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Samuel A. Wickline, MD

Professor, Medicine
Division of Cardiovascular Disease
Adjunct Professor of Physics
Adjunct Professor of Biomedical Engineering

Specialty Areas

Cardiology

Board Certifications

Cardiology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Cardiovascular magnetic resonance imaging, MRI, molecular imaging, backscatter imaging, non-invasive heart imaging; supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, holter, event and loop monitors.

  • Education
  • Publication & Research

Education

Education

Fellowship: Clinical and Research, Cardiology, Barnes Hospital, St. Louis, Missouri 1987
Residency: Internal Medicine, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri 1983
Medical Degree: University Of Hawaii, Honolulu, Hawaii 1980
B.A.: Pomona College, Claremont, California 1974

Publication & Research

Publication & Research

Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury.
Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN
Precis Nanomed. 2019; 2(1)245-248. doi: 10.33218/prnano2(1).181129.1.

PMID:
    31681908
    [PubMed]
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Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles.
Strand MS, Krasnick BA, Pan H, Zhang X, Bi Y, Brooks C, Wetzel C, Sankpal N, Fleming T, Goedegebuure SP, DeNardo DG, Gillanders WE, Hawkins WG, Wickline SA, Fields RC
Oncotarget. 2019 Jul 30; 10(46)4761-4775. doi: 10.18632/oncotarget.27109.

PMID:
    31413817
    [PubMed]
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Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.
McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund RE, Schechtman KB, Razani B, Kastan MB, McClain DA, de Las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF
Diabetol Metab Syndr. 2019; 1161. doi: 10.1186/s13098-019-0456-4.

PMID:
    31384309
    [PubMed]
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A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions.
MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, Pan H, Wickline SA, Oh JY, Patel RP, He L, Torres BA, Maheshwari A
Nat Commun. 2019 Aug 2; 10(1)3494. doi: 10.1038/s41467-019-11199-5.

PMID:
    31375667
    [PubMed - in process]
Related citations


Applications of RNA interference in the treatment of arthritis.
Rai MF, Pan H, Yan H, Sandell LJ, Pham CTN, Wickline SA
Transl Res. 2019 Dec; 2141-16. doi: 10.1016/j.trsl.2019.07.002.

PMID:
    31351032
    [PubMed - in process]
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Resolution of Murine Toxic Hepatic Injury Quantified With Ultrasound Entropy Metrics.
Marsh JN, Korenblat KM, Liu TC, McCarthy JE, Wickline SA
Ultrasound Med Biol. 2019 Oct; 45(10)2777-2786. doi: 10.1016/j.ultrasmedbio.2019.06.412.

PMID:
    31320149
    [PubMed - in process]
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Division of labor in honey bees is associated with transcriptional regulatory plasticity in the brain.
Hamilton AR, Traniello IM, Ray AM, Caldwell AS, Wickline SA, Robinson GE
J Exp Biol. 2019 Jul 16; 222(Pt 14)pii: jeb200196. doi: 10.1242/jeb.200196.

PMID:
    31138635
    [PubMed - in process]
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p5RHH nanoparticle-mediated delivery of AXL siRNA inhibits metastasis of ovarian and uterine cancer cells in mouse xenografts.
Mills KA, Quinn JM, Roach ST, Palisoul M, Nguyen M, Noia H, Guo L, Fazal J, Mutch DG, Wickline SA, Pan H, Fuh KC
Sci Rep. 2019 Mar 18; 9(1)4762. doi: 10.1038/s41598-019-41122-3.

PMID:
    30886159
    [PubMed - in process]
Related citations


Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery.
Yan H, Duan X, Pan H, Akk A, Sandell LJ, Wickline SA, Rai MF, Pham CTN
Sci Rep. 2019 Jan 24; 9(1)442. doi: 10.1038/s41598-018-37018-3.

PMID:
    30679644
    [PubMed - in process]
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Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function in a Murine Deceased Criteria Donor Model.
Vemuri C, Upadhya GA, Arif B, Jia J, Lin Y, Gaut JP, Fazal J, Pan H, Wickline SA, Chapman WC
Transplant Direct. 2018 Sep; 4(9)e384. doi: 10.1097/TXD.0000000000000817.

PMID:
    30234153
    [PubMed]
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Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
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Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis.
Kabir AU, Lee TJ, Pan H, Berry JC, Krchma K, Wu J, Liu F, Kang HK, Hinman K, Yang L, Hamilton S, Zhou Q, Veis DJ, Mecham RP, Wickline SA, Miller MJ, Choi K
JCI Insight. 2018 Apr 19; 3(8)pii: 97349. doi: 10.1172/jci.insight.97349.

PMID:
    29669933
    [PubMed - in process]
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Quantification of vascular damage in acute kidney injury with fluorine magnetic resonance imaging and spectroscopy.
Moore JK, Chen J, Pan H, Gaut JP, Jain S, Wickline SA
Magn Reson Med. 2018 Jun; 79(6)3144-3153. doi: 10.1002/mrm.26985.

PMID:
    29148253
    [PubMed - indexed for MEDLINE]
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Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice.
Vendrov AE, Stevenson MD, Alahari S, Pan H, Wickline SA, Madamanchi NR, Runge MS
J Am Heart Assoc. 2017 Oct 27; 6(11)pii: e006775. doi: 10.1161/JAHA.117.006775.

PMID:
    29079564
    [PubMed - indexed for MEDLINE]
Related citations


Efficacy of RNA interference knockdown using aerosolized short interfering RNAs bound to nanoparticles in three diverse aphid species.
Thairu MW, Skidmore IH, Bansal R, Nováková E, Hansen TE, Li-Byarlay H, Wickline SA, Hansen AK
Insect Mol Biol. 2017 Jun; 26(3)356-368. doi: 10.1111/imb.12301.

PMID:
    28314050
    [PubMed - indexed for MEDLINE]
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NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis.
Lozhkin A, Vendrov AE, Pan H, Wickline SA, Madamanchi NR, Runge MS
J Mol Cell Cardiol. 2017 Jan; 10210-21. doi: 10.1016/j.yjmcc.2016.12.004.

PMID:
    27986445
    [PubMed - indexed for MEDLINE]
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Antithrombin nanoparticles inhibit stent thrombosis in ex vivo static and flow models.
Palekar RU, Vemuri C, Marsh JN, Arif B, Wickline SA
J Vasc Surg. 2016 Nov; 64(5)1459-1467. doi: 10.1016/j.jvs.2015.08.086.

PMID:
    26482989
    [PubMed - indexed for MEDLINE]
Related citations


Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed - in process]
Related citations


Recent Advances in <sup>19</sup>Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions.
Schmieder AH, Caruthers SD, Keupp J, Wickline SA, Lanza GM
Engineering (Beijing). 2015 Dec; 1(4)475-489.

PMID:
    27110430
    [PubMed]
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Entropy <i>vs.</i> Energy Waveform Processing: A Comparison Based on the Heat Equation.
Hughes MS, McCarthy JE, Bruillard PJ, Marsh JN, Wickline SA
Entropy (Basel). 2015 Jun; 17(6)3518-3551.

PMID:
    27110093
    [PubMed]
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