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Robert M. Senior, MD

Dorothy R. and Hubert C. Moog Professor of Pulmonary Diseases, Medicine
Professor, Cell Biology and Physiology

Specialty Areas

Pulmonary Fibrosis
COPD
Lung Cancer
Pulmonary Rehabilitation

Board Certifications

Internal Medicine
Pulmonary Disease

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Shortness of breath, emphysema, COPD, chronic bronchitis, pulmonary fibrosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-454-8605

Education

Education

Fellowship: Cardio-Respiratory Physiology, Columbia University College of Physicians and Surgeons, New York, NY 1966
Residency: Internal Medicine, The Jewish Hospital of St. Louis, St. Louis, Missouri 1964
Residency: Internal Medicine, Barnes Hospital, St. Louis, Missouri 1963
Medical Degree: George Washington University, Washington, District of Columbia 1961
B.A.: Oberlin College, Oberlin, Ohio 1957

Publication & Research

Publication & Research

Laminin γ2 knockout mice rescued with the human protein exhibit enamel maturation defects.
Wazen RM, Viegas-Costa LC, Fouillen A, Moffatt P, Adair-Kirk TL, Senior RM, Nanci A
Matrix Biol. 2016 May-Jul; 52-54207-218. doi: 10.1016/j.matbio.2016.03.002.

PMID:
    26956061
    [PubMed - indexed for MEDLINE]
Related citations


Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol.
Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, GRADS Sarcoidosis Study Group.
Ann Am Thorac Soc. 2015 Oct; 12(10)1561-71. doi: 10.1513/AnnalsATS.201503-172OT.

PMID:
    26193069
    [PubMed - indexed for MEDLINE]
Related citations


Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol.
Strange C, Senior RM, Sciurba F, O'Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methé BA, Kaminski N, Sandhaus RA, GRADS Alpha-1 Study Group.
Ann Am Thorac Soc. 2015 Oct; 12(10)1551-60. doi: 10.1513/AnnalsATS.201503-143OC.

PMID:
    26153726
    [PubMed - indexed for MEDLINE]
Related citations


The Red journal at 25. A perspective from the founding editors.
Senior RM, Brody JS, Williams MC
Am J Respir Cell Mol Biol. 2014 May; 50(5)840-1. doi: 10.1165/rcmb.2014-0105ED.

PMID:
    24783953
    [PubMed - indexed for MEDLINE]
Related citations


Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels.
Kobayashi T, Kim H, Liu X, Sugiura H, Kohyama T, Fang Q, Wen FQ, Abe S, Wang X, Atkinson JJ, Shipley JM, Senior RM, Rennard SI
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1; 306(11)L1006-15. doi: 10.1152/ajplung.00015.2014.

PMID:
    24705725
    [PubMed - indexed for MEDLINE]
Related citations


Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial.
Woodruff PG, Chatila W, Connett JE, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Marchetti N, Rogers TJ, Scanlon PD, Sin DD, Voelker H, Wendt C, Albert RK, COPD Clinical Research Network.
Eur Respir J. 2014 Jan; 43(1)295-8. doi: 10.1183/09031936.00140613.

PMID:
    24136332
    [PubMed - indexed for MEDLINE]
Related citations


The role of the lung microbiome in health and disease. A National Heart, Lung, and Blood Institute workshop report.
Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD, Senior RM
Am J Respir Crit Care Med. 2013 Jun 15; 187(12)1382-7. doi: 10.1164/rccm.201303-0488WS.

PMID:
    23614695
    [PubMed - indexed for MEDLINE]
Related citations


Accurate measurement of small airways on low-dose thoracic CT scans in smokers.
Lutey BA, Conradi SH, Atkinson JJ, Zheng J, Schechtman KB, Senior RM, Gierada DS
Chest. 2013 May; 143(5)1321-1329. doi: 10.1378/chest.12-0034.

PMID:
    23172175
    [PubMed - indexed for MEDLINE]
Related citations


The fibrotic matrix in control: does the extracellular matrix drive progression of idiopathic pulmonary fibrosis?
Tschumperlin DJ, Jones JC, Senior RM
Am J Respir Crit Care Med. 2012 Nov 1; 186(9)814-6. doi: 10.1164/rccm.201208-1561ED.

