Patient Portal

Misty Good, MD, MS

Assistant Professor, Pediatrics
Division of Newborn Medicine

Specialty Areas

Newborn Medicine - Neonatology
Neonatal/Perinatal Medicine

Board Certifications

Pediatrics
Neonatal-Perinatal Medicine

Hospital Affiliations

St. Louis Children's Hospital
Barnes-Jewish Hospital

Areas of Clinical Interest

Premature infants; neonatal intensive care, necrotizing enterocolitis

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: Neonatal Intensive Care Unit
Floor: 5th floor

Barnes-Jewish Hospital

1 Barnes-Jewish Hospital Plaza
St. Louis, MO 63110

Suite: Labor and delivery

Education

Education

Fellowship: Neonatal-Perinatal : Children's Hospital of Pittburgh Magee-Womens Hospital of UPMC, Pittsburgh, PA 2011
Chief Resident: Pediatrics: Children's Hospital of Illinois, Peoria, Illinois 2008
Medical Degree: American University of the Caribbean School of Medicine, St. Maarten, Netherland Antilles 2005
MS: Medical Sciences: American University of the Caribbean School of Medicine, St. Maarten, Netherland Antilles 2002

Publication & Research

Publication & Research

  1. Afrazi A, Sodhi CP, Richardson WM, Neal MD, Good M, Siggers R, Hackam DJ.  New Insights into the Pathogenesis and Treatment of Necrotizing Enterocolitis:  Toll-like Receptors and Beyond.  Pediatr Res 2011 Mar;69(3):183-8. PMID: 21135755. PMCID:PMC3125129.
  2. Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol. 2012 May 1;188(9):4543-57. PMID: 22461698. PMCID:PMC3331906.
  3. Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. PMID: 22733781. PMCID:PMC3396489.
  4. Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Intestinal Epithelial Toll-like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice. Gastroenterology. 2012 Sep;143(3):708-718.e1-5. PMID: 22796522. PMCID:PMC3584415.
  5. Neal MD, Sodhi CP, Jia H, Dyer M, Egan C, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T, Grant Z, Ozolek J, Hackam DJ. Toll like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53-upregulated modulator of apoptosis. J Biol Chem. 2012 Oct 26;287(44):37296-308. PMID: 22955282. PMCID:PMC3481327.
  6. Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ. A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis. J Immunol. 2013 Apr 1;190(7):3541-51. PMID: 23455503. PMCID:PMC3608826.
  7. Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg. 2013 May;22(2):76-82. PMID: 23611610. PMCID:PMC3644853.
  8. Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. PMID: 23650378. PMCID:PMC3677476.
  9. Hackam DJ, Afrazi A, Good M, and Sodhi CP. Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis. Clinical and Developmental Immunology. 2013;2013:475415. PMID: 23762089. PMCID:PMC3677005.
  10. Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, et al. (2013) Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors. PLoS ONE. 2013 Jun 12;8(6):e65779. PMID: 23776545. PMCID:PMC3680486.
  11. Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen KP, Kaser A, Blumberg R, Hackam DJ. Toll Like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis. J Biol Chem. 2014 Apr 4;289(14):9584-99. PMID: 24519940. PMCID:PMC3975009.
  12. Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ. Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G1021-32. PMID: 24742987. PMCID: PMC4042115. *APS Select Article.

Areas of Research Interest

Dr. Good's laboratory focuses on the intestinal mucosal immune response involved in the development of a gastrointestinal disease affecting premature babies called necrotizing enterocolitis (NEC). 
Specifically, her laboratory is interested in:
- Determining the components of breast milk that are protective against NEC.
- Understanding the signaling pathways that are involved in NEC development.
- Evaluating the biological signature and genetic susceptibility of premature infants to NEC.