Intensive Care Med. 2013 Oct; 39(10)1760-75.

PMID:
    23958738
    [PubMed - indexed for MEDLINE]
Related citations


Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Intensive Care Med. 2013 Feb; 39(2)165-228. doi: 10.1007/s00134-012-2769-8.

PMID:
    23361625
    [PubMed - indexed for MEDLINE]
Related citations


Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Crit Care Med. 2013 Feb; 41(2)580-637. doi: 10.1097/CCM.0b013e31827e83af.

PMID:
    23353941
    [PubMed - indexed for MEDLINE]
Related citations


Low-dose steroids in adult septic shock: results of the Surviving Sepsis Campaign.
Casserly B, Gerlach H, Phillips GS, Lemeshow S, Marshall JC, Osborn TM, Levy MM
Intensive Care Med. 2012 Dec; 38(12)1946-54. doi: 10.1007/s00134-012-2720-z.

PMID:
    23064466
    [PubMed - indexed for MEDLINE]
Related citations


Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department.
Perman SM, Chang AM, Hollander JE, Gaieski DF, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI
Acad Emerg Med. 2011 Feb; 18(2)219-22. doi: 10.1111/j.1553-2712.2010.00968.x.

PMID:
    21314784
    [PubMed - indexed for MEDLINE]
Related citations


The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis.
Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP
Ann Emerg Med. 2010 Jul; 56(1)52-59.e1. doi: 10.1016/j.annemergmed.2010.02.010.

PMID:
    20363526
    [PubMed - indexed for MEDLINE]
Related citations


Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP
PLoS One. 2009; 4(3)e4928. doi: 10.1371/journal.pone.0004928.

PMID:
    19293932
    [PubMed - indexed for MEDLINE]
Related citations


A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.
Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP
Crit Care Med. 2009 Jan; 37(1)96-104. doi: 10.1097/CCM.0b013e318192fd9d.

PMID:
    19050610
    [PubMed - indexed for MEDLINE]
Related citations


Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis.
Osborn TM, Verdrengh M, Stossel TP, Tarkowski A, Bokarewa M
Arthritis Res Ther. 2008; 10(5)R117. doi: 10.1186/ar2520.

PMID:
    18822171
    [PubMed - indexed for MEDLINE]
Related citations


Critical care and emergency medicine.
DeBlieux PM, Osborn TM
Emerg Med Clin North Am. 2008 Aug; 26(3)xv-xvi. doi: 10.1016/j.emc.2008.06.003.

PMID:
    18655936
    [PubMed - indexed for MEDLINE]
Related citations


Preparation of the neck for microvascular reconstruction of the head and neck.
Potter JK, Osborn TM
Oral Maxillofac Surg Clin North Am. 2008 Aug; 20(3)521-6. doi: 10.1016/j.coms.2008.04.004.

PMID:
    18603207
    [PubMed - indexed for MEDLINE]
Related citations


Deep space neck infection: principles of surgical management.
Osborn TM, Assael LA, Bell RB
Oral Maxillofac Surg Clin North Am. 2008 Aug; 20(3)353-65. doi: 10.1016/j.coms.2008.04.002.

PMID:
    18603196
    [PubMed - indexed for MEDLINE]
Related citations


Computed tomographic angiography as an aid to clinical decision making in the selective management of penetrating injuries to the neck: a reduction in the need for operative exploration.
Osborn TM, Bell RB, Qaisi W, Long WB
J Trauma. 2008 Jun; 64(6)1466-71. doi: 10.1097/TA.0b013e3181271b32.

PMID:
    18545110
    [PubMed - indexed for MEDLINE]
Related citations