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Regis James O'Keefe, MD, PhD

Fred C. Reynolds Professor of Orthopaedic Surgery
Chairman, Department of Orthopedic Surgery

Specialty Areas

Orthopedics
Musculoskeletal Oncology
Knee Reconstructive Surgery - Adult

Board Certifications

Orthopedic Surgery

Hospital Affiliations

St. Louis Children's Hospital
Shriners Hospital for Children - St. Louis
Barnes-Jewish Hospital

Areas of Clinical Interest

Benign and malignant bone tumors, soft (connective) tissue tumors, infection, skeletal reconstruction

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Orthopedic Surgery Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-514-3500

Suite: A
Floor: 6
Office Phone: (314) 514-3500

Education

Education

Residency, Orthopeadics: University of Rochester School of Medicine and Dentistry, Rochester, NY 1992
Fellowship, Orthopaedic Oncology: Massachusetts General Hospital, Boston, MA 1993
Bachelor of Arts: Yale University, New Haven, CT 1981
Fellowship (research), Orthopaedic Research Laboratories: University of Rochester School of Medicine and Dentistry, Rochester, NY 1988
Medical Degree: Harvard Medical School, Boston, MA 1985
PhD, Biochemistry and Biophysics: University of Rochester School of Medicine and Dentistry, Rochester, NY 2000

Publication & Research

Publication & Research

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.
O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R
J Orthop Res. 2020 Mar; 38(3)485-502. doi: 10.1002/jor.24485.

PMID:
    31994782
    [PubMed - in process]
Related citations


RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.
Duan X, Cai L, Schmidt EJ, Shen J, Tycksen ED, O'Keefe RJ, Cheverud JM, Rai MF
Osteoarthritis Cartilage. 2020 Jan 14; pii: S1063-4584(20)30006-6. doi: 10.1016/j.joca.2020.01.001.

PMID:
    31945456
    [PubMed - as supplied by publisher]
Related citations


Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population.
Ploetze KL, Dalton JF, Calfee RP, McDonald DJ, O'Keefe RJ, Cipriano CA
J Orthop Translat. 2019 Oct; 19143-150. doi: 10.1016/j.jot.2019.02.004.

PMID:
    31844622
    [PubMed]
Related citations


Letter to the Editor: Not the Last Word: Prizes for Cures.
O'Keefe RJ
Clin Orthop Relat Res. 2019 Dec; 477(12)2804-2805. doi: 10.1097/CORR.0000000000001027.

PMID:
    31764354
    [PubMed - in process]
Related citations


American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.
O'Keefe RJ, Tuan RS, Lane NE, Awad HA, Barry F, Bunnell BA, Colnot C, Drake MT, Drissi H, Dyment NA, Fortier LA, Guldberg RE, Kandel R, Little DG, Marshall MF, Mao JJ, Nakamura N, Proffen BL, Rodeo SA, Rosen V, Thomopoulos S, Schwarz EM, Serra R
J Bone Miner Res. 2020 Jan; 35(1)3-17. doi: 10.1002/jbmr.3839.

PMID:
    31545883
    [PubMed - in process]
Related citations


Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Shen J, Wang C, Ying J, Xu T, McAlinden A, O'Keefe RJ
JCI Insight. 2019 Sep 19; 4(18)pii: 128568. doi: 10.1172/jci.insight.128568.

PMID:
    31534049
    [PubMed - in process]
Related citations


Peripheral Blood Stem Cell Therapy Does Not Improve Outcomes of Femoral Head Osteonecrosis With Cap-Shaped Separated Cartilage Defect.
Ying J, Wang P, Ding Q, Shen J, O'Keefe RJ, Chen D, Tong P, Jin H
J Orthop Res. 2020 Feb; 38(2)269-276. doi: 10.1002/jor.24471.

PMID:
    31520480
    [PubMed - in process]
Related citations


Variation in the Delivery of Inpatient Orthopaedic Care to Medicaid Beneficiaries within a Single Metropolitan Region.
Dy CJ, Tipping AD, Nickel KB, Jiang W, O'Keefe RJ, Olsen MA
J Bone Joint Surg Am. 2019 Aug 21; 101(16)1451-1459. doi: 10.2106/JBJS.18.01198.

