Patient Portal

Ramsey Hachem, MD

Professor, Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Pulmonary Medicine
Lung Disease

Board Certifications

Critical Care
Internal Medicine
Pulmonary

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lung disease, lung transplant

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-454-5571

Education

Education

Fellowship: Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 2003
Residency: UT Southwestern Medical Center, Dallas, Texas 2000
Medical Degree: University of Texas, Southern Medical Center in Dallas, Dallas, Texas 1997
B.A.: Chemistry, Southern Methodist University, Dallas, Texas 1992

Publication & Research

Publication & Research

Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT.
Glanville AR, Verleden GM, Todd JL, Benden C, Calabrese F, Gottlieb J, Hachem RR, Levine D, Meloni F, Palmer SM, Roman A, Sato M, Singer LG, Tokman S, Verleden SE, von der Thüsen J, Vos R, Snell G
J Heart Lung Transplant. 2019 May; 38(5)483-492. doi: 10.1016/j.healun.2019.03.008.

PMID:
    31027539
    [PubMed - in process]
Related citations


Development and Optimization of an ELISA to Quantitate C3(H <sub><i>2</i></sub> O) as a Marker of Human Disease.
Elvington M, Liszewski MK, Liszewski AR, Kulkarni HS, Hachem RR, Mohanakumar T, Kim AHJ, Atkinson JP
Front Immunol. 2019; 10703. doi: 10.3389/fimmu.2019.00703.

PMID:
    31019515
    [PubMed - in process]
Related citations


The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches.
Hachem RR
Hum Immunol. 2019 Apr 17; pii: S0198-8859(19)30141-7. doi: 10.1016/j.humimm.2019.04.008.

PMID:
    31005400
    [PubMed - as supplied by publisher]
Related citations


Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid.
Tague LK, Byers DE, Hachem R, Kreisel D, Krupnick AS, Kulkarni HS, Chen C, Huang HJ, Gelman A
Pharmacogenomics J. 2019 Apr 17; doi: 10.1038/s41397-019-0086-0.

PMID:
    30992538
    [PubMed - as supplied by publisher]
Related citations


An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.
Liu Z, Liao F, Scozzi D, Furuya Y, Pugh KN, Hachem R, Chen DL, Cano M, Green JM, Krupnick AS, Kreisel D, Perl AKT, Huang HJ, Brody SL, Gelman AE
JCI Insight. 2019 Apr 16; 5pii: 124732. doi: 10.1172/jci.insight.124732.

PMID:
    30990794
    [PubMed - in process]
Related citations


Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT.
Verleden GM, Glanville AR, Lease ED, Fisher AJ, Calabrese F, Corris PA, Ensor CR, Gottlieb J, Hachem RR, Lama V, Martinu T, Neil DAH, Singer LG, Snell G, Vos R
J Heart Lung Transplant. 2019 May; 38(5)493-503. doi: 10.1016/j.healun.2019.03.009.

PMID:
    30962148
    [PubMed - in process]
Related citations


The role of donor-derived exosomes in lung allograft rejection.
Ravichandran R, Bansal S, Rahman M, Sharma M, Liu W, Bharat A, Hachem R, Omar A, Smith MA, Mohanakumar T
Hum Immunol. 2019 Mar 18; pii: S0198-8859(19)30140-5. doi: 10.1016/j.humimm.2019.03.012.

PMID:
    30898684
    [PubMed - as supplied by publisher]
Related citations


Molecular assessment of rejection and injury in lung transplant biopsies.
Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF
J Heart Lung Transplant. 2019 May; 38(5)504-513. doi: 10.1016/j.healun.2019.01.1317.

PMID:
    30773443
    [PubMed - in process]
Related citations


Chest computed tomography imaging improves potential lung donor assessment.
Gauthier JM, Bierhals AJ, Liu J, Balsara KR, Frederiksen C, Gremminger E, Hachem RR, Witt CA, Trulock EP, Byers DE, Yusen RD, Aguilar PR, Marklin G, Nava RG, Kozower BD, Pasque MK, Meyers BF, Patterson GA, Kreisel D, Puri V
J Thorac Cardiovasc Surg. 2019 Apr; 157(4)1711-1718.e1. doi: 10.1016/j.jtcvs.2018.11.038.

PMID:
    30772037
    [PubMed - in process]
Related citations


Association between Allosensitization and Waiting List Outcomes among Adult Lung Transplant Candidates in the United States.
Tague LK, Witt CA, Byers DE, Yusen RD, Aguilar PR, Kulkarni HS, Bain KB, Fester KA, Puri V, Kreisel D, Mohanakumar T, Trulock EP, Hachem RR
Ann Am Thorac Soc. 2019 Feb 14; doi: 10.1513/AnnalsATS.201810-713OC.

PMID:
    30763122
    [PubMed - as supplied by publisher]
Related citations


Unintended consequences of changes to lung allocation policy.
Puri V, Hachem RR, Frye CC, Harrison MS, Semenkovich TR, Lynch JP, Ridolfi G, Rowe C, Meyers BF, Patterson GA, Kozower BD, Pasque MK, Nava RG, Marklin GF, Brockmeier D, Sweet SC, Chapman WC, Kreisel D
Am J Transplant. 2019 Feb 13; doi: 10.1111/ajt.15307.

