Patient Portal

Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Dominantly Inherited Alzheimer Network (DIAN)., Salloway S, Masters CL, Lee JH, Graff-Radford NR, Chhatwal JP, Bateman RJ, Morris JC, Karch CM, Harari O, Cruchaga C
Nat Neurosci. 2019 Nov; 22(11)1903-1912. doi: 10.1038/s41593-019-0501-5.

PMID:
    31591557
    [PubMed - in process]
Related citations


Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease.
Wang G, Aschenbrenner AJ, Li Y, McDade E, Liu L, Benzinger TLS, Bateman RJ, Morris JC, Hassenstab JJ, Xiong C
Alzheimers Dement (N Y). 2019; 5450-457. doi: 10.1016/j.trci.2019.07.007.

PMID:
    31517032
    [PubMed]
Related citations


A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.
Xiong C, Luo J, Agboola F, Li Y, Albert M, Johnson SC, Koscik RL, Masters CL, Soldan A, Villemagne VL, Li QX, McDade EM, Fagan AM, Massoumzadeh P, Benzinger T, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2019 Sep 7; pii: S1552-5260(19)35122-2. doi: 10.1016/j.jalz.2019.06.4955.

PMID:
    31506247
    [PubMed - as supplied by publisher]
Related citations


High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.
Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ
Neurology. 2019 Oct 22; 93(17)e1647-e1659. doi: 10.1212/WNL.0000000000008081.

PMID:
    31371569
    [PubMed - in process]
Related citations


Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers.
Schultz AP, Kloet RW, Sohrabi HR, van der Weerd L, van Rooden S, Wermer MJH, Moursel LG, Yaqub M, van Berckel BNM, Chatterjee P, Gardener SL, Taddei K, Fagan AM, Benzinger TL, Morris JC, Sperling R, Johnson K, Bateman RJ, Dominantly Inherited Alzheimer Network., Gurol ME, van Buchem MA, Martins R, Chhatwal JP, Greenberg SM
Ann Neurol. 2019 Oct; 86(4)616-625. doi: 10.1002/ana.25560.

PMID:
    31361916
    [PubMed - in process]
Related citations


SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.
Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ
Nat Rev Neurol. 2019 Jul; 15(7)419-427. doi: 10.1038/s41582-019-0222-0.

PMID:
    31222062
    [PubMed - in process]
Related citations


Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease.
Barthélemy NR, Mallipeddi N, Moiseyev P, Sato C, Bateman RJ
Front Aging Neurosci. 2019; 11121. doi: 10.3389/fnagi.2019.00121.

PMID:
    31178717
    [PubMed]
Related citations


Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G
Nat Commun. 2019 May 20; 10(1)2240. doi: 10.1038/s41467-019-10152-w.

PMID:
    31110178
    [PubMed - indexed for MEDLINE]
Related citations


Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report.
Bateman RJ, Blennow K, Doody R, Hendrix S, Lovestone S, Salloway S, Schindler R, Weiner M, Zetterberg H, Aisen P, Vellas B
J Prev Alzheimers Dis. 2019; 6(3)169-173. doi: 10.14283/jpad.2019.21.

PMID:
    31062827
    [PubMed - in process]
Related citations


Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force.
Cummings J, Blennow K, Johnson K, Keeley M, Bateman RJ, Molinuevo JL, Touchon J, Aisen P, Vellas B
J Prev Alzheimers Dis. 2019; 6(3)157-163. doi: 10.14283/jpad.2019.14.

PMID:
    31062825
    [PubMed - in process]
Related citations


The structure of amyloid-β dimers in Alzheimer's disease brain: a step forward for oligomers.
Bateman RJ, Mawuenyega KG, Wildburger NC
Brain. 2019 May 1; 142(5)1168-1169. doi: 10.1093/brain/awz082.

PMID:
    31032843
    [PubMed - in process]
Related citations


The BDNF<sub>Val66Met</sub> SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Buerger K, Levin J, Duering M, Dichgans M, Suárez-Calvet M, Haass C, Gordon BA, Lim YY, Masters CL, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Milz E, Moreno-Grau S, Teipel S, Grothe MJ, Kilimann I, Rossor M, Fox N, Laske C, Chhatwal J, Falkai P, Perneczky R, Lee JH, Spottke A, Boecker H, Brosseron F, Fliessbach K, Heneka MT, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Salloway S, Danek A, Hassenstab J, Yakushev I, Schofield PR, Morris JC, Bateman RJ, Ewers M
Mol Psychiatry. 2019 Mar 21; doi: 10.1038/s41380-019-0404-6.

