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Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

Truncating mutations in APP cause a distinct neurological phenotype.
Klein S, Goldman A, Lee H, Ghahremani S, Bhakta V, UCLA Clinical Genomics Center, Nelson SF, Martinez-Agosto JA
Ann Neurol. 2016 Jul 16; doi: 10.1002/ana.24727.

PMID:
    27422356
    [PubMed - as supplied by publisher]
Related citations


Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.
Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z
Gut. 2016 Jul 18; pii: gutjnl-2015-311224. doi: 10.1136/gutjnl-2015-311224.

PMID:
    27432540
    [PubMed - as supplied by publisher]
Related citations


A survey of medical image registration - under review.
Viergever MA, Maintz JB, Klein S, Murphy K, Staring M, Pluim JP
Med Image Anal. 2016 Jun 21; pii: S1361-8415(16)30107-4. doi: 10.1016/j.media.2016.06.030.

PMID:
    27427472
    [PubMed - as supplied by publisher]
Related citations


Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.
Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L
Aging (Albany NY). 2016 Jul 13;

PMID:
    27410480
    [PubMed - as supplied by publisher]
Related citations


Evidence for climate change in the satellite cloud record.
Norris JR, Allen RJ, Evan AT, Zelinka MD, O'Dell CW, Klein SA
Nature. 2016 Jul 11; doi: 10.1038/nature18273.

PMID:
    27398619
    [PubMed - as supplied by publisher]
Related citations


Pharmacokinetics, pharmacodynamics, safety and tolerability of an intravaginal ring releasing anastrozole and levonorgestrel in healthy premenopausal women: a Phase 1 randomized controlled trial.
Schultze-Mosgau MH, Waellnitz K, Nave R, Klein S, Kraetzschmar J, Rautenberg T, Schmitz H, Rohde B
Hum Reprod. 2016 Jun 19; pii: dew145.

PMID:
    27390369
    [PubMed - as supplied by publisher]
Related citations


Erratum to: Understanding the role of contrasting urban contexts in healthy aging: an international cohort study using wearable sensor devices (the CURHA study protocol).
Kestens Y, Chaix B, Gerber P, Desprès M, Gauvin L, Klein O, Klein S, Köppen B, Lord S, Naud A, Patte M, Payette H, Richard L, Rondier P, Shareck M, Sueur C, Thierry B, Vallée J, Wasfi R
BMC Geriatr. 2016 Jul 5; 16(1)127.

PMID:
    27381027
    [PubMed - as supplied by publisher]
Related citations


Surviving but not thriving: inconsistent responses of zooxanthellate jellyfish polyps to ocean warming and future UV-B scenarios.
Klein SG, Pitt KA, Carroll AR
Sci Rep. 2016 Jul 4; 628859. doi: 10.1038/srep28859.

PMID:
    27374028
    [PubMed - in process]
Related citations


Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report.
Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA
J Dtsch Dermatol Ges. 2016 Jul; 14(7)734-6. doi: 10.1111/ddg.12722.

PMID:
    27373251
    [PubMed - in process]
Related citations


Primär kutane Diphtherie: Management, Diagnostik und therapeutische Konsequenzen anhand eines seltenen Fallberichts.
Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA
J Dtsch Dermatol Ges. 2016 Jul; 14(7)733-5. doi: 10.1111/ddg.12722_g.

PMID:
    27373250
    [PubMed - in process]
Related citations


Single Bout Of Aerobic Exercise Reduces Intrahepatic And Intramyocellular Triglyceride In Obese Individuals With Nafld: 3187 Board #252 June 3, 2: 00 PM - 3: 30 PM.
Kirk EP, Sullivan S, Klein S
Med Sci Sports Exerc. 2016 May; 48(5 Suppl 1)909. doi: 10.1249/01.mss.0000487722.09271.94.

PMID:
    27361756
    [PubMed - in process]
Related citations


The calcium-activated potassium channel KCa3.1 is an important modulator of hepatic injury.
Sevelsted Møller L, Fialla AD, Schierwagen R, Biagini M, Liedtke C, Laleman W, Klein S, Reul W, Koch Hansen L, Rabjerg M, Singh V, Surra J, Osada J, Reinehr R, de Muckadell OB, Köhler R, Trebicka J
Sci Rep. 2016 Jun 29; 628770. doi: 10.1038/srep28770.

PMID:
    27354175
    [PubMed - in process]
Related citations


Towards the development of a paediatric biopharmaceutics classification system: Results of a survey of experts.
Batchelor H, Ernest T, Flanagan T, Klein S, Turner R, Fotaki N, Storey D, EuPFI
Int J Pharm. 2016 Jun 25; pii: S0378-5173(16)30605-6. doi: 10.1016/j.ijpharm.2016.06.115.

PMID:
    27349792
    [PubMed - as supplied by publisher]
Related citations


Peripheral Motor and Sensory Nerve Conduction following Transplantation of Undifferentiated Autologous Adipose Tissue-Derived Stem Cells in a Biodegradable U.S. Food and Drug Administration-Approved Nerve Conduit.
Klein SM, Vykoukal J, Li DP, Pan HL, Zeitler K, Alt E, Geis S, Felthaus O, Prantl L
Plast Reconstr Surg. 2016 Jul; 138(1)132-9. doi: 10.1097/PRS.0000000000002291.

PMID:
    27348645
    [PubMed - in process]
Related citations


The effect of quantitative feed restriction on allometric growth in broilers.
van der Klein SA, Silva FA, Kwakkel RP, Zuidhof MJ
Poult Sci. 2016 Jun 22; pii: pew187.

PMID:
    27333977
    [PubMed - as supplied by publisher]
Related citations


Yeu-Tsu Margaret Lee, MD, FACS: A life of service.
Klein SB
Bull Am Coll Surg. 2016 May; 101(5)46-7.

PMID:
    27311236
    [PubMed - indexed for MEDLINE]
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Sweet dopamine: Sucrose preferences relate differentially to striatal D2 receptor binding and age in obesity.
Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T
Diabetes. 2016 Jun 15; pii: db160407.

PMID:
    27307220
    [PubMed - as supplied by publisher]
Related citations


Knockout of P-glycoprotein does not alter antiepileptic drug efficacy in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Bankstahl M, Klein S, Römermann K, Löscher W
Neuropharmacology. 2016 Jun 7; 109183-195. doi: 10.1016/j.neuropharm.2016.06.007.

PMID:
    27288003
    [PubMed - as supplied by publisher]
Related citations


Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study.
Hoffmann A, Klein SD, Gründemann C, Garcia-Käufer M, Wolf U, Huber R
Phytother Res. 2016 Jun 10; doi: 10.1002/ptr.5649.

PMID:
    27282490
    [PubMed - as supplied by publisher]
Related citations


Changes in Brain Resting-state Functional Connectivity Associated with Peripheral Nerve Block: A Pilot Study.
Melton MS, Browndyke JN, Harshbarger TB, Madden DJ, Nielsen KC, Klein SM
Anesthesiology. 2016 Aug; 125(2)368-77. doi: 10.1097/ALN.0000000000001198.

PMID:
    27272674
    [PubMed - in process]
Related citations