FollowMyHealth Patient Portal

Paul T. Golumbek, MD, PhD

Assistant Professor, Neurology and Pediatrics

Specialty Areas

Pediatric Neurology
Muscle Disorders
ALS - Lou Gehrig's Disease
Electromyography
Nerve Disorders
Neuromuscular Disease

Board Certifications

Neurology
Pediatric Neurology

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Disorders of the brain, spinal cord, nerves, and muscles in adults, general pediatric neurology and neuromuscular disease in children

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Neuroscience Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: 314-362-6981
Fax: 314-362-3752

Barnes-Jewish Hospital
McMillan Building

517 S. Euclid Avenue
St. Louis, MO 63110

Office Phone: 314-362-6981
Fax: 314-362-3752

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Suite D
Floor: 2nd Floor
Office Phone: 314-454-6120
Fax: 314-362-375

Education

Education

Research Fellowship: Washington University School of Medicine, St. Louis, Missouri 2004
Fellowship: Electrophysiology, Veterans Administration Hospital, Puget Sound, Washington 2002
Residency: Pediatric Neurology, University of Washington, Seattle, Washington 1999
M.D., Ph.D.: Johns Hopkins School of Medicine, Baltimore, Maryland 1995
M.S.: Applied Molecular Biology, University of Maryland, Baltimore County, Maryland 1985
B.A.: University of Maryland, Baltimore County, Maryland 1985

Publication & Research

Publication & Research

Clinical trial readiness in non-ambulatory boys and men with duchenne muscular dystrophy: MDA-DMD network follow-up.
Connolly AM, Florence JM, Zaidman CM, Golumbek PT, Mendell JR, Flanigan KM, Karachunski PI, Day JW, McDonald CM, Darras BT, Kang PB, Siener CA, Gadeken RK, Anand P, Schierbecker JR, Malkus EC, Lowes LP, Alfano LN, Johnson L, Nicorici A, Kelecic JM, Quigley J, Pasternak AE, Miller JP, MDA-DMD Clinical Research Network
Muscle Nerve. 2016 Oct; 54(4)681-9. doi: 10.1002/mus.25089.

PMID:
    26930423
    [PubMed - in process]
Related citations


Outcome reliability in non-ambulatory boys/men with Duchenne muscular dystrophy.
Connolly AM, Malkus EC, Mendell JR, Flanigan KM, Miller JP, Schierbecker JR, Siener CA, Golumbek PT, Zaidman CM, Mcdonald CM, Johnson L, Nicorici A, Karachunski PI, Day JW, Kelecic JM, Lowes LP, Alfano LN, Darras BT, Kang PB, Quigley J, Pasternak AE, Florence JM, MDA DMD Clinical Research Network
Muscle Nerve. 2015 Apr; 51(4)522-32. doi: 10.1002/mus.24346.

PMID:
    25056178
    [PubMed - indexed for MEDLINE]
Related citations


One year outcome of boys with Duchenne muscular dystrophy using the Bayley-III scales of infant and toddler development.
Connolly AM, Florence JM, Cradock MM, Eagle M, Flanigan KM, McDonald CM, Karachunski PI, Darras BT, Bushby K, Malkus EC, Golumbek PT, Zaidman CM, Miller JP, Mendell JR, MDA DMD Clinical Research Network
Pediatr Neurol. 2014 Jun; 50(6)557-63. doi: 10.1016/j.pediatrneurol.2014.02.006.

PMID:
    24842254
    [PubMed - indexed for MEDLINE]
Related citations


Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function.
Bibee KP, Cheng YJ, Ching JK, Marsh JN, Li AJ, Keeling RM, Connolly AM, Golumbek PT, Myerson JW, Hu G, Chen J, Shannon WD, Lanza GM, Weihl CC, Wickline SA
FASEB J. 2014 May; 28(5)2047-61. doi: 10.1096/fj.13-237388.

