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Faculty Physicians

Samuel Klein, MD

William H. Danforth Professor of Medicine and Nutritional Science
Director, Center for Human Nutrition
Chief, Division of Geriatrics and Nutritional Science
Director, Center for Applied Research Sciences
Director, Weight Management Program

Specialty Areas

Gastroenterology
Nutrition
Weight Management

Board Certifications

Gastroenterology
Internal Medicine
Nutrition

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Professional Consultation Only

Areas of Clinical Interest

Obesity, nutrition, weight management, gastroenterology, metabolism

  • Education
  • Publication & Research

Education

Education

M.S.: Massachusetts Institute of Technology, Cambridge, Massachusetts 1984
Medical Degree: Temple University Medical School, Philadelphia, Pennsylvania 1979
B.A.: Brandeis University, Waltham, Massachusetts 1974

Publication & Research

Publication & Research

G-Protein-Coupled Receptor MrgD Is a Receptor for Angiotensin-(1-7) Involving Adenylyl Cyclase, cAMP, and Phosphokinase A.
Tetzner A, Gebolys K, Meinert C, Klein S, Uhlich A, Trebicka J, Villacañas Ó, Walther T
Hypertension. 2016 May 23; pii: HYPERTENSIONAHA.116.07572.

PMID:
    27217404
    [PubMed - as supplied by publisher]
Related citations


The weepy nerve-different sensitivity of left and right recurrent laryngeal nerves under tensile stress in a porcine model.
Lamadé W, Béchu M, Lauzana E, Köhler P, Klein S, Tuncer T, Rashid NI, Kahle E, Erdmann B, Meyding-Lamadé U
Langenbecks Arch Surg. 2016 May 21;

PMID:
    27209314
    [PubMed - as supplied by publisher]
Related citations


DeepCAGE transcriptomics identify HOXD10 as transcription factor regulating lymphatic endothelial responses to VEGF-C.
Klein S, Dieterich LC, Mathelier A, Chong C, Sliwa-Primorac A, Hong YK, Shin JW, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, FANTOM consortium, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M
J Cell Sci. 2016 May 19; pii: jcs.186767.

PMID:
    27199372
    [PubMed - as supplied by publisher]
Related citations


Programming social behavior by the maternal fragile X protein.
Zupan B, Sharma A, Frazier A, Klein S, Toth M
Genes Brain Behav. 2016 May 20; doi: 10.1111/gbb.12298.

PMID:
    27198123
    [PubMed - as supplied by publisher]
Related citations


Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.
Schildberg FA, Klein SR, Freeman GJ, Sharpe AH
Immunity. 2016 May 17; 44(5)955-72. doi: 10.1016/j.immuni.2016.05.002.

PMID:
    27192563
    [PubMed - in process]
Related citations


Physicochemical characterisation of fluids and soft foods frequently mixed with oral drug formulations prior to administration to children.
Kersten E, Barry A, Klein S
Pharmazie. 2016 Mar; 71(3)122-7.

PMID:
    27183705
    [PubMed - in process]
Related citations


Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.
Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, van den Brink M, Toth M
Nat Commun. 2016 May 13; 711492. doi: 10.1038/ncomms11492.

PMID:
    27173585
    [PubMed - in process]
Related citations


Proactive and Progressive Approaches in Managing Obesity.
Eckel RH, Bays HE, Klein S, Bade Horn D
Postgrad Med. 2016 May 6; 1-10.

PMID:
    27153316
    [PubMed - as supplied by publisher]
Related citations


Understanding the role of contrasting urban contexts in healthy aging: an international cohort study using wearable sensor devices (the CURHA study protocol).
Kestens Y, Chaix B, Gerber P, Desprès M, Gauvin L, Klein O, Klein S, Köppen B, Lord S, Naud A, Payette H, Richard L, Rondier P, Shareck M, Sueur C, Thierry B, Vallée J, Wasfi R
BMC Geriatr. 2016 May 5; 16(1)96. doi: 10.1186/s12877-016-0273-7.

PMID:
    27151297
    [PubMed - in process]
Related citations


Transposon-Based Reporter Marking Provides Functional Evidence for Intercellular Bridges in the Male Germline of Rabbits.
Hoffmann OI, Kerekes A, Lipták N, Hiripi L, Bodo S, Szaloki G, Klein S, Ivics Z, Kues WA, Bosze Z
PLoS One. 2016; 11(5)e0154489. doi: 10.1371/journal.pone.0154489.

