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Richard Samuel Hotchkiss, MD

Professor of Anesthesiology, Medicine, Surgery, Molecular Biology and Pharmacology

Specialty Areas

Board Certifications

Anesthesiology
Critical Care Anesthesia
Internal Medicine

  • Education
  • Publication & Research

Education

Education

Residency: Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 1984
Fellowship: Respiratory Intensive Care, Massachusetts General Hospital, Boston, Massachusetts 1981
Fellowship: Intensive Care, University of Virginia, Charlottesville, Virginia 1980
Residency: Emory University School of Medicine, Atlanta, Georgia 1979
M.D.: University of Virginia, Charlottesville, Virginia 1976
B.A.: University of Virginia, Charlottesville, Virginia 1972

Publication & Research

Publication & Research

T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer.
Washburn ML, Wang Z, Walton AH, Goedegebuure SP, Figueroa DJ, Van Horn S, Grossman J, Remlinger K, Madsen H, Brown J, Srinivasan R, Wolf AI, Berger SB, Yi VN, Hawkins WG, Fields RC, Hotchkiss RS
J Immunol. 2019 Sep 4; pii: ji1900560. doi: 10.4049/jimmunol.1900560.

PMID:
    31484735
    [PubMed - as supplied by publisher]
Related citations


The authors reply.
Hotchkiss RS, Yende S, Angus DC, Moldawer LL, Crouser E, Martin G, Coopersmith CM, Brakenridge S, Mayr FB, Park PK
Crit Care Med. 2019 Sep; 47(9)e788-e789. doi: 10.1097/CCM.0000000000003887.

PMID:
    31415323
    [PubMed - in process]
Related citations


The Association of Fever and Antipyretic Medication With Outcomes in Mechanically Ventilated Patients: A Cohort Study.
Evans EM, Doctor RJ, Gage BF, Hotchkiss RS, Fuller BM, Drewry AM
Shock. 2019 Aug; 52(2)152-159. doi: 10.1097/SHK.0000000000001368.

PMID:
    31058720
    [PubMed - in process]
Related citations


What Is the Skinny on Obesity During Sepsis?
Crouser ED, Caldwell CC, Hotchkiss RS
Crit Care Med. 2019 May; 47(5)735-736. doi: 10.1097/CCM.0000000000003707.

PMID:
    30985458
    [PubMed - in process]
Related citations


An Aspirin a Day Keeps the Intensivist Away?
Turnbull IR, Hotchkiss RS
Crit Care Med. 2019 Apr; 47(4)603-604. doi: 10.1097/CCM.0000000000003672.

PMID:
    30882429
    [PubMed - in process]
Related citations


Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).
Hotchkiss RS, Colston E, Yende S, Angus DC, Moldawer LL, Crouser ED, Martin GS, Coopersmith CM, Brakenridge S, Mayr FB, Park PK, Ye J, Catlett IM, Girgis IG, Grasela DM
Crit Care Med. 2019 May; 47(5)632-642. doi: 10.1097/CCM.0000000000003685.

PMID:
    30747773
    [PubMed - in process]
Related citations


Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike.
Watanabe E, Thampy LK, Hotchkiss RS
Acute Med Surg. 2018 Oct; 5(4)309-315. doi: 10.1002/ams2.363.

PMID:
    30338075
    [PubMed]
Related citations


Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.
Thampy LK, Remy KE, Walton AH, Hong Z, Liu K, Liu R, Yi V, Burnham CD, Hotchkiss RS
PLoS One. 2018; 13(6)e0199497. doi: 10.1371/journal.pone.0199497.

PMID:
    29944697
    [PubMed - indexed for MEDLINE]
Related citations


Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.
Francois B, Jeannet R, Daix T, Walton AH, Shotwell MS, Unsinger J, Monneret G, Rimmelé T, Blood T, Morre M, Gregoire A, Mayo GA, Blood J, Durum SK, Sherwood ER, Hotchkiss RS
JCI Insight. 2018 Mar 8; 3(5)pii: 98960. doi: 10.1172/jci.insight.98960.

PMID:
    29515037
    [PubMed - in process]
Related citations


Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis.
Drewry AM, Ablordeppey EA, Murray ET, Dalton CM, Fuller BM, Kollef MH, Hotchkiss RS
Shock. 2018 Oct; 50(4)381-387. doi: 10.1097/SHK.0000000000001083.

PMID:
    29240644
    [PubMed - in process]
Related citations


Host-directed therapies for bacterial and viral infections.
Kaufmann SHE, Dorhoi A, Hotchkiss RS, Bartenschlager R
Nat Rev Drug Discov. 2018 Jan; 17(1)35-56. doi: 10.1038/nrd.2017.162.

PMID:
    28935918
    [PubMed - indexed for MEDLINE]
Related citations


Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!
Gaudilliere B, Angst MS, Hotchkiss RS
Crit Care Med. 2017 Sep; 45(9)1577-1578. doi: 10.1097/CCM.0000000000002594.

PMID:
    28816846
    [PubMed - indexed for MEDLINE]
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Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.
Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH
Ann Emerg Med. 2017 Sep; 70(3)406-418.e4. doi: 10.1016/j.annemergmed.2017.01.013.

PMID:
    28259481
    [PubMed - indexed for MEDLINE]
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A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.
Fuller BM, Ferguson IT, Mohr NM, Drewry AM, Palmer C, Wessman BT, Ablordeppey E, Keeperman J, Stephens RJ, Briscoe CC, Kolomiets AA, Hotchkiss RS, Kollef MH
Crit Care Med. 2017 Apr; 45(4)645-652. doi: 10.1097/CCM.0000000000002268.

PMID:
    28157140
    [PubMed - indexed for MEDLINE]
Related citations


Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers. 2016 Jun 30; 216045. doi: 10.1038/nrdp.2016.45.

PMID:
    28117397
    [PubMed - indexed for MEDLINE]
Related citations


Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis.
Matkovich SJ, Al Khiami B, Efimov IR, Evans S, Vader J, Jain A, Brownstein BH, Hotchkiss RS, Mann DL
Crit Care Med. 2017 Mar; 45(3)407-414. doi: 10.1097/CCM.0000000000002207.

PMID:
    28067713
    [PubMed - indexed for MEDLINE]
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Nivolumab plus interferon-γ in the treatment of intractable mucormycosis.
Grimaldi D, Pradier O, Hotchkiss RS, Vincent JL
Lancet Infect Dis. 2017 Jan; 17(1)18. doi: 10.1016/S1473-3099(16)30541-2.

PMID:
    27998559
    [PubMed - indexed for MEDLINE]
Related citations


Anti-PD-L1 peptide improves survival in sepsis.
Shindo Y, McDonough JS, Chang KC, Ramachandra M, Sasikumar PG, Hotchkiss RS
J Surg Res. 2017 Feb; 20833-39. doi: 10.1016/j.jss.2016.08.099.

PMID:
    27993215
    [PubMed - indexed for MEDLINE]
Related citations


Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis.
Crouser ED, Hotchkiss RS
Crit Care Med. 2017 Jan; 45(1)145-147.

PMID:
    27984288
    [PubMed - indexed for MEDLINE]
Related citations


Sepsis: Preventing organ failure in sepsis - the search continues.
Graetz TJ, Hotchkiss RS
Nat Rev Nephrol. 2017 Jan; 13(1)5-6. doi: 10.1038/nrneph.2016.171.

PMID:
    27867191
    [PubMed - indexed for MEDLINE]
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