Patient Portal

Rajendra S. Apte, MD, PhD

Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences

Specialty Areas

Ophthalmology, Retina
Retina
Ophthalmology

Board Certifications

Ophthalmology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Diabetic retinopathy, macular surgery, macular holes, macular pucker, age-related macular degeneration, vitreous substitutes, retinal detachments

  • Maps & Directions
  • Education
  • Publication & Research
  • In the News
  • Financial Disclosures
  • Videos

Maps & Directions

Maps & Directions

Barnes-Jewish Center for Outpatient Health

4901 Forest Park Avenue
St. Louis, MO 63108

Floor: 6th Floor
Office Phone: 314-362-EYES
Fax: 314-362-3725

Center for Advanced Medicine - South County

5201 Midamerica Plaza
St. Louis, MO 63129

Suite: 2500
Office Phone: 314-273-0020
Fax: 314-842-2316

Education

Education

Fellowship: Vitreoretinal, Wilmer Ophthalmological Institute, Baltimore, Maryland 2003
Fellowship: Retinal Vascular, Wilmer Ophthalmological Institute, Baltimore, Maryland 2002
Residency: Ophthalmology, UT Southwestern Medical Center, Dallas, Texas 2001
Ph.D.: Cellular and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 1997
Medical Degree: L.T.M. Medical College, University of Bombay, Bombay, India 1992
Pre-Med: University of Bombay, Bombay, India 1986

Publication & Research

Publication & Research

NAD<sup>+</sup> and sirtuins in retinal degenerative diseases: A look at future therapies.
Lin JB, Apte RS
Prog Retin Eye Res. 2018 Jun 12; pii: S1350-9462(17)30125-8. doi: 10.1016/j.preteyeres.2018.06.002.

PMID:
    29906612
    [PubMed - as supplied by publisher]
Related citations


Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging.
Lin JB, Sene A, Santeford A, Fujiwara H, Sidhu R, Ligon MM, Shankar VA, Ban N, Mysorekar IU, Ory DS, Apte RS
EBioMedicine. 2018 Jun 11; pii: S2352-3964(18)30200-7. doi: 10.1016/j.ebiom.2018.05.035.

PMID:
    29903570
    [PubMed - as supplied by publisher]
Related citations


WNT7A/B promote choroidal neovascularization.
Lin JB, Sene A, Wiley LA, Santeford A, Nudleman E, Nakamura R, Lin JB, Moolani HV, Apte RS
Exp Eye Res. 2018 Jun 1; 174107-112. doi: 10.1016/j.exer.2018.05.033.

PMID:
    29864439
    [PubMed - as supplied by publisher]
Related citations


Role of Sirtuins in Retinal Function Under Basal Conditions.
Lin JB, Kubota S, Mostoslavsky R, Apte RS
Adv Exp Med Biol. 2018; 1074561-567. doi: 10.1007/978-3-319-75402-4_68.

PMID:
    29721988
    [PubMed - in process]
Related citations


Inflammation-Induced Photoreceptor Cell Death.
Sene A, Apte RS
Adv Exp Med Biol. 2018; 1074203-208. doi: 10.1007/978-3-319-75402-4_25.

PMID:
    29721945
    [PubMed - in process]
Related citations


SURGICAL OUTCOMES AFTER INVERTED INTERNAL LIMITING MEMBRANE FLAP VERSUS CONVENTIONAL PEELING FOR VERY LARGE MACULAR HOLES.
Narayanan R, Singh SR, Taylor S, Berrocal MH, Chhablani J, Tyagi M, Ohno-Matsui K, Pappuru RR, Apte RS
Retina. 2018 Apr 23; doi: 10.1097/IAE.0000000000002186.

PMID:
    29689027
    [PubMed - as supplied by publisher]
Related citations


Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN
Nature. 2018 Apr; 556(7702)501-504. doi: 10.1038/s41586-018-0052-z.

PMID:
    29670287
    [PubMed - in process]
Related citations


NAD<sup>+</sup>-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism.
Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J
Am J Physiol Endocrinol Metab. 2018 Apr 10; doi: 10.1152/ajpendo.00057.2018.