PMID:
    27148973
    [PubMed - in process]
Related citations


Dissecting the role of ADAM10 as a mediator of S. aureus α-toxin action.
von Hoven G, Rivas AJ, Neukirch C, Klein S, Hamm C, Qin Q, Meyenburg M, Füser S, Saftig P, Hellmann N, Postina R, Husmann M
Biochem J. 2016 May 4; pii: BCJ20160062.

PMID:
    27147619
    [PubMed - as supplied by publisher]
Related citations


[Surgical reconstructive procedures of the chest wall after mediastinitis].
Ried M, Geis S, Potzger T, Neu R, Klein S, Prantl L, Hofmann HS, Dolderer JH
Chirurg. 2016 May 4;

PMID:
    27146388
    [PubMed - as supplied by publisher]
Related citations


Colloidal Suspensions of Rodlike Nanocrystals and Magnetic Spheres under an External Magnetic Stimulus: Experiment and Molecular Dynamics Simulation.
May K, Eremin A, Stannarius R, Peroukidis SD, Klapp SH, Klein S
Langmuir. 2016 May 24; 32(20)5085-93. doi: 10.1021/acs.langmuir.6b00739.

PMID:
    27119202
    [PubMed - in process]
Related citations


RTS,S Malaria Vaccine and Increased Mortality in Girls.
Klein SL, Shann F, Moss WJ, Benn CS, Aaby P
MBio. 2016 Apr 26; 7(2)pii: e00514-16. doi: 10.1128/mBio.00514-16.

PMID:
    27118593
    [PubMed - in process]
Related citations


Rationale and design of the German-Speaking Myeloma Multicenter Group (GMMG) trial ReLApsE: a randomized, open, multicenter phase III trial of lenalidomide/dexamethasone versus lenalidomide/dexamethasone plus subsequent autologous stem cell transplantation and lenalidomide maintenance in patients with relapsed multiple myeloma.
Baertsch MA, Schlenzka J, Mai EK, Merz M, Hillengaß J, Raab MS, Hose D, Wuchter P, Ho AD, Jauch A, Hielscher T, Kunz C, Luntz S, Klein S, Schmidt-Wolf IG, Goerner M, Schmidt-Hieber M, Reimer P, Graeven U, Fenk R, Salwender H, Scheid C, Nogai A, Haenel M, Lindemann HW, Martin H, Noppeney R, Weisel K, Goldschmidt H
BMC Cancer. 2016 Apr 25; 16(1)290. doi: 10.1186/s12885-016-2321-2.

PMID:
    27114074
    [PubMed - in process]
Related citations


[Effects of socializing piglets in lactation on behaviour, including tail-biting, in growing and finishing pigs].
Klein S, Patzkéwitsch D, Reese S, Erhard M
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2016 Apr 25; 44(3)

PMID:
    27111256
    [PubMed - as supplied by publisher]
Related citations


Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens.
Klein SR, Jiang H, Hossain MB, Fan X, Gumin J, Dong A, Alonso MM, Gomez-Manzano C, Fueyo J
PLoS One. 2016; 11(4)e0153814. doi: 10.1371/journal.pone.0153814.

PMID:
    27093696
    [PubMed - in process]
Related citations


Leukocyte-reduced platelet-rich plasma alters protein expression of adipose-tissue derived mesenchymal stem cells.
Loibl M, Lang S, Hanke A, Herrmann M, Huber M, Brockhoff G, Klein S, Nerlich M, Angele P, Prantl L, Gehmert S
Plast Reconstr Surg. 2016 Apr 6;

PMID:
    27064225
    [PubMed - as supplied by publisher]
Related citations


A modified Delphi study of structures and processes related to medicines management for elderly hospitalised patients in the United Arab Emirates.
Al Shemeili S, Klein S, Strath A, Fares S, Stewart D
J Eval Clin Pract. 2016 Apr 8; doi: 10.1111/jep.12542.

PMID:
    27060885
    [PubMed - as supplied by publisher]
Related citations


Dr. and Mrs. LaSalle D. Leffall, Jr.: Paying it forward.
Klein SB
Bull Am Coll Surg. 2016 Mar; 101(3)45-7.

PMID:
    27051939
    [PubMed - in process]
Related citations