Patient Portal

Ramsey Hachem, MD

Professor, Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Pulmonary Medicine
Lung Disease

Board Certifications

Critical Care
Internal Medicine
Pulmonary

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lung disease, lung transplant

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-454-5571

Education

Education

Fellowship: Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 2003
Residency: UT Southwestern Medical Center, Dallas, Texas 2000
Medical Degree: University of Texas, Southern Medical Center in Dallas, Dallas, Texas 1997
B.A.: Chemistry, Southern Methodist University, Dallas, Texas 1992

Publication & Research

Publication & Research

IL-22 is required for the induction of bronchus-associated lymphoid tissue in tolerant lung allografts.
Tanaka S, Gauthier JM, Fuchs A, Li W, Tong AY, Shea Harrison M, Higashikubo R, Terada Y, Hachem RR, Ruiz-Perez D, Ritter JH, Cella M, Colonna M, Turnbull IR, Krupnick AS, Gelman AE, Kreisel D
Am J Transplant. 2019 Nov 13; doi: 10.1111/ajt.15701.

PMID:
    31721409
    [PubMed - as supplied by publisher]
Related citations


Molecular phenotyping of rejection-related changes in mucosal biopsies from lung transplants.
Halloran K, Parkes MD, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Levine D, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Hirji A, Weinkauf J, Halloran PF
Am J Transplant. 2019 Nov 2; doi: 10.1111/ajt.15685.

PMID:
    31679176
    [PubMed - as supplied by publisher]
Related citations


Pseudomonas aeruginosa and acute rejection independently increase the risk of donor-specific antibodies after lung transplantation.
Kulkarni HS, Tsui K, Sunder S, Ganninger A, Tague LK, Witt CA, Byers DE, Trulock EP, Nava R, Puri V, Kreisel D, Mohanakumar T, Gelman AE, Hachem RR
Am J Transplant. 2019 Nov 2; doi: 10.1111/ajt.15687.

PMID:
    31677358
    [PubMed - as supplied by publisher]
Related citations


The role of the immune system in lung transplantation: towards improved long-term results.
Hachem RR
J Thorac Dis. 2019 Sep; 11(Suppl 14)S1721-S1731. doi: 10.21037/jtd.2019.04.25.

PMID:
    31632749
    [PubMed]
Related citations


Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines.
Crow LD, Jambusaria-Pahlajani A, Chung CL, Baran DA, Lowenstein SE, Abdelmalek M, Ahmed RL, Anadkat MJ, Arcasoy SM, Berg D, Bibee KP, Billingsley E, Black WH, Blalock TW, Bleicher M, Brennan DC, Brodland DG, Brown MR, Carroll BT, Carucci JA, Chang TW, Chaux G, Cusack CA, Dilling DF, Doyle A, Emtiazjoo AM, Ferguson NH, Fosko SW, Fox MC, Goral S, Gray AL, Griffin JR, Hachem RR, Hall SA, Hanlon AM, Hayes D Jr, Hickey GW, Holtz J, Hopkins RS, Hu J, Huang CC, Brian Jiang SI, Kapnadak SG, Kraus ES, Lease ED, Leca N, Lee JC, Leitenberger JJ, Lim MA, Longo MI, Malik SM, Mallea JM, Menter A, Myers SA, Neuburg M, Nijhawan RI, Norman DJ, Otley CC, Paek SY, Parulekar AD, Patel MJ, Patel VA, Patton TJ, Pugliano-Mauro M, Ranganna K, Ravichandran AK, Redenius R, Roll GR, Samie FH, Shin T, Singer JP, Singh P, Soon SL, Soriano T, Squires R, Stasko T, Stein JA, Taler SJ, Terrault NA, Thomas CP, Tokman S, Tomic R, Twigg AR, Wigger MA, Zeitouni NC, Arron ST
Transpl Int. 2019 Dec; 32(12)1268-1276. doi: 10.1111/tri.13520.

PMID:
    31502728
    [PubMed - in process]
Related citations


Rabbit antithymocyte globulin for the treatment of chronic lung allograft dysfunction.
January SE, Fester KA, Bain KB, Kulkarni HS, Witt CA, Byers DE, Alexander-Brett J, Trulock EP, Hachem RR
Clin Transplant. 2019 Oct; 33(10)e13708. doi: 10.1111/ctr.13708.

PMID:
    31494969
    [PubMed - in process]
Related citations


Lung transplant outcomes are influenced by severity of neutropenia and granulocyte colony-stimulating factor treatment.
Tague LK, Scozzi D, Wallendorf M, Gage BF, Krupnick AS, Kreisel D, Byers D, Hachem RR, Gelman AE
Am J Transplant. 2019 Aug 26; doi: 10.1111/ajt.15581.

PMID:
    31452317
    [PubMed - as supplied by publisher]
Related citations


The use of ruxolitinib for acute graft-versus-host disease developing after solid organ transplantation.
Jacobs MT, Olson M, Ferreira BP, Jin R, Hachem R, Byers D, Witt C, Ghobadi A, DiPersio JF, Pusic I
Am J Transplant. 2019 Aug 25; doi: 10.1111/ajt.15579.

PMID:
    31446673
    [PubMed - as supplied by publisher]
Related citations


Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT.
Glanville AR, Verleden GM, Todd JL, Benden C, Calabrese F, Gottlieb J, Hachem RR, Levine D, Meloni F, Palmer SM, Roman A, Sato M, Singer LG, Tokman S, Verleden SE, von der Thüsen J, Vos R, Snell G
J Heart Lung Transplant. 2019 May; 38(5)483-492. doi: 10.1016/j.healun.2019.03.008.

