Patient Portal

Randall J. Bateman, MD

Charles F. and Joanne Knight Distinguished Professor, Neurology
Director of the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Specialty Areas

Dementia
Neurology - Adult
Alzheimer's Disease
Memory Disorders and Diagnosis

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, dementia, geriatric neurology, neurodegenerative diseases, mild cognitive impairment, aging, cognitive function

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985

Education

Education

Clinical Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2005
Residency: Neurology, Barnes-Jewish Hospital, St. Louis, Missouri 2004
Medical Degree: Case Western Reserve University School of Medicine, Cleveland, Ohio 2000
B.S.: Biology, Washington University, St. Louis, Missouri 1996
B.S.: Electrical Engineering, Washington University, St. Louis, Missouri 1996

Publication & Research

Publication & Research

Effect of BDNFVal66Met on disease markers in dominantly inherited AD.
Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, Morris JC, Maruff P, Bateman RJ, Dominantly Inherited Alzheimer Network.
Ann Neurol. 2018 Jul 16; doi: 10.1002/ana.25299.

PMID:
    30014553
    [PubMed - as supplied by publisher]
Related citations


Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.
Li Z, Del-Aguila JL, Dube U, Budde J, Martinez R, Black K, Xiao Q, Cairns NJ, Dominantly Inherited Alzheimer Network (DIAN)., Dougherty JD, Lee JM, Morris JC, Bateman RJ, Karch CM, Cruchaga C, Harari O
Genome Med. 2018 Jun 8; 10(1)43. doi: 10.1186/s13073-018-0551-4.

PMID:
    29880032
    [PubMed - in process]
Related citations


Tau Kinetics in Neurons and the Human Central Nervous System.
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, Karch CM, Bateman RJ
Neuron. 2018 May 16; 98(4)861-864. doi: 10.1016/j.neuron.2018.04.035.

PMID:
    29772204
    [PubMed - in process]
Related citations


A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer's disease.
Wang G, Berry S, Xiong C, Hassenstab J, Quintana M, McDade EM, Delmar P, Vestrucci M, Sethuraman G, Bateman RJ, Dominantly Inherited Alzheimer Network Trials Unit.
Stat Med. 2018 May 14; doi: 10.1002/sim.7811.

PMID:
    29761523
    [PubMed - as supplied by publisher]
Related citations


White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer's disease.
Lee S, Zimmerman ME, Narkhede A, Nasrabady SE, Tosto G, Meier IB, Benzinger TLS, Marcus DS, Fagan AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, Saykin AJ, Masters CL, Ringman JM, Fӧrster S, Schofield PR, Sperling RA, Johnson KA, Chhatwal JP, Salloway S, Correia S, Jack CR Jr, Weiner M, Bateman RJ, Morris JC, Mayeux R, Brickman AM, Dominantly Inherited Alzheimer Network.
PLoS One. 2018; 13(5)e0195838. doi: 10.1371/journal.pone.0195838.

PMID:
    29742105
    [PubMed - in process]
Related citations


Amyloid-β Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer <i>In Vivo</i> and Exhibit Nanoscale Heterogeneity.
Wildburger NC, Gyngard F, Guillermier C, Patterson BW, Elbert D, Mawuenyega KG, Schneider T, Green K, Roth R, Schmidt RE, Cairns NJ, Benzinger TLS, Steinhauser ML, Bateman RJ
Front Neurol. 2018; 9169. doi: 10.3389/fneur.2018.00169.

PMID:
    29623063
    [PubMed]
Related citations


Data-driven models of dominantly-inherited Alzheimer's disease progression.
Oxtoby NP, Young AL, Cash DM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Fox NC, Schott JM, Alexander DC
Brain. 2018 May 1; 141(5)1529-1544. doi: 10.1093/brain/awy050.

PMID:
    29579160
    [PubMed - in process]
Related citations


Tau Kinetics in Neurons and the Human Central Nervous System.
Sato C, Barthélemy NR, Mawuenyega KG, Patterson BW, Gordon BA, Jockel-Balsarotti J, Sullivan M, Crisp MJ, Kasten T, Kirmess KM, Kanaan NM, Yarasheski KE, Baker-Nigh A, Benzinger TLS, Miller TM, Karch CM, Bateman RJ
Neuron. 2018 Mar 21; 97(6)1284-1298.e7. doi: 10.1016/j.neuron.2018.02.015.

PMID:
    29566794
    [PubMed - in process]
Related citations


Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.
Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TLS, Johnson SC, Breitner JCS, Poirier J, Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) Research Group.
JAMA Neurol. 2018 May 1; 75(5)608-619. doi: 10.1001/jamaneurol.2017.5135.