PMID:
    30758137
    [PubMed - as supplied by publisher]
Related citations


Technical Considerations for Lung Transplantation in Kartagener's Syndrome.
Gauthier JM, Takahashi T, Bierhals AJ, Brody SL, Hachem RR, Witt CA, Byers DE, Yusen RD, Trulock EP, Aguilar PR, Nava RG, Kozower BD, Meyers BF, Patterson GA, Kreisel D, Puri V
Ann Thorac Surg. 2019 May; 107(5)e337-e339. doi: 10.1016/j.athoracsur.2018.08.095.

PMID:
    30612988
    [PubMed - in process]
Related citations


Mitochondrial damage-associated molecular patterns released by lung transplants are associated with primary graft dysfunction.
Scozzi D, Ibrahim M, Liao F, Lin X, Hsiao HM, Hachem R, Tague LK, Ricci A, Kulkarni HS, Huang HJ, Sugimoto S, Krupnick AS, Kreisel D, Gelman AE
Am J Transplant. 2019 May; 19(5)1464-1477. doi: 10.1111/ajt.15232.

PMID:
    30582269
    [PubMed - in process]
Related citations


Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.
Li W, Gauthier JM, Higashikubo R, Hsiao HM, Tanaka S, Vuong L, Ritter JH, Tong AY, Wong BW, Hachem RR, Puri V, Bharat A, Krupnick AS, Hsieh CS, Baldwin WM 3rd, Kelly FL, Palmer SM, Gelman AE, Kreisel D
J Clin Invest. 2019 Feb 1; 129(2)556-568. doi: 10.1172/JCI122083.

PMID:
    30561386
    [PubMed - in process]
Related citations


Bronchiolitis obliterans syndrome-free survival after lung transplantation: An International Society for Heart and Lung Transplantation Thoracic Transplant Registry analysis.
Kulkarni HS, Cherikh WS, Chambers DC, Garcia VC, Hachem RR, Kreisel D, Puri V, Kozower BD, Byers DE, Witt CA, Alexander-Brett J, Aguilar PR, Tague LK, Furuya Y, Patterson GA, Trulock EP 3rd, Yusen RD
J Heart Lung Transplant. 2019 Jan; 38(1)5-16. doi: 10.1016/j.healun.2018.09.016.

PMID:
    30391193
    [PubMed - in process]
Related citations


The efficacy of extracorporeal photopheresis to arrest bronchiolitis obliterans in lung allograft recipients was compared between two automated photopheresis instruments.
Chionis L, Grossman BJ, Hachem R, Commean P, Derfler MC, Vedantham S, Dodds K, Spitznagel E, Atkinson J, Despotis G
Transfusion. 2018 Dec; 58(12)2933-2941. doi: 10.1111/trf.14913.

PMID:
    30312482
    [PubMed - indexed for MEDLINE]
Related citations


National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation.
Mulligan MS, Weill D, Davis RD, Christie JD, Farjah F, Singer JP, Hartwig M, Sanchez PG, Kreisel D, Ware LB, Bermudez C, Hachem RR, Weyant MJ, Gries C, Awori Hayanga JW, Griffith BP, Snyder LD, Odim J, Craig JM, Aggarwal NR, Reineck LA
J Thorac Cardiovasc Surg. 2018 Dec; 156(6)2355-2365. doi: 10.1016/j.jtcvs.2018.08.010.

PMID:
    30244865
    [PubMed - in process]
Related citations


Factors Associated With Mortality and Response to Extracorporeal Photopheresis in Lung Allograft Recipients With Bronchiolitis Obliterans Syndrome.
Karnes HE, Schindler EI, Morrell M, Hachem RR, Berman K, Vedantham S, Atkinson J, Spitznagel E, Despotis GJ
Transplantation. 2019 May; 103(5)1036-1042. doi: 10.1097/TP.0000000000002430.

PMID:
    30130331
    [PubMed - in process]
Related citations


Transplantation of Lungs Procured From a Donor With an Atrioesophageal Fistula.
Takahashi T, Gauthier JM, Albertin EK, Damiano RJ Jr, Patterson GA, Bierhals AJ, Pasque MK, Hachem RR, Puri V, Kreisel D
Ann Thorac Surg. 2019 Feb; 107(2)e121-e122. doi: 10.1016/j.athoracsur.2018.06.049.

PMID:
    30081029
    [PubMed - in process]
Related citations


A single-center experience of 1500 lung transplant patients.
Balsara KR, Krupnick AS, Bell JM, Khiabani A, Scavuzzo M, Hachem R, Trulock E, Witt C, Byers DE, Yusen R, Meyers B, Kozower B, Patterson GA, Puri V, Kreisel D
J Thorac Cardiovasc Surg. 2018 Aug; 156(2)894-905.e3. doi: 10.1016/j.jtcvs.2018.03.112.

PMID:
    29891245
    [PubMed - in process]
Related citations

Areas of Research Interest

The focus of my clinical research is lung transplantation. I am specifically interested in the development, prevention, and management of chronic allograft dysfunction, or bronchiolitis obliterans syndrome, after lung transplantation. Our group has identified both allo-immune factors such as minimal acute rejection and the de novo development of anti-HLA antibodies, and non-immune variables such as primary graft dysfunction and viral respiratory tract infections as key risk factors for the development of chronic allograft dysfunction. These highlight the complex interactions between the recipient, the allograft, and the environment that result in allograft injury and remodeling leading to physiologic dysfunction. We are currently investigating therapeutic interventions that might uncouple the relationship between these clinical events and chronic allograft dysfunction, including novel immunosuppressive approaches and anti-inflammatory agents.