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Tammie Benzinger, MD, PhD

Professor of Radiology
Division, Diagnostic Radiology
Section, Neuroradiology

Specialty Areas

Radiology
Neuroradiology
Diagnostic Radiology

Board Certifications

Diagnostic Radiology
Neuroradiology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Neuroradiology

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine - South County

5201 Midamerica Plaza
St. Louis, MO 63129

Education

Education

Fellowship: Neuroradiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 2006
Residency: Diagnostic Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 2005
Medical Degree: University of Chicago, Pritzker School of Medicine, Chicago, Illinois 2000
Ph.D.: Pathology, University of Chicago, Chicago, Illinois 1998
B.A.: Williams College, Williamstown, Massachusetts 1993

Publication & Research

Publication & Research

The effect of ApoE ε4 on longitudinal brain region-specific glucose metabolism in patients with mild cognitive impairment: a FDG-PET study.
Paranjpe MD, Chen X, Liu M, Paranjpe I, Leal JP, Wang R, Pomper MG, Wong DF, Benzinger TLS, Zhou Y, Alzheimer's Disease Neuroimaging Initiative.
Neuroimage Clin. 2019 Mar 28; 22101795. doi: 10.1016/j.nicl.2019.101795.

PMID:
    30991617
    [PubMed - as supplied by publisher]
Related citations


A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer's Disease.
Roe CM, Stout SH, Rajasekar G, Ances BM, Jones JM, Head D, Benzinger TLS, Williams MM, Davis JD, Ott BR, Warren DK, Babulal GM
J Alzheimers Dis. 2019; 68(4)1625-1633. doi: 10.3233/JAD-181242.

PMID:
    30958365
    [PubMed - in process]
Related citations


MRI safety risks in the obese: The case of the disposable lighter stored in the pannus.
Gach HM, Mackey SL, Hausman SE, Jackson DR, Benzinger TL, Henke L, Murphy LA, Fluchel JL, Cai B, Zoberi JE, Garcia-Ramirez J, Mutic S, Schwarz JK
Radiol Case Rep. 2019 May; 14(5)634-638. doi: 10.1016/j.radcr.2019.02.023.

PMID:
    30923590
    [PubMed]
Related citations


Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease.
Wang Q, Wang Y, Liu J, Sutphen CL, Cruchaga C, Blazey T, Gordon BA, Su Y, Chen C, Shimony JS, Ances BM, Cairns NJ, Fagan AM, Morris JC, Benzinger TLS
Neuroimage Clin. 2019 Mar 13; 22101767. doi: 10.1016/j.nicl.2019.101767.

PMID:
    30901713
    [PubMed - as supplied by publisher]
Related citations


The BDNF<sub>Val66Met</sub> SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M
Mol Psychiatry. 2019 Mar 21; doi: 10.1038/s41380-019-0404-6.

PMID:
    30899092
    [PubMed - as supplied by publisher]
Related citations


Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network.
Brain. 2019 May 1; 142(5)1429-1440. doi: 10.1093/brain/awz050.

PMID:
    30897203
    [PubMed - in process]
Related citations


Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.
Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Joseph-Mathurin N, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Jack CR Jr, Farlow MR, Salloway S, Snider BJ, Berman SB, Roberson ED, Brosch J, Jimenez-Velazques I, van Dyck CH, Galasko D, Yuan SH, Jayadev S, Honig LS, Gauthier S, Hsiung GR, Masellis M, Brooks WS, Fulham M, Clarnette R, Masters CL, Wallon D, Hannequin D, Dubois B, Pariente J, Sanchez-Valle R, Mummery C, Ringman JM, Bottlaender M, Klein G, Milosavljevic-Ristic S, McDade E, Xiong C, Morris JC, Bateman RJ, Benzinger TLS
Alzheimers Dement (Amst). 2019 Dec; 11180-190. doi: 10.1016/j.dadm.2018.12.008.

PMID:
    30847382
    [PubMed]
Related citations


Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2019 May; 15(5)655-665. doi: 10.1016/j.jalz.2018.12.019.

