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Roberto Civitelli, MD

Sydney M. and Stella H. Schoenberg Professor, Medicine
Division of Bone & Mineral Diseases
Chief, Division of Bone and Mineral Diseases
Professor, Orthopaedic Surgery
Professor, Cell Biology and Physiology

Specialty Areas

Osteoporosis
Bone and Mineral Diseases
Paget's Disease of Bone
Metabolic Bone Diseases

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Languages

Italian

Areas of Clinical Interest

Diagnosis and treatment of osteoporosis, osteopenia, measurement of bone density, bone metabolism, bone disease, mineral disease, Paget's disease of bone, disorders of phosphate metabolism, hypercalcemia, hypocalcemia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-454-7775
Fax: 314-454-5047

Barnes-Jewish West County Hospital
Medical Building Two

10 Barnes West Drive
Creve Coeur, MO 63141

Suite: 200
Office Phone: 314-454-7775
Fax: 314-996-3087

Center for Advanced Medicine - South County

5201 Midamerica Plaza
St. Louis, MO 63129

Suite: 2300
Office Phone: 314-454-7775
Fax: 314-273-1149

Education

Education

Fellowship: Endocrinology & Metabolism, The Jewish Hospital of St. Louis, Missouri 1989
Residency: Internal Medicine, Siena University, School of Medicine, Siena, Italy 1985
Medical Degree: Siena University School of Medicine, Siena, Italy 1980

Publication & Research

Publication & Research

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.
Alippe Y, Wang C, Ricci B, Xiao J, Qu C, Zou W, Novack DV, Abu-Amer Y, Civitelli R, Mbalaviele G
Sci Rep. 2017 Jul 26; 7(1)6630. doi: 10.1038/s41598-017-07014-0.

PMID:
    28747793
    [PubMed - in process]
Related citations


Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.
Wang C, Xu CX, Alippe Y, Qu C, Xiao J, Schipani E, Civitelli R, Abu-Amer Y, Mbalaviele G
Sci Rep. 2017 Jul 7; 7(1)4880. doi: 10.1038/s41598-017-05033-5.

PMID:
    28687790
    [PubMed - in process]
Related citations


Bone Turnover with Venlafaxine Treatment in Older Adults with Depression.
Rawson KS, Dixon D, Civitelli R, Peterson TR, Mulsant BH, Reynolds CF 3rd, Lenze EJ
J Am Geriatr Soc. 2017 Sep; 65(9)2057-2063. doi: 10.1111/jgs.14936.

PMID:
    28555718
    [PubMed - indexed for MEDLINE]
Related citations


Toward personalized calcium and vitamin D supplementation.
Civitelli R, Peterson T
Am J Clin Nutr. 2017 Apr; 105(4)777-778. doi: 10.3945/ajcn.117.154278.

PMID:
    28330910
    [PubMed - in process]
Related citations


Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study.
Fohtung RB, Brown DL, Koh WJ, Bartz TM, Carbone LD, Civitelli R, Stein PK, Chaves PH, Kestenbaum BR, Kizer JR
J Am Heart Assoc. 2017 Mar 13; 6(3)pii: e004344. doi: 10.1161/JAHA.116.004344.

PMID:
    28288973
    [PubMed - in process]
Related citations


N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.
Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R
J Bone Miner Res. 2017 Jun; 32(6)1332-1342. doi: 10.1002/jbmr.3112.

PMID:
    28240364
    [PubMed - in process]
Related citations


Relationship Between Low Bone Mineral Density and Fractures With Incident Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Veronese N, Stubbs B, Crepaldi G, Solmi M, Cooper C, Harvey NC, Reginster JY, Rizzoli R, Civitelli R, Schofield P, Maggi S, Lamb SE
J Bone Miner Res. 2017 May; 32(5)1126-1135. doi: 10.1002/jbmr.3089.

PMID:
    28138982
    [PubMed - in process]
Related citations


Evaluating Acetate Metabolism for Imaging and Targeting in Multiple Myeloma.
Fontana F, Ge X, Su X, Hathi D, Xiang J, Cenci S, Civitelli R, Shoghi KI, Akers WJ, D'avignon A, Weilbaecher KN, Shokeen M
Clin Cancer Res. 2017 Jan 15; 23(2)416-429. doi: 10.1158/1078-0432.CCR-15-2134.

