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Stefanie Geisler, MD

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Stefanie Geisler, MD

Assistant Professor, Neurology

Specialty Areas

Neuromuscular Disease

Board Certifications

Neurology and Psychiatry
Neuromuscular Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Languages

German

Areas of Clinical Interest

Peripheral neuropathy, myopathy/myositis, ALS-Lou Gehrig’s Disease, motor neuron disease

Location(s)
Education
Publication & Research

Location(s)

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752

Education

Fellowship: Neuromuscular Medicine, Washington University School of Medicine, St. Louis, Missouri 2015
Residency: Neurology, Washington University School of Medicine, St. Louis, Missouri 2013
Postdoctoral Fellow: Neuroscience, St. Louis University School of Medicine 2006
Medical Degree: Humboldt University, Berlin, Germany 2003

Publication & Research

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.
Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A
JCI Insight. 2019 Sep 5; 4(17)pii: 129920. doi: 10.1172/jci.insight.129920.

PMID:
31484833
[PubMed - in process]
Related citations

Treatment-Related Uptake of O-(2-18F-Fluoroethyl)-l-Tyrosine and l-[Methyl-3H]-Methionine After Tumor Resection in Rat Glioma Models.
Geisler S, Stegmayr C, Niemitz N, Lohmann P, Rapp M, Stoffels G, Willuweit A, Galldiks N, Filss C, Sabel MC, Coenen HH, Shah NJ, Langen KJ
J Nucl Med. 2019 Oct; 60(10)1373-1379. doi: 10.2967/jnumed.119.225680.

PMID:
30850492
[PubMed - in process]
Related citations

Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
J Neurosci. 2019 Apr 3; 39(14)2581-2605. doi: 10.1523/JNEUROSCI.2234-18.2019.

PMID:
30683685
[PubMed - in process]
Related citations

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.
Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J
J Exp Med. 2019 Feb 4; 216(2)294-303. doi: 10.1084/jem.20181040.

PMID:
30642945
[PubMed - in process]
Related citations

Correlation of Dynamic O-(2-[18F]Fluoroethyl)-L-Tyrosine Positron Emission Tomography, Conventional Magnetic Resonance Imaging, and Whole-Brain Histopathology in a Pretreated Glioblastoma: A Postmortem Study.
Lohmann P, Piroth MD, Sellhaus B, Weis J, Geisler S, Oros-Peusquens AM, Mohlberg H, Amunts K, Shah NJ, Galldiks N, Langen KJ
World Neurosurg. 2018 Nov; 119e653-e660. doi: 10.1016/j.wneu.2018.07.232.

PMID:
30077752
[PubMed - indexed for MEDLINE]
Related citations

Investigation of cis-4-[18F]Fluoro-D-Proline Uptake in Human Brain Tumors After Multimodal Treatment.
Verger A, Stoffels G, Galldiks N, Lohmann P, Willuweit A, Neumaier B, Geisler S, Langen KJ
Mol Imaging Biol. 2018 Dec; 20(6)1035-1043. doi: 10.1007/s11307-018-1197-8.

PMID:
29687323
[PubMed - indexed for MEDLINE]
Related citations

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A
Brain. 2016 Dec; 139(Pt 12)3092-3108.

PMID:
27797810
[PubMed - indexed for MEDLINE]
Related citations

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.
Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A
J Neurosci. 2016 Apr 27; 36(17)4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016.

PMID:
27122027
[PubMed - indexed for MEDLINE]
Related citations

Characterization of [123I]FP-CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography.
Geisler S, Beindorff N, Cremer M, Hoffmann K, Brenner W, Cumming P, Meyer PT, Langen KJ, Fuchs E, Buchert R
Synapse. 2015 Oct; 69(10)497-504. doi: 10.1002/syn.21838.

PMID:
26126942
[PubMed - indexed for MEDLINE]
Related citations

Emerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits.
Geisler S, Schöpf CL, Obermair GJ
Gen Physiol Biophys. 2015 Apr; 34(2)105-118. doi: 10.4149/gpb_2014037.

