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Faculty Physicians

Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Opinion: Sex inclusion in basic research drives discovery.
Klein SL, Schiebinger L, Stefanick ML, Cahill L, Danska J, de Vries GJ, Kibbe MR, McCarthy MM, Mogil JS, Woodruff TK, Zucker I
Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17)5257-8. doi: 10.1073/pnas.1502843112.

PMID:
    25902532
    [PubMed - indexed for MEDLINE]
Related citations


The empirical status of psychodynamic psychotherapy - an update: Bambi's alive and kicking.
Leichsenring F, Leweke F, Klein S, Steinert C
Psychother Psychosom. 2015; 84(3)129-48. doi: 10.1159/000376584.

PMID:
    25833321
    [PubMed - indexed for MEDLINE]
Related citations


Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections.
Miller LG, Daum RS, Creech CB, Young D, Downing MD, Eells SJ, Pettibone S, Hoagland RJ, Chambers HF, DMID 07-0051 Team
N Engl J Med. 2015 Mar 19; 372(12)1093-103. doi: 10.1056/NEJMoa1403789.

PMID:
    25785967
    [PubMed - indexed for MEDLINE]
Related citations


Endurance exercise: more pain, more metabolic gain.
Yoshino M, Klein S
Ann Intern Med. 2015 Mar 3; 162(5)385-6. doi: 10.7326/M15-0059.

PMID:
    25732283
    [PubMed - indexed for MEDLINE]
Related citations


Evaluation of the Intermittent Exotropia Questionnaire using Rasch analysis.
Leske DA, Holmes JM, Melia BM, Pediatric Eye Disease Investigator Group
JAMA Ophthalmol. 2015 Apr; 133(4)461-5. doi: 10.1001/jamaophthalmol.2014.5622.

PMID:
    25634146
    [PubMed - indexed for MEDLINE]
Related citations


Metabolically normal obese people are protected from adverse effects following weight gain.
Fabbrini E, Yoshino J, Yoshino M, Magkos F, Tiemann Luecking C, Samovski D, Fraterrigo G, Okunade AL, Patterson BW, Klein S
J Clin Invest. 2015 Feb; 125(2)787-95. doi: 10.1172/JCI78425.

PMID:
    25555214
    [PubMed - indexed for MEDLINE]
Related citations


Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation.
Smith GI, Yoshino J, Stromsdorfer KL, Klein SJ, Magkos F, Reeds DN, Klein S, Mittendorfer B
Diabetes. 2015 May; 64(5)1555-63. doi: 10.2337/db14-1279.

PMID:
    25475435
    [PubMed - indexed for MEDLINE]
Related citations


CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt.
Berres ML, Asmacher S, Lehmann J, Jansen C, Görtzen J, Klein S, Meyer C, Strunk HM, Fimmers R, Tacke F, Strassburg CP, Trautwein C, Sauerbruch T, Wasmuth HE, Trebicka J
J Hepatol. 2015 Feb; 62(2)332-9. doi: 10.1016/j.jhep.2014.09.032.

PMID:
    25457205
    [PubMed - indexed for MEDLINE]
Related citations


A coculture model of the lung–blood barrier: the role of activated phagocytic cells.
Luyts K, Napierska D, Dinsdale D, Klein SG, Serchi T, Hoet PH
Toxicol In Vitro. 2015 Feb; 29(1)234-41.

PMID:
    25448809
    [PubMed - indexed for MEDLINE]
Related citations


Significant contribution of the 3'→5' exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ.
Zahurancik WJ, Klein SJ, Suo Z
Nucleic Acids Res. 2014 Dec 16; 42(22)13853-60. doi: 10.1093/nar/gku1184.

PMID:
    25414327
    [PubMed - indexed for MEDLINE]
Related citations


Effects of sex and gender on adaptation to space: immune system.
Kennedy AR, Crucian B, Huff JL, Klein SL, Morens D, Murasko D, Nickerson CA, Sonnenfeld G
J Womens Health (Larchmt). 2014 Nov; 23(11)956-8. doi: 10.1089/jwh.2014.4913.

PMID:
    25401940
    [PubMed - indexed for MEDLINE]
Related citations


Vernier perceptual learning transfers to completely untrained retinal locations after double training: a "piggybacking" effect.
Wang R, Zhang JY, Klein SA, Levi DM, Yu C
J Vis. 2014 Nov 14; 14(13)12. doi: 10.1167/14.13.12.

PMID:
    25398974
    [PubMed - indexed for MEDLINE]
Related citations


The Alexander Technique and musicians: a systematic review of controlled trials.
Klein SD, Bayard C, Wolf U
BMC Complement Altern Med. 2014 Oct 24; 14414. doi: 10.1186/1472-6882-14-414.

PMID:
    25344325
    [PubMed - indexed for MEDLINE]
Related citations


Free-form deformation using lower-order B-spline for nonrigid image registration.
Sun W, Niessen WJ, Klein S
Med Image Comput Comput Assist Interv. 2014; 17(Pt 1)194-201.

PMID:
    25333118
    [PubMed - indexed for MEDLINE]
Related citations


Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss.
Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL, Klein S
Obesity (Silver Spring). 2015 Feb; 23(2)329-34. doi: 10.1002/oby.20923.

PMID:
    25328153
    [PubMed - indexed for MEDLINE]
Related citations


The battle of the bulge: defense versus offense.
Magkos F, Tamboli RA, Abumrad NN, Klein S
Am J Clin Nutr. 2014 Oct; 100(4)991-2. doi: 10.3945/ajcn.114.096529.

PMID:
    25240068
    [PubMed - indexed for MEDLINE]
Related citations


Takotsubo cardiomyopathy after systemic consolidation therapy with high-dose intravenous cytarabine in a patient with acute myeloid leukemia.
Baumann S, Huseynov A, Goranova D, Faust M, Behnes M, Nolte F, Heidenreich D, Hofmann WK, Borggrefe M, Akin I, Klein S
Oncol Res Treat. 2014; 37(9)487-90. doi: 10.1159/000365536.

PMID:
    25231689
    [PubMed - indexed for MEDLINE]
Related citations


Pressure monitoring during lipofilling procedures.
Klein SM, Prantl L, Geis S, Eisenmann-Klein M, Dolderer J, Felthaus O, Loibl M, Heine N
Clin Hemorheol Microcirc. 2014; 58(1)9-17. doi: 10.3233/CH-141872.

PMID:
    25227189
    [PubMed - indexed for MEDLINE]
Related citations


Bias-free double judgment accuracy during spatial attention cueing: performance enhancement from voluntary and involuntary attention.
Pack W, Klein SA, Carney T
Vision Res. 2014 Dec; 105204-12. doi: 10.1016/j.visres.2014.08.004.

PMID:
    25159288
    [PubMed - indexed for MEDLINE]
Related citations


Response to Comment on Fabbrini et al. Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 2014;63:976-981.
Fabbrini E, Serafini M, Klein S
Diabetes. 2014 Sep; 63(9)e19. doi: 10.2337/db14-0885.

PMID:
    25146480
    [PubMed - indexed for MEDLINE]
Related citations