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Robert C. McKinstry III, MD, PhD

Professor, Radiology
Director, Division of Diagnostic Radiology
Pediatric Radiology and Neuroradiology Sections
Professor, Pediatrics

Specialty Areas

Pediatric Neuroradiology
Neuroradiology
Neuro Oncology
Radiology
Pediatric Radiology

Board Certifications

Radiology
Neuroradiology

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Magnetic resonance imaging, MRI, MR imaging of brain development, diffusion tensor imaging, perfusion MR imaging and functional MR imaging, functional neuroimaging with magnetic resonance

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Mallinckrodt Institute of Radiology

510 South Kingshighway Boulevard
St. Louis, MO 63110

Office Phone: 314-362-5949
Fax: 314-362-4886

Education

Education

Fellowship: Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 1999
Residency: Mallinckrodt Institute of Radiology and Barnes-Jewish Hospital, St. Louis, Missouri 1997
Medical Degree: Harvard-MIT Division of Health Sciences & Technology, Harvard Medical School, Boston, Massachusetts 1992
Ph.D.: Radiological Sciences, Massachusetts Institute of Technology, Boston, Massachusetts 1991
B.S.: Boston University, Boston, Massachusetts 1984

Publication & Research

Publication & Research

Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic-ischemic encephalopathy.
Wu YW, Goodman AM, Chang T, Mulkey SB, Gonzalez FF, Mayock DE, Juul SE, Mathur AM, Van Meurs K, McKinstry RC, Redline RW
Pediatr Res. 2019 Jul 1; doi: 10.1038/s41390-019-0493-6.

PMID:
    31261373
    [PubMed - as supplied by publisher]
Related citations


The Importance of Temperament for Understanding Early Manifestations of Autism Spectrum Disorder in High-Risk Infants.
Paterson SJ, Wolff JJ, Elison JT, Winder-Patel B, Zwaigenbaum L, Estes A, Pandey J, Schultz RT, Botteron K, Dager SR, Hazlett HC, Piven J, IBIS Network.
J Autism Dev Disord. 2019 Jul; 49(7)2849-2863. doi: 10.1007/s10803-019-04003-2.

PMID:
    30993502
    [PubMed - indexed for MEDLINE]
Related citations


Noninvasive high-resolution electromyometrial imaging of uterine contractions in a translational sheep model.
Wu W, Wang H, Zhao P, Talcott M, Lai S, McKinstry RC, Woodard PK, Macones GA, Schwartz AL, Cahill AG, Cuculich PS, Wang Y
Sci Transl Med. 2019 Mar 13; 11(483)pii: eaau1428. doi: 10.1126/scitranslmed.aau1428.

PMID:
    30867320
    [PubMed - in process]
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Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia.
Fields ME, Guilliams KP, Ragan D, Binkley MM, Mirro A, Fellah S, Hulbert ML, Blinder M, Eldeniz C, Vo K, Shimony JS, Chen Y, McKinstry RC, An H, Lee JM, Ford AL
Blood. 2019 May 30; 133(22)2436-2444. doi: 10.1182/blood-2018-09-876318.

PMID:
    30858231
    [PubMed - in process]
Related citations


Functional and Radiologic Assessment of the Brain after Reduced-Intensity Unrelated Donor Transplantation for Severe Sickle Cell Disease: Blood and Marrow Transplant Clinical Trials Network Study 0601.
King AA, McKinstry RC, Wu J, Eapen M, Abel R, Varughese T, Kamani N, Shenoy S
Biol Blood Marrow Transplant. 2019 May; 25(5)e174-e178. doi: 10.1016/j.bbmt.2019.01.008.

PMID:
    30639825
    [PubMed - in process]
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Interreader Variability of Dynamic Contrast-enhanced MRI of Recurrent Glioblastoma: The Multicenter ACRIN 6677/RTOG 0625 Study.
Barboriak DP, Zhang Z, Desai P, Snyder BS, Safriel Y, McKinstry RC, Bokstein F, Sorensen G, Gilbert MR, Boxerman JL
Radiology. 2019 Feb; 290(2)467-476. doi: 10.1148/radiol.2019181296.

PMID:
    30480488
    [PubMed - in process]
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Restricted and Repetitive Behavior and Brain Functional Connectivity in Infants at Risk for Developing Autism Spectrum Disorder.
McKinnon CJ, Eggebrecht AT, Todorov A, Wolff JJ, Elison JT, Adams CM, Snyder AZ, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Marrus N, Evans A, Hazlett HC, Dager SR, Paterson SJ, Pandey J, Schultz RT, Styner MA, Gerig G, Schlaggar BL, Petersen SE, Piven J, Pruett JR Jr, IBIS Network.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jan; 4(1)50-61. doi: 10.1016/j.bpsc.2018.09.008.

PMID:
    30446435
    [PubMed - in process]
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Progressive loss of brain volume in children with sickle cell anemia and silent cerebral infarct: A report from the silent cerebral infarct transfusion trial.
Darbari DS, Eigbire-Molen O, Ponisio MR, Milchenko MV, Rodeghier MJ, Casella JF, McKinstry RC, DeBaun MR
Am J Hematol. 2018 Dec; 93(12)E406-E408. doi: 10.1002/ajh.25297.

