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Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

Soluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains.
Esparza TJ, Wildburger NC, Jiang H, Gangolli M, Cairns NJ, Bateman RJ, Brody DL
Sci Rep. 2016 Dec 5; 638187. doi: 10.1038/srep38187.

PMID:
    27917876
    [Unknown status]
Related citations


Human Central Nervous System (CNS) ApoE Isoforms are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared to Plasma.
Baker-Nigh AT, Mawuenyega KG, Bollinger JG, Ovod V, Kasten T, Franklin EE, Liao F, Jiang H, Holtzman D, Cairns NJ, Morris JC, Bateman RJ
J Biol Chem. 2016 Oct 28; pii: jbc.M116.721779.

PMID:
    27793990
    [PubMed - as supplied by publisher]
Related citations


Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease.
Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED
Neurobiol Aging. 2016 Oct 3; pii: S0197-4580(16)30234-2. doi: 10.1016/j.neurobiolaging.2016.09.020.

PMID:
    27793474
    [PubMed - as supplied by publisher]
Related citations


Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN).
Lancet Neurol. 2016 Dec; 15(13)1317-1325. doi: 10.1016/S1474-4422(16)30229-0.

PMID:
    27777020
    [Unknown status]
Related citations


Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group.
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL, Dominantly Inherited Alzheimer Network.
PLoS One. 2016 Sep 20; 11(9)e0163669. doi: 10.1371/journal.pone.0163669.

PMID:
    27649320
    [PubMed - as supplied by publisher]
Related citations


The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.
Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C, DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2016 Aug 29; pii: S1552-5260(16)30048-6. doi: 10.1016/j.jalz.2016.07.005.

PMID:
    27583651
    [PubMed - as supplied by publisher]
Related citations


BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, McDade E, Ringman JM, Rossor M, Salloway S, Schofield PR, Holtzman DM, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network.
Brain. 2016 Oct; 139(Pt 10)2766-2777.

PMID:
    27521573
    [PubMed - as supplied by publisher]
Related citations


Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease.
Muenchhoff J, Poljak A, Thalamuthu A, Gupta VB, Chatterjee P, Raftery M, Masters CL, Morris JC, Bateman RJ, Fagan AM, Martins RN, Sachdev PS
Sci Rep. 2016 Jul 6; 629078. doi: 10.1038/srep29078.

PMID:
    27381087
    [Unknown status]
Related citations


Revolutionizing Alzheimer's disease and clinical trials through biomarkers.
Mattsson N, Carrillo MC, Dean RA, Devous MD Sr, Nikolcheva T, Pesini P, Salter H, Potter WZ, Sperling RS, Bateman RJ, Bain LJ, Liu E
Alzheimers Dement (Amst). 2015 Oct 3; 1(4)412-9. doi: 10.1016/j.dadm.2015.09.001.

PMID:
    27239522
    [PubMed]
Related citations


Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials.
Weninger S, Carrillo MC, Dunn B, Aisen PS, Bateman RJ, Kotz JD, Langbaum JB, Mills SL, Reiman EM, Sperling R, Santacruz AM, Tariot PN, Welsh-Bohmer KA
Alzheimers Dement. 2016 May; 12(5)631-2. doi: 10.1016/j.jalz.2016.04.001.

PMID:
    27157073
    [Unknown status]
Related citations


Challenges, solutions, and recommendations for Alzheimer's disease combination therapy.
Hendrix JA, Bateman RJ, Brashear HR, Duggan C, Carrillo MC, Bain LJ, DeMattos R, Katz RG, Ostrowitzki S, Siemers E, Sperling R, Vitolo OV
Alzheimers Dement. 2016 May; 12(5)623-30. doi: 10.1016/j.jalz.2016.02.007.

PMID:
    27017906
    [Unknown status]
Related citations


White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network.
Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Ryan NS, Förster S, Laske C, Schofield PR, Sperling RA, Salloway S, Correia S, Jack C Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM, Dominantly Inherited Alzheimer Network.
Ann Neurol. 2016 Jun; 79(6)929-39. doi: 10.1002/ana.24647.

PMID:
    27016429
    [Unknown status]
Related citations


Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group.
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL, Dominantly Inherited Alzheimer Network.
PLoS One. 2016 Mar 24; 11(3)e0152082. doi: 10.1371/journal.pone.0152082.

PMID:
    27010959
    [PubMed - indexed for MEDLINE]
Related citations


A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans.
Hölttä M, Dean RA, Siemers E, Mawuenyega KG, Sigurdson W, May PC, Holtzman DM, Portelius E, Zetterberg H, Bateman RJ, Blennow K, Gobom J
Alzheimers Res Ther. 2016 Mar 7; 8(1)11. doi: 10.1186/s13195-016-0178-x.

PMID:
    26948580
    [PubMed - in process]
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Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.
Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN
J Alzheimers Dis. 2016; 50(3)887-94. doi: 10.3233/JAD-150948.

PMID:
    26836186
    [PubMed - indexed for MEDLINE]
Related citations


CAP--advancing the evaluation of preclinical Alzheimer disease treatments.
Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S
Nat Rev Neurol. 2016 Jan; 12(1)56-61. doi: 10.1038/nrneurol.2015.177.

PMID:
    26416539
    [PubMed - indexed for MEDLINE]
Related citations


Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.
Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Förster S, Lane CA, Morris JC, Benzinger TL, Bateman RJ, Dominantly Inherited Alzheimer Network.
Neurology. 2015 Sep 1; 85(9)790-8. doi: 10.1212/WNL.0000000000001903.

PMID:
    26245925
    [PubMed - indexed for MEDLINE]
Related citations


An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.
Lucey BP, Gonzales C, Das U, Li J, Siemers ER, Slemmon JR, Bateman RJ, Huang Y, Fox GB, Claassen JA, Slats D, Verbeek MM, Tong G, Soares H, Savage MJ, Kennedy M, Forman M, Sjögren M, Margolin R, Chen X, Farlow MR, Dean RA, Waring JF
Alzheimers Res Ther. 2015 Jul 29; 7(1)53. doi: 10.1186/s13195-015-0136-z.

PMID:
    26225140
    [PubMed - indexed for MEDLINE]
Related citations


A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease.
Grill JD, Bateman RJ, Buckles V, Oliver A, Morris JC, Masters CL, Klunk WE, Ringman JM, Dominantly Inherited Alzheimer’s Network.
Alzheimers Res Ther. 2015 Jul 22; 7(1)50. doi: 10.1186/s13195-015-0135-0.

PMID:
    26203303
    [PubMed]
Related citations


Factors Contributing to the Post-Lumbar Puncture Headache—Reply.
Bateman RJ, Morris JC
JAMA Neurol. 2015 Jul; 72(7)835. doi: 10.1001/jamaneurol.2015.0691.

PMID:
    26167902
    [PubMed - indexed for MEDLINE]
Related citations