PMID:
    29482212
    [PubMed - in process]
Related citations


Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.
Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, Janowitz D, Catak C, Wolfsgruber S, Wagner M, Teipel S, Kilimann I, Ramirez A, Rossor M, Jucker M, Chhatwal J, Spottke A, Boecker H, Brosseron F, Falkai P, Fliessbach K, Heneka MT, Laske C, Nestor P, Peters O, Fuentes M, Menne F, Priller J, Spruth EJ, Franke C, Schneider A, Kofler B, Westerteicher C, Speck O, Wiltfang J, Bartels C, Araque Caballero MÁ, Metzger C, Bittner D, Weiner M, Lee JH, Salloway S, Danek A, Goate A, Schofield PR, Bateman RJ, Ewers M
Brain. 2018 Apr 1; 141(4)1186-1200. doi: 10.1093/brain/awy008.

PMID:
    29462334
    [PubMed - in process]
Related citations


Reply to "Excess amyloid beta can be degraded in healthy humans".
Lucey BP, Hicks TJ, Elbert DL, Ovod V, Mawuenyega KG, Morris JC, Bateman RJ
Ann Neurol. 2018 Mar; 83(3)650-651. doi: 10.1002/ana.25185.

PMID:
    29457845
    [PubMed - in process]
Related citations


Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture.
McDade E, Bateman RJ
JAMA Neurol. 2018 May 1; 75(5)536-538. doi: 10.1001/jamaneurol.2017.4026.

PMID:
    29435570
    [PubMed - in process]
Related citations


Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study.
Gordon BA, Blazey TM, Su Y, Hari-Raj A, Dincer A, Flores S, Christensen J, McDade E, Wang G, Xiong C, Cairns NJ, Hassenstab J, Marcus DS, Fagan AM, Jack CR Jr, Hornbeck RC, Paumier KL, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal JP, Correia S, Förster S, Fox NC, Graff-Radford NR, la Fougère C, Levin J, Masters CL, Rossor MN, Salloway S, Saykin AJ, Schofield PR, Thompson PM, Weiner MM, Holtzman DM, Raichle ME, Morris JC, Bateman RJ, Benzinger TLS
Lancet Neurol. 2018 Mar; 17(3)241-250. doi: 10.1016/S1474-4422(18)30028-0.

PMID:
    29397305
    [PubMed - in process]
Related citations


Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics.
Lucey BP, Hicks TJ, McLeland JS, Toedebusch CD, Boyd J, Elbert DL, Patterson BW, Baty J, Morris JC, Ovod V, Mawuenyega KG, Bateman RJ
Ann Neurol. 2018 Jan; 83(1)197-204. doi: 10.1002/ana.25117.

PMID:
    29220873
    [PubMed - in process]
Related citations


Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies.
West T, Hu Y, Verghese PB, Bateman RJ, Braunstein JB, Fogelman I, Budur K, Florian H, Mendonca N, Holtzman DM
J Prev Alzheimers Dis. 2017; 4(4)236-241. doi: 10.14283/jpad.2017.36.

PMID:
    29181488
    [PubMed - in process]
Related citations


Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.
Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Deming Y, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, Dominantly Inherited Alzheimer Network (DIAN)., Disease Neuroimaging Initiative (ADNI)., NIA-LOAD family study., Harari O
Alzheimers Dement. 2018 Feb; 14(2)205-214. doi: 10.1016/j.jalz.2017.08.013.

PMID:
    28943286
    [PubMed - in process]
Related citations


Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.
Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL
Sci Rep. 2017 Aug 25; 7(1)9520. doi: 10.1038/s41598-017-10422-x.

PMID:
    28842697
    [PubMed - in process]
Related citations


Loss of Brain Aerobic Glycolysis in Normal Human Aging.
Goyal MS, Vlassenko AG, Blazey TM, Su Y, Couture LE, Durbin TJ, Bateman RJ, Benzinger TL, Morris JC, Raichle ME
Cell Metab. 2017 Aug 1; 26(2)353-360.e3. doi: 10.1016/j.cmet.2017.07.010.

PMID:
    28768174
    [PubMed - indexed for MEDLINE]
Related citations


A novel PSEN1 (S230N) mutation causing early-onset Alzheimer's Disease associated with prosopagnosia, hoarding, and Parkinsonism.
Ringman JM, Casado M, Van Berlo V, Pa J, Joseph-Mathurin N, Fagan AM, Benzinger T, Bateman RJ, Morris JC
Neurosci Lett. 2017 Sep 14; 65711-15. doi: 10.1016/j.neulet.2017.07.046.

PMID:
    28764909
    [PubMed - indexed for MEDLINE]
Related citations


Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial magnetic resonance imaging study.
Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway SP, Correia S, Sperling RA, Chhatwal JP, Mayeux RP, Brickman AM, Martins RN, Farlow MR, Ghetti B, Saykin AJ, Jack CR Jr, Schofield PR, McDade E, Weiner MW, Ringman JM, Thompson PM, Masters CL, Rowe CC, Rossor MN, Ourselin S, Fox NC, Dominantly Inherited Alzheimer Network (DIAN).
Alzheimers Dement. 2018 Jan; 14(1)43-53. doi: 10.1016/j.jalz.2017.06.2268.

PMID:
    28738187
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: C2N Diagnostics

Royalties: $20,000 - $39,999

Equity: Yes

Consulting/Advisory Board: $40,000 - $59,999

Speaker Fees:

Reporting Date: May 01, 2018