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Rebecca L. Aft, MD, PhD

Professor, Surgery
Division of General Surgery
Cancer and Endocrine Surgery Section

Specialty Areas

Breast Oncology
Oncologic Surgery
Sarcoma
Melanoma
Endocrine/Cancer Surgery
Breast Health
Breast Surgery

Board Certifications

General Surgery

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital
VA Medical Center - St. Louis - John Cochran Division

Areas of Clinical Interest

breast disease, breast cancer, oncology, general surgery,  endocrine cancer, melanoma surgery, sarcoma

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Breast Health Center

4921 Parkview Place
St. Louis, MO 63110

Suite: F
Floor: 5
Office Phone: 314-362-2280
Fax: 314-454-5509

Education

Education

Medical Degree: Washington University School of Medicine, St. Louis, MO 1992
Ph.D.: University of Wisconsin, Madison, Wisconsin 1983
B.S.: University of Wisconsin, Madison, Wisconsin 1978

Publication & Research

Publication & Research

Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy.
Wong TTW, Zhang R, Hai P, Zhang C, Pleitez MA, Aft RL, Novack DV, Wang LV
Sci Adv. 2017 May; 3(5)e1602168. doi: 10.1126/sciadv.1602168.

PMID:
    28560329
    [PubMed - in process]
Related citations


Cost Analysis of a Surgical Consensus Guideline in Breast-Conserving Surgery.
Yu J, Elmore LC, Cyr AE, Aft RL, Gillanders WE, Margenthaler JA
J Am Coll Surg. 2017 Apr 14; pii: S1072-7515(17)30369-1. doi: 10.1016/j.jamcollsurg.2017.03.020.

PMID:
    28414115
    [PubMed - as supplied by publisher]
Related citations


Enrichment and Molecular Analysis of Breast Cancer Disseminated Tumor Cells from Bone Marrow Using Microfiltration.
Pillai SG, Zhu P, Siddappa CM, Adams DL, Li S, Makarova OV, Amstutz P, Nunley R, Tang CM, Watson MA, Aft RL
PLoS One. 2017; 12(1)e0170761. doi: 10.1371/journal.pone.0170761.

PMID:
    28129357
    [PubMed - in process]
Related citations


Uneventful versus Successful Reconstruction and Outcome Pathways in Implant-Based Breast Reconstruction with Acellular Dermal Matrices.
Qureshi AA, Broderick KP, Belz J, Funk S, Reaven N, Brandt KE, Tenenbaum MM, Margenthaler JA, Aft RL, Myckatyn TM
Plast Reconstr Surg. 2016 Aug; 138(2)173e-83e. doi: 10.1097/PRS.0000000000002402.

PMID:
    27465177
    [PubMed - indexed for MEDLINE]
Related citations


Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound.
Cyr AE, Tucker N, Ademuyiwa F, Margenthaler JA, Aft RL, Eberlein TJ, Appleton CM, Zoberi I, Thomas MA, Gao F, Gillanders WE
J Am Coll Surg. 2016 Aug; 223(2)399-407. doi: 10.1016/j.jamcollsurg.2016.04.048.

PMID:
    27212005
    [PubMed - in process]
Related citations


Effects of neoadjuvant chemotherapy with or without zoledronic acid on pathological response: A meta-analysis of randomised trials.
Kroep JR, Charehbili A, Coleman RE, Aft RL, Hasegawa Y, Winter MC, Weilbaecher K, Akazawa K, Hinsley S, Putter H, Liefers GJ, Nortier JWR, Kohno N
Eur J Cancer. 2016 Feb; 5457-63. doi: 10.1016/j.ejca.2015.10.011.

PMID:
    26722766
    [PubMed - indexed for MEDLINE]
Related citations


Lymphovascular space invasion and lack of downstaging after neoadjuvant chemotherapy are strong predictors of adverse outcome in young women with locally advanced breast cancer.
Khwaja SS, Ivanovich J, DeWees TA, Ochoa L, Mullen DF, Thomas M, Margenthaler JA, Cyr A, Naughton M, Sanati S, Eberlein TJ, Gillanders WE, Aft RL, Zoberi JE, Zoberi I
Cancer Med. 2016 Feb; 5(2)230-8. doi: 10.1002/cam4.586.

PMID:
    26687192
    [PubMed - indexed for MEDLINE]
Related citations


CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer.
Xiang J, Hurchla MA, Fontana F, Su X, Amend SR, Esser AK, Douglas GJ, Mudalagiriyappa C, Luker KE, Pluard T, Ademuyiwa FO, Romagnoli B, Tuffin G, Chevalier E, Luker GD, Bauer M, Zimmermann J, Aft RL, Dembowsky K, Weilbaecher KN
Mol Cancer Ther. 2015 Nov; 14(11)2473-85. doi: 10.1158/1535-7163.MCT-15-0252.

