Patient Portal

Ramsey Hachem, MD

Professor, Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Pulmonary Medicine
Lung Disease

Board Certifications

Critical Care
Internal Medicine
Pulmonary

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lung disease, lung transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-454-5571

Education

Education

Fellowship: Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 2003
Residency: UT Southwestern Medical Center, Dallas, Texas 2000
Medical Degree: University of Texas, Southern Medical Center in Dallas, Dallas, Texas 1997
B.A.: Chemistry, Southern Methodist University, Dallas, Texas 1992

Publication & Research

Publication & Research

Transplantation of Lungs Procured From a Donor with an Atrioesophageal Fistula.
Takahashi T, Gauthier JM, Albertin EK, Damiano RJ Jr, Patterson GA, Bierhals AJ, Pasque MK, Hachem RR, Puri V, Kreisel D
Ann Thorac Surg. 2018 Aug 3; pii: S0003-4975(18)31053-1. doi: 10.1016/j.athoracsur.2018.06.049.

PMID:
    30081029
    [PubMed - as supplied by publisher]
Related citations


A single-center experience of 1500 lung transplant patients.
Balsara KR, Krupnick AS, Bell JM, Khiabani A, Scavuzzo M, Hachem R, Trulock E, Witt C, Byers DE, Yusen R, Meyers B, Kozower B, Patterson GA, Puri V, Kreisel D
J Thorac Cardiovasc Surg. 2018 Aug; 156(2)894-905.e3. doi: 10.1016/j.jtcvs.2018.03.112.

PMID:
    29891245
    [PubMed - in process]
Related citations


Human leukocyte antigens antibodies after lung transplantation: Primary results of the HALT study.
Hachem RR, Kamoun M, Budev MM, Askar M, Ahya VN, Lee JC, Levine DJ, Pollack MS, Dhillon GS, Weill D, Schechtman KB, Leard LE, Golden JA, Baxter-Lowe L, Mohanakumar T, Tyan DB, Yusen RD
Am J Transplant. 2018 Apr 24; doi: 10.1111/ajt.14893.

PMID:
    29687961
    [PubMed - as supplied by publisher]
Related citations


Diagnosis, Pathophysiology and Experimental Models of Chronic Lung Allograft Rejection.
Gauthier JM, Ruiz-Pérez D, Li W, Hachem RR, Puri V, Gelman AE, Kreisel D
Transplantation. 2018 Apr 21; doi: 10.1097/TP.0000000000002250.

PMID:
    29683998
    [PubMed - as supplied by publisher]
Related citations


Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.
Tambur AR, Campbell P, Claas FH, Feng S, Gebel HM, Jackson AM, Mannon RB, Reed EF, Tinckam K, Askar M, Chandraker A, Chang PP, Colvin M, Demetris AJ, Diamond JM, Dipchand AI, Fairchild RL, Ford ML, Friedewald J, Gill RG, Glotz D, Goldberg H, Hachem R, Knechtle S, Kobashigawa J, Levine DJ, Levitsky J, Mengel M, Milford E, Newell KA, O'Leary JG, Palmer S, Randhawa P, Smith J, Snyder L, Starling RC, Sweet S, Taner T, Taylor CJ, Woodle S, Zeevi A, Nickerson P
Am J Transplant. 2018 Jul; 18(7)1604-1614. doi: 10.1111/ajt.14752.

PMID:
    29603613
    [PubMed - in process]
Related citations


Immunosuppression: Have We Learnt Anything?
Hachem RR
Semin Respir Crit Care Med. 2018 Apr; 39(2)172-180. doi: 10.1055/s-0037-1615798.

PMID:
    29579769
    [PubMed - in process]
Related citations


Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome After Lung Transplantation.
Hachem R, Corris P
Transplantation. 2018 Jul; 102(7)1059-1065. doi: 10.1097/TP.0000000000002168.

PMID:
    29557913
    [PubMed - in process]
Related citations


Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection.
Gunasekaran M, Sharma M, Hachem R, Bremner R, Smith MA, Mohanakumar T
J Immunol. 2018 Apr 15; 200(8)2535-2541. doi: 10.4049/jimmunol.1701587.

PMID:
    29491008
    [PubMed - in process]
Related citations


Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 May; 73(5)489-492. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - in process]
Related citations


Lung Focused Resuscitation at a Specialized Donor Care Facility Improves Lung Procurement Rates.
Chang SH, Kreisel D, Marklin GF, Cook L, Hachem R, Kozower BD, Balsara KR, Bell JM, Frederiksen C, Meyers BF, Patterson GA, Puri V
Ann Thorac Surg. 2018 May; 105(5)1531-1536. doi: 10.1016/j.athoracsur.2017.12.009.