PMID:
    23118079
    [PubMed - indexed for MEDLINE]
Related citations


Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.
Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM
PLoS One. 2012; 7(9)e45546. doi: 10.1371/journal.pone.0045546.

PMID:
    23029085
    [PubMed - indexed for MEDLINE]
Related citations


Pulmonary research in 2013 and beyond: a National Heart, Lung, and Blood Institute perspective.
Kiley JP, Senior RM
Am J Physiol Lung Cell Mol Physiol. 2012 Nov 1; 303(9)L729-32. doi: 10.1152/ajplung.00305.2012.

PMID:
    22962017
    [PubMed - indexed for MEDLINE]
Related citations


Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.
Kim ST, Adair-Kirk TL, Senior RM, Miner JH
PLoS One. 2012; 7(7)e41348. doi: 10.1371/journal.pone.0041348.

PMID:
    22911783
    [PubMed - indexed for MEDLINE]
Related citations


Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy.
Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA Jr, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Sciurba FC, Woodruff P, COPD Clinical Research Network.
COPD. 2012 Feb; 9(1)3-11. doi: 10.3109/15412555.2011.630048.

PMID:
    22292592
    [PubMed - indexed for MEDLINE]
Related citations


Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid.
Lin L, Betsuyaku T, Heimbach L, Li N, Rubenstein D, Shapiro SD, An L, Giudice GJ, Diaz LA, Senior RM, Liu Z
Matrix Biol. 2012 Jan; 31(1)38-44. doi: 10.1016/j.matbio.2011.09.003.

PMID:
    21979170
    [PubMed - indexed for MEDLINE]
Related citations


Azithromycin for prevention of exacerbations of COPD.
Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA Jr, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make B, Marchetti N, Martinez FJ, Madinger NE, McEvoy C, Niewoehner DE, Porsasz J, Price CS, Reilly J, Scanlon PD, Sciurba FC, Scharf SM, Washko GR, Woodruff PG, Anthonisen NR, COPD Clinical Research Network.
N Engl J Med. 2011 Aug 25; 365(8)689-98. doi: 10.1056/NEJMoa1104623.

PMID:
    21864166
    [PubMed - indexed for MEDLINE]
Related citations


In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometry.
Quirk JD, Lutey BA, Gierada DS, Woods JC, Senior RM, Lefrak SS, Sukstanskii AL, Conradi MS, Yablonskiy DA
Radiology. 2011 Sep; 260(3)866-74. doi: 10.1148/radiol.11102226.

PMID:
    21734160
    [PubMed - indexed for MEDLINE]
Related citations


Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Young LR, Kinder BW, Downey GP, Sullivan EJ, Colby TV, McKay RT, Cohen MM, Korbee L, Taveira-DaSilva AM, Lee HS, Krischer JP, Trapnell BC, National Institutes of Health Rare Lung Diseases Consortium., MILES Trial Group.
N Engl J Med. 2011 Apr 28; 364(17)1595-606. doi: 10.1056/NEJMoa1100391.

PMID:
    21410393
    [PubMed - indexed for MEDLINE]
Related citations


The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema.
Atkinson JJ, Lutey BA, Suzuki Y, Toennies HM, Kelley DG, Kobayashi DK, Ijem WG, Deslee G, Moore CH, Jacobs ME, Conradi SH, Gierada DS, Pierce RA, Betsuyaku T, Senior RM
Am J Respir Crit Care Med. 2011 Apr 1; 183(7)876-84. doi: 10.1164/rccm.201005-0718OC.

PMID:
    21057003
    [PubMed - indexed for MEDLINE]
Related citations


Measuring small airways in transverse CT images correction for partial volume averaging and airway tilt.
Conradi SH, Lutey BA, Atkinson JJ, Wang W, Senior RM, Gierada DS
Acad Radiol. 2010 Dec; 17(12)1525-34. doi: 10.1016/j.acra.2010.08.005.

PMID:
    20947386
    [PubMed - indexed for MEDLINE]
Related citations


Maintenance of glomerular filtration barrier integrity requires laminin alpha5.
Goldberg S, Adair-Kirk TL, Senior RM, Miner JH
J Am Soc Nephrol. 2010 Apr; 21(4)579-86. doi: 10.1681/ASN.2009091004.

PMID:
    20150535
    [PubMed - indexed for MEDLINE]
Related citations