Stefanie Geisler, MD

Assistant Professor, Neurology

Specialty Areas

Neuromuscular Disease

Board Certifications

Neurology and Psychiatry
Neuromuscular Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Languages

German

Areas of Clinical Interest

Peripheral neuropathy, myopathy/myositis, ALS-Lou Gehrig’s Disease, motor neuron disease

Location(s)
Education
Publication & Research

Location(s)

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752

Education

Fellowship: Neuromuscular Medicine, Washington University School of Medicine, St. Louis, Missouri 2015
Residency: Neurology, Washington University School of Medicine, St. Louis, Missouri 2013
Postdoctoral Fellow: Neuroscience, St. Louis University School of Medicine 2006
Medical Degree: Humboldt University, Berlin, Germany 2003

Publication & Research

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040. Epub 2019 Jan 14. PubMed PMID: 30642945; PubMed Central PMCID: PMC6363435.

Geisler S, Huang S, Strickland A, Doan R, Summers D, Mao X, Park J, DiAntonio A, Milbrandt J. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. The Journal of Experimental Medicine. 2019 January; :jem.20181040-. doi: 10.1084/jem.20181040.

Geisler S, Doan R, Cheng G, Cetinkaya-Fisgin A, Huang S, Höke A, Milbrandt J, DiAntonio A. Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. JCI Insight. 2019; 4(17):-. doi: 10.1172/jci.insight.129920.

Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain. 2016 Dec;139(Pt 12):3092-3108. doi: 10.1093/brain/aww251. Epub 2016 Oct 25. PubMed PMID: 27797810; PubMed Central PMCID: PMC5840884.

Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016. PubMed PMID: 27122027; PubMed Central PMCID: PMC4846669.

Shin JE, Geisler S, DiAntonio A. Dynamic regulation of SCG10 in regenerating axons after injury. Exp Neurol. 2014 Feb;252:1-11. doi: 10.1016/j.expneurol.2013.11.007. Epub 2013 Nov 15. PubMed PMID: 24246279; PubMed Central PMCID: PMC3947015.

Zahm DS, Cheng AY, Lee TJ, Ghobadi CW, Schwartz ZM, Geisler S, Parsely KP, Gruber C, Veh RW. Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. J Comp Neurol. 2011 Nov 1;519(16):3159-88. doi: 10.1002/cne.22670. PubMed PMID: 21618227; PubMed Central PMCID: PMC3174784.

Brinschwitz K, Dittgen A, Madai VI, Lommel R, Geisler S, Veh RW. Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain. Neuroscience. 2010 Jun 30;168(2):463-76. doi: 10.1016/j.neuroscience.2010.03.050. Epub 2010 Mar 29. PubMed PMID: 20353812.

Zahm DS, Becker ML, Freiman AJ, Strauch S, Degarmo B, Geisler S, Meredith GE, Marinelli M. Fos after single and repeated self-administration of cocaine and saline in the rat: emphasis on the Basal forebrain and recalibration of expression. Neuropsychopharmacology. 2010 Jan;35(2):445-63. doi: 10.1038/npp.2009.149. PubMed PMID: 19794406; PubMed Central PMCID: PMC2795057.

Jhou TC, Geisler S, Marinelli M, Degarmo BA, Zahm DS. The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J Comp Neurol. 2009 Apr 20;513(6):566-96. doi: 10.1002/cne.21891. PubMed PMID: 19235216; PubMed Central PMCID: PMC3116663.

Areas of Research Interest

Dr. Geisler’s laboratory research focuses on elucidating and understanding molecular mechanisms of axonal degeneration and regeneration in neuropathies. The translational goal is to find treatments to prevent axonal degeneration and facilitate regeneration.

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