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Philip M. Barger, MD

Associate Professor, Medicine
Cardiovascular Disease

Specialty Areas

Cardiovascular Disease
Congenital Heart Disease in Adults
Cardiology

Board Certifications

Internal Medicine
Cardiovascular Disease
Adult Congenital Heart Disease

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Congenital heart disease in adults

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: (314) 362-1291
Fax: (314) 747-8213

Education

Education

Master of Science. Zoology: The Ohio State University, Columbus, OH 1984
Bachelor of Science, Zoology: The Ohio State University, Columbus, OH 1982
Medical Degree: Case Western Reserve University, Cleveland, OH 1989
Residency, Internal Medicine: University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 1992
Fellowship (Research) - Internal Medicine: Washington University School of Medicine, St. Louis, MO 1993
Fellowship (Research) - Molecular Biology & Pharmacology: Washington University School of Medicine, St. Louis, MO 1996
Fellowship, Clinical Cardiology: Washington University School of Medicine, St. Louis, MO 1998

Publication & Research

Publication & Research

Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury.
Adamo L, Staloch LJ, Rocha-Resende C, Matkovich SJ, Jiang W, Bajpai G, Weinheimer CJ, Kovacs A, Schilling JD, Barger PM, Bhattacharya D, Mann DL
JCI Insight. 2018 Jun 7; 3(11)pii: 120137. doi: 10.1172/jci.insight.120137.

PMID:
    29875326
    [PubMed - as supplied by publisher]
Related citations


Load-Dependent Changes in Left Ventricular Structure and Function in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure.
Weinheimer CJ, Kovacs A, Evans S, Matkovich SJ, Barger PM, Mann DL
Circ Heart Fail. 2018 May; 11(5)e004351. doi: 10.1161/CIRCHEARTFAILURE.117.004351.

PMID:
    29716898
    [PubMed - in process]
Related citations


TNF receptor-activated factor 2 mediates cardiac protection through noncanonical NF-κB signaling.
Evans S, Tzeng HP, Veis DJ, Matkovich S, Weinheimer C, Kovacs A, Barger PM, Mann DL
JCI Insight. 2018 Feb 8; 3(3)pii: 98278. doi: 10.1172/jci.insight.98278.

PMID:
    29415884
    [PubMed - as supplied by publisher]
Related citations


Impact of pregnancy on autograft dilatation and aortic valve function following the Ross procedure.
Carvajal HG, Lindley KJ, Shah T, Brar AK, Barger PM, Billadello JJ, Eghtesady P
Congenit Heart Dis. 2018 Mar; 13(2)217-221. doi: 10.1111/chd.12554.

PMID:
    29250922
    [PubMed - indexed for MEDLINE]
Related citations


Correction: Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.
Jia Y, Chang HC, Schipma MJ, Liu J, Shete V, Liu N, Sato T, Thorp EB, Barger PM, Zhu YJ, Viswakarma N, Kanwar YS, Ardehali H, Thimmapaya B, Reddy JK
PLoS One. 2016; 11(9)e0164316. doi: 10.1371/journal.pone.0164316.

PMID:
    27690354
    [PubMed - as supplied by publisher]
Related citations


Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.
Jia Y, Chang HC, Schipma MJ, Liu J, Shete V, Liu N, Sato T, Thorp EB, Barger PM, Zhu YJ, Viswakarma N, Kanwar YS, Ardehali H, Thimmapaya B, Reddy JK
PLoS One. 2016; 11(8)e0160755. doi: 10.1371/journal.pone.0160755.

PMID:
    27548259
    [PubMed - indexed for MEDLINE]
Related citations


Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo.
Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM, Mann DL
J Am Heart Assoc. 2015 Jun 2; 4(6)e001993. doi: 10.1161/JAHA.115.001993.

PMID:
    26037082
    [PubMed - indexed for MEDLINE]
Related citations


Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.
Ma X, Liu H, Murphy JT, Foyil SR, Godar RJ, Abuirqeba H, Weinheimer CJ, Barger PM, Diwan A
Mol Cell Biol. 2015 Mar; 35(6)956-76. doi: 10.1128/MCB.01091-14.

