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Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes.
Cremers EM, Westers TM, Alhan C, Cali C, Visser-Wisselaar HA, Chitu DA, van der Velden VH, Te Marvelde JG, Klein SK, Muus P, Vellenga E, De Greef GE, Legdeur MC, Wijermans PW, Stevens-Kroef MJ, da Silva-Coelho P, Jansen JH, Ossenkoppele GJ, van de Loosdrecht AA
Haematologica. 2016 Sep 22; pii: haematol.2016.147843.

PMID:
    27658438
    [PubMed - as supplied by publisher]
Related citations


Phase 1/2 study of lenalidomide combined with low-dose cyclophosphamide and prednisone in lenalidomide-refractory multiple myeloma.
Nijhof IS, Franssen LE, Levin MD, Bos GM, Broijl A, Klein SK, Koene HR, Bloem AC, Beeker A, Faber LM, van der Spek E, Ypma PF, Raymakers R, van Spronsen DJ, Westerweel PE, Oostvogels R, van Velzen J, van Kessel B, Mutis T, Sonneveld P, Zweegman S, Lokhorst HM, van de Donk NW
Blood. 2016 Sep 19; pii: blood-2016-07-729236.

PMID:
    27647864
    [PubMed - as supplied by publisher]
Related citations


FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.
Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W
Sci Rep. 2016 Sep 16; 633453. doi: 10.1038/srep33453.

PMID:
    27634375
    [PubMed - in process]
Related citations


Statins improve NASH via inhibition of RhoA and Ras.
Schierwagen R, Maybüchen L, Hittatiya K, Klein S, Uschner FE, Braga TT, Franklin BS, Nickenig G, Strassburg CP, Plat J, Sauerbruch T, Latz E, Lütjohann D, Zimmer S, Trebicka J
Am J Physiol Gastrointest Liver Physiol. 2016 Sep 15; ajpgi.00063.2016. doi: 10.1152/ajpgi.00063.2016.

PMID:
    27634010
    [PubMed - as supplied by publisher]
Related citations


Progesterone-Based Therapy Protects Against Influenza by Promoting Lung Repair and Recovery in Females.
Hall OJ, Limjunyawong N, Vermillion MS, Robinson DP, Wohlgemuth N, Pekosz A, Mitzner W, Klein SL
PLoS Pathog. 2016 Sep; 12(9)e1005840. doi: 10.1371/journal.ppat.1005840.

PMID:
    27631986
    [PubMed - in process]
Related citations


Exploring peer-mentoring for community dwelling older adults with chronic low back pain: a qualitative study.
Cooper K, Schofield P, Klein S, Smith BH, Jehu LM
Physiotherapy. 2016 May 26; pii: S0031-9406(16)30025-6. doi: 10.1016/j.physio.2016.05.005.

PMID:
    27613081
    [PubMed - as supplied by publisher]
Related citations


Pathogenesis and Molecular Mechanisms of Zika Virus.
Nayak S, Lei J, Pekosz A, Klein S, Burd I
Semin Reprod Med. 2016 Sep 9;

PMID:
    27612156
    [PubMed - as supplied by publisher]
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Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes.
Petersen B, Frenzel A, Lucas-Hahn A, Herrmann D, Hassel P, Klein S, Ziegler M, Hadeler KG, Niemann H
Xenotransplantation. 2016 Sep; 23(5)338-46. doi: 10.1111/xen.12258.

PMID:
    27610605
    [PubMed - in process]
Related citations


New Clinically Relevant Findings about Violence by People with Schizophrenia.
Hodgins S, Klein S
Can J Psychiatry. 2016 Sep 7; pii: 0706743716648300.

PMID:
    27605579
    [PubMed - as supplied by publisher]
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Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF.
Edinger N, Lebendiker M, Klein S, Zigler M, Langut Y, Levitzki A
PLoS One. 2016; 11(9)e0162321. doi: 10.1371/journal.pone.0162321.

PMID:
    27598772
    [PubMed - in process]
Related citations


Intensifying drought eliminates the expected benefits of elevated carbon dioxide for soybean.
Gray SB, Dermody O, Klein SP, Locke AM, McGrath JM, Paul RE, Rosenthal DM, Ruiz-Vera UM, Siebers MH, Strellner R, Ainsworth EA, Bernacchi CJ, Long SP, Ort DR, Leakey AD
Nat Plants. 2016 Sep 5; 2(9)16132. doi: 10.1038/nplants.2016.132.

PMID:
    27595230
    [PubMed - in process]
Related citations


Novel Rat Model of Repetitive Portal Venous Embolization Mimicking Human Non-Cirrhotic Idiopathic Portal Hypertension.
Klein S, Hinüber C, Hittatiya K, Schierwagen R, Uschner FE, Strassburg CP, Fischer HP, Spengler U, Trebicka J
PLoS One. 2016; 11(9)e0162144. doi: 10.1371/journal.pone.0162144.

PMID:
    27589391
    [PubMed - in process]
Related citations


VLDL-triglyceride kinetics in lean, overweight, and obese men and women.
Mittendorfer B, Yoshino M, Patterson BW, Klein S
J Clin Endocrinol Metab. 2016 Sep 2; jc20161500.

