Patient Portal

Nathan O. Stitziel, MD, PhD

Associate Professor, Medicine
Cardiovascular Division
Director, Center for Cardiovascular Genetics

Specialty Areas

Cardiovascular Disease
Cardiovascular Genetics
Cardiology

Board Certifications

Internal Medicine
Cardiovascular Disease

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Cardiovascular genetics; inherited cardiovascular disease; genetic syndromes; cardiomyopathy, arrhythmia genetics

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Heart & Vascular Center

4921 Parkview Place
St. Louis, MO 63110

Suite: A
Floor: 8
Office Phone: (314) 362-1291
Fax: (314) 362-4619

Education

Education

Fellowship, Postdoctoral Research: Harvard Medical School, Boston, MA 2012
BA, Mathematics and Physics: Washington University, St. Louis, MO 1998
Fellowship, Cardiology: Harvard Medical School, Boston, MA 2012
Medical Degree: University of Illinois at Chicago, College of Medicine, Chicago, IL 2006
PhD, Bioinformatics: University of Illinois at Chicago College of Medicine, Chicago, IL 2006
Residency, Internal Medicine: University of Chicago Medical Center, Chicago, IL 2008

Publication & Research

Publication & Research

Genetic architecture of human plasma lipidome and its link to cardiovascular disease.
Tabassum R, Rämö JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Söderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, FinnGen Project., Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S
Nat Commun. 2019 Sep 24; 10(1)4329. doi: 10.1038/s41467-019-11954-8.

PMID:
    31551469
    [PubMed - in process]
Related citations


Exome sequencing of Finnish isolates enhances rare-variant association power.
Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H, FinnGen Project., Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB
Nature. 2019 Aug; 572(7769)323-328. doi: 10.1038/s41586-019-1457-z.

PMID:
    31367044
    [PubMed - in process]
Related citations


Coronary Artery Disease Risk and Lipidomic Profiles Are Similar in Hyperlipidemias With Family History and Population-Ascertained Hyperlipidemias.
Rämö JT, Ripatti P, Tabassum R, Söderlund S, Matikainen N, Gerl MJ, Klose C, Surma MA, Stitziel NO, Havulinna AS, Pirinen M, Salomaa V, Freimer NB, Jauhiainen M, Palotie A, Taskinen MR, Simons K, Ripatti S
J Am Heart Assoc. 2019 Jul 2; 8(13)e012415. doi: 10.1161/JAHA.119.012415.

PMID:
    31256696
    [PubMed - in process]
Related citations


Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.
Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP
JCI Insight. 2019 Jun 18; 5pii: 127748. doi: 10.1172/jci.insight.127748.

PMID:
    31211696
    [PubMed - in process]
Related citations


Roadmap for a precision-medicine initiative in the Nordic region.
Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N, Groop L, Heimer H, Hougaard DM, Hovig E, Hveem K, Jalanko A, Kaprio J, Knudsen GP, Melbye M, Metspalu A, Mortensen PB, Palmgren J, Palotie A, Reed W, Stefánsson H, Stitziel NO, Sullivan PF, Thorsteinsdóttir U, Vaudel M, Vuorio E, Werge T, Stoltenberg C, Stefánsson K
Nat Genet. 2019 Jun; 51(6)924-930. doi: 10.1038/s41588-019-0391-1.

PMID:
    30988515
    [PubMed - indexed for MEDLINE]
Related citations


Capitalizing on Insights from Human Genetics to Identify Novel Therapeutic Targets for Coronary Artery Disease.
Young EP, Stitziel NO
Annu Rev Med. 2019 Jan 27; 7019-32. doi: 10.1146/annurev-med-041717-085853.

PMID:
    30355262
    [PubMed - in process]
Related citations


Rare loss of function variants in candidate genes and risk of colorectal cancer.
Rosenthal EA, Shirts BH, Amendola LM, Horike-Pyne M, Robertson PD, Hisama FM, Bennett RL, Dorschner MO, Nickerson DA, Stanaway IB, Nassir R, Vickers KT, Li C, Grady WM, Peters U, Jarvik GP, NHLBI GO Exome Sequencing Project.
Hum Genet. 2018 Oct; 137(10)795-806. doi: 10.1007/s00439-018-1938-4.

PMID:
    30267214
    [PubMed - indexed for MEDLINE]
Related citations


An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.
Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D, Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM).
NPJ Genom Med. 2018; 321. doi: 10.1038/s41525-018-0060-9.

PMID:
    30131872
    [PubMed]
Related citations


Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.
Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ, Convened by the Familial Hypercholesterolemia Foundation.
J Am Coll Cardiol. 2018 Aug 7; 72(6)662-680. doi: 10.1016/j.jacc.2018.05.044.

