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Nabeel R. Yaseen, MD, PhD

Associate Professor, Pathology & Immunology
Head, Hematopathology Section

Specialty Areas

Pathology
Hematopathology

Board Certifications

Hematology
Anatomic and Clinical Pathology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematopathology, hematology, pathology, leukemia, lymphoma

  • Education
  • Publication & Research

Education

Education

PhD, Molecular and Cellular Biology, Biochemistry: Brown University, Providence, RI 1994
Medical Degree: Baghdad University College of Medicine, Baghdad, Iraq 1983
Fellowship, Hematopathology: Cornell University, New York, NY 2000
Residency, Pathology: Brown University Integrated Residency Program in Pathology, Providence, RI 1995

Publication & Research

Publication & Research

A Young Woman With Blurred Vision and Distal Paresthesias.
Kung NH, Bartlett NL, Yaseen NR, Van Stavern GP, Bucelli RC
JAMA Neurol. 2015 Dec; 72(12)1519-23. doi: 10.1001/jamaneurol.2015.2390.

PMID:
    26501203
    [PubMed - indexed for MEDLINE]
Related citations


A 54 year-old man with progressive vision and hearing loss.
Gru AA, Kolar G, Wagner-Johnston ND, Schmidt R, Yaseen NR
Brain Pathol. 2014 Mar; 24(2)197-200.

PMID:
    25121192
    [PubMed - indexed for MEDLINE]
Related citations


Nucleoporins and nucleocytoplasmic transport in hematologic malignancies.
Takeda A, Yaseen NR
Semin Cancer Biol. 2014 Aug; 273-10. doi: 10.1016/j.semcancer.2014.02.009.

PMID:
    24657637
    [PubMed - indexed for MEDLINE]
Related citations


Dynein Light Chain 1 (DYNLT1) Interacts with Normal and Oncogenic Nucleoporins.
Sarma NJ, Yaseen NR
PLoS One. 2013; 8(6)e67032. doi: 10.1371/journal.pone.0067032.

PMID:
    23840580
    [PubMed - indexed for MEDLINE]
Related citations


Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
Sarma NJ, Yaseen NR
J Biol Chem. 2011 Nov 11; 286(45)38989-9001. doi: 10.1074/jbc.M111.297952.

PMID:
    21937451
    [PubMed - indexed for MEDLINE]
Related citations


Colony forming cell (CFC) assay for human hematopoietic cells.
Sarma NJ, Takeda A, Yaseen NR
J Vis Exp. 2010 Dec 18; (46)pii: 2195. doi: 10.3791/2195.

PMID:
    21252854
    [PubMed - indexed for MEDLINE]
Related citations


In vitro transformation of primary human CD34+ cells by AML fusion oncogenes: early gene expression profiling reveals possible drug target in AML.
Abdul-Nabi AM, Yassin ER, Varghese N, Deshmukh H, Yaseen NR
PLoS One. 2010 Aug 27; 5(8)e12464. doi: 10.1371/journal.pone.0012464.

PMID:
    20805992
    [PubMed - indexed for MEDLINE]
Related citations


Effects of the NUP98-DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif.
Yassin ER, Abdul-Nabi AM, Takeda A, Yaseen NR
Leukemia. 2010 May; 24(5)1001-11. doi: 10.1038/leu.2010.42.

PMID:
    20339440
    [PubMed - indexed for MEDLINE]
Related citations


Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins.
Takeda A, Sarma NJ, Abdul-Nabi AM, Yaseen NR
J Biol Chem. 2010 May 21; 285(21)16248-57. doi: 10.1074/jbc.M109.048785.

PMID:
    20233715
    [PubMed - indexed for MEDLINE]
Related citations


Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9.
Yassin ER, Sarma NJ, Abdul-Nabi AM, Dombrowski J, Han Y, Takeda A, Yaseen NR
PLoS One. 2009 Aug 21; 4(8)e6719. doi: 10.1371/journal.pone.0006719.

PMID:
    19696924
    [PubMed - indexed for MEDLINE]
Related citations


Ultrastructural nuclear import assay.
Zhong H, Shio H, Yaseen NR
Methods. 2006 Aug; 39(4)309-15.

PMID:
    16935003
    [PubMed - indexed for MEDLINE]
Related citations


NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells.
Takeda A, Goolsby C, Yaseen NR
Cancer Res. 2006 Jul 1; 66(13)6628-37.

PMID:
    16818636
    [PubMed - indexed for MEDLINE]
Related citations


Carrier-independent nuclear import of the transcription factor PU.1 via RanGTP-stimulated binding to Nup153.
Zhong H, Takeda A, Nazari R, Shio H, Blobel G, Yaseen NR
J Biol Chem. 2005 Mar 18; 280(11)10675-82.

PMID:
    15632149
    [PubMed - indexed for MEDLINE]
Related citations


Purification of RanGDP, RanGTP, and RanGMPPNP by ion exchange chromatography.
Bibak N, Paul RM, Freymann DM, Yaseen NR
Anal Biochem. 2004 Oct 1; 333(1)57-64.

PMID:
    15351280
    [PubMed - indexed for MEDLINE]
Related citations


CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity.
Takeda A, Matsuda A, Paul RM, Yaseen NR
Blood. 2004 May 1; 103(9)3440-7.

PMID:
    14715639
    [PubMed - indexed for MEDLINE]
Related citations


The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells.
Ghannam G, Takeda A, Camarata T, Moore MA, Viale A, Yaseen NR
J Biol Chem. 2004 Jan 9; 279(2)866-75.

PMID:
    14561764
    [PubMed - indexed for MEDLINE]
Related citations


Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage.
Frater JL, Yaseen NR, Peterson LC, Tallman MS, Goolsby CL
Arch Pathol Lab Med. 2003 Mar; 127(3)356-9.

PMID:
    12653584
    [PubMed - indexed for MEDLINE]
Related citations


The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.
Fontoura BM, Blobel G, Yaseen NR
J Biol Chem. 2000 Oct 6; 275(40)31289-96.

PMID:
    10875935
    [PubMed - indexed for MEDLINE]
Related citations


GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.
Yaseen NR, Blobel G
J Biol Chem. 1999 Sep 10; 274(37)26493-502.

PMID:
    10473610
    [PubMed - indexed for MEDLINE]
Related citations


Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.
Yaseen NR, Blobel G
Proc Natl Acad Sci U S A. 1999 May 11; 96(10)5516-21.

PMID:
    10318915
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr. Yaseen's laboratory studies the molecular pathogenesis of acute myeloid leukemia. The main focus is on the mechanisms by which oncogenic fusions of nucleoporin genes cause leukemic transformation.