Patient Portal

Pietro Mazzoni, MD, PhD

Associate Professor, Neurology

Specialty Areas

Movement Disorders

Board Certifications


Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Parkinson's disease, Parkinsonism, tremor, dystonia, myoclonus, chorea, tics, Tourette syndrome, cerebellar ataxia, normal pressure hydrocephalus, tardive dyskinesia, involuntary movements, gait disorders, freezing of gait

  • Location(s)
  • Education
  • Publication & Research



Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Floor: Lower Level
Office Phone: 314-362-6908



Medical Degree: Harvard Medical School, Boston, Massachusetts 1995
PhD: Systems Neuroscience, Massachusetts Institute of Technology, Boston, Massachusetts 1994

Publication & Research

Publication & Research

Shabbott B, Ravindran R, Schumacher JW, Wasserman PB, Marder KS, Mazzoni P. Learning fast accurate movements requires intact frontostriatal circuits. Front Hum Neurosci. 2013 Nov 13;7:752. doi: 10.3389/fnhum.2013.00752. eCollection 2013. PubMed PMID: 24312037; PubMed Central PMCID: PMC3826079.

Qian N, Jiang Y, Jiang ZP, Mazzoni P. Movement duration, Fitts’s law, and an infinite-horizon optimal feedback control model for biological motor systems. Neural Comput. 2013 Mar;25(3):697-724. doi: 10.1162/NECO_a_00410. Epub 2012 Dec 28. PubMed PMID: 23272916; PubMed Central PMCID: PMC4082818.


Mazzoni P, Shabbott B, Cortés JC. Motor control abnormalities in Parkinson’s disease. Cold Spring Harb Perspect Med. 2012 Jun;2(6):a009282. doi:10.1101/cshperspect.a009282. Review. PubMed PMID: 22675667; PubMed Central PMCID: PMC3367543.


Shmuelof L, Krakauer JW, Mazzoni P. How is a motor skill learned? Change and invariance at the levels of task success and trajectory control. J Neurophysiol. 2012 Jul;108(2):578-94. doi: 10.1152/jn.00856.2011. Epub 2012 Apr 18. PubMed PMID: 22514286; PubMed Central PMCID: PMC3404800.


Pearson TS, Krakauer JW, Mazzoni P. Learning not to generalize: modular adaptation of visuomotor gain. J Neurophysiol. 2010 Jun;103(6):2938-52. doi:10.1152/jn.01089.2009. Epub 2010 Mar 31. PubMed PMID: 20357068; PubMed Central PMCID: PMC2888232.


Mazzoni P, Wexler NS. Parallel explicit and implicit control of reaching. PLoS One. 2009 Oct 22;4(10):e7557. doi: 10.1371/journal.pone.0007557. PubMed PMID: 19847295; PubMed Central PMCID: PMC2760763.


Mazzoni P, Hristova A, Krakauer JW. Why don’t we move faster? Parkinson’s disease, movement vigor, and implicit motivation. J Neurosci. 2007 Jul 4;27(27):7105-16. PubMed PMID: 17611263.


Mazzoni P, Krakauer JW. An implicit plan overrides an explicit strategy during visuomotor adaptation. J Neurosci. 2006 Apr 5;26(14):3642-5. PubMed PMID: 16597717.

Areas of Research Interest

Computational motor control and movement disorders: How movement disorders, such as Parkinson’s disease and Huntington’s disease, affect our ability to control our movements

Research website: