Patient Portal

Ramaswamy Govindan, MD

Professor, Medicine
Division of Medical Oncology

Specialty Areas

Medical Oncology
Esophageal Cancer
Pulmonary Oncology
Lung Cancer

Board Certifications

Hematology
Internal Medicine
Medical Oncology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Esophageal, thoracic and lung cancer

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-747-1171
Fax: 314-362-3895

Education

Education

Fellowship: Hematology - Oncology at Washington University School of Medicine, St. Louis, MO
Residency: Internal Medicine at Michael Reese Hospital and Medical Center, Chicago, IL
Residency: Internal Medicine at JIPMER, India
Medical Degree: University of Madras, Madras, India 1987
B.S.: SIR. MCTM Higher Secondary School, Madras, India 1980

Publication & Research

Publication & Research

Accounting for proximal variants improves neoantigen prediction.
Hundal J, Kiwala S, Feng YY, Liu CJ, Govindan R, Chapman WC, Uppaluri R, Swamidass SJ, Griffith OL, Mardis ER, Griffith M
Nat Genet. 2018 Dec 3; doi: 10.1038/s41588-018-0283-9.

PMID:
    30510237
    [PubMed - as supplied by publisher]
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SELECT: A Phase II Trial of Adjuvant Erlotinib in Patients With Resected Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer.
Pennell NA, Neal JW, Chaft JE, Azzoli CG, Jänne PA, Govindan R, Evans TL, Costa DB, Wakelee HA, Heist RS, Shapiro MA, Muzikansky A, Murthy S, Lanuti M, Rusch VW, Kris MG, Sequist LV
J Clin Oncol. 2018 Nov 16; JCO1800131. doi: 10.1200/JCO.18.00131.

PMID:
    30444685
    [PubMed - as supplied by publisher]
Related citations


A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data.
Ainscough BJ, Barnell EK, Ronning P, Campbell KM, Wagner AH, Fehniger TA, Dunn GP, Uppaluri R, Govindan R, Rohan TE, Griffith M, Mardis ER, Swamidass SJ, Griffith OL
Nat Genet. 2018 Dec; 50(12)1735-1743. doi: 10.1038/s41588-018-0257-y.

PMID:
    30397337
    [PubMed - in process]
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ABOUND.2L+: A randomized phase 2 study of nanoparticle albumin-bound paclitaxel with or without CC-486 as second-line treatment for advanced nonsquamous non-small cell lung cancer (NSCLC).
Morgensztern D, Cobo M, Ponce Aix S, Postmus PE, Lewanski CR, Bennouna J, Fischer JR, Juan-Vidal O, Stewart DJ, Fasola G, Ardizzoni A, Bhore R, Wolfsteiner M, Talbot DC, Jin Ong T, Govindan R, The Abound L Investigators
Cancer. 2018 Nov 1; doi: 10.1002/cncr.31779.

PMID:
    30383906
    [PubMed - as supplied by publisher]
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.
Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Du D, Creighton CJ, Mills GB, Cancer Genome Atlas Research Network., Camargo F, Liang H
Cell Rep. 2018 Oct 30; 25(5)1304-1317.e5. doi: 10.1016/j.celrep.2018.10.001.

PMID:
    30380420
    [PubMed - in process]
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Targeting Resistance to Targeted Therapies: Combating a Resilient Foe.
Devarakonda S, Govindan R
Clin Cancer Res. 2018 Oct 23; doi: 10.1158/1078-0432.CCR-18-3178.

PMID:
    30352903
    [PubMed - as supplied by publisher]
Related citations


A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.
Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Deng C, Resar L, Cancer Genome Atlas Research Network., Weinstein JN, Mishra L, Akbani R
Cell Syst. 2018 Oct 24; 7(4)422-437.e7. doi: 10.1016/j.cels.2018.08.010.

PMID:
    30268436
    [PubMed - in process]
Related citations


Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma.
Yu H, Chen Z, Ballman KV, Watson MA, Govindan R, Lanc I, Beer DG, Bueno R, Chirieac LR, Chui MH, Chen G, Franklin WA, Gandara DR, Genova C, Brovsky KA, Joshi MM, Merrick DT, Richards WG, Rivard CJ, Harpole DH, Tsao MS, van Bokhoven A, Shepherd FA, Hirsch FR
J Thorac Oncol. 2018 Sep 22; pii: S1556-0864(18)33116-2. doi: 10.1016/j.jtho.2018.09.006.

PMID:
    30253973
    [PubMed - as supplied by publisher]
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Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.
Wagner AH, Devarakonda S, Skidmore ZL, Krysiak K, Ramu A, Trani L, Kunisaki J, Masood A, Waqar SN, Spies NC, Morgensztern D, Waligorski J, Ponce J, Fulton RS, Maggi LB Jr, Weber JD, Watson MA, O'Conor CJ, Ritter JH, Olsen RR, Cheng H, Mukhopadhyay A, Can I, Cessna MH, Oliver TG, Mardis ER, Wilson RK, Griffith M, Griffith OL, Govindan R
Nat Commun. 2018 Sep 17; 9(1)3787. doi: 10.1038/s41467-018-06162-9.

