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Peter Nagele, MD, MSc

Associate Professor, Anesthesiology and Genetics
Chief, Section of Trauma Anesthesiology

Specialty Areas

Anesthesiology

Hospital Affiliations

Barnes-Jewish Hospital

Languages

German

  • Education
  • Publication & Research

Education

Education

Residency: Anesthesiology and Critical Care Medicine, University of Vienna, Vienna, Austria 2000
Medical Degree: Leopold-Franzens University, Innsbruck, Austria 1995
MSc : Genetic Epidemiology, Washington University School of Medicine 2010
MSc : Clinical Investigation, Washington University School of Medicine 2009

Publication & Research

Publication & Research

The Case for a Revised Definition of Myocardial Infarction-Resolving the Ambiguity of Type 2 Myocardial Infarction.
Nagele P
JAMA Cardiol. 2016 Jun 1; 1(3)247-8. doi: 10.1001/jamacardio.2016.0511.

PMID:
    27438099
    [PubMed - in process]
Related citations


Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis.
Böttiger BW, Bernhard M, Knapp J, Nagele P
Crit Care. 2016 Jan 9; 204. doi: 10.1186/s13054-015-1156-6.

PMID:
    26747085
    [PubMed - in process]
Related citations


Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy.
Zorumski CF, Nagele P, Mennerick S, Conway CR
Front Psychiatry. 2015; 6172. doi: 10.3389/fpsyt.2015.00172.

PMID:
    26696909
    [PubMed]
Related citations


High-Fidelity Analysis of Perioperative QTc Prolongation.
Duma A, Pal S, Helsten D, Stein PK, Miller JP, Nagele P
Anesth Analg. 2016 Feb; 122(2)439-48. doi: 10.1213/ANE.0000000000001023.

PMID:
    26505572
    [PubMed - indexed for MEDLINE]
Related citations


Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study.
Sheth T, Chan M, Butler C, Chow B, Tandon V, Nagele P, Mitha A, Mrkobrada M, Szczeklik W, Faridah Y, Biccard B, Stewart LK, Heels-Ansdell D, Devereaux PJ, Coronary Computed Tomographic Angiography and Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study Investigators
BMJ. 2015 Apr 22; 350h1907. doi: 10.1136/bmj.h1907.

PMID:
    25902738
    [PubMed - indexed for MEDLINE]
Related citations


The hematological effects of nitrous oxide anesthesia in pediatric patients.
Duma A, Cartmill C, Blood J, Sharma A, Kharasch ED, Nagele P
Anesth Analg. 2015 Jun; 120(6)1325-30. doi: 10.1213/ANE.0000000000000642.

PMID:
    25658315
    [PubMed - indexed for MEDLINE]
Related citations


Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial.
Nagele P, Duma A, Kopec M, Gebara MA, Parsoei A, Walker M, Janski A, Panagopoulos VN, Cristancho P, Miller JP, Zorumski CF, Conway CR
Biol Psychiatry. 2015 Jul 1; 78(1)10-8. doi: 10.1016/j.biopsych.2014.11.016.

PMID:
    25577164
    [PubMed - indexed for MEDLINE]
Related citations


Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes.
Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T, Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Writing Group, on behalf of The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Investigators, Appendix 1. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Study Investigators Writing Group, Appendix 2. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN Operations Committee, Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators
Anesthesiology. 2014 Mar; 120(3)564-78. doi: 10.1097/ALN.0000000000000113.

PMID:
    24534856
    [PubMed - indexed for MEDLINE]
Related citations


In reply.
Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP
Anesthesiology. 2014 Feb; 120(2)515-6. doi: 10.1097/ALN.0000000000000093.

PMID:
    24448089
    [PubMed - indexed for MEDLINE]
Related citations


Letter in response to "Use of preoperative cardiac troponin T to identify patients at risk for acute myocardial infraction and long-term mortality after major noncardiac surgery".
Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG
Am Heart J. 2014 Feb; 167(2)e7. doi: 10.1016/j.ahj.2013.11.009.

