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Faculty Physicians

Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.
Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN
J Alzheimers Dis. 2016 Jan 21;

PMID:
    26836186
    [PubMed - as supplied by publisher]
Related citations


CAP-advancing the evaluation of preclinical Alzheimer disease treatments.
Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S
Nat Rev Neurol. 2016 Jan; 12(1)56-61. doi: 10.1038/nrneurol.2015.177.

PMID:
    26416539
    [PubMed - in process]
Related citations


Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease.
Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, Salloway S, Schofield PR, Masters CL, Martins RN, Rossor MN, Jucker M, Danek A, Förster S, Lane CA, Morris JC, Benzinger TL, Bateman RJ, Dominantly Inherited Alzheimer Network
Neurology. 2015 Sep 1; 85(9)790-8. doi: 10.1212/WNL.0000000000001903.

PMID:
    26245925
    [PubMed - indexed for MEDLINE]
Related citations


An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.
Lucey BP, Gonzales C, Das U, Li J, Siemers ER, Slemmon JR, Bateman RJ, Huang Y, Fox GB, Claassen JA, Slats D, Verbeek MM, Tong G, Soares H, Savage MJ, Kennedy M, Forman M, Sjögren M, Margolin R, Chen X, Farlow MR, Dean RA, Waring JF
Alzheimers Res Ther. 2015; 7(1)53. doi: 10.1186/s13195-015-0136-z.

PMID:
    26225140
    [PubMed - in process]
Related citations


A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease.
Grill JD, Bateman RJ, Buckles V, Oliver A, Morris JC, Masters CL, Klunk WE, Ringman JM, Dominantly Inherited Alzheimer’s Network
Alzheimers Res Ther. 2015; 7(1)50. doi: 10.1186/s13195-015-0135-0.

PMID:
    26203303
    [PubMed]
Related citations


Factors Contributing to the Post-Lumbar Puncture Headache—Reply.
Bateman RJ, Morris JC
JAMA Neurol. 2015 Jul; 72(7)835. doi: 10.1001/jamaneurol.2015.0691.

PMID:
    26167902
    [PubMed - indexed for MEDLINE]
Related citations


In vivo kinetic approach reveals slow SOD1 turnover in the CNS.
Crisp MJ, Mawuenyega KG, Patterson BW, Reddy NC, Chott R, Self WK, Weihl CC, Jockel-Balsarotti J, Varadhachary AS, Bucelli RC, Yarasheski KE, Bateman RJ, Miller TM
J Clin Invest. 2015 Jul 1; 125(7)2772-80. doi: 10.1172/JCI80705.

PMID:
    26075819
    [PubMed - indexed for MEDLINE]
Related citations


Age and amyloid effects on human central nervous system amyloid-beta kinetics.
Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, Bateman RJ
Ann Neurol. 2015 Sep; 78(3)439-53. doi: 10.1002/ana.24454.

PMID:
    26040676
    [PubMed - indexed for MEDLINE]
Related citations


Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN).
Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC, Alzheimer Disease Neuroimaging Initiative, Dominantly Inherited Alzheimer Network
Neuropathology. 2015 Aug; 35(4)390-400. doi: 10.1111/neup.12205.

PMID:
    25964057
    [PubMed - in process]
Related citations


Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study.
Laske C, Sohrabi HR, Jasielec MS, Müller S, Koehler NK, Gräber S, Förster S, Drzezga A, Mueller-Sarnowski F, Danek A, Jucker M, Bateman RJ, Buckles V, Saykin AJ, Martins RN, Morris JC, Dominantly Inherited Alzheimer Network Dian
Biomed Res Int. 2015; 2015828120. doi: 10.1155/2015/828120.

PMID:
    25922840
    [PubMed - indexed for MEDLINE]
Related citations


Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: baseline data from a DIAN cohort subset.
Chatterjee P, Gupta VB, Fagan AM, Jasielec MS, Xiong C, Sohrabi HR, Dhaliwal S, Taddei K, Bourgeat P, Brown BM, Benzinger T, Bateman RJ, Morris JC, Martins RN, Dominantly Inherited Alzheimer Network
Curr Alzheimer Res. 2015; 12(2)157-64.