PMID:
    31027539
    [PubMed - in process]
Related citations


Development and Optimization of an ELISA to Quantitate C3(H <sub><i>2</i></sub> O) as a Marker of Human Disease.
Elvington M, Liszewski MK, Liszewski AR, Kulkarni HS, Hachem RR, Mohanakumar T, Kim AHJ, Atkinson JP
Front Immunol. 2019; 10703. doi: 10.3389/fimmu.2019.00703.

PMID:
    31019515
    [PubMed - in process]
Related citations


The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches.
Hachem RR
Hum Immunol. 2019 Aug; 80(8)583-587. doi: 10.1016/j.humimm.2019.04.008.

PMID:
    31005400
    [PubMed - in process]
Related citations


Impact of SLCO1B3 polymorphisms on clinical outcomes in lung allograft recipients receiving mycophenolic acid.
Tague LK, Byers DE, Hachem R, Kreisel D, Krupnick AS, Kulkarni HS, Chen C, Huang HJ, Gelman A
Pharmacogenomics J. 2019 Apr 17; doi: 10.1038/s41397-019-0086-0.

PMID:
    30992538
    [PubMed - as supplied by publisher]
Related citations


An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.
Liu Z, Liao F, Scozzi D, Furuya Y, Pugh KN, Hachem R, Chen DL, Cano M, Green JM, Krupnick AS, Kreisel D, Perl AKT, Huang HJ, Brody SL, Gelman AE
JCI Insight. 2019 Apr 16; 5pii: 124732. doi: 10.1172/jci.insight.124732.

PMID:
    30990794
    [PubMed - in process]
Related citations


Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT.
Verleden GM, Glanville AR, Lease ED, Fisher AJ, Calabrese F, Corris PA, Ensor CR, Gottlieb J, Hachem RR, Lama V, Martinu T, Neil DAH, Singer LG, Snell G, Vos R
J Heart Lung Transplant. 2019 May; 38(5)493-503. doi: 10.1016/j.healun.2019.03.009.

PMID:
    30962148
    [PubMed - in process]
Related citations


The role of donor-derived exosomes in lung allograft rejection.
Ravichandran R, Bansal S, Rahman M, Sharma M, Liu W, Bharat A, Hachem R, Omar A, Smith MA, Mohanakumar T
Hum Immunol. 2019 Aug; 80(8)588-594. doi: 10.1016/j.humimm.2019.03.012.

PMID:
    30898684
    [PubMed - in process]
Related citations


Molecular assessment of rejection and injury in lung transplant biopsies.
Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF
J Heart Lung Transplant. 2019 May; 38(5)504-513. doi: 10.1016/j.healun.2019.01.1317.

PMID:
    30773443
    [PubMed - in process]
Related citations


Chest computed tomography imaging improves potential lung donor assessment.
Gauthier JM, Bierhals AJ, Liu J, Balsara KR, Frederiksen C, Gremminger E, Hachem RR, Witt CA, Trulock EP, Byers DE, Yusen RD, Aguilar PR, Marklin G, Nava RG, Kozower BD, Pasque MK, Meyers BF, Patterson GA, Kreisel D, Puri V
J Thorac Cardiovasc Surg. 2019 Apr; 157(4)1711-1718.e1. doi: 10.1016/j.jtcvs.2018.11.038.

PMID:
    30772037
    [PubMed - in process]
Related citations


Association between Allosensitization and Waiting List Outcomes among Adult Lung Transplant Candidates in the United States.
Tague LK, Witt CA, Byers DE, Yusen RD, Aguilar PR, Kulkarni HS, Bain KB, Fester KA, Puri V, Kreisel D, Mohanakumar T, Trulock EP, Hachem RR
Ann Am Thorac Soc. 2019 Jul; 16(7)846-852. doi: 10.1513/AnnalsATS.201810-713OC.

PMID:
    30763122
    [PubMed - in process]
Related citations


Unintended consequences of changes to lung allocation policy.
Puri V, Hachem RR, Frye CC, Harrison MS, Semenkovich TR, Lynch JP, Ridolfi G, Rowe C, Meyers BF, Patterson GA, Kozower BD, Pasque MK, Nava RG, Marklin GF, Brockmeier D, Sweet SC, Chapman WC, Kreisel D
Am J Transplant. 2019 Aug; 19(8)2164-2167. doi: 10.1111/ajt.15307.

PMID:
    30758137
    [PubMed - in process]
Related citations


Technical Considerations for Lung Transplantation in Kartagener's Syndrome.
Gauthier JM, Takahashi T, Bierhals AJ, Brody SL, Hachem RR, Witt CA, Byers DE, Yusen RD, Trulock EP, Aguilar PR, Nava RG, Kozower BD, Meyers BF, Patterson GA, Kreisel D, Puri V
Ann Thorac Surg. 2019 May; 107(5)e337-e339. doi: 10.1016/j.athoracsur.2018.08.095.

PMID:
    30612988
    [PubMed - in process]
Related citations

Areas of Research Interest

The focus of my clinical research is lung transplantation. I am specifically interested in the development, prevention, and management of chronic allograft dysfunction, or bronchiolitis obliterans syndrome, after lung transplantation. Our group has identified both allo-immune factors such as minimal acute rejection and the de novo development of anti-HLA antibodies, and non-immune variables such as primary graft dysfunction and viral respiratory tract infections as key risk factors for the development of chronic allograft dysfunction. These highlight the complex interactions between the recipient, the allograft, and the environment that result in allograft injury and remodeling leading to physiologic dysfunction. We are currently investigating therapeutic interventions that might uncouple the relationship between these clinical events and chronic allograft dysfunction, including novel immunosuppressive approaches and anti-inflammatory agents.