FollowMyHealth Patient Portal

Paul W. Hruz, MD, PhD

Associate Professor, Pediatrics
Division of Pediatric Endocrinology and Metabolism
Associate Professor, Cell Biology & Physiology
Director, Division of Pediatric Endocrinology & Diabetes

Specialty Areas

Pediatric Endocrinology
Pediatric Diabetes

Board Certifications

Pediatrics
Pediatric Endocrinology & Metabolism

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric endocrinology, pediatric metabolism

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D, 2nd Floor
Office Phone: 314-454-6051
Fax: 314-454-6225

Education

Education

Fellowship: Pediatric Endocrinology, Washington University School of Medicine, St. Louis, Missouri 2000
Residency: Pediatrics, University of Washington School of Medicine, Seattle, Washington 1997
Medical Degree: Medical College of Wisconsin, Milwaukee, Wisconsin 1993

Publication & Research

Publication & Research

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.
DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH
Sci Signal. 2016 Feb 23; 9(416)ra21. doi: 10.1126/scisignal.aac5472.

PMID:
    26905426
    [PubMed - in process]
Related citations


Commentary.
Hruz PW
Clin Chem. 2015 Dec; 61(12)1444. doi: 10.1373/clinchem.2015.243964.

PMID:
    26614228
    [PubMed - indexed for MEDLINE]
Related citations


Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.
Kraft TE, Hresko RC, Hruz PW
Protein Sci. 2015 Dec; 24(12)2008-19. doi: 10.1002/pro.2812.

PMID:
    26402434
    [PubMed - in process]
Related citations


The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.
Kraft TE, Armstrong C, Heitmeier MR, Odom AR, Hruz PW
Antimicrob Agents Chemother. 2015 Oct; 59(10)6203-9. doi: 10.1128/AAC.00899-15.

PMID:
    26248369
    [PubMed - in process]
Related citations


In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.
Mishra RK, Wei C, Hresko RC, Bajpai R, Heitmeier M, Matulis SM, Nooka AK, Rosen ST, Hruz PW, Schiltz GE, Shanmugam M
J Biol Chem. 2015 Jun 5; 290(23)14441-53. doi: 10.1074/jbc.M114.628826.

PMID:
    25847249
    [PubMed - indexed for MEDLINE]
Related citations


HIV and endocrine disorders.
Hruz PW
Endocrinol Metab Clin North Am. 2014 Sep; 43(3)xvii-xviii. doi: 10.1016/j.ecl.2014.07.001.

PMID:
    25169571
    [PubMed - indexed for MEDLINE]
Related citations


Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.
Hresko RC, Kraft TE, Tzekov A, Wildman SA, Hruz PW
J Biol Chem. 2014 Jun 6; 289(23)16100-13. doi: 10.1074/jbc.M113.528430.

PMID:
    24706759
    [PubMed - indexed for MEDLINE]
Related citations


Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy.
Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW
Cardiovasc Endocrinol. 2012 Dec; 1(4)74-82.

PMID:
    23795310
    [PubMed]
Related citations


GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle.
Aerni-Flessner L, Abi-Jaoude M, Koenig A, Payne M, Hruz PW
Cardiovasc Diabetol. 2012 Jun 8; 1163. doi: 10.1186/1475-2840-11-63.

PMID:
    22681646
    [PubMed - indexed for MEDLINE]
Related citations


HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4.
Hresko RC, Hruz PW
PLoS One. 2011; 6(9)e25237. doi: 10.1371/journal.pone.0025237.

PMID:
    21966466
    [PubMed - indexed for MEDLINE]
Related citations


Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.
Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG
Diabetes. 2011 Oct; 60(10)2515-22. doi: 10.2337/db11-0538.

PMID:
    21813803
    [PubMed - indexed for MEDLINE]
Related citations


Molecular mechanisms for insulin resistance in treated HIV-infection.
Hruz PW
Best Pract Res Clin Endocrinol Metab. 2011 Jun; 25(3)459-68. doi: 10.1016/j.beem.2010.10.017.

PMID:
    21663839
    [PubMed - indexed for MEDLINE]
Related citations


Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.
Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW
PLoS One. 2011 Feb 17; 6(2)e17178. doi: 10.1371/journal.pone.0017178.

PMID:
    21359201
    [PubMed - indexed for MEDLINE]
Related citations


GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.
Hruz PW, Yan Q, Tsai L, Koster J, Xu L, Cihlar T, Callebaut C
Antimicrob Agents Chemother. 2011 Apr; 55(4)1377-82. doi: 10.1128/AAC.01184-10.

PMID:
    21245443
    [PubMed - indexed for MEDLINE]
Related citations


Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.
Gazit V, Weymann A, Hartman E, Finck BN, Hruz PW, Tzekov A, Rudnick DA
Hepatology. 2010 Dec; 52(6)2109-17. doi: 10.1002/hep.23920.

PMID:
    20967828
    [PubMed - indexed for MEDLINE]
Related citations


Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice.
Vyas AK, Koster JC, Tzekov A, Hruz PW
J Biol Chem. 2010 Nov 19; 285(47)36395-400. doi: 10.1074/jbc.M110.176321.

PMID:
    20864532
    [PubMed - indexed for MEDLINE]
Related citations


Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, Miller A, Hruz PW, Hamilton JA, Bhasin S
Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12)2028-32. doi: 10.1161/ATVBAHA.109.191304.

PMID:
    19762785
    [PubMed - indexed for MEDLINE]
Related citations


Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice.
Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W
Diabetes. 2009 Aug; 58(8)1739-48. doi: 10.2337/db09-0349.

PMID:
    19509018
    [PubMed - indexed for MEDLINE]
Related citations


HIV protease inhibitors and insulin resistance: lessons from in-vitro, rodent and healthy human volunteer models.
Hruz PW
Curr Opin HIV AIDS. 2008 Nov; 3(6)660-5. doi: 10.1097/COH.0b013e3283139134.

PMID:
    19373039
    [PubMed]
Related citations


The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications.
Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, Bellamine A
Toxicol Pathol. 2009 Jan; 37(1)65-77. doi: 10.1177/0192623308327119.

PMID:
    19171928
    [PubMed - indexed for MEDLINE]
Related citations