PMID:
    30899092
    [PubMed - as supplied by publisher]
Related citations


Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, Karch CM, Cairns N, Mori H, Schofield PR, Masters CL, Goate A, Buckles V, Fox N, Rossor M, Chrem P, Allegri R, Ringman JM, Höglinger G, Steiner H, Dieterich M, Haass C, Laske C, Morris JC, Bateman RJ, Danek A, Levin J, Dominantly Inherited Alzheimer Network.
Brain. 2019 May 1; 142(5)1429-1440. doi: 10.1093/brain/awz050.

PMID:
    30897203
    [PubMed - in process]
Related citations


Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.
Su Y, Flores S, Wang G, Hornbeck RC, Speidel B, Joseph-Mathurin N, Vlassenko AG, Gordon BA, Koeppe RA, Klunk WE, Jack CR Jr, Farlow MR, Salloway S, Snider BJ, Berman SB, Roberson ED, Brosch J, Jimenez-Velazques I, van Dyck CH, Galasko D, Yuan SH, Jayadev S, Honig LS, Gauthier S, Hsiung GR, Masellis M, Brooks WS, Fulham M, Clarnette R, Masters CL, Wallon D, Hannequin D, Dubois B, Pariente J, Sanchez-Valle R, Mummery C, Ringman JM, Bottlaender M, Klein G, Milosavljevic-Ristic S, McDade E, Xiong C, Morris JC, Bateman RJ, Benzinger TLS
Alzheimers Dement (Amst). 2019 Dec; 11180-190. doi: 10.1016/j.dadm.2018.12.008.

PMID:
    30847382
    [PubMed]
Related citations


Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2019 May; 15(5)655-665. doi: 10.1016/j.jalz.2018.12.019.

PMID:
    30846386
    [PubMed - in process]
Related citations


Staging biomarkers in preclinical autosomal dominant Alzheimer's disease by estimated years to symptom onset.
Wang G, Coble D, McDade EM, Hassenstab J, Fagan AM, Benzinger TLS, Bateman RJ, Morris JC, Xiong C, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2019 Apr; 15(4)506-514. doi: 10.1016/j.jalz.2018.12.008.

PMID:
    30773445
    [PubMed - in process]
Related citations


Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.
Gordon BA, Blazey TM, Christensen J, Dincer A, Flores S, Keefe S, Chen C, Su Y, McDade EM, Wang G, Li Y, Hassenstab J, Aschenbrenner A, Hornbeck R, Jack CR, Ances BM, Berman SB, Brosch JR, Galasko D, Gauthier S, Lah JJ, Masellis M, van Dyck CH, Mintun MA, Klein G, Ristic S, Cairns NJ, Marcus DS, Xiong C, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS
Brain. 2019 Apr 1; 142(4)1063-1076. doi: 10.1093/brain/awz019.

PMID:
    30753379
    [PubMed - in process]
Related citations


Persistent metabolic youth in the aging female brain.
Goyal MS, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME, Vlassenko AG
Proc Natl Acad Sci U S A. 2019 Feb 19; 116(8)3251-3255. doi: 10.1073/pnas.1815917116.

PMID:
    30718410
    [PubMed - indexed for MEDLINE]
Related citations


Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease.
Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLS, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M, Dominantly Inherited Alzheimer Network.
Nat Med. 2019 Feb; 25(2)277-283. doi: 10.1038/s41591-018-0304-3.

PMID:
    30664784
    [PubMed - indexed for MEDLINE]
Related citations


Seizures as an early symptom of autosomal dominant Alzheimer's disease.
Vöglein J, Noachtar S, McDade E, Quaid KA, Salloway S, Ghetti B, Noble J, Berman S, Chhatwal J, Mori H, Fox N, Allegri R, Masters CL, Buckles V, Ringman JM, Rossor M, Schofield PR, Sperling R, Jucker M, Laske C, Paumier K, Morris JC, Bateman RJ, Levin J, Danek A, Dominantly Inherited Alzheimer Network.
Neurobiol Aging. 2019 Apr; 7618-23. doi: 10.1016/j.neurobiolaging.2018.11.022.

PMID:
    30616208
    [PubMed - in process]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: C2N Diagnostics

Royalties: $10,000 - $19,999

Equity: Yes

Consulting/Advisory Board: $40,000 - $59,999

Speaker Fees:

Reporting Date: May 01, 2019