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Steven L. Brody, MD

Dorothy R. and Hubert C. Moog Professor of Pulmonary Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Gene Therapy

Board Certifications

Critical Care Medicine
Internal Medicine
Pulmonary Disease
Emergency Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Critical care medicine, ARDS, septic shock, clinical toxicology, cystic fibrosis, primary ciliary dyskinesia

  • Education
  • Publication & Research

Education

Education

Fellowship: Pulmonary Medicine, National Institute of Health, Bethesda, Maryland 1994
Residency: Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 1983
Medical Degree: University Of Michigan Medical School, Ann Arbor, Michigan 1980
B.S.: Michigan State University, Lyman Briggs Residential College, East Lansing, Michigan 1976

Publication & Research

Publication & Research

Establishment of the early cilia preassembly protein complex during motile ciliogenesis.
Horani A, Ustione A, Huang T, Firth AL, Pan J, Gunsten SP, Haspel JA, Piston DW, Brody SL
Proc Natl Acad Sci U S A. 2018 Feb 6; 115(6)E1221-E1228. doi: 10.1073/pnas.1715915115.

PMID:
    29358401
    [PubMed - in process]
Related citations


The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?
Kulkarni HS, Liszewski MK, Brody SL, Atkinson JP
J Allergy Clin Immunol. 2018 Jan 12; pii: S0091-6749(18)30034-4. doi: 10.1016/j.jaci.2017.11.046.

PMID:
    29339260
    [PubMed - as supplied by publisher]
Related citations


Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.
Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL
Redox Biol. 2018 Apr; 14272-284. doi: 10.1016/j.redox.2017.09.013.

PMID:
    28982074
    [PubMed - in process]
Related citations


17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism.
Abid S, Xie S, Bose M, Shaul PW, Terada LS, Brody SL, Thomas PJ, Katzenellenbogen JA, Kim SH, Greenberg DE, Jain R
Infect Immun. 2017 Oct; 85(10)pii: e00422-17. doi: 10.1128/IAI.00422-17.

PMID:
    28784925
    [PubMed - indexed for MEDLINE]
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Harnessing TGF-β and BMP signaling for expansion of p63-positive epithelial stem cells.
Brody SL, Kaiko GE
Stem Cell Investig. 2016; 382. doi: 10.21037/sci.2016.10.13.

PMID:
    28066784
    [PubMed]
Related citations


PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.
Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL
Radiology. 2017 Jun; 283(3)758-768. doi: 10.1148/radiol.2016161409.

PMID:
    28045644
    [PubMed - indexed for MEDLINE]
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Noninvasive Imaging of CCR2<sup>+</sup> Cells in Ischemia-Reperfusion Injury After Lung Transplantation.
Liu Y, Li W, Luehmann HP, Zhao Y, Detering L, Sultan DH, Hsiao HM, Krupnick AS, Gelman AE, Combadiere C, Gropler RJ, Brody SL, Kreisel D
Am J Transplant. 2016 Oct; 16(10)3016-3023. doi: 10.1111/ajt.13907.

PMID:
    27273836
    [PubMed - indexed for MEDLINE]
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In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging.
Black KC, Ibricevic A, Gunsten SP, Flores JA, Gustafson TP, Raymond JE, Samarajeewa S, Shrestha R, Felder SE, Cai T, Shen Y, Löbs AK, Zhegalova N, Sultan DH, Berezin M, Wooley KL, Liu Y, Brody SL
Biomaterials. 2016 Aug; 9853-63. doi: 10.1016/j.biomaterials.2016.04.040.

PMID:
    27179433
    [PubMed - indexed for MEDLINE]
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p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z
J Biol Chem. 2016 Mar 18; 291(12)6569-82. doi: 10.1074/jbc.M115.706416.

PMID:
    26833564
    [PubMed - indexed for MEDLINE]
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Genetics and biology of primary ciliary dyskinesia.
Horani A, Ferkol TW, Dutcher SK, Brody SL
Paediatr Respir Rev. 2016 Mar; 1818-24. doi: 10.1016/j.prrv.2015.09.001.

PMID:
    26476603
    [PubMed - indexed for MEDLINE]
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Ex Vivo and In Vivo Lentivirus-Mediated Transduction of Airway Epithelial Progenitor Cells.
Leoni G, Wasowicz MY, Chan M, Meng C, Farley R, Brody SL, Inoue M, Hasegawa M, Alton EW, Griesenbach U
Curr Gene Ther. 2015; 15(6)581-90.

PMID:
    26471068
    [PubMed - indexed for MEDLINE]
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IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL
Autophagy. 2016; 12(2)397-409. doi: 10.1080/15548627.2015.1056967.

PMID:
    26062017
    [PubMed - indexed for MEDLINE]
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Visualization of pulmonary clearance mechanisms via noninvasive optical imaging validated by near-infrared flow cytometry.
Zhou H, Gunsten SP, Zhegalova NG, Bloch S, Achilefu S, Christopher Holley J, Schweppe D, Akers W, Brody SL, Eades WC, Berezin MY
Cytometry A. 2015 May; 87(5)419-27. doi: 10.1002/cyto.a.22658.

PMID:
    25808737
    [PubMed - indexed for MEDLINE]
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DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.
Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D
J Immunol. 2015 Apr 15; 194(8)4039-48. doi: 10.4049/jimmunol.1401415.

PMID:
    25762783
    [PubMed - indexed for MEDLINE]
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Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang HJ, Isakow W, Byers DE, Engle JT, Griffin EA, Kemp D, Brody SL, Gropler RJ, Miller JP, Chu W, Zhou D, Pierce RA, Castro M, Mach RH, Chen DL
J Nucl Med. 2015 Jan; 56(1)76-81. doi: 10.2967/jnumed.114.146381.

PMID:
    25525182
    [PubMed - indexed for MEDLINE]
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Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS Jr, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ
J Allergy Clin Immunol. 2014 Dec; 134(6)1402-1412.e7. doi: 10.1016/j.jaci.2014.07.013.

PMID:
    25216987
    [PubMed - indexed for MEDLINE]
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Myb permits multilineage airway epithelial cell differentiation.
Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL
Stem Cells. 2014 Dec; 32(12)3245-56. doi: 10.1002/stem.1814.

PMID:
    25103188
    [PubMed - indexed for MEDLINE]
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Response to Snijders et al.
Horani A, Brody SL, Ferkol TW
Pediatr Res. 2014 Sep; 76(3)322. doi: 10.1038/pr.2014.80.

PMID:
    24933009
    [PubMed - indexed for MEDLINE]
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Antisense peptide nucleic acid-functionalized cationic nanocomplex for in vivo mRNA detection.
Shen Y, Shrestha R, Ibricevic A, Gunsten SP, Welch MJ, Wooley KL, Brody SL, Taylor JS, Liu Y
Interface Focus. 2013 Jun 6; 3(3)20120059. doi: 10.1098/rsfs.2012.0059.

PMID:
    24427537
    [PubMed]
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Picking up speed: advances in the genetics of primary ciliary dyskinesia.
Horani A, Brody SL, Ferkol TW
Pediatr Res. 2014 Jan; 75(1-2)158-64. doi: 10.1038/pr.2013.200.

PMID:
    24192704
    [PubMed - indexed for MEDLINE]
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