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Samuel A. Wickline, MD

Professor, Medicine
Division of Cardiovascular Disease
Adjunct Professor of Physics
Adjunct Professor of Biomedical Engineering

Specialty Areas

Cardiology

Board Certifications

Cardiology
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Physician Referral Required

Areas of Clinical Interest

Cardiovascular magnetic resonance imaging, MRI, molecular imaging, backscatter imaging, non-invasive heart imaging; supervising and interpreting diagnostic tests, such as echocardiograms, stress echocardiograms, treadmill stress test, holter, event and loop monitors.

  • Education
  • Publication & Research

Education

Education

Fellowship: Clinical and Research, Cardiology, Barnes Hospital, St. Louis, Missouri 1987
Residency: Internal Medicine, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri 1983
Medical Degree: University Of Hawaii, Honolulu, Hawaii 1980
B.A.: Pomona College, Claremont, California 1974

Publication & Research

Publication & Research

Antithrombin Perfluorocarbon Nanoparticles Improve Renal Allograft Function in a Murine Deceased Criteria Donor Model.
Vemuri C, Upadhya GA, Arif B, Jia J, Lin Y, Gaut JP, Fazal J, Pan H, Wickline SA, Chapman WC
Transplant Direct. 2018 Sep; 4(9)e384. doi: 10.1097/TXD.0000000000000817.

PMID:
    30234153
    [PubMed]
Related citations


Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
Pan H, Palekar RU, Hou KK, Bacon J, Yan H, Springer LE, Akk A, Yang L, Miller MJ, Pham CT, Schlesinger PH, Wickline SA
Int J Nanomedicine. 2018; 135187-5205. doi: 10.2147/IJN.S168556.

PMID:
    30233180
    [PubMed - indexed for MEDLINE]
Related citations


Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis.
Kabir AU, Lee TJ, Pan H, Berry JC, Krchma K, Wu J, Liu F, Kang HK, Hinman K, Yang L, Hamilton S, Zhou Q, Veis DJ, Mecham RP, Wickline SA, Miller MJ, Choi K
JCI Insight. 2018 Apr 19; 3(8)pii: 97349. doi: 10.1172/jci.insight.97349.

PMID:
    29669933
    [PubMed - as supplied by publisher]
Related citations


Quantification of vascular damage in acute kidney injury with fluorine magnetic resonance imaging and spectroscopy.
Moore JK, Chen J, Pan H, Gaut JP, Jain S, Wickline SA
Magn Reson Med. 2018 Jun; 79(6)3144-3153. doi: 10.1002/mrm.26985.

PMID:
    29148253
    [PubMed - in process]
Related citations


Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice.
Vendrov AE, Stevenson MD, Alahari S, Pan H, Wickline SA, Madamanchi NR, Runge MS
J Am Heart Assoc. 2017 Oct 27; 6(11)pii: e006775. doi: 10.1161/JAHA.117.006775.

PMID:
    29079564
    [PubMed - indexed for MEDLINE]
Related citations


Efficacy of RNA interference knockdown using aerosolized short interfering RNAs bound to nanoparticles in three diverse aphid species.
Thairu MW, Skidmore IH, Bansal R, Nováková E, Hansen TE, Li-Byarlay H, Wickline SA, Hansen AK
Insect Mol Biol. 2017 Jun; 26(3)356-368. doi: 10.1111/imb.12301.

PMID:
    28314050
    [PubMed - indexed for MEDLINE]
Related citations


NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis.
Lozhkin A, Vendrov AE, Pan H, Wickline SA, Madamanchi NR, Runge MS
J Mol Cell Cardiol. 2017 Jan; 10210-21. doi: 10.1016/j.yjmcc.2016.12.004.

PMID:
    27986445
    [PubMed - indexed for MEDLINE]
Related citations


Antithrombin nanoparticles inhibit stent thrombosis in ex vivo static and flow models.
Palekar RU, Vemuri C, Marsh JN, Arif B, Wickline SA
J Vasc Surg. 2016 Nov; 64(5)1459-1467. doi: 10.1016/j.jvs.2015.08.086.

