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Paul T. Kotzbauer, MD, PhD

Associate Professor, Neurology
Division of Adult Neurology

Specialty Areas

Parkinson's Disease
Neurology - Adult
Tremor
Movement Disorders

Board Certifications

Neurology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Parkinson's disease and related disorders, tremor, neurodegeneration with brain iron accumulation (NBIA)

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Floor: Lower Level
Office Phone: 314-362-6908
Fax: 314-747-3258

Education

Education

Fellowship: Movement Disorders, Parkinson's Disease Research, Education, and Clinical Center of the Philadelphia Veterans Medical Center, Philadelphia, Pennsylvania 2003
Residency: Neurology, University of Pennsylania, Philadelphia, Pennsylvania 2001
Ph.D.: Neuroscience, Washington University School of Medicine, St. Louis, Missouri 1997
Medical Degree: Washington University School of Medicine, St. Louis, Missouri 1997
B.S.: Biomedical Engineering Northwestern University, Chicago, Illinois 1989

Publication & Research

Publication & Research

A sensitive assay reveals structural requirements for α-synuclein fibril growth.
Dhavale DD, Tsai C, Bagchi DP, Engel LA, Sarezky J, Kotzbauer PT
J Biol Chem. 2017 Jun 2; 292(22)9034-9050. doi: 10.1074/jbc.M116.767053.

PMID:
    28373279
    [PubMed - indexed for MEDLINE]
Related citations


Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer's Disease.
Sundaram GS, Dhavale DD, Prior JL, Yan P, Cirrito J, Rath NP, Laforest R, Cairns NJ, Lee JM, Kotzbauer PT, Sharma V
Sci Rep. 2016 Nov 2; 635636. doi: 10.1038/srep35636.

PMID:
    27805057
    [PubMed - in process]
Related citations


Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.
Chuang DY, Simonyi A, Kotzbauer PT, Gu Z, Sun GY
J Neuroinflammation. 2015 Oct 31; 12199. doi: 10.1186/s12974-015-0419-0.

PMID:
    26520095
    [PubMed - indexed for MEDLINE]
Related citations


Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease.
Buddhala C, Loftin SK, Kuley BM, Cairns NJ, Campbell MC, Perlmutter JS, Kotzbauer PT
Ann Clin Transl Neurol. 2015 Oct; 2(10)949-59. doi: 10.1002/acn3.246.

PMID:
    26478895
    [PubMed]
Related citations


Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.
Chu W, Zhou D, Gaba V, Liu J, Li S, Peng X, Xu J, Dhavale D, Bagchi DP, d'Avignon A, Shakerdge NB, Bacskai BJ, Tu Z, Kotzbauer PT, Mach RH
J Med Chem. 2015 Aug 13; 58(15)6002-17. doi: 10.1021/acs.jmedchem.5b00571.

PMID:
    26177091
    [PubMed - indexed for MEDLINE]
Related citations


CSF proteins and resting-state functional connectivity in Parkinson disease.
Campbell MC, Koller JM, Snyder AZ, Buddhala C, Kotzbauer PT, Perlmutter JS
Neurology. 2015 Jun 16; 84(24)2413-21. doi: 10.1212/WNL.0000000000001681.

PMID:
    25979701
    [PubMed - indexed for MEDLINE]
Related citations


Correlation between decreased CSF α-synuclein and Aβ₁₋₄₂ in Parkinson disease.
Buddhala C, Campbell MC, Perlmutter JS, Kotzbauer PT
Neurobiol Aging. 2015 Jan; 36(1)476-84. doi: 10.1016/j.neurobiolaging.2014.07.043.

PMID:
    25212463
    [PubMed - indexed for MEDLINE]
Related citations


A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease.
Armstrong RA, Kotzbauer PT, Perlmutter JS, Campbell MC, Hurth KM, Schmidt RE, Cairns NJ
J Neural Transm (Vienna). 2014 Feb; 121(2)171-81. doi: 10.1007/s00702-013-1084-z.

PMID:
    23996276
    [PubMed - indexed for MEDLINE]
Related citations


Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI
Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33)E3138-47. doi: 10.1073/pnas.1301440110.

