Patient Portal

Sidharth Puram, MD, PhD

Assistant Professor, Otolaryngology
Head and Neck Surgery

Specialty Areas

Head and Neck Oncology
Head and Neck Surgery
Thyroid Cancer
Head and Neck Reconstruction
Salivary Gland Disease

Board Certifications

Otolaryngology

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Dr. Puram's clinical interests encompass head and neck cancer, HPV-related head and neck cancer, conditions of the thyroid and parathyroid glands, salivary gland tumors and disorders, and skin cancers and benign tumors of the head and neck. He is extensively trained in advanced head and neck ablative surgery, transoral robotic surgery, skull base surgery,  and microvascular reconstruction.

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Ear, Nose and Throat Center

4921 Parkview Place
St. Louis, MO 63110

Office Phone: 314-362-7059
Fax: 314-747-5592

Education

Education

BS, Biology and Neuroscience: Massachusetts Institute of Technology (MIT), Cambridge, MA 2005
PhD, Biology and Biomedical Science: Harvard Medical School, Boston, MA 2011
Medical Degree: Harvard Medical School, Boston, MA 2013
Post-doctoral Research Fellowship: Massachusetts General / MIT Broad Institute, Boston, MA 2017
Residency, Otolaryngology: Massachusetts Eye and Ear Infirmary, Boston, MA 2018
Clinical Fellowship, Head and Neck Surgical Oncology and Microvascular Free Flap Reconstruction: James Cancer Center / Ohio State University, Columbus, OH 2019

Publication & Research

Publication & Research

Letter to the Editor "Stage II Oral Tongue Cancer: Survival Impact of Adjuvant Radiation Based on Depth of Invasion".
Varvares MA, McIntyre J, Bulbul MG, Puram SV
Otolaryngol Head Neck Surg. 2019 Sep; 161(3)543. doi: 10.1177/0194599819852610.

PMID:
    31478474
    [PubMed - in process]
Related citations


ASO Author Reflections: Margin Analysis in Head and Neck Cancer-State of the Art and Future Directions.
Silverman DA, Li MM, Puram SV, Kang SY
Ann Surg Oncol. 2019 Aug 30; doi: 10.1245/s10434-019-07773-2.

PMID:
    31471843
    [PubMed - as supplied by publisher]
Related citations


Elective neck dissection for salvage laryngectomy: A systematic review and meta-analysis.
Lin C, Puram SV, Bulbul MG, Sethi RK, Rocco JW, Old MO, Kang SY
Oral Oncol. 2019 Sep; 9697-104. doi: 10.1016/j.oraloncology.2019.07.008.

PMID:
    31422220
    [PubMed - in process]
Related citations


Margin Analysis in Head and Neck Cancer: State of the Art and Future Directions.
Li MM, Puram SV, Silverman DA, Old MO, Rocco JW, Kang SY
Ann Surg Oncol. 2019 Aug 5; doi: 10.1245/s10434-019-07645-9.

PMID:
    31385128
    [PubMed - as supplied by publisher]
Related citations


Increased prevalence of neural monitoring during thyroidectomy: Global surgical survey.
Feng AL, Puram SV, Singer MC, Modi R, Kamani D, Randolph GW
Laryngoscope. 2019 Jul 30; doi: 10.1002/lary.28210.

PMID:
    31361342
    [PubMed - as supplied by publisher]
Related citations


Differential variation analysis enables detection of tumor heterogeneity using single-cell RNA-sequencing data.
Davis-Marcisak EF, Sherman TD, Orugunta P, Stein-O'Brien GL, Puram SV, Roussos Torres ET, Hopkins AC, Jaffee EM, Favorov AV, Afsari B, Goff LA, Fertig EJ
Cancer Res. 2019 Jul 23; pii: canres.3882.2018. doi: 10.1158/0008-5472.CAN-18-3882.

PMID:
    31337651
    [PubMed - as supplied by publisher]
Related citations


Preoperative anemia displays a dose-dependent effect on complications in head and neck oncologic surgery.
Abt NB, Tarabanis C, Miller AL, Puram SV, Varvares MA
Head Neck. 2019 Sep; 41(9)3033-3040. doi: 10.1002/hed.25788.

PMID:
    31034668
    [PubMed - in process]
Related citations


A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology.
Barbarite E, Puram SV, Derakhshan A, Rossi ED, Faquin WC, Varvares MA
Laryngoscope. 2019 Mar 8; doi: 10.1002/lary.27905.