PMID:
    26482989
    [PubMed - indexed for MEDLINE]
Related citations


Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.
Yan H, Duan X, Pan H, Holguin N, Rai MF, Akk A, Springer LE, Wickline SA, Sandell LJ, Pham CT
Proc Natl Acad Sci U S A. 2016 Oct 11; 113(41)E6199-E6208.

PMID:
    27681622
    [PubMed - in process]
Related citations


Recent Advances in <sup>19</sup>Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions.
Schmieder AH, Caruthers SD, Keupp J, Wickline SA, Lanza GM
Engineering (Beijing). 2015 Dec; 1(4)475-489.

PMID:
    27110430
    [PubMed]
Related citations


Entropy <i>vs.</i> Energy Waveform Processing: A Comparison Based on the Heat Equation.
Hughes MS, McCarthy JE, Bruillard PJ, Marsh JN, Wickline SA
Entropy (Basel). 2015 Jun; 17(6)3518-3551.

PMID:
    27110093
    [PubMed]
Related citations


Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis.
Palekar RU, Jallouk AP, Myerson JW, Pan H, Wickline SA
Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3)446-55. doi: 10.1161/ATVBAHA.115.306697.

PMID:
    26769047
    [PubMed - indexed for MEDLINE]
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Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model.
Esser AK, Schmieder AH, Ross MH, Xiang J, Su X, Cui G, Zhang H, Yang X, Allen JS, Williams T, Wickline SA, Pan D, Lanza GM, Weilbaecher KN
Nanomedicine. 2016 Jan; 12(1)201-11. doi: 10.1016/j.nano.2015.10.003.

PMID:
    26515754
    [PubMed - indexed for MEDLINE]
Related citations


Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.
Pan D, Pham CT, Weilbaecher KN, Tomasson MH, Wickline SA, Lanza GM
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1)85-106. doi: 10.1002/wnan.1355.

PMID:
    26296541
    [PubMed - indexed for MEDLINE]
Related citations


Peptide-siRNA nanotherapeutics in arthritis.
Pham CT, Pan H, Wickline SA
Oncotarget. 2015 Jun 20; 6(17)14731-2.

PMID:
    26142704
    [PubMed - indexed for MEDLINE]
Related citations


Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles.
Jallouk AP, Palekar RU, Marsh JN, Pan H, Pham CT, Schlesinger PH, Wickline SA
Bioconjug Chem. 2015 Aug 19; 26(8)1640-50. doi: 10.1021/acs.bioconjchem.5b00246.

PMID:
    26083278
    [PubMed - indexed for MEDLINE]
Related citations


Molecular imaging of atherosclerosis with nanoparticle-based fluorinated MRI contrast agents.
Palekar RU, Jallouk AP, Lanza GM, Pan H, Wickline SA
Nanomedicine (Lond). 2015; 10(11)1817-32. doi: 10.2217/nnm.15.26.

PMID:
    26080701
    [PubMed - indexed for MEDLINE]
Related citations


A role for peptides in overcoming endosomal entrapment in siRNA delivery - A focus on melittin.
Hou KK, Pan H, Schlesinger PH, Wickline SA
Biotechnol Adv. 2015 Nov 1; 33(6 Pt 1)931-40. doi: 10.1016/j.biotechadv.2015.05.005.

PMID:
    26025036
    [PubMed - indexed for MEDLINE]
Related citations


Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.
Palekar RU, Jallouk AP, Goette MJ, Chen J, Myerson JW, Allen JS, Akk A, Yang L, Tu Y, Miller MJ, Pham CT, Wickline SA, Pan H
FASEB J. 2015 Jul; 29(7)3100-9. doi: 10.1096/fj.14-269084.

PMID:
    25857553
    [PubMed - indexed for MEDLINE]
Related citations


Modifications of natural peptides for nanoparticle and drug design.
Jallouk AP, Palekar RU, Pan H, Schlesinger PH, Wickline SA
Adv Protein Chem Struct Biol. 2015; 9857-91. doi: 10.1016/bs.apcsb.2014.12.001.

PMID:
    25819276
    [PubMed - indexed for MEDLINE]
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