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Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Searches for Sterile Neutrinos with the IceCube Detector.
Aartsen MG, Abraham K, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Archinger M, Argüelles C, Arlen TC, Auffenberg J, Axani S, Bai X, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berghaus P, Berley D, Bernardini E, Bernhard A, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Boersma DJ, Bohm C, Börner M, Bos F, Bose D, Böser S, Botner O, Braun J, Brayeur L, Bretz HP, Burgman A, Casey J, Casier M, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Coenders S, Collin GH, Conrad JM, Cowen DF, Cruz Silva AH, Daughhetee J, Davis JC, Day M, de André JP, De Clercq C, Del Pino Rosendo E, Dembinski H, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Eberhardt B, Ehrhardt T, Eichmann B, Euler S, Evenson PA, Fahey S, Fazely AR, Feintzeig J, Felde J, Filimonov K, Finley C, Flis S, Fösig CC, Fuchs T, Gaisser TK, Gaior R, Gallagher J, Gerhardt L, Ghorbani K, Giang W, Gladstone L, Glüsenkamp T, Goldschmidt A, Golup G, Gonzalez JG, Góra D, Grant D, Griffith Z, Haj Ismail A, Hallgren A, Halzen F, Hansen E, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Holzapfel K, Homeier A, Hoshina K, Huang F, Huber M, Huelsnitz W, Hultqvist K, In S, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJ, Jurkovic M, Kappes A, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim M, Kintscher T, Kiryluk J, Kittler T, Klein SR, Kohnen G, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Krüger C, Kunnen J, Kunwar S, Kurahashi N, Kuwabara T, Labare M, Lanfranchi JL, Larson MJ, Lennarz D, Lesiak-Bzdak M, Leuermann M, Lu L, Lünemann J, Madsen J, Maggi G, Mahn KB, Mancina S, Mandelartz M, Maruyama R, Mase K, Maunu R, McNally F, Meagher K, Medici M, Meier M, Meli A, Menne T, Merino G, Meures T, Miarecki S, Middell E, Mohrmann L, Montaruli T, Moulai M, Nahnhauer R, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, Omairat A, O'Murchadha A, Palczewski T, Pandya H, Pankova DV, Pepper JA, Pérez de Los Heros C, Pfendner C, Pieloth D, Pinat E, Posselt J, Price PB, Przybylski GT, Quinnan M, Raab C, Rameez M, Rawlins K, Relich M, Resconi E, Rhode W, Richman M, Riedel B, Robertson S, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Sabbatini L, Salvado J, Sanchez Herrera SE, Sandrock A, Sandroos J, Sarkar S, Satalecka K, Schlunder P, Schmidt T, Schöneberg S, Schönwald A, Seckel D, Seunarine S, Soldin D, Song M, Spiczak GM, Spiering C, Stamatikos M, Stanev T, Stasik A, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Ström R, Strotjohann NL, Sullivan GW, Sutherland M, Taavola H, Taboada I, Tatar J, Ter-Antonyan S, Terliuk A, Tešić G, Tilav S, Toale PA, Tobin MN, Toscano S, Tosi D, Tselengidou M, Turcati A, Unger E, Usner M, Vallecorsa S, Vandenbroucke J, van Eijndhoven N, Vanheule S, van Rossem M, van Santen J, Veenkamp J, Voge M, Vraeghe M, Walck C, Wallace A, Wandkowsky N, Weaver Ch, Wendt C, Westerhoff S, Whelan BJ, Wiebe K, Wille L, Williams DR, Wills L, Wissing H, Wolf M, Wood TR, Woolsey E, Woschnagg K, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Zoll M, IceCube Collaboration
Phys Rev Lett. 2016 Aug 12; 117(7)071801. doi: 10.1103/PhysRevLett.117.071801.

PMID:
    27563950
    [PubMed - in process]
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Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma.
Palumbo A, Chanan-Khan A, Weisel K, Nooka AK, Masszi T, Beksac M, Spicka I, Hungria V, Munder M, Mateos MV, Mark TM, Qi M, Schecter J, Amin H, Qin X, Deraedt W, Ahmadi T, Spencer A, Sonneveld P, CASTOR Investigators
N Engl J Med. 2016 Aug 25; 375(8)754-66. doi: 10.1056/NEJMoa1606038.

PMID:
    27557302
    [PubMed - in process]
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Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1.
Mease PJ, van der Heijde D, Ritchlin CT, Okada M, Cuchacovich RS, Shuler CL, Lin CY, Braun DK, Lee CH, Gladman DD, SPIRIT-P1 Study Group
Ann Rheum Dis. 2016 Aug 23; pii: annrheumdis-2016-209709. doi: 10.1136/annrheumdis-2016-209709.

PMID:
    27553214
    [PubMed - as supplied by publisher]
Related citations


Sex differences in immune responses.
Klein SL, Flanagan KL
Nat Rev Immunol. 2016 Aug 22; doi: 10.1038/nri.2016.90.

PMID:
    27546235
    [PubMed - as supplied by publisher]
Related citations


Clinical value of imaging for lymph nodes evaluation with particular emphasis on ultrasonography.
Chiorean L, Cui XW, Klein SA, Budjan J, Sparchez Z, Radzina M, Jenssen C, Dong Y, Dietrich CF
Z Gastroenterol. 2016 Aug; 54(8)774-790.

