Patient Portal

Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease.
Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, Ewers M, Fox NN, Ghetti B, Goate A, Graff-Radford NR, Hassenstab JJ, Hornbeck R, Jack C Jr, Johnson K, Joseph-Mathurin N, Karch CM, Koeppe RA, Lee AKW, Levin J, Masters C, McDade E, Perrin RJ, Rowe CC, Salloway S, Saykin AJ, Sperling R, Su Y, Villemagne VL, Vöglein J, Weiner M, Xiong C, Fagan AM, Morris JC, Bateman RJ, Benzinger TLS, Jucker M, Gordon BA, Dominantly Inherited Alzheimer Network.
Neurobiol Dis. 2020 Jun 6; 142104960. doi: 10.1016/j.nbd.2020.104960.

PMID:
    32522711
    [PubMed - as supplied by publisher]
Related citations


Increased Cerebrospinal Fluid Amyloid-β During Sleep Deprivation in Healthy Middle-Aged Adults Is Not Due to Stress or Circadian Disruption.
Blattner MS, Panigrahi SK, Toedebusch CD, Hicks TJ, McLeland JS, Banks IR, Schaibley C, Ovod V, Mawuenyega KG, Bateman RJ, Wardlaw SL, Lucey BP
J Alzheimers Dis. 2020; 75(2)471-482. doi: 10.3233/JAD-191122.

PMID:
    32250301
    [PubMed - in process]
Related citations


Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification.
Barthélemy NR, Bateman RJ, Hirtz C, Marin P, Becher F, Sato C, Gabelle A, Lehmann S
Alzheimers Res Ther. 2020 Mar 17; 12(1)26. doi: 10.1186/s13195-020-00596-4.

PMID:
    32183883
    [PubMed - in process]
Related citations


A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease.
Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, Berman SB, Ikeuchi T, Mori H, Shimada H, Shoji M, Suzuki K, Noble J, Farlow M, Chhatwal J, Graff-Radford NR, Salloway S, Schofield PR, Masters CL, Martins RN, O'Connor A, Fox NC, Levin J, Jucker M, Gabelle A, Lehmann S, Sato C, Bateman RJ, McDade E, Dominantly Inherited Alzheimer Network.
Nat Med. 2020 Mar; 26(3)398-407. doi: 10.1038/s41591-020-0781-z.

PMID:
    32161412
    [PubMed - indexed for MEDLINE]
Related citations


Another step forward in blood-based diagnostics for Alzheimer's disease.
Bateman RJ, Barthélemy NR, Horie K
Nat Med. 2020 Mar; 26(3)314-316. doi: 10.1038/s41591-020-0797-4.

PMID:
    32132715
    [PubMed - indexed for MEDLINE]
Related citations


Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.
Barthélemy NR, Liu H, Lu W, Kotzbauer PT, Bateman RJ, Lucey BP
Ann Neurol. 2020 May; 87(5)700-709. doi: 10.1002/ana.25702.

PMID:
    32057125
    [PubMed - in process]
Related citations


Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning.
Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, O'Connor A, Chhatwal J, Salloway S, Danek A, Hassenstab J, Schofield PR, Morris JC, Bateman RJ, Alzheimer's disease neuroimaging initiative (ADNI)., Dominantly Inherited Alzheimer Network (DIAN)., Ewers M
Alzheimers Dement. 2020 Mar; 16(3)501-511. doi: 10.1002/alz.12032.

PMID:
    32043733
    [PubMed - in process]
Related citations


Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN).
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, Farlow M, O'Connor A, Ghetti B, Graff-Radford N, Goldman J, Gräber S, Karch CM, Lee JH, Levin J, Martins RN, Masters C, Mori H, Noble J, Salloway S, Schofield P, Morris JC, Bateman RJ, Hassenstab J, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2020 Jan; 16(1)219-228. doi: 10.1002/alz.12010.

PMID:
    31914221
    [PubMed - in process]
Related citations


Biomarkers of Alzheimer Disease.
Budelier MM, Bateman RJ
J Appl Lab Med. 2020 Jan 1; 5(1)194-208. doi: 10.1373/jalm.2019.030080.

PMID:
    31843944
    [PubMed - in process]
Related citations


Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease.
Llibre-Guerra JJ, Li Y, Schindler SE, Gordon BA, Fagan AM, Morris JC, Benzinger TLS, Hassenstab J, Wang G, Allegri R, Berman SB, Chhatwal J, Farlow MR, Holtzman DM, Jucker M, Levin J, Noble JM, Salloway S, Schofield P, Karch C, Fox NC, Xiong C, Bateman RJ, McDade E
JAMA Netw Open. 2019 Dec 2; 2(12)e1917126. doi: 10.1001/jamanetworkopen.2019.17126.

