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Michael S. Diamond, MD, PhD

Herbert S. Gasser Professor of Medicine
Division of Infectious Diseases
Professor, Molecular Microbiology, Pathology and Immunology

Specialty Areas

Infectious Diseases

Board Certifications

Infectious Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

  • Education
  • Publication & Research

Education

Education

Research Fellowship: Department of Public Health, Infectious Disease Unit, University of California, Berkeley, California 2001
Clinical Fellowship: Infectious Disease, University of California, San Francisco, California 1998
Residency: Internal Medicine, University of California, San Francisco, California 1997
Research Fellowship: Molecular and Cell Biology, University of California, Berkeley, California 1995
Medical Degree: Harvard Medical School, Harvard University, Boston, Massachusetts 1994
Ph.D.: Cell and Developmental Biology, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts 1994
B.A.: Political Science, Columbia College of Columbia University, New York, New York 1985

Publication & Research

Publication & Research

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection.
Alsoussi WB, Turner JS, Case JB, Zhao H, Schmitz AJ, Zhou JQ, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH
J Immunol. 2020 Jun 26; pii: ji2000583. doi: 10.4049/jimmunol.2000583.

PMID:
    32591393
    [PubMed - as supplied by publisher]
Related citations


A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
Hassan AO, Case JB, Winkler ES, Thackray LB, Kafai NM, Bailey AL, McCune BT, Fox JM, Chen RE, Alsoussi WB, Turner JS, Schmitz AJ, Lei T, Shrihari S, Keeler SP, Fremont DH, Greco S, McCray PB Jr, Perlman S, Holtzman MJ, Ellebedy AH, Diamond MS
Cell. 2020 Jun 10; pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.

PMID:
    32553273
    [PubMed - as supplied by publisher]
Related citations


Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.
Zost SJ, Gilchuk P, Chen RE, Case JB, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Chen EC, Binshtein E, Shrihari S, Ostrowski M, Chu HY, Didier JE, MacRenaris KW, Jones T, Day S, Myers L, Lee FE, Nguyen DC, Sanz I, Martinez DR, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE
bioRxiv. 2020 May 13; pii: 2020.05.12.091462. doi: 10.1101/2020.05.12.091462.

PMID:
    32511414
    [PubMed]
Related citations


Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals.
Zost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, Martinez DR, Schäfer A, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE
bioRxiv. 2020 May 22; pii: 2020.05.22.111005. doi: 10.1101/2020.05.22.111005.

PMID:
    32511409
    [PubMed]
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Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2.
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ
bioRxiv. 2020 May 18; pii: 2020.05.18.102038. doi: 10.1101/2020.05.18.102038.

PMID:
    32511401
    [PubMed]
Related citations


Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2.
Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T
bioRxiv. 2020 Apr 21; pii: 2020.04.21.053058. doi: 10.1101/2020.04.21.053058.

PMID:
    32511398
    [PubMed]
Related citations


Structural and functional analysis of a potent sarbecovirus neutralizing antibody.
Pinto D, Park YJ, Beltramello M, Walls AC, Tortorici MA, Bianchi S, Jaconi S, Culap K, Zatta F, De Marco A, Peter A, Guarino B, Spreafico R, Cameroni E, Case JB, Chen RE, Havenar-Daughton C, Snell G, Telenti A, Virgin HW, Lanzavecchia A, Diamond MS, Fink K, Veesler D, Corti D
bioRxiv. 2020 Apr 9; pii: 2020.04.07.023903. doi: 10.1101/2020.04.07.023903.

PMID:
    32511354
    [PubMed]
Related citations


Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
Pinto D, Park YJ, Beltramello M, Walls AC, Tortorici MA, Bianchi S, Jaconi S, Culap K, Zatta F, De Marco A, Peter A, Guarino B, Spreafico R, Cameroni E, Case JB, Chen RE, Havenar-Daughton C, Snell G, Telenti A, Virgin HW, Lanzavecchia A, Diamond MS, Fink K, Veesler D, Corti D
Nature. 2020 May 18; doi: 10.1038/s41586-020-2349-y.

