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Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.
Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL
Sci Rep. 2017 Aug 25; 7(1)9520. doi: 10.1038/s41598-017-10422-x.

PMID:
    28842697
    [PubMed - in process]
Related citations


Loss of Brain Aerobic Glycolysis in Normal Human Aging.
Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME
Cell Metab. 2017 Aug 1; 26(2)353-360.e3. doi: 10.1016/j.cmet.2017.07.010.

PMID:
    28768174
    [PubMed - in process]
Related citations


A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism.
Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, Morris JC
Neurosci Lett. 2017 Sep 14; 65711-15. doi: 10.1016/j.neulet.2017.07.046.

PMID:
    28764909
    [PubMed - in process]
Related citations


Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study.
Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2017 Jul 22; pii: S1552-5260(17)32521-9. doi: 10.1016/j.jalz.2017.06.2268.

PMID:
    28738187
    [PubMed - as supplied by publisher]
Related citations


Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis.
Ovod V, Ramsey KN, Mawuenyega KG, Bollinger JG, Hicks T, Schneider T, Sullivan M, Paumier K, Holtzman DM, Morris JC, Benzinger T, Fagan AM, Patterson BW, Bateman RJ
Alzheimers Dement. 2017 Aug; 13(8)841-849. doi: 10.1016/j.jalz.2017.06.2266.

PMID:
    28734653
    [PubMed - in process]
Related citations


Stop Alzheimer's before it starts.
McDade E, Bateman RJ
Nature. 2017 Jul 12; 547(7662)153-155. doi: 10.1038/547153a.

PMID:
    28703214
    [PubMed - in process]
Related citations


Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.
Brown BM, Sohrabi HR, Taddei K, Gardener SL, Rainey-Smith SR, Peiffer JJ, Xiong C, Fagan AM, Benzinger T, Buckles V, Erickson KI, Clarnette R, Shah T, Masters CL, Weiner M, Cairns N, Rossor M, Graff-Radford NR, Salloway S, Vöglein J, Laske C, Noble J, Schofield PR, Bateman RJ, Morris JC, Martins RN, Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2017 May 11; pii: S1552-5260(17)30147-4. doi: 10.1016/j.jalz.2017.03.008.

PMID:
    28501451
    [PubMed - as supplied by publisher]
Related citations


Diurnal oscillation of CSF Aβ and other AD biomarkers.
Lucey BP, Fagan AM, Holtzman DM, Morris JC, Bateman RJ
Mol Neurodegener. 2017 May 8; 12(1)36. doi: 10.1186/s13024-017-0161-4.

PMID:
    28478762
    [PubMed - in process]
Related citations


Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease.
Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, Quaid KA, Salloway S, Xiong C, Benzinger T, Buckles V, Masters CL, Sperling R, Bateman RJ, Morris JC, Laske C
Sci Rep. 2017 Apr 27; 7(1)1225. doi: 10.1038/s41598-017-01327-w.

PMID:
    28450713
    [PubMed - in process]
Related citations


The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.
Schoenfeld HA, West T, Verghese PB, Holubasch M, Shenoy N, Kagan D, Buono C, Zhou W, DeCristofaro M, Douville J, Goodrich GG, Mansfield K, Saravanan C, Cumin F, Webb RL, Bateman RJ
Toxicol Appl Pharmacol. 2017 May 15; 32353-65. doi: 10.1016/j.taap.2017.03.014.

PMID:
    28315356
    [PubMed - indexed for MEDLINE]
Related citations


Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System.
Lucey BP, Mawuenyega KG, Patterson BW, Elbert DL, Ovod V, Kasten T, Morris JC, Bateman RJ
JAMA Neurol. 2017 Feb 1; 74(2)207-215. doi: 10.1001/jamaneurol.2016.4202.

PMID:
    27992627
    [PubMed - indexed for MEDLINE]
Related citations


Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.
Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C, Dominantly Inherited Alzheimer Network.
Sci Transl Med. 2016 Dec 14; 8(369)369ra178.

PMID:
    27974666
    [PubMed - in process]
Related citations


Soluble Amyloid-beta Aggregates from Human Alzheimer's Disease Brains.
Esparza TJ, Wildburger NC, Jiang H, Gangolli M, Cairns NJ, Bateman RJ, Brody DL
Sci Rep. 2016 Dec 5; 638187. doi: 10.1038/srep38187.

PMID:
    27917876
    [PubMed - in process]
Related citations


Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.
Baker-Nigh AT, Mawuenyega KG, Bollinger JG, Ovod V, Kasten T, Franklin EE, Liao F, Jiang H, Holtzman D, Cairns NJ, Morris JC, Bateman RJ
J Biol Chem. 2016 Dec 30; 291(53)27204-27218. doi: 10.1074/jbc.M116.721779.

PMID:
    27793990
    [PubMed - indexed for MEDLINE]
Related citations


Clinical, imaging, pathological, and biochemical characterization of a novel presenilin 1 mutation (N135Y) causing Alzheimer's disease.
Natelson Love M, Clark DG, Cochran JN, Den Beste KA, Geldmacher DS, Benzinger TL, Gordon BA, Morris JC, Bateman RJ, Roberson ED
Neurobiol Aging. 2017 Jan; 49216.e7-216.e13. doi: 10.1016/j.neurobiolaging.2016.09.020.

PMID:
    27793474
    [PubMed - in process]
Related citations


Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS).
Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, Ghetti B, Graff-Radford NR, Laske C, Martins RN, Masters CL, Mayeux RP, Ringman JM, Rossor MN, Salloway SP, Schofield PR, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN).
Lancet Neurol. 2016 Dec; 15(13)1317-1325. doi: 10.1016/S1474-4422(16)30229-0.

PMID:
    27777020
    [PubMed - indexed for MEDLINE]
Related citations


Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group.
Su Y, Blazey TM, Owen CJ, Christensen JJ, Friedrichsen K, Joseph-Mathurin N, Wang Q, Hornbeck RC, Ances BM, Snyder AZ, Cash LA, Koeppe RA, Klunk WE, Galasko D, Brickman AM, McDade E, Ringman JM, Thompson PM, Saykin AJ, Ghetti B, Sperling RA, Johnson KA, Salloway SP, Schofield PR, Masters CL, Villemagne VL, Fox NC, Förster S, Chen K, Reiman EM, Xiong C, Marcus DS, Weiner MW, Morris JC, Bateman RJ, Benzinger TL, Dominantly Inherited Alzheimer Network.
PLoS One. 2016; 11(9)e0163669. doi: 10.1371/journal.pone.0163669.

PMID:
    27649320
    [PubMed - as supplied by publisher]
Related citations


The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model.
Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C, DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network.
Alzheimers Dement. 2017 Jan; 13(1)8-19. doi: 10.1016/j.jalz.2016.07.005.

PMID:
    27583651
    [PubMed - in process]
Related citations


BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, McDade E, Ringman JM, Rossor M, Salloway S, Schofield PR, Holtzman DM, Morris JC, Bateman RJ, Dominantly Inherited Alzheimer Network.
Brain. 2016 Oct; 139(Pt 10)2766-2777.

PMID:
    27521573
    [PubMed - as supplied by publisher]
Related citations


Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer's disease.
Muenchhoff J, Poljak A, Thalamuthu A, Gupta VB, Chatterjee P, Raftery M, Masters CL, Morris JC, Bateman RJ, Fagan AM, Martins RN, Sachdev PS
Sci Rep. 2016 Jul 6; 629078. doi: 10.1038/srep29078.

PMID:
    27381087
    [PubMed - in process]
Related citations