Patient Portal

Robyn Sue Klein, MD, PhD

Professor, Medicine
Division of Infectious Diseases

Specialty Areas

Infectious Diseases

Board Certifications

Internal Medicine
Infectious Diseases

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Infectious diseases

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Taylor Ave. Building Extension

620 South Taylor Ave.
Suite 100
St. Louis, MO 63110

Office Phone: 314-747-1206
Fax: 314-222-6252

Education

Education

Research Fellowship: Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 2000
Clinical Fellowship: Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 1997
Residency: Brigham & Women's Hospital, Boston, Massachusetts 1996
Medical Degree: Albert Einstein College of Medicine, New York, New York 1993
Ph.D.: Neuroscience, Albert Einstein College of Medicine, Bronx, New York 1993
M.S.: Neuroscience, Albert Einstein College of Medicine, Bronx, New York 1990
B.A.: Barnard College, Columbia University, New York, New York 1985

Publication & Research

Publication & Research

Mechanisms of Pathogen Invasion into the Central Nervous System.
Cain MD, Salimi H, Diamond MS, Klein RS
Neuron. 2019 Sep 4; 103(5)771-783. doi: 10.1016/j.neuron.2019.07.015.

PMID:
    31487528
    [PubMed - in process]
Related citations


Differential <i>In Vitro</i> Infection of Neural Cells by Astroviruses.
Janowski AB, Klein RS, Wang D
MBio. 2019 Jul 9; 10(4)pii: e01455-19. doi: 10.1128/mBio.01455-19.

PMID:
    31289185
    [PubMed - in process]
Related citations


Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor.
Luo Z, Liu H, Klein RS, Tu Z
Bioorg Med Chem. 2019 Aug 15; 27(16)3619-3631. doi: 10.1016/j.bmc.2019.06.047.

PMID:
    31279524
    [PubMed - in process]
Related citations


T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS
Nat Neurosci. 2019 Aug; 22(8)1276-1288. doi: 10.1038/s41593-019-0427-y.

PMID:
    31235930
    [PubMed - in process]
Related citations


Neuroinflammation During RNA Viral Infections.
Klein RS, Garber C, Funk KE, Salimi H, Soung A, Kanmogne M, Manivasagam S, Agner S, Cain M
Annu Rev Immunol. 2019 Apr 26; 3773-95. doi: 10.1146/annurev-immunol-042718-041417.

PMID:
    31026414
    [PubMed - in process]
Related citations


An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System.
Santiago-Tirado FH, Klein RS, Doering TL
Curr Protoc Microbiol. 2019 Jun; 53(1)e78. doi: 10.1002/cpmc.78.

PMID:
    30776307
    [PubMed - in process]
Related citations


CSF1R antagonism limits local restimulation of antiviral CD8<sup>+</sup> T cells during viral encephalitis.
Funk KE, Klein RS
J Neuroinflammation. 2019 Jan 31; 16(1)22. doi: 10.1186/s12974-019-1397-4.

PMID:
    30704498
    [PubMed - indexed for MEDLINE]
Related citations


Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA
Nat Microbiol. 2018 Nov; 3(11)1327. doi: 10.1038/s41564-018-0281-9.

PMID:
    30327492
    [PubMed]
Related citations


Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes.
Soung A, Klein RS
Trends Mol Med. 2018 Nov; 24(11)950-962. doi: 10.1016/j.molmed.2018.09.001.

PMID:
    30314877
    [PubMed - indexed for MEDLINE]
Related citations


Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.
Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T
J Clin Invest. 2018 Nov 1; 128(11)4980-4991. doi: 10.1172/JCI99902.

PMID:
    30247157
    [PubMed - indexed for MEDLINE]
Related citations


Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA
Nat Microbiol. 2018 Oct; 3(10)1099-1108. doi: 10.1038/s41564-018-0245-0.

PMID:
    30224802
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.
Hoye ML, Archambault AS, Gordon TM, Oetjen LK, Cain MD, Klein RS, Crosby SD, Kim BS, Miller TM, Wu GF
Immunology. 2018 Sep; 155(1)112-122. doi: 10.1111/imm.12934.

PMID:
    29749614
    [PubMed - indexed for MEDLINE]
Related citations


Viruses have multiple paths to central nervous system pathology.
Agner SC, Klein RS
Curr Opin Neurol. 2018 Jun; 31(3)313-317. doi: 10.1097/WCO.0000000000000556.

PMID:
    29561519
    [PubMed - indexed for MEDLINE]
Related citations


Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.
Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS
Nat Immunol. 2018 Feb; 19(2)151-161. doi: 10.1038/s41590-017-0021-y.

PMID:
    29292385
    [PubMed - indexed for MEDLINE]
Related citations


Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.
Luo Z, Yue X, Yang H, Liu H, Klein RS, Tu Z
Bioorg Med Chem Lett. 2018 Feb 1; 28(3)488-496. doi: 10.1016/j.bmcl.2017.12.010.

PMID:
    29249563
    [PubMed - indexed for MEDLINE]
Related citations


Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly.
Klein RS
Cell Host Microbe. 2017 Jul 12; 22(1)9-11. doi: 10.1016/j.chom.2017.06.015.

PMID:
    28704657
    [PubMed - indexed for MEDLINE]
Related citations


Protective and Pathological Immunity during Central Nervous System Infections.
Klein RS, Hunter CA
Immunity. 2017 Jun 20; 46(6)891-909. doi: 10.1016/j.immuni.2017.06.012.

PMID:
    28636958
    [PubMed - indexed for MEDLINE]
Related citations


Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection.
Cain MD, Salimi H, Gong Y, Yang L, Hamilton SL, Heffernan JR, Hou J, Miller MJ, Klein RS
J Neuroimmunol. 2017 Jul 15; 308118-130. doi: 10.1016/j.jneuroim.2017.04.008.

PMID:
    28501330
    [PubMed - indexed for MEDLINE]
Related citations


Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.
Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE
PLoS One. 2017; 12(5)e0177142. doi: 10.1371/journal.pone.0177142.

PMID:
    28475625
    [PubMed - indexed for MEDLINE]
Related citations


Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.
Blackard JT, Ma G, Welge JA, Taylor LE, Mayer KH, Klein RS, Celentano DD, Sobel JD, Jamieson DJ, King CC
J Med Virol. 2017 Nov; 89(11)1904-1911. doi: 10.1002/jmv.24836.

PMID:
    28460153
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Molecular basis of inflammation - associated dysfunction and damage in central nervous system