Patient Portal

Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Striatal Dopamine Responses to Feeding are Altered in People with Obesity.
Eisenstein SA, Black KJ, Samara A, Koller JM, Dunn JP, Hershey T, Klein S, Smith GI
Obesity (Silver Spring). 2020 Feb 21; doi: 10.1002/oby.22753.

PMID:
    32086877
    [PubMed - as supplied by publisher]
Related citations


Emergence of negative affect as motivation for drug taking in rats chronically self-administering cocaine.
Klein SD, Beacher NJ, Kulik JM, Estrin DJ, Pawlak AP, West MO
Psychopharmacology (Berl). 2020 Feb 3; doi: 10.1007/s00213-020-05468-1.

PMID:
    32009196
    [PubMed - as supplied by publisher]
Related citations


Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity.
An YA, Crewe C, Asterholm IW, Sun K, Chen S, Zhang F, Shao M, Funcke JB, Zhang Z, Straub L, Klein S, Kusminski CM, Scherer PE
Nat Metab. 2019 Dec; 1(12)1243-1257. doi: 10.1038/s42255-019-0149-1.

PMID:
    31984308
    [PubMed]
Related citations


Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease.
Smith GI, Shankaran M, Yoshino M, Schweitzer GG, Chondronikola M, Beals JW, Okunade AL, Patterson BW, Nyangau E, Field T, Sirlin CB, Talukdar S, Hellerstein MK, Klein S
J Clin Invest. 2020 Feb 4; pii: 134165. doi: 10.1172/JCI134165.

PMID:
    31805015
    [PubMed - as supplied by publisher]
Related citations


The Bedside Ice Pack Test for Myasthenia Gravis.
Klein S, Feldman R, Chhabra N
J Emerg Med. 2019 Nov 30; pii: S0736-4679(19)30923-0. doi: 10.1016/j.jemermed.2019.10.020.

PMID:
    31796223
    [PubMed - as supplied by publisher]
Related citations


A word of caution against excessive protein intake.
Mittendorfer B, Klein S, Fontana L
Nat Rev Endocrinol. 2020 Jan; 16(1)59-66. doi: 10.1038/s41574-019-0274-7.

PMID:
    31728051
    [PubMed - in process]
Related citations


Adipose tissue NAD<sup>+</sup> biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice.
Yamaguchi S, Franczyk MP, Chondronikola M, Qi N, Gunawardana SC, Stromsdorfer KL, Porter LC, Wozniak DF, Sasaki Y, Rensing N, Wong M, Piston DW, Klein S, Yoshino J
Proc Natl Acad Sci U S A. 2019 Nov 19; 116(47)23822-23828. doi: 10.1073/pnas.1909917116.

PMID:
    31694884
    [PubMed - in process]
Related citations


Biliopancreatic Diversion Induces Greater Metabolic Improvement Than Roux-en-Y Gastric Bypass.
Harris LA, Kayser BD, Cefalo C, Marini L, Watrous JD, Ding J, Jain M, McDonald JG, Thompson BM, Fabbrini E, Eagon JC, Patterson BW, Mittendorfer B, Mingrone G, Klein S
Cell Metab. 2019 Nov 5; 30(5)855-864.e3. doi: 10.1016/j.cmet.2019.09.002.

PMID:
    31588013
    [PubMed - in process]
Related citations


Knockdown of <i>Ant2</i> Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM
Nat Metab. 2019 Jan; 1(1)86-97. doi: 10.1038/s42255-018-0003-x.

PMID:
    31528845
    [PubMed]
Related citations


Metabolically healthy obesity: facts and fantasies.
Smith GI, Mittendorfer B, Klein S
J Clin Invest. 2019 Oct 1; 129(10)3978-3989. doi: 10.1172/JCI129186.

PMID:
    31524630
    [PubMed - in process]
Related citations


Obesity dysregulates fasting-induced changes in glucagon secretion.
Stern JH, Smith G, Chen S, Unger R, Klein S, Scherer PE
J Endocrinol. 2019 Aug 1; pii: JOE-19-0201.R1. doi: 10.1530/JOE-19-0201.

