Patient Portal

Philip C Spinella, MD

Professor, Pediatrics
Division of Critical Care Medicine

Specialty Areas

Pediatric Critical Care Medicine

Board Certifications

Pediatrics
Pediatric Critical Care

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

pediatric intensive care,

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-2527

Education

Education

Residency: Pediatrics, Tripler Army Medical Centern Honolulu, Hawaii 1998
BS (Biology): Tufts University, Medford, MA, 1991
Medical Degree: New York Medical College, Valhalla, NY 1996
Fellowship: Pediatric Critical Care Medicine, Children's Hospital of Pennsylvania 2003

Publication & Research

Publication & Research

The use of low-titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic hemorrhage.
Shea SM, Staudt AM, Thomas KA, Schuerer D, Mielke JE, Folkerts D, Lowder E, Martin C, Bochicchio GV, Spinella PC
Transfusion. 2020 Jun 1; doi: 10.1111/trf.15696.

PMID:
    32478896
    [PubMed - as supplied by publisher]
Related citations


An international survey on the use of low titer group O whole blood for the resuscitation of civilian trauma patients in 2020.
Yazer MH, Spinella PC
Transfusion. 2020 Jun 1; doi: 10.1111/trf.15601.

PMID:
    32478858
    [PubMed - as supplied by publisher]
Related citations


Current advances in transfusion medicine: a 2019 review of selected topics from the AABB Clinical Transfusion Medicine Committee.
Pagano MB, Allen ES, Chou ST, Dunbar NM, Gniadek T, Goel R, Harm SK, Hopkins CK, Jacobson J, Lokhandwala PM, Metcalf RA, Raval JS, Schwartz J, Shan H, Spinella PC, Storch E, Cohn CS
Transfusion. 2020 May 29; doi: 10.1111/trf.15848.

PMID:
    32472580
    [PubMed - as supplied by publisher]
Related citations


Predicting Mortality in Children With Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study.
Yehya N, Harhay MO, Klein MJ, Shein SL, Piñeres-Olave BE, Izquierdo L, Sapru A, Emeriaud G, Spinella PC, Flori HR, Dahmer MK, Maddux AB, Lopez-Fernandez YM, Haileselassie B, Hsing DD, Chima RS, Hassinger AB, Valentine SL, Rowan CM, Kneyber MCJ, Smith LS, Khemani RG, Thomas NJ, Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) V1 Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.
Crit Care Med. 2020 Jun; 48(6)e514-e522. doi: 10.1097/CCM.0000000000004345.

PMID:
    32271186
    [PubMed - in process]
Related citations


Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation.
Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP
Vox Sang. 2020 Mar 12; doi: 10.1111/vox.12911.

PMID:
    32166810
    [PubMed - as supplied by publisher]
Related citations


Early Use of Adjunctive Therapies for Pediatric Acute Respiratory Distress Syndrome: A PARDIE Study.
Rowan CM, Klein MJ, Hsing DD, Dahmer MK, Spinella PC, Emeriaud G, Hassinger AB, Piñeres-Olave BE, Flori HR, Haileselassie B, Lopez-Fernandez YM, Chima RS, Shein SL, Maddux AB, Lillie J, Izquierdo L, Kneyber MCJ, Smith LS, Khemani RG, Thomas NJ, Yehya N
Am J Respir Crit Care Med. 2020 Jun 1; 201(11)1389-1397. doi: 10.1164/rccm.201909-1807OC.

PMID:
    32130867
    [PubMed - in process]
Related citations


Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO.
Chlebowski MM, Baltagi S, Carlson M, Levy JH, Spinella PC
Crit Care. 2020 Jan 20; 24(1)19. doi: 10.1186/s13054-020-2726-9.

PMID:
    31959232
    [PubMed - in process]
Related citations


TEG Platelet Mapping and Impedance Aggregometry to Predict Platelet Transfusion During Cardiopulmonary Bypass in Pediatric Patients.
Barker EE, Saini A, Gazit AZ, Shea SM, Baltagi S, Gage BF, Spinella PC
Front Pediatr. 2019; 7509. doi: 10.3389/fped.2019.00509.

PMID:
    31921722
    [PubMed]
Related citations


Metabolic phenotypes of standard and cold-stored platelets.
D'Alessandro A, Thomas KA, Stefanoni D, Gamboni F, Shea SM, Reisz JA, Spinella PC
Transfusion. 2019 Dec 27; doi: 10.1111/trf.15651.

PMID:
    31880330
    [PubMed - as supplied by publisher]
Related citations


Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.
Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.
JAMA. 2019 Dec 10; 322(22)2179-2190. doi: 10.1001/jama.2019.17478.

PMID:
    31821429
    [PubMed - indexed for MEDLINE]
Related citations


Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.
Yazer MH, Spinella PC, Doyle L, Kaufman RM, Dunn R, Hess JR, Filho LA, Fontaine M, Gathof B, Jackson B, Murphy MF, Pasion J, Raval JS, Rosinski K, Seheult J, Shih AW, Sperry J, Staves J, Tuott EE, Ziman A, Triulzi DJ, Biomedical Excellence for Safer Transfusion Collaborative*.
Anesthesiology. 2020 Mar; 132(3)525-534. doi: 10.1097/ALN.0000000000003069.

