FollowMyHealth Patient Portal

Faculty Physicians

Thomas W. Ferkol Jr., MD

Alexis Hartmann Professor, Pediatrics
Division of Pediatric Allergy, Immunology and Pulmonary Medicine
Director, Division of Pediatric Allergy, Immunology and Pulmonary Medicine

Specialty Areas

Pediatric Pulmonary Disease
Pediatric Asthma
Pediatric Cystic Fibrosis

Board Certifications

Pediatrics
Pediatric Pulmonary Disease

Areas of Clinical Interest

Cystic fibrosis, pulmonary inflammation and disease in children

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite C
Office Phone: 314-454-2694
Fax: 314-454-2515

Education

Education

Fellowship: Pediatric Pulmonology, Case Western Reserve University, Cleveland, Ohio 1989
Chief Resident: University of North Carolina, Chapel Hill, North Carolina 1989
Residency: Pediatrics, University of North Carolina, Chapel Hill, North Carolina 1988
Medical Degree: Ohio State University College of Medicine, Cleveland, Ohio 1985
B.S.: Case Western Reserve University, Cleveland, Ohio 1981

Publication & Research

Publication & Research

Official American Thoracic Society technical standards: flexible airway endoscopy in children.
Faro A, Wood RE, Schechter MS, Leong AB, Wittkugel E, Abode K, Chmiel JF, Daines C, Davis S, Eber E, Huddleston C, Kilbaugh T, Kurland G, Midulla F, Molter D, Montgomery GS, Retsch-Bogart G, Rutter MJ, Visner G, Walczak SA, Ferkol TW, Michelson PH, American Thoracic Society Ad Hoc Committee on Flexible Airway Endoscopy in Children
Am J Respir Crit Care Med. 2015 May 1; 191(9)1066-80. doi: 10.1164/rccm.201503-0474ST.

PMID:
    25932763
    [PubMed - indexed for MEDLINE]
Related citations


Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype.
Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, Leigh MW
Am J Respir Crit Care Med. 2015 Feb 1; 191(3)316-24. doi: 10.1164/rccm.201409-1672OC.

PMID:
    25493340
    [PubMed - indexed for MEDLINE]
Related citations


Response to Snijders et al.
Horani A, Brody SL, Ferkol TW
Pediatr Res. 2014 Sep; 76(3)322. doi: 10.1038/pr.2014.80.

PMID:
    24933009
    [PubMed - indexed for MEDLINE]
Related citations


Sources of methodological variability in phase angles from respiratory inductance plethysmography in preterm infants.
Ulm LN, Hamvas A, Ferkol TW, Rodriguez OM, Cleveland CM, Linneman LA, Hoffmann JA, Sicard-Su MJ, Kemp JS
Ann Am Thorac Soc. 2014 Jun; 11(5)753-60. doi: 10.1513/AnnalsATS.201310-363OC.

PMID:
    24716708
    [PubMed - indexed for MEDLINE]
Related citations


The global burden of respiratory disease-impact on child health.
Zar HJ, Ferkol TW
Pediatr Pulmonol. 2014 May; 49(5)430-4. doi: 10.1002/ppul.23030.

PMID:
    24610581
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype.
Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hurd TW, Gee HY, Otto EA, Halbritter J, Kohl S, Kircher M, Krischer J, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Zariwala MA
Am J Respir Crit Care Med. 2014 Mar 15; 189(6)707-17. doi: 10.1164/rccm.201311-2047OC.

PMID:
    24568568
    [PubMed - indexed for MEDLINE]
Related citations


Picking up speed: advances in the genetics of primary ciliary dyskinesia.
Horani A, Brody SL, Ferkol TW
Pediatr Res. 2014 Jan; 75(1-2)158-64. doi: 10.1038/pr.2013.200.

PMID:
    24192704
    [PubMed - indexed for MEDLINE]
Related citations


Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F
Am J Hum Genet. 2013 Oct 3; 93(4)672-86. doi: 10.1016/j.ajhg.2013.08.015.

PMID:
    24094744
    [PubMed - indexed for MEDLINE]
Related citations


FDG PET imaging in cystic fibrosis.
Chen DL, Atkinson JJ, Ferkol TW
Semin Nucl Med. 2013 Nov; 43(6)412-9. doi: 10.1053/j.semnuclmed.2013.06.002.

PMID:
    24094708
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms.
Knowles MR, Ostrowski LE, Loges NT, Hurd T, Leigh MW, Huang L, Wolf WE, Carson JL, Hazucha MJ, Yin W, Davis SD, Dell SD, Ferkol TW, Sagel SD, Olivier KN, Jahnke C, Olbrich H, Werner C, Raidt J, Wallmeier J, Pennekamp P, Dougherty GW, Hjeij R, Gee HY, Otto EA, Halbritter J, Chaki M, Diaz KA, Braun DA, Porath JD, Schueler M, Baktai G, Griese M, Turner EH, Lewis AP, Bamshad MJ, Nickerson DA, Hildebrandt F, Shendure J, Omran H, Zariwala MA
Am J Hum Genet. 2013 Oct 3; 93(4)711-20. doi: 10.1016/j.ajhg.2013.07.025.