PMID:
    31436652
    [PubMed - indexed for MEDLINE]
Related citations


Embracing Differences to Improve Success: American Orthopaedic Association Presidential Address, Boston, Massachusetts, June 23, 2017: AOA Critical Issues.
O'Keefe RJ
J Bone Joint Surg Am. 2019 May 1; 101(9)e37. doi: 10.2106/JBJS.19.00023.

PMID:
    31045676
    [PubMed - indexed for MEDLINE]
Related citations


Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair.
Feigenson M, Jonason JH, Shen J, Loiselle AE, Awad HA, O'Keefe RJ
Ann Biomed Eng. 2020 Mar; 48(3)927-939. doi: 10.1007/s10439-019-02264-7.

PMID:
    30980293
    [PubMed - in process]
Related citations


Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.
Zhou Y, Chen M, O'Keefe RJ, Shen J, Li Z, Zhou J, Zhou X, Mao JJ
Am J Transl Res. 2019; 11(3)1736-1747.

PMID:
    30972197
    [PubMed]
Related citations


Treatment of intra-articular hip malignancy with extra-articular resection, preservation of the acetabular columns, and total hip arthroplasty.
Wells JE, Clohisy JC, O'Keefe RJ
Arthroplast Today. 2018 Dec; 4(4)431-435. doi: 10.1016/j.artd.2018.07.007.

PMID:
    30560171
    [PubMed]
Related citations


Safety of Overlapping Inpatient Orthopaedic Surgery: A Multicenter Study.
Dy CJ, Osei DA, Maak TG, Gottschalk MB, Zhang AL, Maloney MD, Presson AP, O'Keefe RJ
J Bone Joint Surg Am. 2018 Nov 21; 100(22)1902-1911. doi: 10.2106/JBJS.17.01625.

PMID:
    30480594
    [PubMed - indexed for MEDLINE]
Related citations


Scholarly Success of Orthopaedic Surgeons Participating in the Clinician Scholar Career Development Program.
Bernstein DN, Lawson M, Menga EN, O'Keefe RJ, Rubery PT, Mesfin A
J Bone Joint Surg Am. 2018 Sep 5; 100(17)e115. doi: 10.2106/JBJS.17.01605.

PMID:
    30180065
    [PubMed - indexed for MEDLINE]
Related citations


Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis.
Wang C, Silverman RM, Shen J, O'Keefe RJ
J Orthop Translat. 2018 Jan; 1266-73. doi: 10.1016/j.jot.2017.12.004.

PMID:
    29662780
    [PubMed]
Related citations


Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates.
Ding Q, Ren Y, Che H, Ma C, Li H, Yu S, Zhang Y, An H, O'Keefe RJ, Chen D, Block JA, Yin G, Li T
Am J Transl Res. 2018; 10(3)718-730.

PMID:
    29636862
    [PubMed]
Related citations


Teriparatide (human PTH<sub>1-34</sub>) compensates for impaired fracture healing in COX-2 deficient mice.
Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ
Bone. 2018 May; 110150-159. doi: 10.1016/j.bone.2018.02.001.

PMID:
    29408411
    [PubMed - indexed for MEDLINE]
Related citations


Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.
Wang C, Abu-Amer Y, O'Keefe RJ, Shen J
J Bone Miner Res. 2018 Feb; 33(2)283-297. doi: 10.1002/jbmr.3305.

PMID:
    29024060
    [PubMed - indexed for MEDLINE]
Related citations


Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.
Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE
Sci Rep. 2017 Aug 17; 7(1)8658. doi: 10.1038/s41598-017-09407-7.

PMID:
    28819185
    [PubMed - indexed for MEDLINE]
Related citations


DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.
Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ
JCI Insight. 2017 Jun 15; 2(12)pii: 93612. doi: 10.1172/jci.insight.93612.

PMID:
    28614801
    [PubMed]
Related citations

Areas of Research Interest

Cartilage research, bone repair, skeletal development, cancer, inflammatory diseases of bone.