PMID:
    30071997
    [PubMed - indexed for MEDLINE]
Related citations


Genetics of the extracellular matrix in aortic aneurysmal diseases.
Lin CJ, Lin CY, Stitziel NO
Matrix Biol. 2018 Oct; 71-72128-143. doi: 10.1016/j.matbio.2018.04.005.

PMID:
    29656146
    [PubMed - indexed for MEDLINE]
Related citations


Reply: Loss-of-Function Mutations to Estimate Pharmacological ANGPTL3 Inhibition.
Stitziel NO, Musunuru K, Kathiresan S
J Am Coll Cardiol. 2017 Oct 17; 70(16)2099-2100. doi: 10.1016/j.jacc.2017.07.794.

PMID:
    29025568
    [PubMed - indexed for MEDLINE]
Related citations


Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.
Emdin CA, Khera AV, Klarin D, Natarajan P, Zekavat SM, Nomura A, Haas M, Aragam K, Ardissino D, Wilson JG, Schunkert H, McPherson R, Watkins H, Elosua R, Bown MJ, Samani NJ, Baber U, Erdmann J, Gormley P, Palotie A, Stitziel NO, Gupta N, Danesh J, Saleheen D, Gabriel S, Kathiresan S
Circulation. 2018 Jan 16; 137(3)222-232. doi: 10.1161/CIRCULATIONAHA.117.028021.

PMID:
    28982690
    [PubMed - indexed for MEDLINE]
Related citations


Genetic association studies in cardiovascular diseases: Do we have enough power?
Auer PL, Stitziel NO
Trends Cardiovasc Med. 2017 Aug; 27(6)397-404. doi: 10.1016/j.tcm.2017.03.005.

PMID:
    28456354
    [PubMed - indexed for MEDLINE]
Related citations


ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.
Stitziel NO, Khera AV, Wang X, Bierhals AJ, Vourakis AC, Sperry AE, Natarajan P, Klarin D, Emdin CA, Zekavat SM, Nomura A, Erdmann J, Schunkert H, Samani NJ, Kraus WE, Shah SH, Yu B, Boerwinkle E, Rader DJ, Gupta N, Frossard PM, Rasheed A, Danesh J, Lander ES, Gabriel S, Saleheen D, Musunuru K, Kathiresan S, PROMIS and Myocardial Infarction Genetics Consortium Investigators.
J Am Coll Cardiol. 2017 Apr 25; 69(16)2054-2063. doi: 10.1016/j.jacc.2017.02.030.

PMID:
    28385496
    [PubMed - indexed for MEDLINE]
Related citations


Comments on Letter to the Editor entitled: "Role of electrophysiological evaluation for the best device choice to prevent sudden cardiac death in patients with Myotonic Dystrophy Type1 and Emery Dreifuss Muscular Dystrophy".
Sommerville RB, Vincenti MG, Winborn K, Casey A, Stitziel NO, Connolly AM, Mann DL
Trends Cardiovasc Med. 2017 Feb 7; pii: S1050-1738(17)30014-2. doi: 10.1016/j.tcm.2017.02.002.

PMID:
    28291654
    [PubMed - as supplied by publisher]
Related citations


Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S, Myocardial Infarction Genetics Consortium, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium.
JAMA. 2017 Mar 7; 317(9)937-946. doi: 10.1001/jama.2017.0972.

PMID:
    28267856
    [PubMed - indexed for MEDLINE]
Related citations


Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting.
Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth A, Rader DJ, Ford I, Sattar N, Kathiresan S
Circulation. 2017 May 30; 135(22)2091-2101. doi: 10.1161/CIRCULATIONAHA.116.024436.

PMID:
    28223407
    [PubMed - indexed for MEDLINE]
Related citations


Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.
Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M, Wellcome Trust Case Control Consortium., Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J, MORGAM Investigators., Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ, Schunkert H, Deloukas P, Kathiresan S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators.
J Am Coll Cardiol. 2017 Feb 21; 69(7)823-836. doi: 10.1016/j.jacc.2016.11.056.

PMID:
    28209224
    [PubMed - indexed for MEDLINE]
Related citations


Variants in ANGPTL4 and the Risk of Coronary Artery Disease.
Stitziel NO, the Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators.
N Engl J Med. 2016 Dec 8; 375(23)2306. doi: 10.1056/NEJMc1607380.

PMID:
    28112900
    [PubMed]
Related citations


Human genetic insights into lipoproteins and risk of cardiometabolic disease.
Stitziel NO
Curr Opin Lipidol. 2017 Apr; 28(2)113-119. doi: 10.1097/MOL.0000000000000389.

PMID:
    28059951
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Genetics of Mendelian cardiovascular disease; genetics of complex cardiovascular diseases and traits.