Patient Portal

Nupur Ghoshal, MD, PhD

Associate Professor, Neurology
Division of Adult Neurology

Specialty Areas

Alzheimer's Disease
Neurology - Adult

Board Certifications


Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Alzheimer's disease, neurodegenerative disease, neurodegenerative disorders, dementia, Parkinson's disease, memory loss, Lewy body dementia, cognitive function, geriatric neurology

  • Location(s)
  • Education
  • Publication & Research



Center for Advanced Medicine
Memory Diagnostic Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 6
Office Phone: (314) 286-1967
Fax: (314) 286-1985



Ph.D.: Cell and Molecular Biology, Northwestern University, Evanston, Illinois 2001
Medical Degree: Northwestern University Feinberg School of Mediicne, Evanston, Illinois 2003
B.S.: Genetics, Iowa State University of Science and Technology, Ames, Iowa 1995
Fellowship: Dementia, Washington University School of Medicine, St. Louis, Missouri 2009
Residency: Internal Medicine, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri 2004
Residency: Neurology, Barnes-Jewish Hospital at Washington University School of Medicine, St. Louis, Missouri 2007

Publication & Research

Publication & Research

1Ghoshal N. Proteinase inhibitor II increases electrical activity in transgenic tobacco and poplar: method development. 6th Annual National Conference on Undergraduate Research (NCUR) 1992;3:1565-70.
2.         Ghoshal N, Smiley JF, DeMaggio AJ, Hoekstra MF, Cochran EJ, Binder LI, Kuret J. A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. The American journal of pathology 1999;155:1163-72.
3.         Abraha A, Ghoshal N, Gamblin TC, Cryns V, Berry RW, Kuret J, Binder LI. C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. Journal of cell science 2000;113 Pt 21:3737-45.
4.         Schwab C, DeMaggio AJ, Ghoshal N, Binder LI, Kuret J, McGeer PL. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiol Aging 2000;21:503-10.
5.         Berry RW, Quinn B, Johnson N, Cochran EJ, Ghoshal N, Binder LI. Pathological glial tau accumulations in neurodegenerative disease: review and case report. Neurochemistry international 2001;39:469-79.
6.         Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. Journal of cell science 2001;114:1179-87.
7.         Ghoshal N, Garcia-Sierra F, Fu Y, Beckett LA, Mufson EJ, Kuret J, Berry RW, Binder LI. Tau-66: evidence for a novel tau conformation in Alzheimer's disease. Journal of neurochemistry 2001;77:1372-85.
8.         King ME, Ghoshal N, Wall JS, Binder LI, Ksiezak-Reding H. Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. The American journal of pathology 2001;158:1481-90.
9.         Ghoshal N, Garcia-Sierra F, Wuu J, Leurgans S, Bennett DA, Berry RW, Binder LI. Tau conformational changes correspond to impairments of episodic memory in mild cognitive impairment and Alzheimer's disease. Experimental neurology 2002;177:475-93.
10.       Garcia-Sierra F, Ghoshal N, Quinn B, Berry RW, Binder LI. Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease. Journal of Alzheimer's disease : JAD 2003;5:65-77.
11.       Ghoshal N, Cali I, Perrin RJ, Josephson SA, Sun N, Gambetti P, Morris JC. Codistribution of amyloid beta plaques and spongiform degeneration in familial Creutzfeldt-Jakob disease with the E200K-129M haplotype. Arch Neurol 2009;66:1240-6.
12.       Cairns NJ, Ghoshal N. FUS: A new actor on the frontotemporal lobar degeneration stage. Neurology 2010;74:354-6.
13.       Roe CM, Mintun MA, Ghoshal N, Williams MM, Grant EA, Marcus DS, Morris JC. Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept. Neurology 2010;75:42-8.
14.       Roe CM, Fagan AM, Williams MM, Ghoshal N, Aeschleman M, Grant EA, Marcus DS, Mintun MA, Holtzman DM, Morris JC. Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease. Neurology 2011;76:501-10.
15.       Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ. Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Neurobiol Dis 2012;45:395-408.
16.       Ghoshal N, Cairns NJ. Unravelling the mysteries of frontotemporal dementia. Missouri medicine 2013;110:411-6.
17.       Monsell SE, Mock C, Roe CM, Ghoshal N, Morris JC, Cairns NJ, Kukull W. Comparison of symptomatic and asymptomatic persons with Alzheimer disease neuropathology. Neurology 2013;80:2121-9.
18.       Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR, Bapineuzumab, Clinical Trial I. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. The New England journal of medicine 2014;370:322-33.
            *Ghoshal, N. Listed under Bapineuzumab 301 and 302 Clinical Trial Investigators
19.       Ghoshal N, Perry A, McKeel D, Schmidt RE, Carter D, Norton J, Zou WQ, Xiao X, Puoti G, Notari S, Gambetti P, Morris JC, Cairns NJ. Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old. Alzheimer disease and associated disorders 2015;29:173-6.
20.       Hurth K*, Tarawneh R*, Ghoshal N*, Benzinger TLS, Clifford DB, Geschwind M, Morris JC, Galvin JE, Schmidt RE, Cairns NJ. Whipple's disease masquerades as dementia with Lewy bodies. Alzheimer disease and associated disorders 2015;29:85-9.
*All contributed equally.
21.       Vernon EK, Babulal GM, Head D, Carr D, Ghoshal N, Barco PP, Morris JC, Roe CM. Adults Aged 65 and Older Use Potentially Distracting Electronic Devices While Driving. J Am Geriatr Soc 2015;63:1251-4.
22.       Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TL, Fagan AM, Morris JC, Roe CM. Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels. Am J Geriatr Psychiatry 2016;24:1095-104.
23.       Babulal GM, Addison A, Ghoshal N, Stout SH, Vernon EK, Sellan M, Roe CM. Development and interval testing of a naturalistic driving methodology to evaluate driving behavior in clinical research. F1000Res 2016;5:1716.
24.       Roe CM, Babulal GM, Head DM, Stout SH, Vernon EK, Ghoshal N, Garland B, Barco PP, Williams MM, Johnson A, Fierberg R, Fague MS, Xiong C, Mormino E, Grant EA, Holtzman DM, Benzinger TLS, Fagan AM, Ott BR, Carr DB, Morris JC. Preclinical Alzheimer's disease and longitudinal driving decline. Alzheimer's & dementia 2017;3:74-82.
25.       Roe CM, Barco PP, Head DM, Ghoshal N, Selsor N, Babulal GM, Fierberg R, Vernon EK, Shulman N, Johnson A, Fague S, Xiong C, Grant EA, Campbell A, Ott BR, Holtzman DM, Benzinger TL, Fagan AM, Carr DB, Morris JC. Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals. Alzheimer disease and associated disorders 2017;31:69-72.