PMID:
    31454790
    [PubMed - as supplied by publisher]
Related citations


One-year postpartum anthropometric outcomes in mothers and children in the LIFE-Moms lifestyle intervention clinical trials.
Phelan S, Clifton RG, Haire-Joshu D, Redman LM, Van Horn L, Evans M, Joshipura K, Couch KA, Arteaga SS, Cahill AG, Drews KL, Franks PW, Gallagher D, Josefson JL, Klein S, Knowler WC, Martin CK, Peaceman AM, Thom EA, Wing RR, Yanovski SZ, Pi-Sunyer X, LIFE-Moms Research Group.
Int J Obes (Lond). 2020 Jan; 44(1)57-68. doi: 10.1038/s41366-019-0410-4.

PMID:
    31292531
    [PubMed - in process]
Related citations


How I monitor cerebral autoregulation.
Klein SP, Depreitere B, Meyfroidt G
Crit Care. 2019 May 7; 23(1)160. doi: 10.1186/s13054-019-2454-1.

PMID:
    31064383
    [PubMed - indexed for MEDLINE]
Related citations


Adipose Tissue CTGF Expression is Associated with Adiposity and Insulin Resistance in Humans.
Yoshino J, Patterson BW, Klein S
Obesity (Silver Spring). 2019 Jun; 27(6)957-962. doi: 10.1002/oby.22463.

PMID:
    31004409
    [PubMed - in process]
Related citations


Peroxisomal regulation of redox homeostasis and adipocyte metabolism.
Liu J, Lu W, Shi B, Klein S, Su X
Redox Biol. 2019 Jun; 24101167. doi: 10.1016/j.redox.2019.101167.

PMID:
    30921635
    [PubMed - in process]
Related citations


Randomized Controlled Trial of Home-Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity.
Haire-Joshu D, Cahill AG, Stein RI, Cade WT, Woolfolk CL, Moley K, Mathur A, Schwarz CD, Schechtman KB, Klein S
Obesity (Silver Spring). 2019 Apr; 27(4)535-541. doi: 10.1002/oby.22413.

PMID:
    30900408
    [PubMed - in process]
Related citations


Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat diet.
Hjorth MF, Astrup A, Zohar Y, Urban LE, Sayer RD, Patterson BW, Herring SJ, Klein S, Zemel BS, Foster GD, Wyatt HR, Hill JO
Int J Obes (Lond). 2019 Oct; 43(10)2037-2044. doi: 10.1038/s41366-018-0298-4.

PMID:
    30568260
    [PubMed - in process]
Related citations


Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.
Acevedo MB, Ferrando R, Patterson BW, Eagon JC, Klein S, Pepino MY
Surg Obes Relat Dis. 2019 Jan; 15(1)36-42. doi: 10.1016/j.soard.2018.10.021.

PMID:
    30545748
    [PubMed - indexed for MEDLINE]
Related citations


Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis.
Peaceman AM, Clifton RG, Phelan S, Gallagher D, Evans M, Redman LM, Knowler WC, Joshipura K, Haire-Joshu D, Yanovski SZ, Couch KA, Drews KL, Franks PW, Klein S, Martin CK, Pi-Sunyer X, Thom EA, Van Horn L, Wing RR, Cahill AG, LIFE‐Moms Research Group.
Obesity (Silver Spring). 2018 Sep; 26(9)1396-1404. doi: 10.1002/oby.22250.

PMID:
    30230252
    [PubMed - indexed for MEDLINE]
Related citations


The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone.
van Vliet S, Smith GI, Porter L, Ramaswamy R, Reeds DN, Okunade AL, Yoshino J, Klein S, Mittendorfer B
J Physiol. 2018 Oct; 596(19)4681-4692. doi: 10.1113/JP276504.

PMID:
    30054913
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Aspire Bariatrics

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2019


Company Name: Human Longevity

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2019