PMID:
    27529528
    [PubMed - as supplied by publisher]
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Randomly perturbed B-splines for nonrigid image registration.
Sun W, Niessen WJ, Klein S
IEEE Trans Pattern Anal Mach Intell. 2016 Aug 4;

PMID:
    27514038
    [PubMed - as supplied by publisher]
Related citations


Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures.
Lizama-Manibusan BN, Klein S, McKenzie JR, Cliffel DE, McLaughlin B
ACS Chem Neurosci. 2016 Aug 24;

PMID:
    27504748
    [PubMed - as supplied by publisher]
Related citations


Time-resolved 3D rotational angiography: display of detailed neurovascular anatomy in patients with intracranial vascular malformations.
Lescher S, Gehrisch S, Klein S, Berkefeld J
J Neurointerv Surg. 2016 Aug 4; pii: neurintsurg-2016-012462. doi: 10.1136/neurintsurg-2016-012462.

PMID:
    27492375
    [PubMed - as supplied by publisher]
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Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.
Schrantee A, Tamminga HG, Bouziane C, Bottelier MA, Bron EE, Mutsaerts HM, Zwinderman AH, Groote IR, Rombouts SA, Lindauer RJ, Klein S, Niessen WJ, Opmeer BC, Boer F, Lucassen PJ, Andersen SL, Geurts HM, Reneman L
JAMA Psychiatry. 2016 Aug 3; doi: 10.1001/jamapsychiatry.2016.1572.

PMID:
    27487479
    [PubMed - as supplied by publisher]
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Reducing Anesthesia and Health Care Cost Through Utilization of Child Life Specialists in Pediatric Radiation Oncology.
Scott MT, Todd KE, Oakley H, Bradley JA, Rotondo RL, Morris CG, Klein S, Mendenhall NP, Indelicato DJ
Int J Radiat Oncol Biol Phys. 2016 Jun 5; pii: S0360-3016(16)30298-X. doi: 10.1016/j.ijrobp.2016.06.001.

PMID:
    27475669
    [PubMed - as supplied by publisher]
Related citations


Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial.
Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT
Am J Clin Nutr. 2016 Jul 27; pii: ajcn131391.

PMID:
    27465384
    [PubMed - as supplied by publisher]
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Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z
Gut. 2016 Jul 18; pii: gutjnl-2015-311224. doi: 10.1136/gutjnl-2015-311224.

PMID:
    27432540
    [PubMed - as supplied by publisher]
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A survey of medical image registration - under review.
Viergever MA, Maintz JB, Klein S, Murphy K, Staring M, Pluim JP
Med Image Anal. 2016 Oct; 33140-4. doi: 10.1016/j.media.2016.06.030.

PMID:
    27427472
    [PubMed - in process]
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Stochastic optimization with randomized smoothing for image registration.
Sun W, Poot DH, Smal I, Yang X, Niessen WJ, Klein S
Med Image Anal. 2016 Jul 6; 35146-158. doi: 10.1016/j.media.2016.07.003.

PMID:
    27423112
    [PubMed - as supplied by publisher]
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Truncating mutations in APP cause a distinct neurological phenotype.
Klein S, Goldman A, Lee H, Ghahremani S, Bhakta V, UCLA Clinical Genomics Center, Nelson SF, Martinez-Agosto JA
Ann Neurol. 2016 Jul 16; doi: 10.1002/ana.24727.

PMID:
    27422356
    [PubMed - as supplied by publisher]
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Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.
Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L
Aging (Albany NY). 2016 Jul; 8(7)1416-31. doi: 10.18632/aging.100994.

PMID:
    27410480
    [PubMed - in process]
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Evidence for climate change in the satellite cloud record.
Norris JR, Allen RJ, Evan AT, Zelinka MD, O'Dell CW, Klein SA
Nature. 2016 Aug 4; 536(7614)72-5.

PMID:
    27398619
    [PubMed - in process]
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Pharmacokinetics, pharmacodynamics, safety and tolerability of an intravaginal ring releasing anastrozole and levonorgestrel in healthy premenopausal women: a Phase 1 randomized controlled trial.
Schultze-Mosgau MH, Waellnitz K, Nave R, Klein S, Kraetzschmar J, Rautenberg T, Schmitz H, Rohde B
Hum Reprod. 2016 Aug; 31(8)1713-22. doi: 10.1093/humrep/dew145.

PMID:
    27390369
    [PubMed - in process]
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Erratum to: Understanding the role of contrasting urban contexts in healthy aging: an international cohort study using wearable sensor devices (the CURHA study protocol).
Kestens Y, Chaix B, Gerber P, Desprès M, Gauvin L, Klein O, Klein S, Köppen B, Lord S, Naud A, Patte M, Payette H, Richard L, Rondier P, Shareck M, Sueur C, Thierry B, Vallée J, Wasfi R
BMC Geriatr. 2016 Jul 5; 16(1)127.

PMID:
    27381027
    [PubMed - as supplied by publisher]
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Surviving but not thriving: inconsistent responses of zooxanthellate jellyfish polyps to ocean warming and future UV-B scenarios.
Klein SG, Pitt KA, Carroll AR
Sci Rep. 2016 Jul 4; 628859. doi: 10.1038/srep28859.

PMID:
    27374028
    [PubMed - in process]
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