PMID:
    24439992
    [PubMed - indexed for MEDLINE]
Related citations


Neuraxial block, death, and serious cardiovascular morbidity in the POISE trial.
Nagele P
Br J Anaesth. 2014 Feb; 112(2)392. doi: 10.1093/bja/aet573.

PMID:
    24431369
    [PubMed - indexed for MEDLINE]
Related citations


The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain.
Duma A, Helsten D, Brown F, Bottros MM, Nagele P
Reg Anesth Pain Med. 2014 Jan-Feb; 39(1)31-6. doi: 10.1097/AAP.0000000000000039.

PMID:
    24310050
    [PubMed - indexed for MEDLINE]
Related citations


Exome sequencing: one small step for malignant hyperthermia, one giant step for our specialty--why exome sequencing matters to all of us, not just the experts.
Nagele P
Anesthesiology. 2013 Nov; 119(5)1006-8. doi: 10.1097/ALN.0b013e3182a8a90c.

PMID:
    24195944
    [PubMed - indexed for MEDLINE]
Related citations


The potential impact of wrong TBSA estimations on fluid resuscitation in patients suffering from burns: things to keep in mind.
Parvizi D, Kamolz LP, Giretzlehner M, Haller HL, Trop M, Selig H, Nagele P, Lumenta DB
Burns. 2014 Mar; 40(2)241-5. doi: 10.1016/j.burns.2013.06.019.

PMID:
    24050977
    [PubMed - indexed for MEDLINE]
Related citations


High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery.
Nagele P, Brown F, Gage BF, Gibson DW, Miller JP, Jaffe AS, Apple FS, Scott MG
Am Heart J. 2013 Aug; 166(2)325-332.e1. doi: 10.1016/j.ahj.2013.04.018.

PMID:
    23895816
    [PubMed - indexed for MEDLINE]
Related citations


Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial.
Nagele P, Brown F, Francis A, Scott MG, Gage BF, Miller JP, VINO Study Team
Anesthesiology. 2013 Jul; 119(1)19-28. doi: 10.1097/ALN.0b013e31829761e3.

PMID:
    23856660
    [PubMed - indexed for MEDLINE]
Related citations


Perioperative torsade de pointes: a systematic review of published case reports.
Johnston J, Pal S, Nagele P
Anesth Analg. 2013 Sep; 117(3)559-64. doi: 10.1213/ANE.0b013e318290c380.

PMID:
    23744954
    [PubMed - indexed for MEDLINE]
Related citations


A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics.
Blake CM, Kharasch ED, Schwab M, Nagele P
Clin Pharmacol Ther. 2013 Sep; 94(3)394-9. doi: 10.1038/clpt.2013.96.

PMID:
    23665868
    [PubMed - indexed for MEDLINE]
Related citations


[Thermal injuries in the OEAMTC air rescue service. Epidemiological characteristics of burns/scalds in children and adults].
Selig HF, Nagele P, Lumenta DB, Voelckel WG, Trimmel H, Hüpfl M, Kamolz LP
Unfallchirurg. 2014 Apr; 117(4)334-40. doi: 10.1007/s00113-012-2321-x.

PMID:
    23420061
    [PubMed - indexed for MEDLINE]
Related citations


The epidemiology of amputation injuries in the Austrian helicopter emergency medical service: a retrospective, nationwide cohort study.
Selig HF, Nagele P, Voelckel WG, Trimmel H, Hüpfl M, Lumenta DB, Kamolz LP
Eur J Trauma Emerg Surg. 2012 Dec; 38(6)651-7. doi: 10.1007/s00068-012-0211-0.

PMID:
    26814552
    [PubMed]
Related citations

Areas of Research Interest

Perioperative Myocardial Infarction – perioperative beta-blockers; Nitrous Oxide Pharmacology; Nitrous Oxide and Major Depression; Pharmacogenomics and Personalized Medicine; Cardiac biomarkers; Cardio-pulmonary resuscitation (CPR) and prehospital emergency and trauma care