PMID:
    24500923
    [PubMed - indexed for MEDLINE]
Related citations


Motor and cognitive assessment of infants and young boys with Duchenne Muscular Dystrophy: results from the Muscular Dystrophy Association DMD Clinical Research Network.
Connolly AM, Florence JM, Cradock MM, Malkus EC, Schierbecker JR, Siener CA, Wulf CO, Anand P, Golumbek PT, Zaidman CM, Philip Miller J, Lowes LP, Alfano LN, Viollet-Callendret L, Flanigan KM, Mendell JR, McDonald CM, Goude E, Johnson L, Nicorici A, Karachunski PI, Day JW, Dalton JC, Farber JM, Buser KK, Darras BT, Kang PB, Riley SO, Shriber E, Parad R, Bushby K, Eagle M, MDA DMD Clinical Research Network
Neuromuscul Disord. 2013 Jul; 23(7)529-39. doi: 10.1016/j.nmd.2013.04.005.

PMID:
    23726376
    [PubMed - indexed for MEDLINE]
Related citations


Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis.
Lees JR, Golumbek PT, Sim J, Dorsey D, Russell JH
J Exp Med. 2008 Oct 27; 205(11)2633-42. doi: 10.1084/jem.20080155.

PMID:
    18852291
    [PubMed - indexed for MEDLINE]
Related citations


RAG2 gene knockout in mice causes fatigue.
Golumbek PT, Keeling RM, Connolly AM
Muscle Nerve. 2007 Oct; 36(4)471-6.

PMID:
    17554799
    [PubMed - indexed for MEDLINE]
Related citations


Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout.
Golumbek PT, Keeling RM, Connolly AM
Neuromuscul Disord. 2007 May; 17(5)376-84.

PMID:
    17452104
    [PubMed - indexed for MEDLINE]
Related citations


Weekly oral prednisolone improves survival and strength in male mdx mice.
Keeling RM, Golumbek PT, Streif EM, Connolly AM
Muscle Nerve. 2007 Jan; 35(1)43-8.

PMID:
    16969833
    [PubMed - indexed for MEDLINE]
Related citations


Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy.
Connolly AM, Chez M, Streif EM, Keeling RM, Golumbek PT, Kwon JM, Riviello JJ, Robinson RG, Neuman RJ, Deuel RM
Biol Psychiatry. 2006 Feb 15; 59(4)354-63.

PMID:
    16181614
    [PubMed - indexed for MEDLINE]
Related citations


Effects of flunarizine on spontaneous synaptic currents in rat neocortex.
Golumbek PT, Rho JM, Spain WJ, van Brederode JF
Naunyn Schmiedebergs Arch Pharmacol. 2004 Sep; 370(3)176-82.

PMID:
    15340775
    [PubMed - indexed for MEDLINE]
Related citations


Neurologic manifestations of celiac disease: proven, or just a gut feeling?
Cross AH, Golumbek PT
Neurology. 2003 May 27; 60(10)1566-8.

PMID:
    12771239
    [PubMed - indexed for MEDLINE]
Related citations


Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design.
Golumbek PT, Azhari R, Jaffee EM, Levitsky HI, Lazenby A, Leong K, Pardoll DM
Cancer Res. 1993 Dec 15; 53(24)5841-4.

PMID:
    8261390
    [PubMed - indexed for MEDLINE]
Related citations


Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Golumbek PT, Hamzeh FM, Jaffee EM, Levitsky H, Lietman PS, Pardoll DM
J Immunother (1991). 1992 Nov; 12(4)224-30.

PMID:
    1335754
    [PubMed - indexed for MEDLINE]
Related citations


Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.
Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM
Science. 1991 Nov 1; 254(5032)713-6.

PMID:
    1948050
    [PubMed - indexed for MEDLINE]
Related citations


The fate of CD4-8- T cell receptor-alpha beta+ thymocytes.
Levitsky HI, Golumbek PT, Pardoll DM
J Immunol. 1991 Feb 15; 146(4)1113-7.

PMID:
    1825103
    [PubMed - indexed for MEDLINE]
Related citations


Selective activation of transcription by a novel CCAAT binding factor.
Maity SN, Golumbek PT, Karsenty G, de Crombrugghe B
Science. 1988 Jul 29; 241(4865)582-5.

PMID:
    3399893
    [PubMed - indexed for MEDLINE]
Related citations


A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding.
Hatamochi A, Golumbek PT, Van Schaftingen E, de Crombrugghe B
J Biol Chem. 1988 Apr 25; 263(12)5940-7.

PMID:
    3281949
    [PubMed - indexed for MEDLINE]
Related citations