PMID:
    27588438
    [PubMed - as supplied by publisher]
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Searches for Sterile Neutrinos with the IceCube Detector.
Aartsen MG, Abraham K, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Archinger M, Argüelles C, Arlen TC, Auffenberg J, Axani S, Bai X, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berghaus P, Berley D, Bernardini E, Bernhard A, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Boersma DJ, Bohm C, Börner M, Bos F, Bose D, Böser S, Botner O, Braun J, Brayeur L, Bretz HP, Burgman A, Casey J, Casier M, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Coenders S, Collin GH, Conrad JM, Cowen DF, Cruz Silva AH, Daughhetee J, Davis JC, Day M, de André JP, De Clercq C, Del Pino Rosendo E, Dembinski H, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Eberhardt B, Ehrhardt T, Eichmann B, Euler S, Evenson PA, Fahey S, Fazely AR, Feintzeig J, Felde J, Filimonov K, Finley C, Flis S, Fösig CC, Fuchs T, Gaisser TK, Gaior R, Gallagher J, Gerhardt L, Ghorbani K, Giang W, Gladstone L, Glüsenkamp T, Goldschmidt A, Golup G, Gonzalez JG, Góra D, Grant D, Griffith Z, Haj Ismail A, Hallgren A, Halzen F, Hansen E, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Holzapfel K, Homeier A, Hoshina K, Huang F, Huber M, Huelsnitz W, Hultqvist K, In S, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJ, Jurkovic M, Kappes A, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim M, Kintscher T, Kiryluk J, Kittler T, Klein SR, Kohnen G, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Krüger C, Kunnen J, Kunwar S, Kurahashi N, Kuwabara T, Labare M, Lanfranchi JL, Larson MJ, Lennarz D, Lesiak-Bzdak M, Leuermann M, Lu L, Lünemann J, Madsen J, Maggi G, Mahn KB, Mancina S, Mandelartz M, Maruyama R, Mase K, Maunu R, McNally F, Meagher K, Medici M, Meier M, Meli A, Menne T, Merino G, Meures T, Miarecki S, Middell E, Mohrmann L, Montaruli T, Moulai M, Nahnhauer R, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, Omairat A, O'Murchadha A, Palczewski T, Pandya H, Pankova DV, Pepper JA, Pérez de Los Heros C, Pfendner C, Pieloth D, Pinat E, Posselt J, Price PB, Przybylski GT, Quinnan M, Raab C, Rameez M, Rawlins K, Relich M, Resconi E, Rhode W, Richman M, Riedel B, Robertson S, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Sabbatini L, Salvado J, Sanchez Herrera SE, Sandrock A, Sandroos J, Sarkar S, Satalecka K, Schlunder P, Schmidt T, Schöneberg S, Schönwald A, Seckel D, Seunarine S, Soldin D, Song M, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stasik A, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Ström R, Strotjohann NL, Sullivan GW, Sutherland M, Taavola H, Taboada I, Tatar J, Ter-Antonyan S, Terliuk A, Tešić G, Tilav S, Toale PA, Tobin MN, Toscano S, Tosi D, Tselengidou M, Turcati A, Unger E, Usner M, Vallecorsa S, Vandenbroucke J, van Eijndhoven N, Vanheule S, van Rossem M, van Santen J, Veenkamp J, Voge M, Vraeghe M, Walck C, Wallace A, Wandkowsky N, Weaver Ch, Wendt C, Westerhoff S, Whelan BJ, Wiebe K, Wille L, Williams DR, Wills L, Wissing H, Wolf M, Wood TR, Woolsey E, Woschnagg K, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Zoll M, IceCube Collaboration
Phys Rev Lett. 2016 Aug 12; 117(7)071801. doi: 10.1103/PhysRevLett.117.071801.

PMID:
    27563950
    [PubMed - in process]
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Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma.
Palumbo A, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I, Hungria V, Munder M, Mateos MV, Mark TM, Qi M, Schecter J, Amin H, Qin X, Deraedt W, Ahmadi T, Spencer A, Sonneveld P, CASTOR Investigators
N Engl J Med. 2016 Aug 25; 375(8)754-66. doi: 10.1056/NEJMoa1606038.

PMID:
    27557302
    [PubMed - indexed for MEDLINE]
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Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1.
Mease PJ, van der Heijde D, Ritchlin CT, Okada M, Cuchacovich RS, Shuler CL, Lin CY, Braun DK, Lee CH, Gladman DD, SPIRIT-P1 Study Group
Ann Rheum Dis. 2016 Aug 23; pii: annrheumdis-2016-209709. doi: 10.1136/annrheumdis-2016-209709.

PMID:
    27553214
    [PubMed - as supplied by publisher]
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Sex differences in immune responses.
Klein SL, Flanagan KL
Nat Rev Immunol. 2016 Oct; 16(10)626-38. doi: 10.1038/nri.2016.90.

PMID:
    27546235
    [PubMed - in process]
Related citations


Clinical value of imaging for lymph nodes evaluation with particular emphasis on ultrasonography.
Chiorean L, Cui XW, Klein SA, Budjan J, Sparchez Z, Radzina M, Jenssen C, Dong Y, Dietrich CF
Z Gastroenterol. 2016 Aug; 54(8)774-90. doi: 10.1055/s-0042-108656.

PMID:
    27529528
    [PubMed - in process]
Related citations


Randomly perturbed B-splines for nonrigid image registration.
Sun W, Niessen WJ, Klein S
IEEE Trans Pattern Anal Mach Intell. 2016 Aug 4;

PMID:
    27514038
    [PubMed - as supplied by publisher]
Related citations


Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures.
Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B
ACS Chem Neurosci. 2016 Sep 21; 7(9)1188-91. doi: 10.1021/acschemneuro.6b00215.

PMID:
    27504748
    [PubMed - in process]
Related citations