PMID:
    25561470
    [PubMed - indexed for MEDLINE]
Related citations


Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy.
Yang KC, Ma X, Liu H, Murphy J, Barger PM, Mann DL, Diwan A
Circ Heart Fail. 2015 Jan; 8(1)175-87. doi: 10.1161/CIRCHEARTFAILURE.114.001635.

PMID:
    25339503
    [PubMed - indexed for MEDLINE]
Related citations


Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury.
Tzeng HP, Evans S, Gao F, Chambers K, Topkara VK, Sivasubramanian N, Barger PM, Mann DL
J Am Heart Assoc. 2014 Feb 26; 3(1)e000662. doi: 10.1161/JAHA.113.000662.

PMID:
    24572254
    [PubMed - indexed for MEDLINE]
Related citations


Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart.
Divakaran VG, Evans S, Topkara VK, Diwan A, Burchfield J, Gao F, Dong J, Tzeng HP, Sivasubramanian N, Barger PM, Mann DL
Circ Heart Fail. 2013 May; 6(3)535-43. doi: 10.1161/CIRCHEARTFAILURE.112.000080.

PMID:
    23493088
    [PubMed - indexed for MEDLINE]
Related citations


Myocardial recovery and the failing heart: myth, magic, or molecular target?
Mann DL, Barger PM, Burkhoff D
J Am Coll Cardiol. 2012 Dec 18; 60(24)2465-72. doi: 10.1016/j.jacc.2012.06.062.

PMID:
    23158527
    [PubMed - indexed for MEDLINE]
Related citations


The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions.
Zhang W, Chancey AL, Tzeng HP, Zhou Z, Lavine KJ, Gao F, Sivasubramanian N, Barger PM, Mann DL
Circulation. 2011 Nov 8; 124(19)2106-16. doi: 10.1161/CIRCULATIONAHA.111.052399.

PMID:
    22025605
    [PubMed - indexed for MEDLINE]
Related citations


Therapeutic targeting of innate immunity in the failing heart.
Topkara VK, Evans S, Zhang W, Epelman S, Staloch L, Barger PM, Mann DL
J Mol Cell Cardiol. 2011 Oct; 51(4)594-9. doi: 10.1016/j.yjmcc.2010.11.003.

PMID:
    21074541
    [PubMed - indexed for MEDLINE]
Related citations


Innate immunity in the adult mammalian heart: for whom the cell tolls.
Mann DL, Topkara VK, Evans S, Barger PM
Trans Am Clin Climatol Assoc. 2010; 12134-50; discussion 50-1.

PMID:
    20697548
    [PubMed - indexed for MEDLINE]
Related citations


Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity.
Thakker GD, Frangogiannis NG, Zymek PT, Sharma S, Raya JL, Barger PM, Taegtmeyer H, Entman ML, Ballantyne CM
Obesity (Silver Spring). 2008 Dec; 16(12)2593-600. doi: 10.1038/oby.2008.414.

PMID:
    18833212
    [PubMed - indexed for MEDLINE]
Related citations


Targeted gene silencing of tumor necrosis factor attenuates the negative inotropic effects of lipopolysaccharide in isolated contracting cardiac myocytes.
Ramabadran RS, Chancey A, Vallejo JG, Barger PM, Sivasubramanian N, Mann DL
Tex Heart Inst J. 2008; 35(1)16-21.

PMID:
    18427645
    [PubMed - indexed for MEDLINE]
Related citations


Inhibition of PPAR-alpha activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-beta/Smad3.
Sekiguchi K, Tian Q, Ishiyama M, Burchfield J, Gao F, Mann DL, Barger PM
Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3)H1443-51.

PMID:
    17098824
    [PubMed - indexed for MEDLINE]
Related citations


Deranged energy substrate metabolism in the failing heart.
Tian Q, Barger PM
Curr Hypertens Rep. 2006 Dec; 8(6)465-71.

PMID:
    17087857
    [PubMed - indexed for MEDLINE]
Related citations


Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.
Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD
EMBO J. 2004 Sep 1; 23(17)3559-69.

PMID:
    15297879
    [PubMed - indexed for MEDLINE]
Related citations