PMID:
    30848480
    [PubMed - as supplied by publisher]
Related citations


Postoperative care in an intermediate-level medical unit after head and neck microvascular free flap reconstruction.
Yu PK, Sethi RKV, Rathi V, Puram SV, Lin DT, Emerick KS, Durand ML, Deschler DG
Laryngoscope Investig Otolaryngol. 2019 Feb; 4(1)39-42. doi: 10.1002/lio2.221.

PMID:
    30828617
    [PubMed]
Related citations


Surgery versus radiation for T1 glottic carcinoma: Second primary considerations.
Puram SV, Bhattacharyya N
Laryngoscope. 2019 Feb 15; doi: 10.1002/lary.27854.

PMID:
    30767222
    [PubMed - as supplied by publisher]
Related citations


Salvage laryngectomy following organ-preservation therapy - An evidence-based review.
Silverman DA, Puram SV, Rocco JW, Old MO, Kang SY
Oral Oncol. 2019 Jan; 88137-144. doi: 10.1016/j.oraloncology.2018.11.022.

PMID:
    30616784
    [PubMed - in process]
Related citations


Induction of smell through transethmoid electrical stimulation of the olfactory bulb.
Holbrook EH, Puram SV, See RB, Tripp AG, Nair DG
Int Forum Allergy Rhinol. 2019 Feb; 9(2)158-164. doi: 10.1002/alr.22237.

PMID:
    30480384
    [PubMed - in process]
Related citations


Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer.
Puram SV, Parikh AS, Tirosh I
Mol Cell Oncol. 2018; 5(3)e1448244. doi: 10.1080/23723556.2018.1448244.

PMID:
    30250901
    [PubMed]
Related citations


Transfusion in Head and Neck Cancer Patients Undergoing Pedicled Flap Reconstruction.
Abt NB, Puram SV, Sinha S, Sethi RKV, Goyal N, Emerick KS, Lin DT, Deschler DG
Laryngoscope. 2018 Dec; 128(12)E409-E415. doi: 10.1002/lary.27393.

PMID:
    30247764
    [PubMed - indexed for MEDLINE]
Related citations


Opioid Prescription Patterns Among Patients With Head and Neck Cancer.
Sethi RKV, Panth N, Puram SV, Varvares MA
JAMA Otolaryngol Head Neck Surg. 2018 Apr 1; 144(4)382-383. doi: 10.1001/jamaoto.2017.3343.

PMID:
    29522065
    [PubMed - indexed for MEDLINE]
Related citations


Preoperative laboratory data are associated with complications and surgical site infection in composite head and neck surgical resections.
Abt NB, Sethi RK, Puram SV, Varvares MA
Am J Otolaryngol. 2018 May - Jun; 39(3)261-265. doi: 10.1016/j.amjoto.2018.01.017.

PMID:
    29398185
    [PubMed - indexed for MEDLINE]
Related citations


Identifying Metrics before and after Readmission following Head and Neck Surgery and Factors Affecting Readmission Rate.
Puram SV, Bhattacharyya N
Otolaryngol Head Neck Surg. 2018 May; 158(5)860-866. doi: 10.1177/0194599817750373.

PMID:
    29336226
    [PubMed - in process]
Related citations


Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell. 2017 Dec 14; 171(7)1611-1624.e24. doi: 10.1016/j.cell.2017.10.044.

PMID:
    29198524
    [PubMed - indexed for MEDLINE]
Related citations


US Food and Drug Administration Clearance of Moderate-Risk Otolaryngologic Devices via the 510(k) Process, 1997-2016.
Rathi VK, Gadkaree SK, Ross JS, Kozin ED, Sethi RK, Naunheim MR, Puram SV, Gray ST
Otolaryngol Head Neck Surg. 2017 Oct; 157(4)608-617. doi: 10.1177/0194599817721689.

PMID:
    28786317
    [PubMed - indexed for MEDLINE]
Related citations


Auditory Brainstem Implant Array Position Varies Widely Among Adult and Pediatric Patients and Is Associated With Perception.
Barber SR, Kozin ED, Remenschneider AK, Puram SV, Smith M, Herrmann BS, Cunnane ME, Brown MC, Lee DJ
Ear Hear. 2017 Nov/Dec; 38(6)e343-e351. doi: 10.1097/AUD.0000000000000448.

PMID:
    28700445
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Puram's research focuses on understanding tumor heterogeneity in head and neck cancer, and how heterogeneity among malignant, stromal, and immune cells may contribute to prognosis, treatment response/resistance, and underlying cancer biology. He has formal training in research through a PhD in Biology and Biomedical Sciences and has advanced the field through the use of cutting edge sequencing technologies that allow tumors to be characterized at a single cell resolution.