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Faculty Physicians

Patrick Y. Jay, MD, PhD

Associate Professor, Pediatrics
Division of Pediatric Cardiology

Specialty Areas

Pediatric Cardiology

Board Certifications

Pediatrics
Pediatric Cardiology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Heart disease in children, congenital heart condition, pediatric cardiology, 2nd opinion,

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Second Floor, Suite D
Office Phone: 314-454-6095
Fax: 314-454-2561

Education

Education

Fellowship: Post Doctorate Research, Beth Israel Deaconness Medical Ctr, Harvard Medical School, Boston, MA 2004
Fellowship: Pediatric Cardiology, Children's Hospital, Boston, MA 2001
Residency: Children's Hospital, Boston, MA 1997
Ph.D.: Washington University School of Medicine, St. Louis, MO 1995
Medical Degree: Washington University School of Medicine, St. Louis, MO 1995

Publication & Research

Publication & Research

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.
Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R
Development. 2015 Jul 15; 142(14)2452-63. doi: 10.1242/dev.125492.

PMID:
    26062937
    [PubMed - indexed for MEDLINE]
Related citations


Reprogramming the conduction system: Onward toward a biological pacemaker.
Meyers JD, Jay PY, Rentschler S
Trends Cardiovasc Med. 2016 Jan; 26(1)14-20. doi: 10.1016/j.tcm.2015.03.015.

PMID:
    25937044
    [PubMed - in process]
Related citations


Rhythm genes sing more than one tune: noncanonical functions of cardiac ion channels.
Akhirome E, Jay PY
Circ Arrhythm Electrophysiol. 2015 Apr; 8(2)261-2. doi: 10.1161/CIRCEP.115.002834.

PMID:
    25900989
    [PubMed - indexed for MEDLINE]
Related citations


The maternal-age-associated risk of congenital heart disease is modifiable.
Schulkey CE, Regmi SD, Magnan RA, Danzo MT, Luther H, Hutchinson AK, Panzer AA, Grady MM, Wilson DB, Jay PY
Nature. 2015 Apr 9; 520(7546)230-3. doi: 10.1038/nature14361.

PMID:
    25830876
    [PubMed - indexed for MEDLINE]
Related citations


Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model.
Tanaka M, Yamaguchi S, Yamazaki Y, Kinoshita H, Kuwahara K, Nakao K, Jay PY, Noda T, Nakamura T
Sci Rep. 2015 Jan 16; 57826. doi: 10.1038/srep07826.

PMID:
    25591392
    [PubMed - in process]
Related citations


Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.
Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB
Mol Cell Endocrinol. 2015 Jan 5; 399122-30. doi: 10.1016/j.mce.2014.09.029.

PMID:
    25289806
    [PubMed - indexed for MEDLINE]
Related citations


Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.
Prendiville T, Jay PY, Pu WT
Cold Spring Harb Perspect Med. 2014 Oct 1; 4(10)pii: a013946. doi: 10.1101/cshperspect.a013946.

PMID:
    25274754
    [PubMed - indexed for MEDLINE]
Related citations


Ex vivo, microelectrode analysis of conduction through the AV node of wild-type and Nkx2-5 mutant mouse hearts as guided by a Cx40-eGFP transgenic reporter.
Gazit AZ, Li A, Choi JS, Miquerol L, Jay PY
Physiol Rep. 2014; 2(4)e00285. doi: 10.14814/phy2.285.

PMID:
    24771692
    [PubMed]
Related citations


A single misstep in cardiac development explains the co-occurrence of tetralogy of fallot and complete atrioventricular septal defect in Down syndrome.
Nguyen HH, Jay PY
J Pediatr. 2014 Jul; 165(1)194-6. doi: 10.1016/j.jpeds.2014.02.065.

PMID:
    24721467
    [PubMed - indexed for MEDLINE]
Related citations


Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.
Udager AM, Prakash A, Saenz DA, Schinke M, Moriguchi T, Jay PY, Lim KC, Engel JD, Gumucio DL
Gastroenterology. 2014 Jan; 146(1)157-65.e10. doi: 10.1053/j.gastro.2013.10.008.

PMID:
    24120474
    [PubMed - indexed for MEDLINE]
Related citations


Tissue Doppler septal Tei index indicates severity of illness in pediatric patients with congestive heart failure.
Sanchez Mejia AA, Simpson KE, Hildebolt CF, Pahl E, Matthews KL, Rainey CA, Canter CE, Jay PY, Johnson MC
Pediatr Cardiol. 2014 Mar; 35(3)411-8. doi: 10.1007/s00246-013-0794-1.

PMID:
    24061276
    [PubMed - indexed for MEDLINE]
Related citations


Saxagliptin Improves Glucose Tolerance but not Survival in a Murine Model of Dilated Cardiomyopathy.
Vyas AK, Aerni-Flessner LB, Payne MA, Kovacs A, Jay PY, Hruz PW
Cardiovasc Endocrinol. 2012 Dec; 1(4)74-82.

PMID:
    23795310
    [PubMed]
Related citations


Association of genes with physiological functions by comparative analysis of pooled expression microarray data.
Chen IB, Rathi VK, DeAndrade DS, Jay PY
Physiol Genomics. 2013 Jan 15; 45(2)69-78. doi: 10.1152/physiolgenomics.00116.2012.

PMID:
    23170034
    [PubMed - indexed for MEDLINE]
Related citations


Complex trait analysis of ventricular septal defects caused by Nkx2-5 mutation.
Winston JB, Schulkey CE, Chen IB, Regmi SD, Efimova M, Erlich JM, Green CA, Aluko A, Jay PY
Circ Cardiovasc Genet. 2012 Jun; 5(3)293-300. doi: 10.1161/CIRCGENETICS.111.961136.

PMID:
    22534315
    [PubMed - indexed for MEDLINE]
Related citations


GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.
Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB
Endocrinology. 2012 Jun; 153(6)2599-611. doi: 10.1210/en.2011-2135.

PMID:
    22461617
    [PubMed - indexed for MEDLINE]
Related citations


Gαi2 signaling: friend or foe in cardiac injury and heart failure?
Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR
Naunyn Schmiedebergs Arch Pharmacol. 2012 May; 385(5)443-53. doi: 10.1007/s00210-011-0705-z.

PMID:
    22411356
    [PubMed - indexed for MEDLINE]
Related citations


Enhanced cardiac PI3Kα signalling mitigates arrhythmogenic electrical remodelling in pathological hypertrophy and heart failure.
Yang KC, Jay PY, McMullen JR, Nerbonne JM
Cardiovasc Res. 2012 Feb 1; 93(2)252-62. doi: 10.1093/cvr/cvr283.

PMID:
    22038742
    [PubMed - indexed for MEDLINE]
Related citations


Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.
Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN
J Mol Cell Cardiol. 2011 Jul; 51(1)120-8. doi: 10.1016/j.yjmcc.2011.04.009.

PMID:
    21549711
    [PubMed - indexed for MEDLINE]
Related citations


Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.
Vyas AK, Yang KC, Woo D, Tzekov A, Kovacs A, Jay PY, Hruz PW
PLoS One. 2011 Feb 17; 6(2)e17178. doi: 10.1371/journal.pone.0017178.

PMID:
    21359201
    [PubMed - indexed for MEDLINE]
Related citations


GATA4 deficiency impairs ovarian function in adult mice.
Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB
Biol Reprod. 2011 May; 84(5)1033-44. doi: 10.1095/biolreprod.110.086850.

PMID:
    21248289
    [PubMed - indexed for MEDLINE]
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