PMID:
    30224629
    [PubMed - in process]
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Ensuring signal quality of cerebral near infrared spectroscopy during continuous longterm monitoring.
Govindan RB, Massaro AN, du Plessis A
J Neurosci Methods. 2018 Nov 1; 309147-152. doi: 10.1016/j.jneumeth.2018.09.003.

PMID:
    30189283
    [PubMed - in process]
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Tumor Mutation Burden as a Biomarker in Resected Non-Small-Cell Lung Cancer.
Devarakonda S, Rotolo F, Tsao MS, Lanc I, Brambilla E, Masood A, Olaussen KA, Fulton R, Sakashita S, McLeer-Florin A, Ding K, Le Teuff G, Shepherd FA, Pignon JP, Graziano SL, Kratzke R, Soria JC, Seymour L, Govindan R, Michiels S
J Clin Oncol. 2018 Aug 14; JCO2018781963. doi: 10.1200/JCO.2018.78.1963.

PMID:
    30106638
    [PubMed - as supplied by publisher]
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Comprehensive Characterization of Cancer Driver Genes and Mutations.
Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Kwok-Shing Ng P, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Cortés-Ciriano I, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, MC3 Working Group., Cancer Genome Atlas Research Network., Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L
Cell. 2018 Aug 9; 174(4)1034-1035. doi: 10.1016/j.cell.2018.07.034.

PMID:
    30096302
    [PubMed - in process]
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Phase Ib/II study of the pan-cyclin-dependent kinase inhibitor roniciclib in combination with chemotherapy in patients with extensive-disease small-cell lung cancer.
Cho BC, Dy GK, Govindan R, Kim DW, Pennell NA, Zalcman G, Besse B, Kim JH, Koca G, Rajagopalan P, Langer S, Ocker M, Nogai H, Barlesi F
Lung Cancer. 2018 Sep; 12314-21. doi: 10.1016/j.lungcan.2018.04.022.

PMID:
    30089585
    [PubMed - in process]
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Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.
Kahles A, Lehmann KV, Toussaint NC, Hüser M, Stark SG, Sachsenberg T, Stegle O, Kohlbacher O, Sander C, Cancer Genome Atlas Research Network., Rätsch G
Cancer Cell. 2018 Aug 13; 34(2)211-224.e6. doi: 10.1016/j.ccell.2018.07.001.

PMID:
    30078747
    [PubMed - in process]
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Autonomic nervous system depression at term in neurologically normal premature infants.
Mulkey SB, Kota S, Swisher CB, Hitchings L, Metzler M, Wang Y, Maxwell GL, Baker R, du Plessis AJ, Govindan R
Early Hum Dev. 2018 Aug; 12311-16. doi: 10.1016/j.earlhumdev.2018.07.003.

PMID:
    30025221
    [PubMed - in process]
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Proteogenomic Analysis of Surgically Resected Lung Adenocarcinoma.
Sharpnack MF, Ranbaduge N, Srivastava A, Cerciello F, Codreanu SG, Liebler DC, Mascaux C, Miles WO, Morris R, McDermott JE, Sharpnack JL, Amann J, Maher CA, Machiraju R, Wysocki VH, Govindan R, Mallick P, Coombes KR, Huang K, Carbone DP
J Thorac Oncol. 2018 Oct; 13(10)1519-1529. doi: 10.1016/j.jtho.2018.06.025.

PMID:
    30017829
    [PubMed - in process]
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The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC).
Brahmer JR, Govindan R, Anders RA, Antonia SJ, Sagorsky S, Davies MJ, Dubinett SM, Ferris A, Gandhi L, Garon EB, Hellmann MD, Hirsch FR, Malik S, Neal JW, Papadimitrakopoulou VA, Rimm DL, Schwartz LH, Sepesi B, Yeap BY, Rizvi NA, Herbst RS
J Immunother Cancer. 2018 Jul 17; 6(1)75. doi: 10.1186/s40425-018-0382-2.

PMID:
    30012210
    [PubMed - in process]
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NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 5.2018.
Ettinger DS, Aisner DL, Wood DE, Akerley W, Bauman J, Chang JY, Chirieac LR, D'Amico TA, Dilling TJ, Dobelbower M, Govindan R, Gubens MA, Hennon M, Horn L, Lackner RP, Lanuti M, Leal TA, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Patel SP, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M
J Natl Compr Canc Netw. 2018 Jul; 16(7)807-821. doi: 10.6004/jnccn.2018.0062.

PMID:
    30006423
    [PubMed - in process]
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Direct Visualization of the Conformational Dynamics of Single Influenza Hemagglutinin Trimers.
Das DK, Govindan R, Nikić-Spiegel I, Krammer F, Lemke EA, Munro JB
Cell. 2018 Aug 9; 174(4)926-937.e12. doi: 10.1016/j.cell.2018.05.050.

PMID:
    29961575
    [PubMed - in process]
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.
Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network., Spellman PT, Rathmell WK, Linehan WM
Cell Rep. 2018 Jun 19; 23(12)3698. doi: 10.1016/j.celrep.2018.06.032.

PMID:
    29925010
    [PubMed - in process]
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