PMID:
    31789634
    [PubMed - in process]
Related citations


Thromboelastography Variables, Immune Markers, and Endothelial Factors Associated With Shock and NPMODS in Children With Severe Sepsis.
Saini A, Spinella PC, Ignell SP, Lin JC
Front Pediatr. 2019; 7422. doi: 10.3389/fped.2019.00422.

PMID:
    31681719
    [PubMed]
Related citations


Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Pediatric Critical Care Blood Research Network (BloodNet), and the PlasmaTV Investigators and the P3T Investigators.
Pediatr Crit Care Med. 2020 Mar; 21(3)267-275. doi: 10.1097/PCC.0000000000002160.

PMID:
    31644453
    [PubMed - in process]
Related citations


Bleeding Assessment Scale in Critically Ill Children (BASIC): Physician-Driven Diagnostic Criteria for Bleeding Severity.
Nellis ME, Tucci M, Lacroix J, Spinella PC, Haque KD, Stock A, Steiner ME, Faustino EVS, Zantek ND, Davis PJ, Stanworth SJ, Cholette JM, Parker RI, Demaret P, Kneyber MCJ, Russell RT, Stricker PA, Vogel AM, Willems A, Josephson CD, Luban NLC, Loftis LL, Leteurtre S, Stocker CF, Goobie SM, Karam O, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; and the Pediatric Critical Care Blood Research Network (BloodNet).
Crit Care Med. 2019 Dec; 47(12)1766-1772. doi: 10.1097/CCM.0000000000004025.

PMID:
    31567407
    [PubMed - indexed for MEDLINE]
Related citations


Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient.
Scorer TG, Reddoch-Cardenas KM, Thomas KA, Cap AP, Spinella PC
Hematol Oncol Clin North Am. 2019 Oct; 33(5)873-885. doi: 10.1016/j.hoc.2019.05.012.

PMID:
    31466610
    [PubMed - indexed for MEDLINE]
Related citations


The effect of platelet storage temperature on haemostatic, immune, and endothelial function: potential for personalised medicine.
Shea SM, Thomas KA, Spinella PC
Blood Transfus. 2019 Jul; 17(4)321-330. doi: 10.2450/2019.0095-19.

PMID:
    31385802
    [PubMed - indexed for MEDLINE]
Related citations


Effects of whole blood leukoreduction on platelet function and hemostatic parameters.
Morris MC, Veile R, Friend LA, Oh D, Pritts TA, Dorlac WC, Spinella PC, Goodman MD
Transfus Med. 2019 Oct; 29(5)351-357. doi: 10.1111/tme.12622.

PMID:
    31382318
    [PubMed - indexed for MEDLINE]
Related citations


Low titer group O whole blood for prehospital hemorrhagic shock: It is an offer we cannot refuse.
Spinella PC, Gurney J, Yazer MH
Transfusion. 2019 Jul; 59(7)2177-2179. doi: 10.1111/trf.15408.

PMID:
    31268592
    [PubMed - indexed for MEDLINE]
Related citations


The Dead Sea needs salt water… massively bleeding patients need whole blood: The evolution of blood product resuscitation.
Seheult JN, Bahr MP, Spinella PC, Triulzi DJ, Yazer MH
Transfus Clin Biol. 2019 Sep; 26(3)174-179. doi: 10.1016/j.tracli.2019.06.003.

PMID:
    31262629
    [PubMed - indexed for MEDLINE]
Related citations


Critical developments of 2018: A review of the literature from selected topics in transfusion. A committee report from the AABB's Clinical Transfusion Medicine Committee.
Cohn CS, Allen ES, Cushing MM, Dunbar NM, Friedman DF, Goel R, Harm SK, Heddle N, Hopkins CK, Klapper E, Perumbeti A, Ramsey G, Raval JS, Schwartz J, Shaz BH, Spinella PC, Pagano MB
Transfusion. 2019 Aug; 59(8)2733-2748. doi: 10.1111/trf.15348.

PMID:
    31148175
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2019:

Company Name: Entegrion

Royalties:

Equity: No

Consulting/Advisory Board: $100,000 - $149,999

Speaker Fees:

Reporting Date: May 01, 2020


Company Name: KaloCyte

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2020


Company Name: New Health Sciences

Royalties:

Equity: No

Consulting/Advisory Board: $60,000 - $79,999

Speaker Fees:

Reporting Date: May 01, 2020


Company Name: Secure Transfusion Services

Royalties:

Equity: Yes

Consulting/Advisory Board: $80,000 - $99,999

Speaker Fees:

Reporting Date: May 01, 2020

Areas of Research Interest

As director of the critical care translational research program at Washington University and St. Louis Children's Hospital, Dr. Spinella has a wide range of research interests.  Most recently, he is studying blood product storage lesion effects on microvasculature and clinical outcomes coagulation monitoring