PMID:
25504062
[PubMed - indexed for MEDLINE]
Related citations

Isomers of 4-[18F]fluoro-proline: radiosynthesis, biological evaluation and results in humans using PET.
Geisler S, Ermert J, Stoffels G, Willuweit A, Galldiks N, Filss CP, Shah NJ, Coenen HH, Langen KJ
Curr Radiopharm. 2014; 7(2)123-32.

PMID:
25183212
[PubMed - indexed for MEDLINE]
Related citations

Short- and long-term treatment of mouse cortical primary astrocytes with β-amyloid differentially regulates the mRNA expression of L-type calcium channels.
Daschil N, Geisler S, Obermair GJ, Humpel C
Pharmacology. 2014; 93(1-2)24-31. doi: 10.1159/000357383.

PMID:
24435206
[PubMed - indexed for MEDLINE]
Related citations

Dynamic regulation of SCG10 in regenerating axons after injury.
Shin JE, Geisler S, DiAntonio A
Exp Neurol. 2014 Feb; 2521-11. doi: 10.1016/j.expneurol.2013.11.007.

PMID:
24246279
[PubMed - indexed for MEDLINE]
Related citations

Uptake of O-(2-[18F]fluoroethyl)-L-tyrosine in reactive astrocytosis in the vicinity of cerebral gliomas.
Piroth MD, Prasath J, Willuweit A, Stoffels G, Sellhaus B, van Osterhout A, Geisler S, Shah NJ, Eble MJ, Coenen HH, Langen KJ
Nucl Med Biol. 2013 Aug; 40(6)795-800. doi: 10.1016/j.nucmedbio.2013.05.001.

PMID:
23769262
[PubMed - indexed for MEDLINE]
Related citations

Detection of remote neuronal reactions in the Thalamus and Hippocampus induced by rat glioma using the PET tracer cis-4-[¹⁸F]fluoro-D-proline.
Geisler S, Willuweit A, Schroeter M, Zilles K, Hamacher K, Galldiks N, Shah NJ, Coenen HH, Langen KJ
J Cereb Blood Flow Metab. 2013 May; 33(5)724-31. doi: 10.1038/jcbfm.2013.8.

PMID:
23385199
[PubMed - indexed for MEDLINE]
Related citations

Early deficits in declarative and procedural memory dependent behavioral function in a transgenic rat model of Huntington's disease.
Kirch RD, Meyer PT, Geisler S, Braun F, Gehrig S, Langen KJ, von Hörsten S, Nikkhah G, Cassel JC, Döbrössy MD
Behav Brain Res. 2013 Feb 15; 23915-26. doi: 10.1016/j.bbr.2012.10.048.

PMID:
23137697
[PubMed - indexed for MEDLINE]
Related citations

Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors.
Zahm DS, Cheng AY, Lee TJ, Ghobadi CW, Schwartz ZM, Geisler S, Parsely KP, Gruber C, Veh RW
J Comp Neurol. 2011 Nov 1; 519(16)3159-88. doi: 10.1002/cne.22670.

PMID:
21618227
[PubMed - indexed for MEDLINE]
Related citations

Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the Basal forebrain and recalibration of expression.
Zahm DS, Becker ML, Freiman AJ, Strauch S, Degarmo B, Geisler S, Meredith GE, Marinelli M
Neuropsychopharmacology. 2010 Jan; 35(2)445-63. doi: 10.1038/npp.2009.149.

PMID:
19794406
[PubMed - indexed for MEDLINE]
Related citations

The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta.
Jhou TC, Geisler S, Marinelli M, Degarmo BA, Zahm DS
J Comp Neurol. 2009 Apr 20; 513(6)566-96. doi: 10.1002/cne.21891.

PMID:
19235216
[PubMed - indexed for MEDLINE]
Related citations

Functional implications of glutamatergic projections to the ventral tegmental area.
Geisler S, Wise RA
Rev Neurosci. 2008; 19(4-5)227-44.

PMID:
19145985
[PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Geisler’s laboratory research focuses on elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies. The translational goal is to find treatments to prevent axonal degeneration and facilitate regeneration.

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