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Robyn Sue Klein, MD, PhD

Professor, Medicine
Division of Infectious Diseases

Specialty Areas

Infectious Diseases

Board Certifications

Internal Medicine
Infectious Diseases

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Infectious diseases

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Taylor Ave. Building Extension

620 South Taylor Ave.
Suite 100
St. Louis, MO 63110

Office Phone: 314-747-1206
Fax: 314-222-6252

Education

Education

Research Fellowship: Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 2000
Clinical Fellowship: Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 1997
Residency: Brigham & Women's Hospital, Boston, Massachusetts 1996
Medical Degree: Albert Einstein College of Medicine, New York, New York 1993
Ph.D.: Neuroscience, Albert Einstein College of Medicine, Bronx, New York 1993
M.S.: Neuroscience, Albert Einstein College of Medicine, Bronx, New York 1990
B.A.: Barnard College, Columbia University, New York, New York 1985

Publication & Research

Publication & Research

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nat Immunol. 2018 Jan 1; doi: 10.1038/s41590-017-0021-y.

PMID:
    29292385
    [PubMed - as supplied by publisher]
Related citations


Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.
Luo Z, Yue X, Yang H, Liu H, Klein RS, Tu Z
Bioorg Med Chem Lett. 2017 Dec 6; pii: S0960-894X(17)31170-8. doi: 10.1016/j.bmcl.2017.12.010.

PMID:
    29249563
    [PubMed - as supplied by publisher]
Related citations


Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly.
Klein RS
Cell Host Microbe. 2017 Jul 12; 22(1)9-11. doi: 10.1016/j.chom.2017.06.015.

PMID:
    28704657
    [PubMed - in process]
Related citations


Protective and Pathological Immunity during Central Nervous System Infections.
Klein RS, Hunter CA
Immunity. 2017 Jun 20; 46(6)891-909. doi: 10.1016/j.immuni.2017.06.012.

PMID:
    28636958
    [PubMed - indexed for MEDLINE]
Related citations


Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection.
Cain MD, Salimi H, Gong Y, Yang L, Hamilton SL, Heffernan JR, Hou J, Miller MJ, Klein RS
J Neuroimmunol. 2017 Jul 15; 308118-130. doi: 10.1016/j.jneuroim.2017.04.008.

PMID:
    28501330
    [PubMed - indexed for MEDLINE]
Related citations


Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.
Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE
PLoS One. 2017; 12(5)e0177142. doi: 10.1371/journal.pone.0177142.

PMID:
    28475625
    [PubMed - indexed for MEDLINE]
Related citations


Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.
Blackard JT, Ma G, Welge JA, Taylor LE, Mayer KH, Klein RS, Celentano DD, Sobel JD, Jamieson DJ, King CC
J Med Virol. 2017 Nov; 89(11)1904-1911. doi: 10.1002/jmv.24836.

PMID:
    28460153
    [PubMed - in process]
Related citations


Speaking out about gender imbalance in invited speakers improves diversity.
Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH
Nat Immunol. 2017 Apr 18; 18(5)475-478. doi: 10.1038/ni.3707.

PMID:
    28418385
    [PubMed - in process]
Related citations


Sex Drives Dimorphic Immune Responses to Viral Infections.
Ghosh S, Klein RS
J Immunol. 2017 Mar 1; 198(5)1782-1790. doi: 10.4049/jimmunol.1601166.

PMID:
    28223406
    [PubMed - indexed for MEDLINE]
Related citations


Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.
Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL
MBio. 2017 Jan 31; 8(1)pii: e02183-16. doi: 10.1128/mBio.02183-16.

PMID:
    28143979
    [PubMed - indexed for MEDLINE]
Related citations


Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.
Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS
J Clin Invest. 2017 Mar 1; 127(3)843-856. doi: 10.1172/JCI88720.

PMID:
    28134626
    [PubMed - indexed for MEDLINE]
Related citations


Infectious immunity in the central nervous system and brain function.
Klein RS, Garber C, Howard N
Nat Immunol. 2017 Feb; 18(2)132-141. doi: 10.1038/ni.3656.

PMID:
    28092376
    [PubMed - indexed for MEDLINE]
Related citations


Sporotrichoid fluctuant nodules.
Peart JM, Klein RS, Xu X, Stewart C, Rosenbach M
Cutis. 2016 Aug; 98(2)82;96.

PMID:
    27622258
    [PubMed - indexed for MEDLINE]
Related citations


A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS
Nature. 2016 Jun 23; 534(7608)538-43. doi: 10.1038/nature18283.

PMID:
    27337340
    [PubMed - indexed for MEDLINE]
Related citations


Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.
Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE
MBio. 2016 Jun 7; 7(3)pii: e00617-16. doi: 10.1128/mBio.00617-16.

PMID:
    27273825
    [PubMed - indexed for MEDLINE]
Related citations


Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.
Salimi H, Cain MD, Klein RS
Neurotherapeutics. 2016 Jul; 13(3)514-34. doi: 10.1007/s13311-016-0443-5.

PMID:
    27220616
    [PubMed - indexed for MEDLINE]
Related citations


Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.
Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS
Cell. 2016 May 19; 165(5)1081-1091. doi: 10.1016/j.cell.2016.05.008.

PMID:
    27180225
    [PubMed - indexed for MEDLINE]
Related citations


Viral interactions with the blood-brain barrier: old dog, new tricks.
Hou J, Baker LA, Zhou L, Klein RS
Tissue Barriers. 2016 Jan-Mar; 4(1)e1142492. doi: 10.1080/21688370.2016.1142492.

PMID:
    27141421
    [PubMed - in process]
Related citations


The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.
Durrant DM, Ghosh S, Klein RS
ACS Chem Neurosci. 2016 Apr 20; 7(4)464-9. doi: 10.1021/acschemneuro.6b00043.

PMID:
    27058872
    [PubMed - indexed for MEDLINE]
Related citations


Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice.
Selvaraj UM, Ortega SB, Hu R, Gilchrist R, Kong X, Partin A, Plautz EJ, Klein RS, Gidday JM, Stowe AM
J Cereb Blood Flow Metab. 2017 Mar; 37(3)801-813. doi: 10.1177/0271678X16639327.

PMID:
    27006446
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Molecular basis of inflammation - associated dysfunction and damage in central nervous system