PMID:
    31825500
    [PubMed - indexed for MEDLINE]
Related citations


An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.
Dube U, Del-Aguila JL, Li Z, Budde JP, Jiang S, Hsu S, Ibanez L, Fernandez MV, Farias F, Norton J, Gentsch J, Wang F, Dominantly Inherited Alzheimer Network (DIAN)., Salloway S, Masters CL, Lee JH, Graff-Radford NR, Chhatwal JP, Bateman RJ, Morris JC, Karch CM, Harari O, Cruchaga C
Nat Neurosci. 2019 Nov; 22(11)1903-1912. doi: 10.1038/s41593-019-0501-5.

PMID:
    31591557
    [PubMed - indexed for MEDLINE]
Related citations


Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: Applications to Alzheimer's disease.
Wang G, Aschenbrenner AJ, Li Y, McDade E, Liu L, Benzinger TLS, Bateman RJ, Morris JC, Hassenstab JJ, Xiong C
Alzheimers Dement (N Y). 2019; 5450-457. doi: 10.1016/j.trci.2019.07.007.

PMID:
    31517032
    [PubMed]
Related citations


A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.
Xiong C, Luo J, Agboola F, Li Y, Albert M, Johnson SC, Koscik RL, Masters CL, Soldan A, Villemagne VL, Li QX, McDade EM, Fagan AM, Massoumzadeh P, Benzinger T, Hassenstab J, Bateman RJ, Morris JC, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2019 Nov; 15(11)1448-1457. doi: 10.1016/j.jalz.2019.06.4955.

PMID:
    31506247
    [PubMed - in process]
Related citations


High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis.
Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ
Neurology. 2019 Oct 22; 93(17)e1647-e1659. doi: 10.1212/WNL.0000000000008081.

PMID:
    31371569
    [PubMed - indexed for MEDLINE]
Related citations


Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers.
Schultz AP, Kloet RW, Sohrabi HR, van der Weerd L, van Rooden S, Wermer MJH, Moursel LG, Yaqub M, van Berckel BNM, Chatterjee P, Gardener SL, Taddei K, Fagan AM, Benzinger TL, Morris JC, Sperling R, Johnson K, Bateman RJ, Dominantly Inherited Alzheimer Network., Gurol ME, van Buchem MA, Martins R, Chhatwal JP, Greenberg SM
Ann Neurol. 2019 Oct; 86(4)616-625. doi: 10.1002/ana.25560.

PMID:
    31361916
    [PubMed - indexed for MEDLINE]
Related citations


SILK studies - capturing the turnover of proteins linked to neurodegenerative diseases.
Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ
Nat Rev Neurol. 2019 Jul; 15(7)419-427. doi: 10.1038/s41582-019-0222-0.

PMID:
    31222062
    [PubMed - indexed for MEDLINE]
Related citations


Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer's Disease.
Barthélemy NR, Mallipeddi N, Moiseyev P, Sato C, Bateman RJ
Front Aging Neurosci. 2019; 11121. doi: 10.3389/fnagi.2019.00121.

PMID:
    31178717
    [PubMed]
Related citations


Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G
Nat Commun. 2019 May 20; 10(1)2240. doi: 10.1038/s41467-019-10152-w.

PMID:
    31110178
    [PubMed - indexed for MEDLINE]
Related citations


Plasma Biomarkers of AD Emerging as Essential Tools for Drug Development: An EU/US CTAD Task Force Report.
Bateman RJ, Blennow K, Doody R, Hendrix S, Lovestone S, Salloway S, Schindler R, Weiner M, Zetterberg H, Aisen P, Vellas B
J Prev Alzheimers Dis. 2019; 6(3)169-173. doi: 10.14283/jpad.2019.21.

PMID:
    31062827
    [PubMed - in process]
Related citations


Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force.
Cummings J, Blennow K, Johnson K, Keeley M, Bateman RJ, Molinuevo JL, Touchon J, Aisen P, Vellas B
J Prev Alzheimers Dis. 2019; 6(3)157-163. doi: 10.14283/jpad.2019.14.

PMID:
    31062825
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2019:

Company Name: C2N Diagnostics

Royalties: $10,000 - $19,999

Equity: Yes

Consulting/Advisory Board: $40,000 - $59,999

Speaker Fees:

Reporting Date: May 01, 2020