PMID:
    23898162
    [PubMed - indexed for MEDLINE]
Related citations


Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.
Bagchi DP, Yu L, Perlmutter JS, Xu J, Mach RH, Tu Z, Kotzbauer PT
PLoS One. 2013; 8(2)e55031. doi: 10.1371/journal.pone.0055031.

PMID:
    23405108
    [PubMed - indexed for MEDLINE]
Related citations


Increased risk of parkinsonism associated with welding exposure.
Racette BA, Criswell SR, Lundin JI, Hobson A, Seixas N, Kotzbauer PT, Evanoff BA, Perlmutter JS, Zhang J, Sheppard L, Checkoway H
Neurotoxicology. 2012 Oct; 33(5)1356-61. doi: 10.1016/j.neuro.2012.08.011.

PMID:
    22975422
    [PubMed - indexed for MEDLINE]
Related citations


Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia.
Kotzbauer PT, Cairns NJ, Campbell MC, Willis AW, Racette BA, Tabbal SD, Perlmutter JS
Arch Neurol. 2012 Oct; 69(10)1326-31.

PMID:
    22825369
    [PubMed - indexed for MEDLINE]
Related citations


Synthesis and in vitro evaluation of α-synuclein ligands.
Yu L, Cui J, Padakanti PK, Engel L, Bagchi DP, Kotzbauer PT, Tu Z
Bioorg Med Chem. 2012 Aug 1; 20(15)4625-34. doi: 10.1016/j.bmc.2012.06.023.

PMID:
    22789706
    [PubMed - indexed for MEDLINE]
Related citations


Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism.
Engel LA, Jing Z, O'Brien DE, Sun M, Kotzbauer PT
PLoS One. 2010 Sep 23; 5(9)e12897. doi: 10.1371/journal.pone.0012897.

PMID:
    20886109
    [PubMed - indexed for MEDLINE]
Related citations


Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.
Li M, Husic N, Lin Y, Christensen H, Malik I, McIver S, LaPash Daniels CM, Harris DA, Kotzbauer PT, Goldberg MP, Snider BJ
J Neurosci Methods. 2010 May 30; 189(1)56-64. doi: 10.1016/j.jneumeth.2010.03.019.

PMID:
    20347873
    [PubMed - indexed for MEDLINE]
Related citations


Neurodegeneration associated with genetic defects in phospholipase A(2).
Gregory A, Westaway SK, Holm IE, Kotzbauer PT, Hogarth P, Sonek S, Coryell JC, Nguyen TM, Nardocci N, Zorzi G, Rodriguez D, Desguerre I, Bertini E, Simonati A, Levinson B, Dias C, Barbot C, Carrilho I, Santos M, Malik I, Gitschier J, Hayflick SJ
Neurology. 2008 Oct 28; 71(18)1402-9. doi: 10.1212/01.wnl.0000327094.67726.28.

PMID:
    18799783
    [PubMed - indexed for MEDLINE]
Related citations


Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.
Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM
J Neurosci. 2008 Jul 23; 28(30)7687-98. doi: 10.1523/JNEUROSCI.0143-07.2008.

PMID:
    18650345
    [PubMed - indexed for MEDLINE]
Related citations


Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.
Malik I, Turk J, Mancuso DJ, Montier L, Wohltmann M, Wozniak DF, Schmidt RE, Gross RW, Kotzbauer PT
Am J Pathol. 2008 Feb; 172(2)406-16. doi: 10.2353/ajpath.2008.070823.

PMID:
    18202189
    [PubMed - indexed for MEDLINE]
Related citations


Expectations and challenges in the therapeutic use of neurotrophic factors.
Kotzbauer PT, Holtzman DM
Ann Neurol. 2006 Mar; 59(3)444-7.

PMID:
    16489617
    [PubMed - indexed for MEDLINE]
Related citations


Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation.
Liang TW, Truax AC, Trojanowski JQ, Lee VM, Stern MB, Kotzbauer PT
Mov Disord. 2006 May; 21(5)718-22.

PMID:
    16450344
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Neurodegenerative disease research.