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Faculty Physicians

Paul W. Hruz, MD, PhD

Associate Professor, Pediatrics
Division of Pediatric Endocrinology and Metabolism
Associate Professor, Cell Biology & Physiology
Director, Division of Pediatric Endocrinology & Diabetes

Specialty Areas

Pediatric Endocrinology
Pediatric Diabetes

Board Certifications

Pediatrics
Pediatric Endocrinology & Metabolism

Areas of Clinical Interest

Pediatric endocrinology, pediatric metabolism

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D, 2nd Floor
Office Phone: 314-454-6051
Fax: 314-454-6225

Education

Education

Fellowship: Pediatric Endocrinology, Washington University School of Medicine, St. Louis, Missouri 2000
Residency: Pediatrics, University of Washington School of Medicine, Seattle, Washington 1997
Medical Degree: Medical College of Wisconsin, Milwaukee, Wisconsin 1993

Publication & Research

Publication & Research

In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.
Mishra RK, Wei C, Hresko RC, Bajpai R, Heitmeier M, Matulis SM, Nooka AK, Rosen ST, Hruz PW, Schiltz GE, Shanmugam M
J Biol Chem. 2015 Jun 5; 290(23)14441-53. doi: 10.1074/jbc.M114.628826.

PMID:
    25847249
    [PubMed - indexed for MEDLINE]
Related citations


HIV and endocrine disorders.
Hruz PW
Endocrinol Metab Clin North Am. 2014 Sep; 43(3)xvii-xviii. doi: 10.1016/j.ecl.2014.07.001.

PMID:
    25169571
    [PubMed - indexed for MEDLINE]
Related citations


Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.
Hresko RC, Kraft TE, Tzekov A, Wildman SA, Hruz PW
J Biol Chem. 2014 Jun 6; 289(23)16100-13. doi: 10.1074/jbc.M113.528430.

PMID:
    24706759
    [PubMed - indexed for MEDLINE]
Related citations


Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.
Remedi MS, Agapova SE, Vyas AK, Hruz PW, Nichols CG
Diabetes. 2011 Oct; 60(10)2515-22. doi: 10.2337/db11-0538.

PMID:
    21813803
    [PubMed - indexed for MEDLINE]
Related citations


Molecular mechanisms for insulin resistance in treated HIV-infection.
Hruz PW
Best Pract Res Clin Endocrinol Metab. 2011 Jun; 25(3)459-68. doi: 10.1016/j.beem.2010.10.017.

PMID:
    21663839
    [PubMed - indexed for MEDLINE]
Related citations


GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system.
Hruz PW, Yan Q, Tsai L, Koster J, Xu L, Cihlar T, Callebaut C
Antimicrob Agents Chemother. 2011 Apr; 55(4)1377-82. doi: 10.1128/AAC.01184-10.

PMID:
    21245443
    [PubMed - indexed for MEDLINE]
Related citations


Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, Miller A, Hruz PW, Hamilton JA, Bhasin S
Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12)2028-32. doi: 10.1161/ATVBAHA.109.191304.

PMID:
    19762785
    [PubMed - indexed for MEDLINE]
Related citations


The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: cellular mechanisms and clinical implications.
Flint OP, Noor MA, Hruz PW, Hylemon PB, Yarasheski K, Kotler DP, Parker RA, Bellamine A
Toxicol Pathol. 2009 Jan; 37(1)65-77. doi: 10.1177/0192623308327119.

PMID:
    19171928
    [PubMed - indexed for MEDLINE]
Related citations


HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy.
Hruz PW, Yan Q, Struthers H, Jay PY
FASEB J. 2008 Jul; 22(7)2161-7. doi: 10.1096/fj.07-102269.

PMID:
    18256305
    [PubMed - indexed for MEDLINE]
Related citations


Investigating the cellular targets of HIV protease inhibitors: implications for metabolic disorders and improvements in drug therapy.
Murata H, Hruz PW, Mueckler M
Curr Drug Targets Infect Disord. 2002 Mar; 2(1)1-8.

PMID:
    12462148
    [PubMed - indexed for MEDLINE]
Related citations


Structural analysis of the GLUT1 facilitative glucose transporter (review).
Hruz PW, Mueckler MM
Mol Membr Biol. 2001 Jul-Sep; 18(3)183-93.

PMID:
    11681785
    [PubMed - indexed for MEDLINE]
Related citations


Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism.
Hruz PW, Murata H, Mueckler M
Am J Physiol Endocrinol Metab. 2001 Apr; 280(4)E549-53.

PMID:
    11254460
    [PubMed - indexed for MEDLINE]
Related citations


Cysteine-scanning mutagenesis of transmembrane segment 11 of the GLUT1 facilitative glucose transporter.
Hruz PW, Mueckler MM
Biochemistry. 2000 Aug 8; 39(31)9367-72.

PMID:
    10924131
    [PubMed - indexed for MEDLINE]
Related citations


The mechanism of insulin resistance caused by HIV protease inhibitor therapy.
Murata H, Hruz PW, Mueckler M
J Biol Chem. 2000 Jul 7; 275(27)20251-4.

PMID:
    10806189
    [PubMed - indexed for MEDLINE]
Related citations


Cysteine-scanning mutagenesis of transmembrane segment 7 of the GLUT1 glucose transporter.
Hruz PW, Mueckler MM
J Biol Chem. 1999 Dec 17; 274(51)36176-80.

PMID:
    10593902
    [PubMed - indexed for MEDLINE]
Related citations


3-Hydroxy-3-methylglutaryl-CoA lyase: expression and isolation of the recombinant human enzyme and investigation of a mechanism for regulation of enzyme activity.
Roberts JR, Narasimhan C, Hruz PW, Mitchell GA, Miziorko HM
J Biol Chem. 1994 Jul 8; 269(27)17841-6.

PMID:
    8027038
    [PubMed - indexed for MEDLINE]
Related citations


3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.
Mitchell GA, Robert MF, Hruz PW, Wang S, Fontaine G, Behnke CE, Mende-Mueller LM, Schappert K, Lee C, Gibson KM, Miziorko HM
J Biol Chem. 1993 Feb 25; 268(6)4376-81.

PMID:
    8440722
    [PubMed - indexed for MEDLINE]
Related citations