PMID:
    26269605
    [PubMed - indexed for MEDLINE]
Related citations


US breast cancer mortality trends in young women according to race.
Ademuyiwa FO, Gao F, Hao L, Morgensztern D, Aft RL, Ma CX, Ellis MJ
Cancer. 2015 May 1; 121(9)1469-76. doi: 10.1002/cncr.29178.

PMID:
    25483625
    [PubMed - indexed for MEDLINE]
Related citations


IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity.
Carreno BM, Becker-Hapak M, Huang A, Chan M, Alyasiry A, Lie WR, Aft RL, Cornelius LA, Trinkaus KM, Linette GP
J Clin Invest. 2013 Aug; 123(8)3383-94. doi: 10.1172/JCI68395.

PMID:
    23867552
    [PubMed - indexed for MEDLINE]
Related citations


Assessment of cellular proliferation in tumors by PET using 18F-ISO-1.
Dehdashti F, Laforest R, Gao F, Shoghi KI, Aft RL, Nussenbaum B, Kreisel FH, Bartlett NL, Cashen A, Wagner-Johnston N, Mach RH
J Nucl Med. 2013 Mar; 54(3)350-7. doi: 10.2967/jnumed.112.111948.

PMID:
    23359657
    [PubMed - indexed for MEDLINE]
Related citations


Disease recurrence in sentinel node-positive breast cancer patients forgoing axillary lymph node dissection.
Cyr A, Gao F, Gillanders WE, Aft RL, Eberlein TJ, Margenthaler JA
Ann Surg Oncol. 2012 Oct; 19(10)3185-91. doi: 10.1245/s10434-012-2547-4.

PMID:
    22890591
    [PubMed - indexed for MEDLINE]
Related citations


Effect of (Neo)adjuvant zoledronic acid on disease-free and overall survival in clinical stage II/III breast cancer.
Aft RL, Naughton M, Trinkaus K, Weilbaecher K
Br J Cancer. 2012 Jun 26; 107(1)7-11. doi: 10.1038/bjc.2012.210.

PMID:
    22617128
    [PubMed - indexed for MEDLINE]
Related citations


Compromised margins following mastectomy for stage I-III invasive breast cancer.
Yu J, Al Mushawah F, Taylor ME, Cyr AE, Gillanders WE, Aft RL, Eberlein TJ, Gao F, Margenthaler JA
J Surg Res. 2012 Sep; 177(1)102-8. doi: 10.1016/j.jss.2012.03.046.

PMID:
    22520579
    [PubMed - indexed for MEDLINE]
Related citations


Positive margin rates following breast-conserving surgery for stage I-III breast cancer: palpable versus nonpalpable tumors.
Atkins J, Al Mushawah F, Appleton CM, Cyr AE, Gillanders WE, Aft RL, Eberlein TJ, Gao F, Margenthaler JA
J Surg Res. 2012 Sep; 177(1)109-15. doi: 10.1016/j.jss.2012.03.045.

PMID:
    22516344
    [PubMed - indexed for MEDLINE]
Related citations


Quality of life over time in women diagnosed with ductal carcinoma in situ, early-stage invasive breast cancer, and age-matched controls.
Jeffe DB, Pérez M, Liu Y, Collins KK, Aft RL, Schootman M
Breast Cancer Res Treat. 2012 Jul; 134(1)379-91. doi: 10.1007/s10549-012-2048-y.

PMID:
    22484800
    [PubMed - indexed for MEDLINE]
Related citations


Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models.
Ma CX, Cai S, Li S, Ryan CE, Guo Z, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, Aft RL, Ellis MJ, Piwnica-Worms H
J Clin Invest. 2012 Apr; 122(4)1541-52. doi: 10.1172/JCI58765.

PMID:
    22446188
    [PubMed - indexed for MEDLINE]
Related citations


Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione.
Dehdashti F, Laforest R, Gao F, Aft RL, Dence CS, Zhou D, Shoghi KI, Siegel BA, Katzenellenbogen JA, Welch MJ
J Nucl Med. 2012 Mar; 53(3)363-70. doi: 10.2967/jnumed.111.098319.

PMID:
    22331216
    [PubMed - indexed for MEDLINE]
Related citations


Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence.
Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD
Mol Cancer Res. 2011 Dec; 9(12)1644-57. doi: 10.1158/1541-7786.MCR-11-0371.

PMID:
    22006115
    [PubMed - indexed for MEDLINE]
Related citations


Neoadjuvant chemotherapy is associated with improved survival compared with adjuvant chemotherapy in patients with triple-negative breast cancer only after complete pathologic response.
Fisher CS, Ma CX, Gillanders WE, Aft RL, Eberlein TJ, Gao F, Margenthaler JA
Ann Surg Oncol. 2012 Jan; 19(1)253-8. doi: 10.1245/s10434-011-1877-y.

PMID:
    21725686
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

breast disease, breast cancer, oncology