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Faculty Physicians

Robert C. McKinstry III, MD, PhD

Professor, Radiology
Division of Diagnostic Radiology
Pediatric Radiology and Neuroradiology Sections
Chief, Pediatric Radiology
Professor, Pediatrics

Specialty Areas

Pediatric Neuroradiology
Neuroradiology
Neuro Oncology
Radiology
Pediatric Radiology

Board Certifications

Radiology
Neuroradiology

Areas of Clinical Interest

Magnetic resonance imaging, MRI, MR imaging of brain development, diffusion tensor imaging, perfusion MR imaging and functional MR imaging, functional neuroimaging with magnetic resonance

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital
Mallinckrodt Institute of Radiology

510 South Kingshighway Boulevard
St. Louis, MO 63110

Office Phone: 314-362-5949
Fax: 314-362-4886

Education

Education

Fellowship: Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 1999
Residency: Mallinckrodt Institute of Radiology and Barnes-Jewish Hospital, St. Louis, Missouri 1997
Medical Degree: Harvard-MIT Division of Health Sciences & Technology, Harvard Medical School, Boston, Massachusetts 1992
Ph.D.: Radiological Sciences, Massachusetts Institute of Technology, Boston, Massachusetts 1991
B.S.: Boston University, Boston, Massachusetts 1984

Publication & Research

Publication & Research

The accuracy of linear indices of ventricular volume in pediatric hydrocephalus: technical note.
Ragan DK, Cerqua J, Nash T, McKinstry RC, Shimony JS, Jones BV, Mangano FT, Holland SK, Yuan W, Limbrick DD Jr
J Neurosurg Pediatr. 2015 Jun; 15(6)547-51. doi: 10.3171/2014.10.PEDS14209.

PMID:
    25745953
    [PubMed - indexed for MEDLINE]
Related citations


Prolonged exposure to high and variable phenylalanine levels over the lifetime predicts brain white matter integrity in children with phenylketonuria.
Hood A, Antenor-Dorsey JA, Rutlin J, Hershey T, Shimony JS, McKinstry RC, Grange DK, Christ SE, Steiner R, White DA
Mol Genet Metab. 2015 Jan; 114(1)19-24. doi: 10.1016/j.ymgme.2014.11.007.

PMID:
    25481106
    [PubMed - indexed for MEDLINE]
Related citations


The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, Fisher MJ, Tabori U, Allen JC, Schiffman JD, Gutmann DH, Rubin JB
Cancer Res. 2015 Jan 1; 75(1)16-21. doi: 10.1158/0008-5472.CAN-14-1891.

PMID:
    25381154
    [PubMed - indexed for MEDLINE]
Related citations


Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.
DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS Jr, Hirtz D, Casella JF
N Engl J Med. 2014 Aug 21; 371(8)699-710. doi: 10.1056/NEJMoa1401731.

PMID:
    25140956
    [PubMed - indexed for MEDLINE]
Related citations


Reproducibility of detecting silent cerebral infarcts in pediatric sickle cell anemia.
Liem RI, Liu J, Gordon MO, Vendt BA, McKinstry RC 3rd, Kraut MA, Strouse JJ, Ball WS, DeBaun MR
J Child Neurol. 2014 Dec; 29(12)1685-91. doi: 10.1177/0883073813506491.

PMID:
    24309240
    [PubMed - indexed for MEDLINE]
Related citations


Parent education and biologic factors influence on cognition in sickle cell anemia.
King AA, Strouse JJ, Rodeghier MJ, Compas BE, Casella JF, McKinstry RC, Noetzel MJ, Quinn CT, Ichord R, Dowling MM, Miller JP, Debaun MR
Am J Hematol. 2014 Feb; 89(2)162-7. doi: 10.1002/ajh.23604.

PMID:
    24123128
    [PubMed - indexed for MEDLINE]
Related citations


White matter microstructural abnormality in children with hydrocephalus detected by probabilistic diffusion tractography.
Rajagopal A, Shimony JS, McKinstry RC, Altaye M, Maloney T, Mangano FT, Limbrick DD, Holland SK, Jones BV, Simpson S, Mercer D, Yuan W
AJNR Am J Neuroradiol. 2013 Dec; 34(12)2379-85. doi: 10.3174/ajnr.A3737.

PMID:
    24072621
    [PubMed - indexed for MEDLINE]
Related citations


White matter integrity and executive abilities following treatment with tetrahydrobiopterin (BH4) in individuals with phenylketonuria.
White DA, Antenor-Dorsey JA, Grange DK, Hershey T, Rutlin J, Shimony JS, McKinstry RC, Christ SE
Mol Genet Metab. 2013 Nov; 110(3)213-7. doi: 10.1016/j.ymgme.2013.07.010.

PMID:
    23928118
    [PubMed - indexed for MEDLINE]
Related citations


Anxious/depressed symptoms are linked to right ventromedial prefrontal cortical thickness maturation in healthy children and young adults.
Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Nguyen TV, Truong C, Evans AC, Karama S, Brain Development Cooperative Group
Cereb Cortex. 2014 Nov; 24(11)2941-50. doi: 10.1093/cercor/bht151.