PMID:
    32422645
    [PubMed - as supplied by publisher]
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Identification of Dengue Virus Serotype 3 Specific Antigenic Sites Targeted by Neutralizing Human Antibodies.
Young E, Carnahan RH, Andrade DV, Kose N, Nargi RS, Fritch EJ, Munt JE, Doyle MP, White L, Baric TJ, Stoops M, DeSilva A, Tse LV, Martinez DR, Zhu D, Metz S, Wong MP, Espinosa DA, Montoya M, Biering SB, Sukulpolvi-Petty S, Kuan G, Balmaseda A, Diamond MS, Harris E, Crowe JE Jr, Baric RS
Cell Host Microbe. 2020 May 13; 27(5)710-724.e7. doi: 10.1016/j.chom.2020.04.007.

PMID:
    32407709
    [PubMed - in process]
Related citations


The Challenges of Vaccine Development against a New Virus during a Pandemic.
Diamond MS, Pierson TC
Cell Host Microbe. 2020 May 13; 27(5)699-703. doi: 10.1016/j.chom.2020.04.021.

PMID:
    32407708
    [PubMed - indexed for MEDLINE]
Related citations


TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM, Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA, Whelan SPJ, Ding S
Sci Immunol. 2020 May 13; 5(47)pii: eabc3582. doi: 10.1126/sciimmunol.abc3582.

PMID:
    32404436
    [PubMed - indexed for MEDLINE]
Related citations


The continued threat of emerging flaviviruses.
Pierson TC, Diamond MS
Nat Microbiol. 2020 Jun; 5(6)796-812. doi: 10.1038/s41564-020-0714-0.

PMID:
    32367055
    [PubMed - in process]
Related citations


Human monoclonal antibodies against Ross River virus target epitopes within the E2 protein and protect against disease.
Powell LA, Fox JM, Kose N, Kim AS, Majedi M, Bombardi R, Carnahan RH, Slaughter JC, Morrison TE, Diamond MS, Crowe JE Jr
PLoS Pathog. 2020 May; 16(5)e1008517. doi: 10.1371/journal.ppat.1008517.

PMID:
    32365139
    [PubMed - in process]
Related citations


Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity.
Morrison AH, Diamond MS, Hay CA, Byrne KT, Vonderheide RH
Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14)8022-8031. doi: 10.1073/pnas.1918971117.

PMID:
    32213589
    [PubMed - in process]
Related citations


Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response.
Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS
mBio. 2020 Mar 10; 11(2)pii: e00136-20. doi: 10.1128/mBio.00136-20.

PMID:
    32156810
    [PubMed - in process]
Related citations


Chikungunya Virus Evades Antiviral CD8<sup>+</sup> T Cell Responses To Establish Persistent Infection in Joint-Associated Tissues.
Davenport BJ, Bullock C, McCarthy MK, Hawman DW, Murphy KM, Kedl RM, Diamond MS, Morrison TE
J Virol. 2020 Apr 16; 94(9)pii: e02036-19. doi: 10.1128/JVI.02036-19.

PMID:
    32102875
    [PubMed - in process]
Related citations


An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.
Kim AS, Zimmerman O, Fox JM, Nelson CA, Basore K, Zhang R, Durnell L, Desai C, Bullock C, Deem SL, Oppenheimer J, Shapiro B, Wang T, Cherry S, Coyne CB, Handley SA, Landis MJ, Fremont DH, Diamond MS
Cell Host Microbe. 2020 Mar 11; 27(3)428-440.e9. doi: 10.1016/j.chom.2020.01.008.

PMID:
    32075743
    [PubMed - indexed for MEDLINE]
Related citations


Author Correction: Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection.
Fernandez E, Dejnirattisai W, Cao B, Scheaffer SM, Supasa P, Wongwiwat W, Esakky P, Drury A, Mongkolsapaya J, Moley KH, Mysorekar IU, Screaton GR, Diamond MS
Nat Immunol. 2020 Mar; 21(3)354. doi: 10.1038/s41590-019-0560-5.

PMID:
    32001822
    [PubMed]
Related citations


MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.
McCarthy MK, Reynoso GV, Winkler ES, Mack M, Diamond MS, Hickman HD, Morrison TE
PLoS Pathog. 2020 Jan; 16(1)e1008292. doi: 10.1371/journal.ppat.1008292.

PMID:
    31999809
    [PubMed - indexed for MEDLINE]
Related citations


Immune correlates of tuberculosis disease and risk translate across species.
Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA
Sci Transl Med. 2020 Jan 29; 12(528)pii: eaay0233. doi: 10.1126/scitranslmed.aay0233.

PMID:
    31996462
    [PubMed - in process]
Related citations

Areas of Research Interest

West Nile virus, Dengue virus, Chikungunya virus, antibody immunity, interferon immunity