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Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

An adipo-biliary-uridine axis that regulates energy homeostasis.
Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE
Science. 2017 Mar 17; 355(6330)pii: eaaf5375. doi: 10.1126/science.aaf5375.

PMID:
    28302796
    [PubMed - in process]
Related citations


HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity.
Reeds DN, Pietka TA, Yarasheski KE, Cade WT, Patterson BW, Okunade A, Abumrad NA, Klein S
Obesity (Silver Spring). 2017 Feb 28; doi: 10.1002/oby.21793.

PMID:
    28245099
    [PubMed - as supplied by publisher]
Related citations


Reverse Anterior Cruciate Ligament Reconstruction Fixation: A Biomechanical Comparison Study of Tibial Cross-Pin and Femoral Interference Screw Fixation.
Lawley RJ, Klein SE, Chudik SC
Arthroscopy. 2017 Mar; 33(3)625-632. doi: 10.1016/j.arthro.2016.09.006.

PMID:
    27939069
    [PubMed - in process]
Related citations


VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women.
Mittendorfer B, Yoshino M, Patterson BW, Klein S
J Clin Endocrinol Metab. 2016 Nov; 101(11)4151-4160.

PMID:
    27588438
    [PubMed - in process]
Related citations


High-Protein Intake during Weight Loss Therapy Eliminates the Weight-Loss-Induced Improvement in Insulin Action in Obese Postmenopausal Women.
Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B
Cell Rep. 2016 Oct 11; 17(3)849-861. doi: 10.1016/j.celrep.2016.09.047.

PMID:
    27732859
    [PubMed - in process]
Related citations


Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial.
Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT
Am J Clin Nutr. 2016 Sep; 104(3)576-86. doi: 10.3945/ajcn.116.131391.

PMID:
    27465384
    [PubMed - in process]
Related citations


Sweet Dopamine: Sucrose Preferences Relate Differentially to Striatal D2 Receptor Binding and Age in Obesity.
Pepino MY, Eisenstein SA, Bischoff AN, Klein S, Moerlein SM, Perlmutter JS, Black KJ, Hershey T
Diabetes. 2016 Sep; 65(9)2618-23. doi: 10.2337/db16-0407.

PMID:
    27307220
    [PubMed - in process]
Related citations


Proactive and Progressive Approaches in Managing Obesity.
Eckel RH, Bays HE, Klein S, Bade Horn D
Postgrad Med. 2016 Oct; 128 Suppl 121-30. doi: 10.1080/00325481.2016.1181412.

PMID:
    27153316
    [PubMed - indexed for MEDLINE]
Related citations


Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.
Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S
Cell Metab. 2016 Apr 12; 23(4)591-601. doi: 10.1016/j.cmet.2016.02.005.

PMID:
    26916363
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose.
Magkos F, Bradley D, Eagon JC, Patterson BW, Klein S
Am J Clin Nutr. 2016 Jan; 103(1)61-5. doi: 10.3945/ajcn.115.116111.

PMID:
    26607940
    [PubMed - indexed for MEDLINE]
Related citations


Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP
Sleep. 2015 Dec 1; 38(12)1849-60. doi: 10.5665/sleep.5226.

PMID:
    26564131
    [PubMed - indexed for MEDLINE]
Related citations


Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.
Funai K, Lodhi IJ, Spears LD, Yin L, Song H, Klein S, Semenkovich CF
Diabetes. 2016 Feb; 65(2)358-70. doi: 10.2337/db15-0659.

PMID:
    26512026
    [PubMed - indexed for MEDLINE]
Related citations


Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.
Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO, CALERIE Study Group.
Aging Cell. 2016 Feb; 15(1)22-7. doi: 10.1111/acel.12400.

PMID:
    26443692
    [PubMed - indexed for MEDLINE]
Related citations


Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors' Expert Forum.
Cefalu WT, Bray GA, Home PD, Garvey WT, Klein S, Pi-Sunyer FX, Hu FB, Raz I, Van Gaal L, Wolfe BM, Ryan DH
Diabetes Care. 2015 Aug; 38(8)1567-82.

PMID:
    26421334
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Duodenal-Jejunal Bypass Surgery on Glycemic Control in Type 2 Diabetes: A Randomized Controlled Trial.
Petry TZ, Fabbrini E, Otoch JP, Carmona MA, Caravatto PP, Salles JE, Sarian T, Correa JL, Schiavon CA, Patterson BW, Cohen R, Klein S
Obesity (Silver Spring). 2015 Oct; 23(10)1973-9. doi: 10.1002/oby.21190.

PMID:
    26414562
    [PubMed - indexed for MEDLINE]
Related citations


Physiological Mechanisms of Weight Gain-Induced Steatosis in People With Obesity.
Fabbrini E, Tiemann Luecking C, Love-Gregory L, Okunade AL, Yoshino M, Fraterrigo G, Patterson BW, Klein S
Gastroenterology. 2016 Jan; 150(1)79-81.e2. doi: 10.1053/j.gastro.2015.09.003.

PMID:
    26376348
    [PubMed - indexed for MEDLINE]
Related citations


Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.
Davies MJ, Bergenstal R, Bode B, Kushner RF, Lewin A, Skjøth TV, Andreasen AH, Jensen CB, DeFronzo RA, NN8022-1922 Study Group.
JAMA. 2015 Aug 18; 314(7)687-99. doi: 10.1001/jama.2015.9676.

PMID:
    26284720
    [PubMed - indexed for MEDLINE]
Related citations


Effect of Roux-en-Y Gastric Bypass Surgery: Converting 2 Alcoholic Drinks to 4.
Pepino MY, Okunade AL, Eagon JC, Bartholow BD, Bucholz K, Klein S
JAMA Surg. 2015 Nov; 150(11)1096-8. doi: 10.1001/jamasurg.2015.1884.

PMID:
    26244751
    [PubMed - indexed for MEDLINE]
Related citations


A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.
Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB, CALERIE Study Group.
J Gerontol A Biol Sci Med Sci. 2015 Sep; 70(9)1097-104. doi: 10.1093/gerona/glv057.

PMID:
    26187233
    [PubMed - indexed for MEDLINE]
Related citations


Is the β-cell the key for remission of diabetes after bariatric surgery?
Magkos F, Klein S
J Physiol. 2015 Jul 15; 593(14)2989-90. doi: 10.1113/JP270782.

PMID:
    26173823
    [PubMed - indexed for MEDLINE]
Related citations