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Ramsey Hachem, MD

Professor, Medicine
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Pulmonary Medicine
Lung Disease

Board Certifications

Critical Care
Internal Medicine
Pulmonary

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Lung disease, lung transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917
Fax: 314-454-5571

Education

Education

Fellowship: Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri 2003
Residency: UT Southwestern Medical Center, Dallas, Texas 2000
Medical Degree: University of Texas, Southern Medical Center in Dallas, Dallas, Texas 1997
B.A.: Chemistry, Southern Methodist University, Dallas, Texas 1992

Publication & Research

Publication & Research

Acute graft-versus-host disease following lung transplantation in a patient with a novel <i>TERT</i> mutation.
Brestoff JR, Vessoni AT, Brenner KA, Uy GL, DiPersio JF, Blinder M, Witt CA, Byers DE, Hachem RR, Truclock EP, Early DS, Anadkat MJ, Musiek A, Javidan-Nejad C, Balfe DM, Rosman IS, Liu C, Zhang L, Despotis GJ, Ruzinova MB, Sehn JK, Amarillo I, Heusel JW, Swat W, Kim BS, Wartman LD, Yusen RD, Batista LFZ
Thorax. 2018 Jan 30; pii: thoraxjnl-2017-211121. doi: 10.1136/thoraxjnl-2017-211121.

PMID:
    29382801
    [PubMed - as supplied by publisher]
Related citations


Lung Focused Resuscitation at a Specialized Donor Care Facility Improves Lung Procurement Rates.
Chang SH, Kreisel D, Marklin GF, Cook L, Hachem R, Kozower BD, Balsara KR, Bell JM, Frederiksen C, Meyers BF, Patterson GA, Puri V
Ann Thorac Surg. 2018 Jan 11; pii: S0003-4975(18)30015-8. doi: 10.1016/j.athoracsur.2017.12.009.

PMID:
    29337122
    [PubMed - as supplied by publisher]
Related citations


Lung autoantibodies: Ready for prime time?
Milross L, Hachem R, Levine D, Glanville AR
J Heart Lung Transplant. 2017 Nov 8; pii: S1053-2498(17)32095-8. doi: 10.1016/j.healun.2017.10.026.

PMID:
    29198928
    [PubMed - as supplied by publisher]
Related citations


Acute Rejection and Antibody-Mediated Rejection in Lung Transplantation.
Hachem RR
Clin Chest Med. 2017 Dec; 38(4)667-675. doi: 10.1016/j.ccm.2017.07.008.

PMID:
    29128017
    [PubMed - in process]
Related citations


Extracorporeal photopheresis for the management of lung allograft rejection.
Witt CA, Hachem RR
Clin Transplant. 2017 Oct; 31(10)doi: 10.1111/ctr.13084.

PMID:
    28853182
    [PubMed - in process]
Related citations


Impact of Delayed Chest Closure on Surgical Site Infection After Lung Transplantation.
Aguilar PR, Bemiss BC, Witt C, Byers DE, Kreisel D, Puri V, Meyers B, Patterson GA, Krupnick AS, Yusen RD, Trulock EP, Hachem RR
Ann Thorac Surg. 2017 Oct; 104(4)1208-1214. doi: 10.1016/j.athoracsur.2017.05.023.

PMID:
    28821338
    [PubMed - indexed for MEDLINE]
Related citations


Zbtb7a induction in alveolar macrophages is implicated in anti-HLA-mediated lung allograft rejection.
Nayak DK, Zhou F, Xu M, Huang J, Tsuji M, Yu J, Hachem R, Gelman AE, Bremner RM, Smith MA, Mohanakumar T
Sci Transl Med. 2017 Jul 12; 9(398)pii: eaal1243. doi: 10.1126/scitranslmed.aal1243.

PMID:
    28701473
    [PubMed - in process]
Related citations


Rapid detection of donor cell free DNA in lung transplant recipients with rejections using donor-recipient HLA mismatch.
Zou J, Duffy B, Slade M, Young AL, Steward N, Hachem R, Mohanakumar T
Hum Immunol. 2017 Apr; 78(4)342-349. doi: 10.1016/j.humimm.2017.03.002.

PMID:
    28267558
    [PubMed - indexed for MEDLINE]
Related citations


Update on Chronic Lung Allograft Dysfunction.
Gauthier JM, Hachem RR, Kreisel D
Curr Transplant Rep. 2016 Sep; 3(3)185-191. doi: 10.1007/s40472-016-0112-y.

PMID:
    28090432
    [PubMed]
Related citations


Antibody-mediated Rejection in Lung Transplantation.
Kulkarni HS, Bemiss BC, Hachem RR
Curr Transplant Rep. 2015 Dec; 2(4)316-323.