PMID:
    23749874
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion imaging quality control via entropy of principal direction distribution.
Farzinfar M, Oguz I, Smith RG, Verde AR, Dietrich C, Gupta A, Escolar ML, Piven J, Pujol S, Vachet C, Gouttard S, Gerig G, Dager S, McKinstry RC, Paterson S, Evans AC, IBIS network, Styner MA
Neuroimage. 2013 Nov 15; 821-12. doi: 10.1016/j.neuroimage.2013.05.022.

PMID:
    23684874
    [PubMed - indexed for MEDLINE]
Related citations


Teaching NeuroImages: T2 hyperintensities in neurofibromatosis type 1.
Ostendorf AP, McKinstry RC, Shimony JS, Gutmann DH
Neurology. 2013 May 14; 80(20)e215-6. doi: 10.1212/WNL.0b013e3182929f7c.

PMID:
    23671349
    [PubMed - indexed for MEDLINE]
Related citations


Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.
Ratai EM, Zhang Z, Snyder BS, Boxerman JL, Safriel Y, McKinstry RC, Bokstein F, Gilbert MR, Sorensen AG, Barboriak DP
Neuro Oncol. 2013 Jul; 15(7)936-44. doi: 10.1093/neuonc/not044.

PMID:
    23645534
    [PubMed - indexed for MEDLINE]
Related citations


Optic nerve tortuosity in children with neurofibromatosis type 1.
Ji J, Shimony J, Gao F, McKinstry RC, Gutmann DH
Pediatr Radiol. 2013 Oct; 43(10)1336-43. doi: 10.1007/s00247-013-2694-1.

PMID:
    23636538
    [PubMed - indexed for MEDLINE]
Related citations


White matter integrity and executive abilities in individuals with phenylketonuria.
Antenor-Dorsey JA, Hershey T, Rutlin J, Shimony JS, McKinstry RC, Grange DK, Christ SE, White DA
Mol Genet Metab. 2013 Jun; 109(2)125-31. doi: 10.1016/j.ymgme.2013.03.020.

PMID:
    23608077
    [PubMed - indexed for MEDLINE]
Related citations


CT for pediatric, acute, minor head trauma: clinician conformity to published guidelines.
Linscott LL, Kessler MM, Kitchin DR, Quayle KS, Hildebolt CF, McKinstry RC, Don S
AJNR Am J Neuroradiol. 2013 Jun-Jul; 34(6)1252-6. doi: 10.3174/ajnr.A3366.

PMID:
    23221949
    [PubMed - indexed for MEDLINE]
Related citations


Acute silent cerebral ischemic events in children with sickle cell anemia.
Quinn CT, McKinstry RC, Dowling MM, Ball WS, Kraut MA, Casella JF, Dlamini N, Ichord RN, Jordan LC, Kirkham FJ, Noetzel MJ, Roach ES, Strouse JJ, Kwiatkowski JL, Hirtz D, DeBaun MR
JAMA Neurol. 2013 Jan; 70(1)58-65. doi: 10.1001/jamaneurol.2013.576.

PMID:
    23108767
    [PubMed - indexed for MEDLINE]
Related citations


Adaptive prior probability and spatial temporal intensity change estimation for segmentation of the one-year-old human brain.
Kim SH, Fonov VS, Dietrich C, Vachet C, Hazlett HC, Smith RG, Graves MM, Piven J, Gilmore JH, Dager SR, McKinstry RC, Paterson S, Evans AC, Collins DL, Gerig G, Styner MA, IBIS network
J Neurosci Methods. 2013 Jan 15; 212(1)43-55. doi: 10.1016/j.jneumeth.2012.09.018.

PMID:
    23032117
    [PubMed - indexed for MEDLINE]
Related citations


Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia.
Thangarajh M, Yang G, Fuchs D, Ponisio MR, McKinstry RC, Jaju A, Noetzel MJ, Casella JF, Barron-Casella E, Hooper WC, Boulet SL, Bean CJ, Pyle ME, Payne AB, Driggers J, Trau HA, Vendt BA, Rodeghier M, DeBaun MR
Br J Haematol. 2012 Nov; 159(3)352-9. doi: 10.1111/bjh.12034.

PMID:
    22958163
    [PubMed - indexed for MEDLINE]
Related citations


Diffusion tensor imaging properties and neurobehavioral outcomes in children with hydrocephalus.
Yuan W, McKinstry RC, Shimony JS, Altaye M, Powell SK, Phillips JM, Limbrick DD Jr, Holland SK, Jones BV, Rajagopal A, Simpson S, Mercer D, Mangano FT
AJNR Am J Neuroradiol. 2013 Feb; 34(2)439-45. doi: 10.3174/ajnr.A3218.

PMID:
    22899790
    [PubMed - indexed for MEDLINE]
Related citations


Developmental changes in organization of structural brain networks.
Khundrakpam BS, Reid A, Brauer J, Carbonell F, Lewis J, Ameis S, Karama S, Lee J, Chen Z, Das S, Evans AC, Brain Development Cooperative Group
Cereb Cortex. 2013 Sep; 23(9)2072-85. doi: 10.1093/cercor/bhs187.

PMID:
    22784607
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2014.

Company Name: Siemans

Royalties:

Equity: No

Consulting/Advisory Board: $10,001 - $25,000

Speaker Fees:

Reporting Date: May 01, 2015