PMID:
    29337122
    [PubMed - in process]
Related citations


Lung autoantibodies: Ready for prime time?
Milross L, Hachem R, Levine D, Glanville AR
J Heart Lung Transplant. 2017 Nov 8; pii: S1053-2498(17)32095-8. doi: 10.1016/j.healun.2017.10.026.

PMID:
    29198928
    [PubMed - as supplied by publisher]
Related citations


Acute Rejection and Antibody-Mediated Rejection in Lung Transplantation.
Hachem RR
Clin Chest Med. 2017 Dec; 38(4)667-675. doi: 10.1016/j.ccm.2017.07.008.

PMID:
    29128017
    [PubMed - indexed for MEDLINE]
Related citations


Extracorporeal photopheresis for the management of lung allograft rejection.
Witt CA, Hachem RR
Clin Transplant. 2017 Oct; 31(10)doi: 10.1111/ctr.13084.

PMID:
    28853182
    [PubMed - in process]
Related citations


Impact of Delayed Chest Closure on Surgical Site Infection After Lung Transplantation.
Aguilar PR, Bemiss BC, Witt C, Byers DE, Kreisel D, Puri V, Meyers B, Patterson GA, Krupnick AS, Yusen RD, Trulock EP, Hachem RR
Ann Thorac Surg. 2017 Oct; 104(4)1208-1214. doi: 10.1016/j.athoracsur.2017.05.023.

PMID:
    28821338
    [PubMed - indexed for MEDLINE]
Related citations


Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.
Nayak DK, Zhou F, Xu M, Huang J, Tsuji M, Yu J, Hachem R, Gelman AE, Bremner RM, Smith MA, Mohanakumar T
Sci Transl Med. 2017 Jul 12; 9(398)pii: eaal1243. doi: 10.1126/scitranslmed.aal1243.

PMID:
    28701473
    [PubMed - indexed for MEDLINE]
Related citations


Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch.
Zou J, Duffy B, Slade M, Young AL, Steward N, Hachem R, Mohanakumar T
Hum Immunol. 2017 Apr; 78(4)342-349. doi: 10.1016/j.humimm.2017.03.002.

PMID:
    28267558
    [PubMed - indexed for MEDLINE]
Related citations


Update on Chronic Lung Allograft Dysfunction.
Gauthier JM, Hachem RR, Kreisel D
Curr Transplant Rep. 2016 Sep; 3(3)185-191. doi: 10.1007/s40472-016-0112-y.

PMID:
    28090432
    [PubMed]
Related citations


Antibody-mediated Rejection in Lung Transplantation.
Kulkarni HS, Bemiss BC, Hachem RR
Curr Transplant Rep. 2015 Dec; 2(4)316-323.

PMID:
    27896040
    [PubMed]
Related citations


Significant role for microRNA-21 affecting toll-like receptor pathway in primary graft dysfunction after human lung transplantation.
Xu Z, Sharma M, Gelman A, Hachem R, Mohanakumar T
J Heart Lung Transplant. 2017 Mar; 36(3)331-339. doi: 10.1016/j.healun.2016.08.028.

PMID:
    27773452
    [PubMed - indexed for MEDLINE]
Related citations


Evaluation of Enoxaparin Dosing as a Risk Factor for Bleeding in Lung Transplant Recipients.
Sofjan AK, Iuppa JA, Bain KB, Deal EN, Witt CA, Hachem RR, Yusen RD
Ann Pharmacother. 2016 Oct; 50(10)824-31. doi: 10.1177/1060028016656434.

PMID:
    27363845
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

The focus of my clinical research is lung transplantation. I am specifically interested in the development, prevention, and management of chronic allograft dysfunction, or bronchiolitis obliterans syndrome, after lung transplantation. Our group has identified both allo-immune factors such as minimal acute rejection and the de novo development of anti-HLA antibodies, and non-immune variables such as primary graft dysfunction and viral respiratory tract infections as key risk factors for the development of chronic allograft dysfunction. These highlight the complex interactions between the recipient, the allograft, and the environment that result in allograft injury and remodeling leading to physiologic dysfunction. We are currently investigating therapeutic interventions that might uncouple the relationship between these clinical events and chronic allograft dysfunction, including novel immunosuppressive approaches and anti-inflammatory agents.