Patient Portal

Steven L. Brody, MD

Dorothy R. and Hubert C. Moog Professor of Pulmonary Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Gene Therapy

Board Certifications

Critical Care Medicine
Internal Medicine
Pulmonary Disease
Emergency Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Critical care medicine, ARDS, septic shock, clinical toxicology, cystic fibrosis, primary ciliary dyskinesia

  • Education
  • Publication & Research

Education

Education

Fellowship: Pulmonary Medicine, National Institute of Health, Bethesda, Maryland 1994
Residency: Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 1983
Medical Degree: University Of Michigan Medical School, Ann Arbor, Michigan 1980
B.S.: Michigan State University, Lyman Briggs Residential College, East Lansing, Michigan 1976

Publication & Research

Publication & Research

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-Associated Cell Death.
Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP
Am J Respir Cell Mol Biol. 2018 Aug 29; doi: 10.1165/rcmb.2017-0405OC.

PMID:
    30156437
    [PubMed - as supplied by publisher]
Related citations


Blood Exposure Causes Ventricular Zone Disruption and Glial Activation In Vitro.
Castaneyra-Ruiz L, Morales DM, McAllister JP, Brody SL, Isaacs AM, Strahle JM, Dahiya SM, Limbrick DD
J Neuropathol Exp Neurol. 2018 Sep 1; 77(9)803-813. doi: 10.1093/jnen/nly058.

PMID:
    30032242
    [PubMed - in process]
Related citations


Quantifying Ciliary Dynamics during Assembly Reveals Stepwise Waveform Maturation in Airway Cells.
Oltean A, Schaffer AJ, Bayly PV, Brody SL
Am J Respir Cell Mol Biol. 2018 Oct; 59(4)511-522. doi: 10.1165/rcmb.2017-0436OC.

PMID:
    29851510
    [PubMed - in process]
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Visualization of Monocytic Cells in Regressing Atherosclerotic Plaques by Intravital 2-Photon and Positron Emission Tomography-Based Imaging-Brief Report.
Li W, Luehmann HP, Hsiao HM, Tanaka S, Higashikubo R, Gauthier JM, Sultan D, Lavine KJ, Brody SL, Gelman AE, Gropler RJ, Liu Y, Kreisel D
Arterioscler Thromb Vasc Biol. 2018 May; 38(5)1030-1036. doi: 10.1161/ATVBAHA.117.310517.

PMID:
    29567678
    [PubMed - in process]
Related citations


Development of Fully Degradable Phosphonium-Functionalized Amphiphilic Diblock Copolymers for Nucleic Acids Delivery.
Borguet YP, Khan S, Noel A, Gunsten SP, Brody SL, Elsabahy M, Wooley KL
Biomacromolecules. 2018 Apr 9; 19(4)1212-1222. doi: 10.1021/acs.biomac.8b00069.

PMID:
    29526096
    [PubMed - in process]
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Establishment of the early cilia preassembly protein complex during motile ciliogenesis.
Horani A, Ustione A, Huang T, Firth AL, Pan J, Gunsten SP, Haspel JA, Piston DW, Brody SL
Proc Natl Acad Sci U S A. 2018 Feb 6; 115(6)E1221-E1228. doi: 10.1073/pnas.1715915115.

PMID:
    29358401
    [PubMed - indexed for MEDLINE]
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The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?
Kulkarni HS, Liszewski MK, Brody SL, Atkinson JP
J Allergy Clin Immunol. 2018 May; 141(5)1582-1586.e1. doi: 10.1016/j.jaci.2017.11.046.

PMID:
    29339260
    [PubMed - in process]
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Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.
Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL
Redox Biol. 2018 Apr; 14272-284. doi: 10.1016/j.redox.2017.09.013.

PMID:
    28982074
    [PubMed - indexed for MEDLINE]
Related citations


17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism.
Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R
Infect Immun. 2017 Oct; 85(10)pii: e00422-17. doi: 10.1128/IAI.00422-17.

PMID:
    28784925
    [PubMed - indexed for MEDLINE]
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Harnessing TGF-β and BMP signaling for expansion of p63-positive epithelial stem cells.
Brody SL, Kaiko GE
Stem Cell Investig. 2016; 382. doi: 10.21037/sci.2016.10.13.

PMID:
    28066784
    [PubMed]
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PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.
Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL
Radiology. 2017 Jun; 283(3)758-768. doi: 10.1148/radiol.2016161409.

PMID:
    28045644
    [PubMed - indexed for MEDLINE]
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Noninvasive Imaging of CCR2<sup>+</sup> Cells in Ischemia-Reperfusion Injury After Lung Transplantation.
Liu Y, Li W, Luehmann HP, Zhao Y, Detering L, Sultan DH, Hsiao HM, Krupnick AS, Gelman AE, Combadiere C, Gropler RJ, Brody SL, Kreisel D
Am J Transplant. 2016 Oct; 16(10)3016-3023. doi: 10.1111/ajt.13907.

PMID:
    27273836
    [PubMed - indexed for MEDLINE]
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In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging.
Black KC, Ibricevic A, Gunsten SP, Flores JA, Gustafson TP, Raymond JE, Samarajeewa S, Shrestha R, Felder SE, Cai T, Shen Y, Löbs AK, Zhegalova N, Sultan DH, Berezin M, Wooley KL, Liu Y, Brody SL
Biomaterials. 2016 Aug; 9853-63. doi: 10.1016/j.biomaterials.2016.04.040.

PMID:
    27179433
    [PubMed - indexed for MEDLINE]
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p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z
J Biol Chem. 2016 Mar 18; 291(12)6569-82. doi: 10.1074/jbc.M115.706416.

PMID:
    26833564
    [PubMed - indexed for MEDLINE]
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Genetics and biology of primary ciliary dyskinesia.
Horani A, Ferkol TW, Dutcher SK, Brody SL
Paediatr Respir Rev. 2016 Mar; 1818-24. doi: 10.1016/j.prrv.2015.09.001.

PMID:
    26476603
    [PubMed - indexed for MEDLINE]
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Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells.
Leoni G, Wasowicz MY, Chan M, Meng C, Farley R, Brody SL, Inoue M, Hasegawa M, Alton EW, Griesenbach U
Curr Gene Ther. 2015; 15(6)581-90.

PMID:
    26471068
    [PubMed - indexed for MEDLINE]
Related citations


IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL
Autophagy. 2016; 12(2)397-409. doi: 10.1080/15548627.2015.1056967.

PMID:
    26062017
    [PubMed - indexed for MEDLINE]
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Visualization of pulmonary clearance mechanisms via noninvasive optical imaging validated by near-infrared flow cytometry.
Zhou H, Gunsten SP, Zhegalova NG, Bloch S, Achilefu S, Christopher Holley J, Schweppe D, Akers W, Brody SL, Eades WC, Berezin MY
Cytometry A. 2015 May; 87(5)419-27. doi: 10.1002/cyto.a.22658.

PMID:
    25808737
    [PubMed - indexed for MEDLINE]
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DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.
Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D
J Immunol. 2015 Apr 15; 194(8)4039-48. doi: 10.4049/jimmunol.1401415.

PMID:
    25762783
    [PubMed - indexed for MEDLINE]
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Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang HJ, Isakow W, Byers DE, Engle JT, Griffin EA, Kemp D, Brody SL, Gropler RJ, Miller JP, Chu W, Zhou D, Pierce RA, Castro M, Mach RH, Chen DL
J Nucl Med. 2015 Jan; 56(1)76-81. doi: 10.2967/jnumed.114.146381.

PMID:
    25525182
    [PubMed - indexed for MEDLINE]
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