PMID:
    29634313
    [PubMed - as supplied by publisher]
Related citations


Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration.
Lin JB, Moolani HV, Sene A, Sidhu R, Kell P, Lin JB, Dong Z, Ban N, Ory DS, Apte RS
JCI Insight. 2018 Apr 5; 3(7)pii: 120157. doi: 10.1172/jci.insight.120157.

PMID:
    29618664
    [PubMed - as supplied by publisher]
Related citations


Gene Therapy for Retinal Degeneration.
Apte RS
Cell. 2018 Mar 22; 173(1)5. doi: 10.1016/j.cell.2018.03.021.

PMID:
    29570997
    [PubMed - in process]
Related citations


Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Does Flavor Matter?
Apte RS
JAMA Ophthalmol. 2018 Mar 1; 136(3)269-270. doi: 10.1001/jamaophthalmol.2017.6559.

PMID:
    29392302
    [PubMed - in process]
Related citations


Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications.
Ban N, Siegfried CJ, Apte RS
Trends Mol Med. 2018 Jan; 24(1)7-17. doi: 10.1016/j.molmed.2017.11.004.

PMID:
    29233479
    [PubMed - in process]
Related citations


Neuroprotective role of retinal SIRT3 against acute photo-stress.
Ban N, Ozawa Y, Osada H, Lin JB, Toda E, Watanabe M, Yuki K, Kubota S, Apte RS, Tsubota K
NPJ Aging Mech Dis. 2017; 319. doi: 10.1038/s41514-017-0017-8.

PMID:
    29214052
    [PubMed]
Related citations


Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration.
Cheung CMG, Gan A, Fan Q, Chee ML, Apte RS, Khor CC, Yeo I, Mathur R, Cheng CY, Wong TY, Tai ES
J Lipid Res. 2017 Sep; 58(9)1785-1796. doi: 10.1194/jlr.M073684.

PMID:
    28698208
    [PubMed - indexed for MEDLINE]
Related citations


Tyrosine Kinase Inhibitors in Age-Related Macular Degeneration.
Apte RS
JAMA Ophthalmol. 2017 Jul 1; 135(7)767-768. doi: 10.1001/jamaophthalmol.2017.1600.

PMID:
    28570729
    [PubMed - in process]
Related citations


GDF15 is elevated in mice following retinal ganglion cell death and in glaucoma patients.
Ban N, Siegfried CJ, Lin JB, Shui YB, Sein J, Pita-Thomas W, Sene A, Santeford A, Gordon M, Lamb R, Dong Z, Kelly SC, Cavalli V, Yoshino J, Apte RS
JCI Insight. 2017 May 4; 2(9)pii: 91455. doi: 10.1172/jci.insight.91455.

PMID:
    28469085
    [PubMed - as supplied by publisher]
Related citations


MEKanisms of a Serous Complication.
Montana CL, Apte RS
JAMA Ophthalmol. 2017 May 1; 135(5)413-414. doi: 10.1001/jamaophthalmol.2017.0275.

PMID:
    28358947
    [PubMed - in process]
Related citations


Anti-VEGF Injections and Glaucoma Surgery.
Apte RS, Gordon M, Kass MA
JAMA Ophthalmol. 2017 Apr 1; 135(4)368-369. doi: 10.1001/jamaophthalmol.2017.0148.

PMID:
    28301640
    [PubMed - in process]
Related citations


Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms of Eye Fatigue.
Lin JB, Gerratt BW, Bassi CJ, Apte RS
Invest Ophthalmol Vis Sci. 2017 Jan 1; 58(1)442-447. doi: 10.1167/iovs.16-20663.

PMID:
    28118668
    [PubMed - indexed for MEDLINE]
Related citations


Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI
Cell Metab. 2016 Dec 13; 24(6)795-806. doi: 10.1016/j.cmet.2016.09.013.

PMID:
    28068222
    [PubMed - indexed for MEDLINE]
Related citations

In the News

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Metro Midwest Biotech

Royalties: $1 - $9,999

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018


Company Name: Ophthotech

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018

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