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Richard Samuel Hotchkiss, MD

Professor of Anesthesiology, Medicine, Surgery, Molecular Biology and Pharmacology

Specialty Areas

Board Certifications

Anesthesiology
Critical Care Anesthesia
Internal Medicine

  • Education
  • Publication & Research

Education

Education

Residency: Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 1984
Fellowship: Respiratory Intensive Care, Massachusetts General Hospital, Boston, Massachusetts 1981
Fellowship: Intensive Care, University of Virginia, Charlottesville, Virginia 1980
Residency: Emory University School of Medicine, Atlanta, Georgia 1979
M.D.: University of Virginia, Charlottesville, Virginia 1976
B.A.: University of Virginia, Charlottesville, Virginia 1972

Publication & Research

Publication & Research

Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
Gaudilliere B, Angst MS, Hotchkiss RS
Crit Care Med. 2017 Sep; 45(9)1577-1578. doi: 10.1097/CCM.0000000000002594.

PMID:
    28816846
    [PubMed - in process]
Related citations


Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.
Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH
Ann Emerg Med. 2017 Sep; 70(3)406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013.

PMID:
    28259481
    [PubMed - in process]
Related citations


A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.
Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH
Crit Care Med. 2017 Apr; 45(4)645-652. doi: 10.1097/CCM.0000000000002268.

PMID:
    28157140
    [PubMed - indexed for MEDLINE]
Related citations


Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers. 2016 Jun 30; 216045. doi: 10.1038/nrdp.2016.45.

PMID:
    28117397
    [PubMed - in process]
Related citations


Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.
Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL
Crit Care Med. 2017 Mar; 45(3)407-414. doi: 10.1097/CCM.0000000000002207.

PMID:
    28067713
    [PubMed - indexed for MEDLINE]
Related citations


Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.
Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL
Lancet Infect Dis. 2017 Jan; 17(1)18. doi: 10.1016/S1473-3099(16)30541-2.

PMID:
    27998559
    [PubMed - in process]
Related citations


Anti-PD-L1 peptide improves survival in sepsis.
Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS
J Surg Res. 2017 Feb; 20833-39. doi: 10.1016/j.jss.2016.08.099.

PMID:
    27993215
    [PubMed - indexed for MEDLINE]
Related citations


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.
Crouser ED, Hotchkiss RS
Crit Care Med. 2017 Jan; 45(1)145-147.

PMID:
    27984288
    [PubMed - in process]
Related citations


Sepsis: Preventing organ failure in sepsis - the search continues.
Graetz TJ, Hotchkiss RS
Nat Rev Nephrol. 2017 Jan; 13(1)5-6. doi: 10.1038/nrneph.2016.171.

PMID:
    27867191
    [PubMed - in process]
Related citations


Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.
Drewry AM, Ablordeppey EA, Murray ET, Beiter ER, Walton AH, Hall MW, Hotchkiss RS
Crit Care. 2016 Oct 20; 20(1)334. doi: 10.1186/s13054-016-1505-0.

PMID:
    27760554
    [PubMed - in process]
Related citations


Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice.
Doerflinger M, Glab J, Nedeva C, Jose I, Lin A, O'Reilly L, Allison C, Pellegrini M, Hotchkiss RS, Puthalakath H
Sci Rep. 2016 Oct 3; 634702. doi: 10.1038/srep34702.

PMID:
    27694827
    [PubMed - in process]
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Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.
Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS
J Leukoc Biol. 2016 Dec; 100(6)1239-1254.

PMID:
    27671246
    [PubMed - indexed for MEDLINE]
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Understanding host-pathogen interaction.
Asehnoune K, Villadangos J, Hotchkiss RS
Intensive Care Med. 2016 Dec; 42(12)2084-2086.

PMID:
    27665508
    [PubMed - in process]
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Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia.
Shindo Y, Fuchs AG, Davis CG, Eitas T, Unsinger J, Burnham CD, Green JM, Morre M, Bochicchio GV, Hotchkiss RS
J Leukoc Biol. 2017 Feb; 101(2)543-554. doi: 10.1189/jlb.4A1215-581R.

PMID:
    27630218
    [PubMed - indexed for MEDLINE]
Related citations


Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients.
Santos CA, Hotchkiss RS, Chapman WC, Olsen MA
Transplant Direct. 2016 Mar; 2(3)e67. doi: 10.1097/TXD.0000000000000573.

PMID:
    27458606
    [PubMed]
Related citations


Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications.
Fuller BM, Ferguson I, Mohr NM, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH
BMJ Open. 2016 Apr 11; 6(4)e010991. doi: 10.1136/bmjopen-2015-010991.

PMID:
    27067896
    [PubMed - indexed for MEDLINE]
Related citations


Understanding why clinicians should care about danger-associated molecular patterns.
Asehnoune K, Hotchkiss RS, Monneret G
Intensive Care Med. 2016 Apr; 42(4)611-614. doi: 10.1007/s00134-015-4198-y.

PMID:
    26912314
    [PubMed]
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC
JAMA. 2016 Feb 23; 315(8)801-10. doi: 10.1001/jama.2016.0287.

PMID:
    26903338
    [PubMed - indexed for MEDLINE]
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Erratum to: Is this critically ill patient immunocompromised?
Pène F, Pickkers P, Hotchkiss RS
Intensive Care Med. 2016 Jun; 42(6)1106.

PMID:
    26820879
    [PubMed - as supplied by publisher]
Related citations


T cells from patients with Candida sepsis display a suppressive immunophenotype.
Spec A, Shindo Y, Burnham CA, Wilson S, Ablordeppey EA, Beiter ER, Chang K, Drewry AM, Hotchkiss RS
Crit Care. 2016 Jan 20; 2015. doi: 10.1186/s13054-016-1182-z.

PMID:
    26786705
    [PubMed - indexed for MEDLINE]
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