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Faculty Physicians

Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification.
Sharma A, Klein SS, Barboza L, Lohdi N, Toth M
J Neurosci. 2016 Feb 3; 36(5)1711-22. doi: 10.1523/JNEUROSCI.4037-15.2016.

PMID:
    26843651
    [PubMed - in process]
Related citations


[Einfluss des therapeutischen Qi auf die Herzratenvariabilität bei Akupunktur: Eine randomisierte kontrollierte Studie].
Hochstrasser RJ, Endler PC, Klein SD
Forsch Komplementmed. 2015; 22(6)389-93. doi: 10.1159/000442398.

PMID:
    26840421
    [PubMed - in process]
Related citations


Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype.
Petric S, Klein S, Dannenberg L, Lahres T, Clasen L, Schmidt KG, Ding Z, Donner BC
Cell Physiol Biochem. 2016 Feb 1; 38(2)487-501.

PMID:
    26828725
    [PubMed - as supplied by publisher]
Related citations


Assessment of beta-blocker response by expression of beta-Arrestin2 and RhoA/ROCK2 in antrum mucosa in cirrhotic patients.
Trebicka J, von Heydebrand M, Lehmann J, Tofteng F, Busk T, Jensen HL, Rohde J, Reiberger T, Mortensen C, Schierwagen R, Klein S, Møller S, Bendtsen F, Krag A
J Hepatol. 2016 Jan 28; pii: S0168-8278(16)00057-X. doi: 10.1016/j.jhep.2016.01.022.

PMID:
    26827791
    [PubMed - as supplied by publisher]
Related citations


PCA-based groupwise image registration for quantitative MRI.
Huizinga W, Poot DH, Guyader JM, Klaassen R, Coolen BF, van Kranenburg M, van Geuns RJ, Uitterdijk A, Polfliet M, Vandemeulebroucke J, Leemans A, Niessen WJ, Klein S
Med Image Anal. 2016 Apr; 2965-78. doi: 10.1016/j.media.2015.12.004.

PMID:
    26802910
    [PubMed - in process]
Related citations


Lenalidomide plus melphalan and prednisone, followed by lenalidomide maintenance versus thalidomide plus melphalan and prednisone, followed by thalidomide maintenance; results of the randomised phase 3 HOVON 87/NMSG18 trial.
Zweegman S, van der Holt B, Mellqvist UH, Salomo M, Bos GM, Levin MD, Visser-Wisselaar H, Hansson M, van der Velden AW, Deenik W, Gruber A, Coenen JL, Plesner T, Klein SK, Tanis BC, Szatkowski DL, Brouwer RE, Westerman M, Leys MR, Sinnige HA, Haukås E, van der Hem KG, Durian MF, Mattijssen EV, van de Donk NW, Stevens-Kroef MJ, Sonneveld P, Waage A
Blood. 2016 Jan 22; pii: blood-2015-11-679415.

PMID:
    26802176
    [PubMed - as supplied by publisher]
Related citations


Creating Quality Online Materials for Specialty Nurse Practitioner Content: Filling a Need for the Graduate Nurse Practitioner.
Hoffmann RL, Klein SJ, Rosenzweig MQ
J Cancer Educ. 2016 Jan 18;

PMID:
    26781695
    [PubMed - as supplied by publisher]
Related citations


Evaluation of antibiotic resistance to orally administrable antibiotics in staphylococcal bone and joint infections in one of the largest university hospitals in Germany: is there a role for fusidic acid?
Klein S, Nurjadi D, Eigenbrod T, Bode KA
Int J Antimicrob Agents. 2016 Feb; 47(2)155-7. doi: 10.1016/j.ijantimicag.2015.12.002.

PMID:
    26774158
    [PubMed - in process]
Related citations


Lack of netrin-4 modulates pathologic neovascularization in the eye.
Kociok N, Crespo-Garcia S, Liang Y, Klein SV, Nürnberg C, Reichhart N, Skosyrski S, Moritz E, Maier AK, Brunken WJ, Strauß O, Koch M, Joussen AM
Sci Rep. 2016 Jan 6; 618828. doi: 10.1038/srep18828.

