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Regis James O'Keefe, MD, PhD

Professor, Orthopedic Surgery
Chairman, Department of Orthopedic Surgery

Specialty Areas

Orthopedics
Musculoskeletal Oncology
Knee Reconstructive Surgery - Adult

Board Certifications

Orthopedic Surgery

Hospital Affiliations

St. Louis Children's Hospital
Shriners Hospital for Children - St. Louis
Barnes-Jewish Hospital

Areas of Clinical Interest

Benign and malignant bone tumors, soft (connective) tissue tumors, infection, skeletal reconstruction

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Orthopedic Surgery Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-514-3500

Suite: A
Floor: 6
Office Phone: (314) 514-3500

Education

Education

Residency, Orthopeadics: University of Rochester School of Medicine and Dentistry, Rochester, NY 1992
Fellowship, Orthopaedic Oncology: Massachusetts General Hospital, Boston, MA 1993
Bachelor of Arts: Yale University, New Haven, CT 1981
Fellowship (research), Orthopaedic Research Laboratories: University of Rochester School of Medicine and Dentistry, Rochester, NY 1988
Medical Degree: Harvard Medical School, Boston, MA 1985
PhD, Biochemistry and Biophysics: University of Rochester School of Medicine and Dentistry, Rochester, NY 2000

Publication & Research

Publication & Research

Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.
Wang C, Abu-Amer Y, O'Keefe RJ, Shen J
J Bone Miner Res. 2017 Oct 10; doi: 10.1002/jbmr.3305.

PMID:
    29024060
    [PubMed - as supplied by publisher]
Related citations


Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.
Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE
Sci Rep. 2017 Aug 17; 7(1)8658. doi: 10.1038/s41598-017-09407-7.

PMID:
    28819185
    [PubMed - in process]
Related citations


DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ
JCI Insight. 2017 Jun 15; 2(12)pii: 93612. doi: 10.1172/jci.insight.93612.

PMID:
    28614801
    [PubMed - as supplied by publisher]
Related citations


PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.
Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ
J Cell Biochem. 2017 Dec; 118(12)4383-4393. doi: 10.1002/jcb.26092.

PMID:
    28444901
    [PubMed - indexed for MEDLINE]
Related citations


Inflammation and epigenetic regulation in osteoarthritis.
Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A
Connect Tissue Res. 2017 Jan; 58(1)49-63. doi: 10.1080/03008207.2016.1208655.

PMID:
    27389927
    [PubMed - indexed for MEDLINE]
Related citations


BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling.
Zhang Y, O'Keefe RJ, Jonason JH
J Cell Biochem. 2017 Jan; 118(1)204-210. doi: 10.1002/jcb.25626.

PMID:
    27293199
    [PubMed - indexed for MEDLINE]
Related citations


NOTCH signaling in skeletal progenitors is critical for fracture repair.
Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ
J Clin Invest. 2016 Apr 1; 126(4)1471-81. doi: 10.1172/JCI80672.

PMID:
    26950423
    [PubMed - indexed for MEDLINE]
Related citations


Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing.
Orner CA, Geary MB, Hammert WC, O'Keefe RJ, Loiselle AE
Plast Reconstr Surg. 2016 Mar; 137(3)545e-553e. doi: 10.1097/01.prs.0000475823.01907.53.

PMID:
    26910699
    [PubMed - indexed for MEDLINE]
Related citations


Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.
Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ
Bone Res. 2015; 315021. doi: 10.1038/boneres.2015.21.

PMID:
    26558140
    [PubMed]
Related citations


Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.
Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ
Osteoarthritis Cartilage. 2016 Apr; 24(4)740-51. doi: 10.1016/j.joca.2015.10.015.

PMID:
    26522700
    [PubMed - indexed for MEDLINE]
Related citations


Fibrinolysis as a Target to Enhance Fracture Healing.
O'Keefe RJ
N Engl J Med. 2015 Oct 29; 373(18)1776-8. doi: 10.1056/NEJMcibr1510090.

PMID:
    26510027
    [PubMed - indexed for MEDLINE]
Related citations


Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis.
Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W
J Bone Oncol. 2015 Sep; 4(3)69-76.

PMID:
    26478857
    [PubMed]
Related citations


CCN1 Regulates Chondrocyte Maturation and Cartilage Development.
Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ
J Bone Miner Res. 2016 Mar; 31(3)549-59. doi: 10.1002/jbmr.2712.

PMID:
    26363286
    [PubMed - indexed for MEDLINE]
Related citations


Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.
Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE
PLoS One. 2015; 10(8)e0136351. doi: 10.1371/journal.pone.0136351.

PMID:
    26312751
    [PubMed - indexed for MEDLINE]
Related citations


Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses.
Chimenti PC, Drinkwater CJ, Li W, Lemay CA, Franklin PD, O'Keefe RJ
J Arthroplasty. 2016 Jan; 31(1)176-9. doi: 10.1016/j.arth.2015.07.028.

PMID:
    26276572
    [PubMed - indexed for MEDLINE]
Related citations


A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ
Sci Signal. 2015 Jul 21; 8(386)ra71. doi: 10.1126/scisignal.aaa3792.

PMID:
    26198357
    [PubMed - indexed for MEDLINE]
Related citations


Demonstrating the value of orthopaedic surgery through multicenter trials: AOA critical issues.
Hilibrand AS, Spindler K, O'Keefe RJ
J Bone Joint Surg Am. 2015 Apr 1; 97(7)e35. doi: 10.2106/JBJS.N.00159.

PMID:
    25834087
    [PubMed - indexed for MEDLINE]
Related citations


Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair.
Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ
J Orthop Res. 2015 Jun; 33(6)859-66. doi: 10.1002/jor.22890.

PMID:
    25761254
    [PubMed - indexed for MEDLINE]
Related citations


How do you know it is true? Integrity in research and publications: AOA critical issues.
Buckwalter JA, Tolo VT, O'Keefe RJ
J Bone Joint Surg Am. 2015 Jan 7; 97(1)e2. doi: 10.2106/JBJS.N.00245.

PMID:
    25568400
    [PubMed - indexed for MEDLINE]
Related citations


Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.
Wang C, Shen J, Yukata K, Inzana JA, O'Keefe RJ, Awad HA, Hilton MJ
Bone. 2015 Apr; 7377-89. doi: 10.1016/j.bone.2014.12.007.

PMID:
    25527421
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Cartilage research, bone repair, skeletal development, cancer, inflammatory diseases of bone.