PMID:
    27896040
    [PubMed]
Related citations


Significant role for microRNA-21 affecting toll-like receptor pathway in primary graft dysfunction after human lung transplantation.
Xu Z, Sharma M, Gelman A, Hachem R, Mohanakumar T
J Heart Lung Transplant. 2017 Mar; 36(3)331-339. doi: 10.1016/j.healun.2016.08.028.

PMID:
    27773452
    [PubMed - in process]
Related citations


Evaluation of Enoxaparin Dosing as a Risk Factor for Bleeding in Lung Transplant Recipients.
Sofjan AK, Iuppa JA, Bain KB, Deal EN, Witt CA, Hachem RR, Yusen RD
Ann Pharmacother. 2016 Oct; 50(10)824-31. doi: 10.1177/1060028016656434.

PMID:
    27363845
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA-144 is unlikely to play a role in bronchiolitis obliterans syndrome.
Xu Z, Ramachandran S, Gunasekaran M, Zhou F, Trulock E, Kreisel D, Hachem R, Mohanakumar T
J Heart Lung Transplant. 2016 Apr; 35(4)543-4. doi: 10.1016/j.healun.2016.01.022.

PMID:
    27044533
    [PubMed - indexed for MEDLINE]
Related citations


Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.
Levine DJ, Glanville AR, Aboyoun C, Belperio J, Benden C, Berry GJ, Hachem R, Hayes D Jr, Neil D, Reinsmoen NL, Snyder LD, Sweet S, Tyan D, Verleden G, Westall G, Yusen RD, Zamora M, Zeevi A
J Heart Lung Transplant. 2016 Apr; 35(4)397-406. doi: 10.1016/j.healun.2016.01.1223.

PMID:
    27044531
    [PubMed - indexed for MEDLINE]
Related citations


Humoral responses after lung transplantation.
Hachem RR
Curr Opin Organ Transplant. 2016 Jun; 21(3)267-71. doi: 10.1097/MOT.0000000000000308.

PMID:
    26967997
    [PubMed - indexed for MEDLINE]
Related citations


Hyperammonemia Syndrome After Lung Transplantation: A Single Center Experience.
Chen C, Bain KB, Iuppa JA, Yusen RD, Byers DE, Patterson GA, Trulock EP, Hachem RR, Witt CA
Transplantation. 2016 Mar; 100(3)678-84. doi: 10.1097/TP.0000000000000868.

PMID:
    26335916
    [PubMed - indexed for MEDLINE]
Related citations


The impact of pre-transplant allosensitization on outcomes after lung transplantation.
Bosanquet JP, Witt CA, Bemiss BC, Byers DE, Yusen RD, Patterson AG, Kreisel D, Mohanakumar T, Trulock EP, Hachem RR
J Heart Lung Transplant. 2015 Nov; 34(11)1415-22. doi: 10.1016/j.healun.2015.06.003.

PMID:
    26169666
    [PubMed - indexed for MEDLINE]
Related citations


MicroRNA-144 dysregulates the transforming growth factor-β signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation.
Xu Z, Ramachandran S, Gunasekaran M, Zhou F, Trulock E, Kreisel D, Hachem R, Mohanakumar T
J Heart Lung Transplant. 2015 Sep; 34(9)1154-62. doi: 10.1016/j.healun.2015.03.021.

PMID:
    25979625
    [PubMed - indexed for MEDLINE]
Related citations


De novo-developed antibodies to donor MHC antigens lead to dysregulation of microRNAs and induction of MHC class II.
Xu Z, Nayak DK, Benshoff N, Hachem R, Gelman AE, Mohanakumar T
J Immunol. 2015 Jun 15; 194(12)6133-43. doi: 10.4049/jimmunol.1401848.

PMID:
    25941328
    [PubMed - indexed for MEDLINE]
Related citations


Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans.
Bharat A, Cunningham SA, Scott Budinger GR, Kreisel D, DeWet CJ, Gelman AE, Waites K, Crabb D, Xiao L, Bhorade S, Ambalavanan N, Dilling DF, Lowery EM, Astor T, Hachem R, Krupnick AS, DeCamp MM, Ison MG, Patel R
Sci Transl Med. 2015 Apr 22; 7(284)284re3. doi: 10.1126/scitranslmed.aaa8419.

PMID:
    25904745
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

The focus of my clinical research is lung transplantation. I am specifically interested in the development, prevention, and management of chronic allograft dysfunction, or bronchiolitis obliterans syndrome, after lung transplantation. Our group has identified both allo-immune factors such as minimal acute rejection and the de novo development of anti-HLA antibodies, and non-immune variables such as primary graft dysfunction and viral respiratory tract infections as key risk factors for the development of chronic allograft dysfunction. These highlight the complex interactions between the recipient, the allograft, and the environment that result in allograft injury and remodeling leading to physiologic dysfunction. We are currently investigating therapeutic interventions that might uncouple the relationship between these clinical events and chronic allograft dysfunction, including novel immunosuppressive approaches and anti-inflammatory agents.