PMID:
    26732856
    [PubMed - in process]
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Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.
Görtzen J, Schierwagen R, Bierwolf J, Klein S, Uschner FE, van der Ven PF, Fürst DO, Strassburg CP, Laleman W, Pollok JM, Trebicka J
Front Physiol. 2015; 6359. doi: 10.3389/fphys.2015.00359.

PMID:
    26696895
    [PubMed]
Related citations


Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.
Peretz J, Pekosz A, Lane AP, Klein SL
Am J Physiol Lung Cell Mol Physiol. 2015 Dec 18; ajplung.00398.2015. doi: 10.1152/ajplung.00398.2015.

PMID:
    26684252
    [PubMed - as supplied by publisher]
Related citations


Reproductive senescence, fertility and reproductive tumour profile in ageing female Han Wistar rats.
Mitchard TL, Klein S
Exp Toxicol Pathol. 2015 Dec 4; pii: S0940-2993(15)30031-2. doi: 10.1016/j.etp.2015.11.006.

PMID:
    26655996
    [PubMed - as supplied by publisher]
Related citations


Correction: Usage of Complementary Medicine in Switzerland: Results of the Swiss Health Survey 2012 and Development Since 2007.
Klein SD, Torchetti L, Frei-Erb M, Wolf U
PLoS One. 2015; 10(12)e0144676. doi: 10.1371/journal.pone.0144676.

PMID:
    26650080
    [PubMed - as supplied by publisher]
Related citations


Reduced salinity increases susceptibility of zooxanthellate jellyfish to herbicide toxicity during a simulated rainfall event.
Klein SG, Pitt KA, Carroll AR
Environ Pollut. 2016 Feb; 20979-86. doi: 10.1016/j.envpol.2015.11.012.

PMID:
    26647170
    [PubMed - in process]
Related citations


The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh.
Kmush BL, Labrique A, Li W, Klein SL, Schulze K, Shaikh S, Ali H, Engle RE, Wu L, Purcell RH, Mehra S, Christian P, West K Jr, Nelson K
Am J Trop Med Hyg. 2016 Jan 6; 94(1)203-11. doi: 10.4269/ajtmh.15-0238.

PMID:
    26621563
    [PubMed - in process]
Related citations


ELM 2016-data update and new functionality of the eukaryotic linear motif resource.
Dinkel H, Van Roey K, Michael S, Kumar M, Uyar B, Altenberg B, Milchevskaya V, Schneider M, Kühn H, Behrendt A, Dahl SL, Damerell V, Diebel S, Kalman S, Klein S, Knudsen AC, Mäder C, Merrill S, Staudt A, Thiel V, Welti L, Davey NE, Diella F, Gibson TJ
Nucleic Acids Res. 2016 Jan 4; 44(D1)D294-300. doi: 10.1093/nar/gkv1291.

PMID:
    26615199
    [PubMed - in process]
Related citations


Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose.
Magkos F, Bradley D, Eagon JC, Patterson BW, Klein S
Am J Clin Nutr. 2016 Jan; 103(1)61-5. doi: 10.3945/ajcn.115.116111.

PMID:
    26607940
    [PubMed - in process]
Related citations


Models of Care for High-Need, High-Cost Patients: An Evidence Synthesis.
McCarthy D, Ryan J, Klein S
Issue Brief (Commonw Fund). 2015 Oct; 311-19.

PMID:
    26591906
    [PubMed - indexed for MEDLINE]
Related citations


Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study.
van Tiel J, Kotek G, Reijman M, Bos PK, Bron EE, Klein S, Nasserinejad K, van Osch GJ, Verhaar JA, Krestin GP, Weinans H, Oei EH
Radiology. 2015 Nov 20; 150693.

PMID:
    26588020
    [PubMed - as supplied by publisher]
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Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP
Sleep. 2015 Dec 1; 38(12)1849-60. doi: 10.5665/sleep.5226.

PMID:
    26564131
    [PubMed - in process]
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