PMID:
    27486177
    [PubMed - in process]
Related citations


Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes.
Sellmeyer DE, Civitelli R, Hofbauer LC, Khosla S, Lecka-Czernik B, Schwartz AV
Diabetes. 2016 Jul; 65(7)1757-66. doi: 10.2337/db16-0063.

PMID:
    27329951
    [PubMed - indexed for MEDLINE]
Related citations


A Functional Assay to Assess Connexin 43-Mediated Cell-to-Cell Communication of Second Messengers in Cultured Bone Cells.
Stains JP, Civitelli R
Methods Mol Biol. 2016; 1437193-201. doi: 10.1007/978-1-4939-3664-9_14.

PMID:
    27207296
    [PubMed - in process]
Related citations


Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.
Wang C, Qu C, Alippe Y, Bonar SL, Civitelli R, Abu-Amer Y, Hottiger MO, Mbalaviele G
Cell Death Dis. 2016 Mar 24; 7e2153. doi: 10.1038/cddis.2016.58.

PMID:
    27010854
    [PubMed - indexed for MEDLINE]
Related citations


Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).
Cooper C, Bardin T, Brandi ML, Cacoub P, Caminis J, Civitelli R, Cutolo M, Dere W, Devogelaer JP, Diez-Perez A, Einhorn TA, Emonts P, Ethgen O, Kanis JA, Kaufman JM, Kvien TK, Lems WF, McCloskey E, Miossec P, Reiter S, Ringe J, Rizzoli R, Saag K, Reginster JY
Aging Clin Exp Res. 2016 Feb; 28(1)1-16. doi: 10.1007/s40520-015-0522-1.

PMID:
    26746234
    [PubMed - indexed for MEDLINE]
Related citations


Connexins in the skeleton.
Stains JP, Civitelli R
Semin Cell Dev Biol. 2016 Feb; 5031-9. doi: 10.1016/j.semcdb.2015.12.017.

PMID:
    26740471
    [PubMed - indexed for MEDLINE]
Related citations


p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.
Chang KH, Sengupta A, Nayak RC, Duran A, Lee SJ, Pratt RG, Wellendorf AM, Hill SE, Watkins M, Gonzalez-Nieto D, Aronow BJ, Starczynowski DT, Civitelli R, Diaz-Meco MT, Moscat J, Cancelas JA
Cell Rep. 2014 Dec 24; 9(6)2084-97. doi: 10.1016/j.celrep.2014.11.031.

PMID:
    25533346
    [PubMed - indexed for MEDLINE]
Related citations


NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.
Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G
FASEB J. 2015 Apr; 29(4)1269-79. doi: 10.1096/fj.14-264804.

PMID:
    25477279
    [PubMed - indexed for MEDLINE]
Related citations


Deletion of connexin43 in osteoblasts/osteocytes leads to impaired muscle formation in mice.
Shen H, Grimston S, Civitelli R, Thomopoulos S
J Bone Miner Res. 2015 Apr; 30(4)596-605. doi: 10.1002/jbmr.2389.

PMID:
    25348938
    [PubMed - indexed for MEDLINE]
Related citations


N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.
Revollo L, Kading J, Jeong SY, Li J, Salazar V, Mbalaviele G, Civitelli R
J Bone Miner Res. 2015 Feb; 30(2)274-85. doi: 10.1002/jbmr.2323.

PMID:
    25088803
    [PubMed - indexed for MEDLINE]
Related citations


Depression, antidepressants, and bone health in older adults: a systematic review.
Gebara MA, Shea ML, Lipsey KL, Teitelbaum SL, Civitelli R, Müller DJ, Reynolds CF 3rd, Mulsant BH, Lenze EJ
J Am Geriatr Soc. 2014 Aug; 62(8)1434-41. doi: 10.1111/jgs.12945.

PMID:
    25039259
    [PubMed - indexed for MEDLINE]
Related citations


Connexin43 modulates post-natal cortical bone modeling and mechano-responsiveness.
Grimston SK, Watkins MP, Stains JP, Civitelli R
Bonekey Rep. 2013 Nov 13; 2446. doi: 10.1038/bonekey.2013.180.

PMID:
    24422141
    [PubMed]
Related citations


Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.
Salazar VS, Zarkadis N, Huang L, Watkins M, Kading J, Bonar S, Norris J, Mbalaviele G, Civitelli R
J Cell Sci. 2013 Dec 15; 126(Pt 24)5598-609. doi: 10.1242/jcs.132233.

PMID:
    24101723
    [PubMed - indexed for MEDLINE]
Related citations