PMID:
    25654503
    [PubMed - indexed for MEDLINE]
Related citations


Factors associated with the onset and persistence of post-lumbar puncture headache.
Monserrate AE, Ryman DC, Ma S, Xiong C, Noble JM, Ringman JM, Morris JC, Danek A, Müller-Sarnowski F, Clifford DB, McDade EM, Brooks WS, Darby DG, Masters CL, Weston PS, Farlow MR, Graff-Radford NR, Salloway SP, Fagan AM, Oliver A, Bateman RJ, Dominantly Inherited Alzheimer Network
JAMA Neurol. 2015 Mar; 72(3)325-32. doi: 10.1001/jamaneurol.2014.3974.

PMID:
    25622095
    [PubMed - indexed for MEDLINE]
Related citations


Reply to comment on "An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice".
Sheline YI, West T, Yarasheski K, Jasielec MS, Hettinger JC, Tripoli DL, Xiong C, Frederiksen C, Grzelak MV, Bateman RJ, Morris JC, Lee JM, Cirrito JR
Sci Transl Med. 2014 Dec 24; 6(268)268lr4. doi: 10.1126/scitranslmed.3010609.

PMID:
    25540323
    [PubMed - indexed for MEDLINE]
Related citations


Analysis of a compartmental model of amyloid beta production, irreversible loss and exchange in humans.
Elbert DL, Patterson BW, Bateman RJ
Math Biosci. 2015 Mar; 26148-61. doi: 10.1016/j.mbs.2014.11.004.

PMID:
    25497960
    [PubMed - in process]
Related citations


Partial volume correction in quantitative amyloid imaging.
Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash L, Christensen JJ, Friedrichsen K, Hornbeck RC, Farrar AM, Owen CJ, Mayeux R, Brickman AM, Klunk W, Price JC, Thompson PM, Ghetti B, Saykin AJ, Sperling RA, Johnson KA, Schofield PR, Buckles V, Morris JC, Benzinger TL, Dominantly Inherited Alzheimer Network
Neuroimage. 2015 Feb 15; 10755-64. doi: 10.1016/j.neuroimage.2014.11.058.

PMID:
    25485714
    [PubMed - indexed for MEDLINE]
Related citations


Amyloid-β efflux from the central nervous system into the plasma.
Roberts KF, Elbert DL, Kasten TP, Patterson BW, Sigurdson WC, Connors RE, Ovod V, Munsell LY, Mawuenyega KG, Miller-Thomas MM, Moran CJ, Cross DT 3rd, Derdeyn CP, Bateman RJ
Ann Neurol. 2014 Dec; 76(6)837-44. doi: 10.1002/ana.24270.

PMID:
    25205593
    [PubMed - indexed for MEDLINE]
Related citations


Functional connectivity in autosomal dominant and late-onset Alzheimer disease.
Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, Ourselin S, Schofield PR, Masters CL, Martins RN, Weiner MW, Thompson PM, Fox NC, Koeppe RA, Jack CR Jr, Mathis CA, Oliver A, Blazey TM, Moulder K, Buckles V, Hornbeck R, Chhatwal J, Schultz AP, Goate AM, Fagan AM, Cairns NJ, Marcus DS, Morris JC, Ances BM
JAMA Neurol. 2014 Sep; 71(9)1111-22. doi: 10.1001/jamaneurol.2014.1654.

PMID:
    25069482
    [PubMed - indexed for MEDLINE]
Related citations


Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis.
Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, Moreno S, Reiman EM, Ringman JM, Salloway S, Schofield PR, Sperling R, Tariot PN, Xiong C, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network
Neurology. 2014 Jul 15; 83(3)253-60. doi: 10.1212/WNL.0000000000000596.

PMID:
    24928124
    [PubMed - indexed for MEDLINE]
Related citations


CNS amyloid-β, soluble APP-α and -β kinetics during BACE inhibition.
Dobrowolska JA, Michener MS, Wu G, Patterson BW, Chott R, Ovod V, Pyatkivskyy Y, Wildsmith KR, Kasten T, Mathers P, Dancho M, Lennox C, Smith BE, Gilberto D, McLoughlin D, Holder DJ, Stamford AW, Yarasheski KE, Kennedy ME, Savage MJ, Bateman RJ
J Neurosci. 2014 Jun 11; 34(24)8336-46. doi: 10.1523/JNEUROSCI.0540-14.2014.

PMID:
    24920637
    [PubMed - indexed for MEDLINE]
Related citations


Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis.
Lucey BP, Bateman RJ
Neurobiol Aging. 2014 Sep; 35 Suppl 2S29-34. doi: 10.1016/j.neurobiolaging.2014.03.035.

PMID:
    24910393
    [PubMed - indexed for MEDLINE]
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