Patient Portal

Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research
  • Financial Disclosures

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery.
Acevedo MB, Ferrando R, Patterson BW, Eagon JC, Klein S, Pepino MY
Surg Obes Relat Dis. 2018 Nov 2; pii: S1550-7289(18)30534-3. doi: 10.1016/j.soard.2018.10.021.

PMID:
    30545748
    [PubMed - as supplied by publisher]
Related citations


Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis.
Peaceman AM, Clifton RG, Phelan S, Gallagher D, Evans M, Redman LM, Knowler WC, Joshipura K, Haire-Joshu D, Yanovski SZ, Couch KA, Drews KL, Franks PW, Klein S, Martin CK, Pi-Sunyer X, Thom EA, Van Horn L, Wing RR, Cahill AG, LIFE‐Moms Research Group.
Obesity (Silver Spring). 2018 Sep; 26(9)1396-1404. doi: 10.1002/oby.22250.

PMID:
    30230252
    [PubMed - in process]
Related citations


The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone.
van Vliet S, Smith GI, Porter L, Ramaswamy R, Reeds DN, Okunade AL, Yoshino J, Klein S, Mittendorfer B
J Physiol. 2018 Oct; 596(19)4681-4692. doi: 10.1113/JP276504.

PMID:
    30054913
    [PubMed - in process]
Related citations


Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.
Liss KHH, Lutkewitte AJ, Pietka T, Finck BN, Franczyk M, Yoshino J, Klein S, Hall AM
J Lipid Res. 2018 Sep; 59(9)1630-1639. doi: 10.1194/jlr.M084947.

PMID:
    29853530
    [PubMed - in process]
Related citations


Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.
Smith GI, Commean PK, Reeds DN, Klein S, Mittendorfer B
Obesity (Silver Spring). 2018 May; 26(5)854-861. doi: 10.1002/oby.22169.

PMID:
    29687650
    [PubMed - indexed for MEDLINE]
Related citations


Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress.
Yoshino J, Almeda-Valdes P, Moseley AC, Mittendorfer B, Klein S
Physiol Rep. 2018 Apr; 6(8)e13679. doi: 10.14814/phy2.13679.

PMID:
    29687616
    [PubMed - in process]
Related citations


Comparison of Intracranial Pressure and Pressure Reactivity Index Obtained Through Pressure Measurements in the Ventricle and in the Parenchyma During and Outside Cerebrospinal Fluid Drainage Episodes in a Manipulation-Free Patient Setting.
Klein SP, Bruyninckx D, Callebaut I, Depreitere B
Acta Neurochir Suppl. 2018; 126287-290. doi: 10.1007/978-3-319-65798-1_56.

PMID:
    29492576
    [PubMed - indexed for MEDLINE]
Related citations


What Determines Outcome in Patients That Suffer Raised Intracranial Pressure After Traumatic Brain Injury?
Klein SP, Depreitere B
Acta Neurochir Suppl. 2018; 12651-54. doi: 10.1007/978-3-319-65798-1_11.

PMID:
    29492531
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.
Chondronikola M, Magkos F, Yoshino J, Okunade AL, Patterson BW, Muehlbauer MJ, Newgard CB, Klein S
Obesity (Silver Spring). 2018 Apr; 26(4)683-688. doi: 10.1002/oby.22129.

PMID:
    29476613
    [PubMed - indexed for MEDLINE]
Related citations


Weight Control Program and Gestational Weight Gain in Disadvantaged Women with Overweight or Obesity: A Randomized Clinical Trial.
Cahill AG, Haire-Joshu D, Cade WT, Stein RI, Woolfolk CL, Moley K, Mathur A, Schechtman K, Klein S
Obesity (Silver Spring). 2018 Mar; 26(3)485-491. doi: 10.1002/oby.22070.

PMID:
    29464907
    [PubMed - indexed for MEDLINE]
Related citations


Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4.
Acevedo MB, Eagon JC, Bartholow BD, Klein S, Bucholz KK, Pepino MY
Surg Obes Relat Dis. 2018 Mar; 14(3)277-283. doi: 10.1016/j.soard.2017.11.010.

