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Paul W. Hruz, MD, PhD

Associate Professor, Pediatrics
Division of Pediatric Endocrinology and Metabolism
Associate Professor, Cell Biology & Physiology

Specialty Areas

Pediatric Endocrinology
Pediatric Diabetes

Board Certifications

Pediatrics
Pediatric Endocrinology & Metabolism

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric endocrinology, pediatric metabolism

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D, 2nd Floor
Office Phone: 314-454-6051
Fax: 314-454-6225

Education

Education

Fellowship: Pediatric Endocrinology, Washington University School of Medicine, St. Louis, Missouri 2000
Residency: Pediatrics, University of Washington School of Medicine, Seattle, Washington 1997
Medical Degree: Medical College of Wisconsin, Milwaukee, Wisconsin 1993

Publication & Research

Publication & Research

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.
Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW
PLoS One. 2019; 14(5)e0216457. doi: 10.1371/journal.pone.0216457.

PMID:
    31071153
    [PubMed - in process]
Related citations


Letter to the Editor: "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline".
Laidlaw MK, Van Meter QL, Hruz PW, Van Mol A, Malone WJ
J Clin Endocrinol Metab. 2019 Mar 1; 104(3)686-687. doi: 10.1210/jc.2018-01925.

PMID:
    30476120
    [PubMed - in process]
Related citations


Contribution of systemic inflammation to permanence of K<sub>ATP</sub>-induced neonatal diabetes in mice.
Emfinger CH, Yan Z, Welscher A, Hung P, McAllister W, Hruz PW, Nichols CG, Remedi MS
Am J Physiol Endocrinol Metab. 2018 Dec 1; 315(6)E1121-E1132. doi: 10.1152/ajpendo.00137.2018.

PMID:
    30226997
    [PubMed - in process]
Related citations


TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose.
Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani B, Graham MJ, Hruz PW, DeBosch BJ
Autophagy. 2018; 14(11)1959-1975. doi: 10.1080/15548627.2018.1493044.

PMID:
    29996716
    [PubMed - in process]
Related citations


Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia.
Heitmeier MR, Payne MA, Weinheimer C, Kovacs A, Hresko RC, Jay PY, Hruz PW
Sci Rep. 2018 Apr 24; 8(1)6475. doi: 10.1038/s41598-018-24867-1.

PMID:
    29691457
    [PubMed - in process]
Related citations


Evaluating the Efficacy of GLUT Inhibitors Using a Seahorse Extracellular Flux Analyzer.
Wei C, Heitmeier M, Hruz PW, Shanmugam M
Methods Mol Biol. 2018; 171369-75. doi: 10.1007/978-1-4939-7507-5_6.

PMID:
    29218518
    [PubMed - indexed for MEDLINE]
Related citations


Development of GLUT4-selective antagonists for multiple myeloma therapy.
Wei C, Bajpai R, Sharma H, Heitmeier M, Jain AD, Matulis SM, Nooka AK, Mishra RK, Hruz PW, Schiltz GE, Shanmugam M
Eur J Med Chem. 2017 Oct 20; 139573-586. doi: 10.1016/j.ejmech.2017.08.029.

PMID:
    28837922
    [PubMed - indexed for MEDLINE]
Related citations


MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.
Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO
Sci Rep. 2017 Aug 21; 7(1)8400. doi: 10.1038/s41598-017-07159-y.

PMID:
    28827774
    [PubMed - indexed for MEDLINE]
Related citations


SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy.
Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ
Sci Rep. 2016 Dec 6; 638586. doi: 10.1038/srep38586.

PMID:
    27922102
    [PubMed - indexed for MEDLINE]
Related citations


A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose Transporters.
Kraft TE, Heitmeier MR, Putanko M, Edwards RL, Ilagan MX, Payne MA, Autry JM, Thomas DD, Odom AR, Hruz PW
Antimicrob Agents Chemother. 2016 Dec; 60(12)7407-7414.

PMID:
    27736766
    [PubMed - indexed for MEDLINE]
Related citations


Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids.
Hresko RC, Kraft TE, Quigley A, Carpenter EP, Hruz PW
J Biol Chem. 2016 Aug 12; 291(33)17271-82. doi: 10.1074/jbc.M116.730168.

PMID:
    27302065
    [PubMed - indexed for MEDLINE]
Related citations


Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.
DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH
Sci Signal. 2016 Feb 23; 9(416)ra21. doi: 10.1126/scisignal.aac5472.

PMID:
    26905426
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Hruz PW
Clin Chem. 2015 Dec; 61(12)1444. doi: 10.1373/clinchem.2015.243964.

PMID:
    26614228
    [PubMed - indexed for MEDLINE]
Related citations


Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4.
Kraft TE, Hresko RC, Hruz PW
Protein Sci. 2015 Dec; 24(12)2008-19. doi: 10.1002/pro.2812.

PMID:
    26402434
    [PubMed - indexed for MEDLINE]
Related citations


The Glucose Transporter PfHT1 Is an Antimalarial Target of the HIV Protease Inhibitor Lopinavir.
Kraft TE, Armstrong C, Heitmeier MR, Odom AR, Hruz PW
Antimicrob Agents Chemother. 2015 Oct; 59(10)6203-9. doi: 10.1128/AAC.00899-15.

PMID:
    26248369
    [PubMed - indexed for MEDLINE]
Related citations


In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy.
Mishra RK, Wei C, Hresko RC, Bajpai R, Heitmeier M, Matulis SM, Nooka AK, Rosen ST, Hruz PW, Schiltz GE, Shanmugam M
J Biol Chem. 2015 Jun 5; 290(23)14441-53. doi: 10.1074/jbc.M114.628826.

PMID:
    25847249
    [PubMed - indexed for MEDLINE]
Related citations


HIV and endocrine disorders.
Hruz PW
Endocrinol Metab Clin North Am. 2014 Sep; 43(3)xvii-xviii. doi: 10.1016/j.ecl.2014.07.001.

PMID:
    25169571
    [PubMed - indexed for MEDLINE]
Related citations


Isoform-selective inhibition of facilitative glucose transporters: elucidation of the molecular mechanism of HIV protease inhibitor binding.
Hresko RC, Kraft TE, Tzekov A, Wildman SA, Hruz PW
J Biol Chem. 2014 Jun 6; 289(23)16100-13. doi: 10.1074/jbc.M113.528430.

PMID:
    24706759
    [PubMed - indexed for MEDLINE]
Related citations


Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy.
Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW
Cardiovasc Endocrinol. 2012 Dec; 1(4)74-82.

PMID:
    23795310
    [PubMed]
Related citations


GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle.
Aerni-Flessner L, Abi-Jaoude M, Koenig A, Payne M, Hruz PW
Cardiovasc Diabetol. 2012 Jun 8; 1163. doi: 10.1186/1475-2840-11-63.

PMID:
    22681646
    [PubMed - indexed for MEDLINE]
Related citations