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Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Design and rationale for a real-world observational cohort of patients with nonalcoholic fatty liver disease: The TARGET-NASH study.
Barritt AS Th, Gitlin N, Klein S, Lok AS, Loomba R, Malahias L, Powell M, Vos MB, Weiss LM, Cusi K, Neuschwander-Tetri BA, Sanyal A
Contemp Clin Trials. 2017 Jul 19; 6133-38. doi: 10.1016/j.cct.2017.07.015.

PMID:
    28735109
    [PubMed - as supplied by publisher]
Related citations


Exercise and NAFLD: Is it worth the effort?
Schweitzer GG, Klein S
Hepatology. 2017 Jul 7; doi: 10.1002/hep.29356.

PMID:
    28688146
    [PubMed - as supplied by publisher]
Related citations


Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion-Induced Insulin Resistance.
Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade AL, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B
Diabetes. 2017 Jul; 66(7)1871-1878. doi: 10.2337/db16-1475.

PMID:
    28473464
    [PubMed - in process]
Related citations


Advances in Obesity: Causes, Consequences, and Therapy.
Berthoud HR, Klein S
Gastroenterology. 2017 May; 152(7)1635-1637. doi: 10.1053/j.gastro.2017.03.045.

PMID:
    28389209
    [PubMed - in process]
Related citations


An adipo-biliary-uridine axis that regulates energy homeostasis.
Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE
Science. 2017 Mar 17; 355(6330)pii: eaaf5375. doi: 10.1126/science.aaf5375.

PMID:
    28302796
    [PubMed - in process]
Related citations


HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity.
Reeds DN, Pietka TA, Yarasheski KE, Cade WT, Patterson BW, Okunade A, Abumrad NA, Klein S
Obesity (Silver Spring). 2017 Apr; 25(4)682-688. doi: 10.1002/oby.21793.

PMID:
    28245099
    [PubMed - indexed for MEDLINE]
Related citations


Reverse Anterior Cruciate Ligament Reconstruction Fixation: A Biomechanical Comparison Study of Tibial Cross-Pin and Femoral Interference Screw Fixation.
Lawley RJ, Klein SE, Chudik SC
Arthroscopy. 2017 Mar; 33(3)625-632. doi: 10.1016/j.arthro.2016.09.006.

PMID:
    27939069
    [PubMed - in process]
Related citations


VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women.
Mittendorfer B, Yoshino M, Patterson BW, Klein S
J Clin Endocrinol Metab. 2016 Nov; 101(11)4151-4160.

PMID:
    27588438
    [PubMed - indexed for MEDLINE]
Related citations


High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women.
Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B
Cell Rep. 2016 Oct 11; 17(3)849-861. doi: 10.1016/j.celrep.2016.09.047.

PMID:
    27732859
    [PubMed - in process]
Related citations


Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial.
Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT
Am J Clin Nutr. 2016 Sep; 104(3)576-86. doi: 10.3945/ajcn.116.131391.

PMID:
    27465384
    [PubMed - indexed for MEDLINE]
Related citations


Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D2 Receptor Binding and Age in Obesity.
Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T
Diabetes. 2016 Sep; 65(9)2618-23. doi: 10.2337/db16-0407.

PMID:
    27307220
    [PubMed - indexed for MEDLINE]
Related citations


Proactive and Progressive Approaches in Managing Obesity.
Eckel RH, Bays HE, Klein S, Bade Horn D
Postgrad Med. 2016 Oct; 128 Suppl 121-30. doi: 10.1080/00325481.2016.1181412.

PMID:
    27153316
    [PubMed - indexed for MEDLINE]
Related citations


Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.
Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S
Cell Metab. 2016 Apr 12; 23(4)591-601. doi: 10.1016/j.cmet.2016.02.005.

PMID:
    26916363
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose.
Magkos F, Bradley D, Eagon JC, Patterson BW, Klein S
Am J Clin Nutr. 2016 Jan; 103(1)61-5. doi: 10.3945/ajcn.115.116111.

PMID:
    26607940
    [PubMed - indexed for MEDLINE]
Related citations


Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP
Sleep. 2015 Dec 1; 38(12)1849-60. doi: 10.5665/sleep.5226.

PMID:
    26564131
    [PubMed - indexed for MEDLINE]
Related citations


Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.
Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF
Diabetes. 2016 Feb; 65(2)358-70. doi: 10.2337/db15-0659.

PMID:
    26512026
    [PubMed - indexed for MEDLINE]
Related citations


Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.
Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO, CALERIE Study Group.
Aging Cell. 2016 Feb; 15(1)22-7. doi: 10.1111/acel.12400.

PMID:
    26443692
    [PubMed - indexed for MEDLINE]
Related citations


Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors' Expert Forum.
Cefalu WT, Bray GA, Home PD, Garvey WT, Klein S, Pi-Sunyer FX, Hu FB, Raz I, Van Gaal L, Wolfe BM, Ryan DH
Diabetes Care. 2015 Aug; 38(8)1567-82.

PMID:
    26421334
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Duodenal-Jejunal Bypass Surgery on Glycemic Control in Type 2 Diabetes: A Randomized Controlled Trial.
Petry TZ, Fabbrini E, Otoch JP, Carmona MA, Caravatto PP, Salles JE, Sarian T, Correa JL, Schiavon CA, Patterson BW, Cohen R, Klein S
Obesity (Silver Spring). 2015 Oct; 23(10)1973-9. doi: 10.1002/oby.21190.

PMID:
    26414562
    [PubMed - indexed for MEDLINE]
Related citations


Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity.
Fabbrini E, Tiemann Luecking C, Love-Gregory L, Okunade AL, Yoshino M, Fraterrigo G, Patterson BW, Klein S
Gastroenterology. 2016 Jan; 150(1)79-81.e2. doi: 10.1053/j.gastro.2015.09.003.

PMID:
    26376348
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Aspire Bariatrics

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Endobar

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Human Longevity

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2017


Company Name: Merck

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2017