PMID:
    30846386
    [PubMed - in process]
Related citations


Tau positron emission tomography imaging in C9orf72 repeat expansion carriers.
Ly CV, Koenig L, Christensen J, Gordon B, Beaumont H, Dahiya S, Chen J, Su Y, Nelson B, Jockel-Balsarotti J, Drain C, Jerome G, Morris JC, Fagan AM, Harms MB, Benzinger TLS, Miller TM, Ances BM
Eur J Neurol. 2019 Feb 20; doi: 10.1111/ene.13940.

PMID:
    30790403
    [PubMed - as supplied by publisher]
Related citations


Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset.
Wang G, Coble D, McDade EM, Hassenstab J, Fagan AM, Benzinger TLS, Bateman RJ, Morris JC, Xiong C, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2019 Apr; 15(4)506-514. doi: 10.1016/j.jalz.2018.12.008.

PMID:
    30773445
    [PubMed - in process]
Related citations


Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.
Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS
Brain. 2019 Apr 1; 142(4)1063-1076. doi: 10.1093/brain/awz019.

PMID:
    30753379
    [PubMed - in process]
Related citations


Structural signature of sporadic Creutzfeldt-Jakob disease.
Navid J, Day GS, Strain J, Perrin RJ, Bucelli RC, Dincer A, Wisch JK, Soleimani-Meigooni D, Morris JC, Benzinger TLS, Ances BM
Eur J Neurol. 2019 Feb 8; doi: 10.1111/ene.13930.

PMID:
    30735286
    [PubMed - as supplied by publisher]
Related citations


Persistent metabolic youth in the aging female brain.
Goyal MS, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME, Vlassenko AG
Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8)3251-3255. doi: 10.1073/pnas.1815917116.

PMID:
    30718410
    [PubMed - indexed for MEDLINE]
Related citations


Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.
Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M, Dominantly Inherited Alzheimer Network.
Nat Med. 2019 Feb; 25(2)277-283. doi: 10.1038/s41591-018-0304-3.

PMID:
    30664784
    [PubMed - indexed for MEDLINE]
Related citations


Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV
Nat Med. 2019 Feb; 25(2)270-276. doi: 10.1038/s41591-018-0297-y.

PMID:
    30643288
    [PubMed - indexed for MEDLINE]
Related citations


Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease.
Lucey BP, McCullough A, Landsness EC, Toedebusch CD, McLeland JS, Zaza AM, Fagan AM, McCue L, Xiong C, Morris JC, Benzinger TLS, Holtzman DM
Sci Transl Med. 2019 Jan 9; 11(474)pii: eaau6550. doi: 10.1126/scitranslmed.aau6550.

PMID:
    30626715
    [PubMed - in process]
Related citations


Assessment of Racial Disparities in Biomarkers for Alzheimer Disease.
Morris JC, Schindler SE, McCue LM, Moulder KL, Benzinger TLS, Cruchaga C, Fagan AM, Grant E, Gordon BA, Holtzman DM, Xiong C
JAMA Neurol. 2019 Jan 7; doi: 10.1001/jamaneurol.2018.4249.

PMID:
    30615028
    [PubMed - as supplied by publisher]
Related citations


Simultaneously evaluating the effect of baseline levels and longitudinal changes in disease biomarkers on cognition in dominantly inherited Alzheimer's disease.
Wang G, Xiong C, McDade EM, Hassenstab J, Aschenbrenner AJ, Fagan AM, Benzinger TLS, Gordon BA, Morris JC, Li Y, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement (N Y). 2018; 4669-676. doi: 10.1016/j.trci.2018.10.009.

PMID:
    30569014
    [PubMed]
Related citations


Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals.
Cooley SA, Strain JF, Beaumont H, Boerwinkle AH, Doyle J, Morris JC, Benzinger TL, Ances BM
J Infect Dis. 2018 Dec 17; doi: 10.1093/infdis/jiy663.

PMID:
    30561665
    [PubMed - as supplied by publisher]
Related citations


Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network.
Bussy A, Snider BJ, Coble D, Xiong C, Fagan AM, Cruchaga C, Benzinger TLS, Gordon BA, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Neurobiol Aging. 2019 Mar; 7542-50. doi: 10.1016/j.neurobiolaging.2018.10.011.

PMID:
    30530186
    [PubMed - in process]
Related citations