PMID:
    30264867
    [PubMed - indexed for MEDLINE]
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Silent infarcts in sickle cell disease occur in the border zone region and are associated with low cerebral blood flow.
Ford AL, Ragan DK, Fellah S, Binkley MM, Fields ME, Guilliams KP, An H, Jordan LC, McKinstry RC, Lee JM, DeBaun MR
Blood. 2018 Oct 18; 132(16)1714-1723. doi: 10.1182/blood-2018-04-841247.

PMID:
    30061156
    [PubMed - indexed for MEDLINE]
Related citations


Development of White Matter Circuitry in Infants With Fragile X Syndrome.
Swanson MR, Wolff JJ, Shen MD, Styner M, Estes A, Gerig G, McKinstry RC, Botteron KN, Piven J, Hazlett HC, Infant Brain Imaging Study (IBIS) Network.
JAMA Psychiatry. 2018 May 1; 75(5)505-513. doi: 10.1001/jamapsychiatry.2018.0180.

PMID:
    29617515
    [PubMed - in process]
Related citations


Children with sickle cell anemia with normal transcranial Doppler ultrasounds and without silent infarcts have a low incidence of new strokes.
Jordan LC, Roberts Williams DO, Rodeghier MJ, Covert Greene BV, Ponisio MR, Casella JF, McKinstry RC, Noetzel MJ, Kirkham FJ, Meier ER, Fuh B, McNaull M, Sarnaik S, Majumdar S, McCavit TL, DeBaun MR
Am J Hematol. 2018 Jun; 93(6)760-768. doi: 10.1002/ajh.25085.

PMID:
    29520844
    [PubMed - indexed for MEDLINE]
Related citations


Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease.
Fields ME, Guilliams KP, Ragan DK, Binkley MM, Eldeniz C, Chen Y, Hulbert ML, McKinstry RC, Shimony JS, Vo KD, Doctor A, An H, Ford AL, Lee JM
Neurology. 2018 Mar 27; 90(13)e1134-e1142. doi: 10.1212/WNL.0000000000005194.

PMID:
    29500287
    [PubMed - indexed for MEDLINE]
Related citations


Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Massaro AN, Wu YW, Bammler TK, Comstock B, Mathur A, McKinstry RC, Chang T, Mayock DE, Mulkey SB, Van Meurs K, Juul S
J Pediatr. 2018 Mar; 19467-75.e1. doi: 10.1016/j.jpeds.2017.10.060.

PMID:
    29478510
    [PubMed - indexed for MEDLINE]
Related citations


Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia.
Choudhury NA, DeBaun MR, Rodeghier M, King AA, Strouse JJ, McKinstry RC
Neurology. 2018 Jan 16; 90(3)e239-e246. doi: 10.1212/WNL.0000000000004832.

PMID:
    29263226
    [PubMed - indexed for MEDLINE]
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Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia.
Guilliams KP, Fields ME, Ragan DK, Eldeniz C, Binkley MM, Chen Y, Comiskey LS, Doctor A, Hulbert ML, Shimony JS, Vo KD, McKinstry RC, An H, Lee JM, Ford AL
Blood. 2018 Mar 1; 131(9)1012-1021. doi: 10.1182/blood-2017-06-789842.

PMID:
    29255068
    [PubMed - indexed for MEDLINE]
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Walking, Gross Motor Development, and Brain Functional Connectivity in Infants and Toddlers.
Marrus N, Eggebrecht AT, Todorov A, Elison JT, Wolff JJ, Cole L, Gao W, Pandey J, Shen MD, Swanson MR, Emerson RW, Klohr CL, Adams CM, Estes AM, Zwaigenbaum L, Botteron KN, McKinstry RC, Constantino JN, Evans AC, Hazlett HC, Dager SR, Paterson SJ, Schultz RT, Styner MA, Gerig G, IBIS Network., Schlaggar BL, Piven J, Pruett JR Jr
Cereb Cortex. 2018 Feb 1; 28(2)750-763. doi: 10.1093/cercor/bhx313.

PMID:
    29186388
    [PubMed - indexed for MEDLINE]
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Intracranial vasculopathy and infarct recurrence in children with sickle cell anaemia, silent cerebral infarcts and normal transcranial Doppler velocities.
Choudhury NA, DeBaun MR, Ponisio MR, Jordan LC, Rodeghier M, Pruthi S, McKinstry RC
Br J Haematol. 2018 Oct; 183(2)324-326. doi: 10.1111/bjh.14979.

PMID:
    29076125
    [PubMed - indexed for MEDLINE]
Related citations


CEDNIK: Phenotypic and Molecular Characterization of an Additional Patient and Review of the Literature.
Hsu T, Coughlin CC, Monaghan KG, Fiala E, McKinstry RC, Paciorkowski AR, Shinawi M
Child Neurol Open. 2017 Jan-Dec; 42329048X17733214. doi: 10.1177/2329048X17733214.

PMID:
    29051910
    [PubMed]
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A validated clinical MRI injury scoring system in neonatal hypoxic-ischemic encephalopathy.
Trivedi SB, Vesoulis ZA, Rao R, Liao SM, Shimony JS, McKinstry RC, Mathur AM
Pediatr Radiol. 2017 Oct; 47(11)1491-1499. doi: 10.1007/s00247-017-3893-y.

PMID:
    28623417
    [PubMed - indexed for MEDLINE]
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