PMID:
    24055112
    [PubMed - indexed for MEDLINE]
Related citations


Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia.
Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR
Ann Am Thorac Soc. 2013 Dec; 10(6)574-81. doi: 10.1513/AnnalsATS.201305-110OC.

PMID:
    24024753
    [PubMed - indexed for MEDLINE]
Related citations


CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia.
Horani A, Brody SL, Ferkol TW, Shoseyov D, Wasserman MG, Ta-shma A, Wilson KS, Bayly PV, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Elpeleg O, Kerem E
PLoS One. 2013; 8(8)e72299. doi: 10.1371/journal.pone.0072299.

PMID:
    23991085
    [PubMed - indexed for MEDLINE]
Related citations


ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.
Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R, Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT, Rosenfeld M, Diaz KA, Olbrich H, Wolf WE, Sheridan E, Batten TF, Halbritter J, Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns KA, Ferkol TW, Sagel SD, Olivier KN, Morgan LC, Werner C, Raidt J, Pennekamp P, Sun Z, Zhou W, Airik R, Natarajan S, Allen SJ, Amirav I, Wieczorek D, Landwehr K, Nielsen K, Schwerk N, Sertic J, Köhler G, Washburn J, Levy S, Fan S, Koerner-Rettberg C, Amselem S, Williams DS, Mitchell BJ, Drummond IA, Otto EA, Omran H, Knowles MR, Hildebrandt F
Am J Hum Genet. 2013 Aug 8; 93(2)336-45. doi: 10.1016/j.ajhg.2013.06.007.

PMID:
    23891469
    [PubMed - indexed for MEDLINE]
Related citations


LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects.
Horani A, Ferkol TW, Shoseyov D, Wasserman MG, Oren YS, Kerem B, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Brody SL, Elpeleg O, Kerem E
PLoS One. 2013; 8(3)e59436. doi: 10.1371/journal.pone.0059436.

PMID:
    23527195
    [PubMed - indexed for MEDLINE]
Related citations


Primary ciliary dyskinesia-causing mutations in Amish and Mennonite communities.
Ferkol TW, Puffenberger EG, Lie H, Helms C, Strauss KA, Bowcock A, Carson JL, Hazucha M, Morton DH, Patel AC, Leigh MW, Knowles MR, Zariwala MA
J Pediatr. 2013 Aug; 163(2)383-7. doi: 10.1016/j.jpeds.2013.01.061.

PMID:
    23477994
    [PubMed - indexed for MEDLINE]
Related citations


Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.
Knowles MR, Leigh MW, Ostrowski LE, Huang L, Carson JL, Hazucha MJ, Yin W, Berg JS, Davis SD, Dell SD, Ferkol TW, Rosenfeld M, Sagel SD, Milla CE, Olivier KN, Turner EH, Lewis AP, Bamshad MJ, Nickerson DA, Shendure J, Zariwala MA, Genetic Disorders of Mucociliary Clearance Consortium
Am J Hum Genet. 2013 Jan 10; 92(1)99-106. doi: 10.1016/j.ajhg.2012.11.003.

PMID:
    23261302
    [PubMed - indexed for MEDLINE]
Related citations


Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD, Uk10k, Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM
Hum Mutat. 2013 Mar; 34(3)462-72. doi: 10.1002/humu.22261.

PMID:
    23255504
    [PubMed - indexed for MEDLINE]
Related citations


Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia.
Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, Knowles MR, Brody SL, Dutcher SK, Ferkol TW
Am J Hum Genet. 2012 Oct 5; 91(4)685-93. doi: 10.1016/j.ajhg.2012.08.022.

PMID:
    23040496
    [PubMed - indexed for MEDLINE]
Related citations


Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, Olbrich H, Becker-Heck A, Schmidts M, Werner C, Omran H, Zariwala MA, Genetic Disorders of Mucociliary Clearance Consortium
Thorax. 2012 May; 67(5)433-41. doi: 10.1136/thoraxjnl-2011-200301.

PMID:
    22184204
    [PubMed - indexed for MEDLINE]
Related citations


Ciliopathies: the central role of cilia in a spectrum of pediatric disorders.
Ferkol TW, Leigh MW
J Pediatr. 2012 Mar; 160(3)366-71. doi: 10.1016/j.jpeds.2011.11.024.

PMID:
    22177992
    [PubMed - indexed for MEDLINE]
Related citations