PMID:
    29305304
    [PubMed - indexed for MEDLINE]
Related citations


Effects of Sleeve Gastrectomy vs. Roux-en-Y Gastric Bypass on Eating Behavior and Sweet Taste Perception in Subjects with Obesity.
Nance K, Eagon JC, Klein S, Pepino MY
Nutrients. 2017 Dec 24; 10(1)pii: E18. doi: 10.3390/nu10010018.

PMID:
    29295558
    [PubMed - indexed for MEDLINE]
Related citations


Diurnal Variation in PDK4 Expression Is Associated With Plasma Free Fatty Acid Availability in People.
Yamaguchi S, Moseley AC, Almeda-Valdes P, Stromsdorfer KL, Franczyk MP, Okunade AL, Patterson BW, Klein S, Yoshino J
J Clin Endocrinol Metab. 2018 Mar 1; 103(3)1068-1076. doi: 10.1210/jc.2017-02230.

PMID:
    29294006
    [PubMed - indexed for MEDLINE]
Related citations


Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial.
Pettus J, Reeds D, Cavaiola TS, Boeder S, Levin M, Tobin G, Cava E, Thai D, Shi J, Yan H, Bautista E, McMillan J, Unger R, Henry RR, Klein S
Diabetes Obes Metab. 2018 May; 20(5)1302-1305. doi: 10.1111/dom.13202.

PMID:
    29283470
    [PubMed - in process]
Related citations


Effect of Weight Gain and Weight Loss on In Vivo Colonocyte Proliferation Rate in People with Obesity.
Magkos F, Sullivan S, Fitch M, Smith G, Fabbrini E, Mittendorfer B, Hellerstein M, Klein S
Obesity (Silver Spring). 2017 Nov; 25 Suppl 2S81-S86. doi: 10.1002/oby.21983.

PMID:
    29086514
    [PubMed - indexed for MEDLINE]
Related citations


Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion.
Harris LLS, Smith GI, Mittendorfer B, Eagon JC, Okunade AL, Patterson BW, Klein S
J Clin Endocrinol Metab. 2017 Oct 1; 102(10)3858-3864. doi: 10.1210/jc.2017-01295.

PMID:
    28938478
    [PubMed - indexed for MEDLINE]
Related citations


Design and rationale for a real-world observational cohort of patients with nonalcoholic fatty liver disease: The TARGET-NASH study.
Barritt AS 4th, Gitlin N, Klein S, Lok AS, Loomba R, Malahias L, Powell M, Vos MB, Weiss LM, Cusi K, Neuschwander-Tetri BA, Sanyal A
Contemp Clin Trials. 2017 Oct; 6133-38. doi: 10.1016/j.cct.2017.07.015.

PMID:
    28735109
    [PubMed - indexed for MEDLINE]
Related citations


Exercise and NAFLD: Is it worth the effort?
Schweitzer GG, Klein S
Hepatology. 2017 Nov; 66(5)1691-1694. doi: 10.1002/hep.29356.

PMID:
    28688146
    [PubMed - indexed for MEDLINE]
Related citations


Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion-Induced Insulin Resistance.
Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade AL, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B
Diabetes. 2017 Jul; 66(7)1871-1878. doi: 10.2337/db16-1475.

PMID:
    28473464
    [PubMed - indexed for MEDLINE]
Related citations


Advances in Obesity: Causes, Consequences, and Therapy.
Berthoud HR, Klein S
Gastroenterology. 2017 May; 152(7)1635-1637. doi: 10.1053/j.gastro.2017.03.045.

PMID:
    28389209
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Aspire Bariatrics

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018


Company Name: Human Longevity

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018


Company Name: Merck

Royalties:

Equity: No

Consulting/Advisory Board: $1,000 - $10,000

Speaker Fees: $1,000 - $10,000

Reporting Date: May 01, 2018