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Tammie Benzinger, MD, PhD

Professor of Radiology
Division, Diagnostic Radiology
Section, Neuroradiology

Specialty Areas

Radiology
Neuroradiology
Diagnostic Radiology

Board Certifications

Diagnostic Radiology
Neuroradiology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Neuroradiology

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine - South County

5201 Midamerica Plaza
St. Louis, MO 63129

Education

Education

Fellowship: Neuroradiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 2006
Residency: Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 2005
Medical Degree: University of Chicago, Pritzker School of Medicine, Chicago, Illinois 2000
Ph.D.: Pathology, University of Chicago, Chicago, Illinois 1998
B.A.: Williams College, Williamstown, Massachusetts 1993

Publication & Research

Publication & Research

Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset.
Wang G, Coble D, McDade EM, Hassenstab J, Fagan AM, Benzinger TLS, Bateman RJ, Morris JC, Xiong C, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2019 Feb 14; pii: S1552-5260(18)33625-2. doi: 10.1016/j.jalz.2018.12.008.

PMID:
    30773445
    [PubMed - as supplied by publisher]
Related citations


Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.
Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR Jr, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS
Brain. 2019 Feb 11; doi: 10.1093/brain/awz019.

PMID:
    30753379
    [PubMed - as supplied by publisher]
Related citations


The Structural Signature of Sporadic Creutzfeldt-Jakob Disease.
Navid J, Day GS, Strain J, Perrin RJ, Bucelli RC, Dincer A, Wisch JK, Soleimani-Meigooni D, Morris JC, Benzinger TLS, Ances BM
Eur J Neurol. 2019 Feb 8; doi: 10.1111/ene.13930.

PMID:
    30735286
    [PubMed - as supplied by publisher]
Related citations


Persistent metabolic youth in the aging female brain.
Goyal MS, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME, Vlassenko AG
Proc Natl Acad Sci U S A. 2019 Feb 4; pii: 201815917. doi: 10.1073/pnas.1815917116.

PMID:
    30718410
    [PubMed - as supplied by publisher]
Related citations


Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.
Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M, Dominantly Inherited Alzheimer Network.
Nat Med. 2019 Feb; 25(2)277-283. doi: 10.1038/s41591-018-0304-3.

PMID:
    30664784
    [PubMed - in process]
Related citations


Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV
Nat Med. 2019 Feb; 25(2)270-276. doi: 10.1038/s41591-018-0297-y.

PMID:
    30643288
    [PubMed - in process]
Related citations


Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease.
Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM
Sci Transl Med. 2019 Jan 9; 11(474)pii: eaau6550. doi: 10.1126/scitranslmed.aau6550.

PMID:
    30626715
    [PubMed - in process]
Related citations


Assessment of Racial Disparities in Biomarkers for Alzheimer Disease.
Morris JC, Schindler SE, McCue LM, Moulder KL, Benzinger TLS, Cruchaga C, Fagan AM, Grant E, Gordon BA, Holtzman DM, Xiong C
JAMA Neurol. 2019 Jan 7; doi: 10.1001/jamaneurol.2018.4249.

PMID:
    30615028
    [PubMed - as supplied by publisher]
Related citations


Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease.
Wang G, Xiong C, McDade EM, Hassenstab J, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Gordon BA, Morris JC, Li Y, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement (N Y). 2018; 4669-676. doi: 10.1016/j.trci.2018.10.009.

PMID:
    30569014
    [PubMed]
Related citations


Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.
Cooley SA, Strain JF, Beaumont H, Boerwinkle AH, Doyle J, Morris JC, Benzinger TL, Ances BM
J Infect Dis. 2018 Dec 17; doi: 10.1093/infdis/jiy663.

PMID:
    30561665
    [PubMed - as supplied by publisher]
Related citations


Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network.
Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Neurobiol Aging. 2019 Mar; 7542-50. doi: 10.1016/j.neurobiolaging.2018.10.011.

PMID:
    30530186
    [PubMed - in process]
Related citations


Examining the Complicated Relationship Between Depressive Symptoms and Cognitive Impairment in Preclinical Alzheimer Disease.
Javaherian K, Newman BM, Weng H, Hassenstab J, Xiong C, Coble D, Fagan AM, Benzinger T, Morris JC
Alzheimer Dis Assoc Disord. 2018 Nov 26; doi: 10.1097/WAD.0000000000000284.

PMID:
    30489279
    [PubMed - as supplied by publisher]
Related citations


The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, Nordberg A, White LR, Nielsen HM, Dominantly Inherited Alzheimer Network (DIAN).
Acta Neuropathol Commun. 2018 Nov 26; 6(1)130. doi: 10.1186/s40478-018-0624-z.

PMID:
    30477568
    [PubMed - in process]
Related citations


Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, Goate A, Jack CR Jr, Karch C, Klunk W, Koeppe RA, Marcus DS, Mayeux R, McDade E, Noble JM, Ringman J, Saykin AJ, Thompson PM, Xiong C, Morris JC, Bateman RJ, Benzinger TLS, Dominantly Inherited Alzheimer Network.
Alzheimers Dement (Amst). 2018; 10669-677. doi: 10.1016/j.dadm.2018.08.012.

PMID:
    30417072
    [PubMed]
Related citations


Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.
Babulal GM, Chen S, Williams MM, Trani JF, Bakhshi P, Chao GL, Stout SH, Fagan AM, Benzinger TLS, Holtzman DM, Morris JC, Roe CM
J Alzheimers Dis. 2018; 66(3)1213-1221. doi: 10.3233/JAD-180564.

PMID:
    30400098
    [PubMed - in process]
Related citations


Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers.
Roe CM, Ances BM, Head D, Babulal GM, Stout SH, Grant EA, Hassenstab J, Xiong C, Holtzman DM, Benzinger TLS, Schindler SE, Fagan AM, Morris JC
Brain. 2018 Nov 1; 141(11)3233-3248. doi: 10.1093/brain/awy244.

PMID:
    30304397
    [PubMed - in process]
Related citations


Widespread distribution of tauopathy in preclinical Alzheimer's disease.
Schultz SA, Gordon BA, Mishra S, Su Y, Perrin RJ, Cairns NJ, Morris JC, Ances BM, Benzinger TLS
Neurobiol Aging. 2018 Dec; 72177-185. doi: 10.1016/j.neurobiolaging.2018.08.022.

PMID:
    30292840
    [PubMed - in process]
Related citations


Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease.
Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Fox NN, Graff-Radford NR, Levin J, Danek A, Vöglein J, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2018 Nov; 14(11)1427-1437. doi: 10.1016/j.jalz.2018.06.3059.

PMID:
    30266303
    [PubMed - in process]
Related citations


White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease.
Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, Rossor M, Fox NC, Lee JH, Salloway S, Danek A, Goate A, Yakushev I, Hassenstab J, Schofield PR, Haass C, Ewers M
Brain. 2018 Oct 1; 141(10)3065-3080. doi: 10.1093/brain/awy229.

PMID:
    30239611
    [PubMed - in process]
Related citations


Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.
McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, Berman SB, Klunk W, Noble J, Ringman J, Ghetti B, Farlow M, Sperling RA, Chhatwal J, Salloway S, Graff-Radford NR, Schofield PR, Masters C, Rossor MN, Fox NC, Levin J, Jucker M, Bateman RJ, Dominantly Inherited Alzheimer Network.
Neurology. 2018 Oct 2; 91(14)e1295-e1306. doi: 10.1212/WNL.0000000000006277.

PMID:
    30217935
    [PubMed - in process]
Related citations