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Michael S. Diamond, MD, PhD

Herbert S. Gasser Professor of Medicine
Division of Infectious Diseases
Professor, Molecular Microbiology, Pathology and Immunology

Specialty Areas

Infectious Diseases

Board Certifications

Infectious Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

  • Education
  • Publication & Research

Education

Education

Research Fellowship: Department of Public Health, Infectious Disease Unit, University of California, Berkeley, California 2001
Clinical Fellowship: Infectious Disease, University of California, San Francisco, California 1998
Residency: Internal Medicine, University of California, San Francisco, California 1997
Research Fellowship: Molecular and Cell Biology, University of California, Berkeley, California 1995
Medical Degree: Harvard Medical School, Harvard University, Boston, Massachusetts 1994
Ph.D.: Cell and Developmental Biology, Graduate School of Arts and Sciences, Harvard University, Boston, Massachusetts 1994
B.A.: Political Science, Columbia College of Columbia University, New York, New York 1985

Publication & Research

Publication & Research

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
Weiss CM, Trobaugh DW, Sun C, Lucas TM, Diamond MS, Ryman KD, Klimstra WB
mSphere. 2018 Sep 19; 3(5)pii: e00209-18. doi: 10.1128/mSphere.00209-18.

PMID:
    30232164
    [PubMed - in process]
Related citations


The emergence of Zika virus and its new clinical syndromes.
Pierson TC, Diamond MS
Nature. 2018 Aug; 560(7720)573-581. doi: 10.1038/s41586-018-0446-y.

PMID:
    30158602
    [PubMed - in process]
Related citations


Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement.
Lofano G, Gorman MJ, Yousif AS, Yu WH, Fox JM, Dugast AS, Ackerman ME, Suscovich TJ, Weiner J, Barouch D, Streeck H, Little S, Smith D, Richman D, Lauffenburger D, Walker BD, Diamond MS, Alter G
Sci Immunol. 2018 Aug 17; 3(26)pii: eaat7796. doi: 10.1126/sciimmunol.aat7796.

PMID:
    30120121
    [PubMed - in process]
Related citations


Cross-reactive Dengue virus-specific CD8<sup>+</sup> T cells protect against Zika virus during pregnancy.
Regla-Nava JA, Elong Ngono A, Viramontes KM, Huynh AT, Wang YT, Nguyen AT, Salgado R, Mamidi A, Kim K, Diamond MS, Shresta S
Nat Commun. 2018 Aug 2; 9(1)3042. doi: 10.1038/s41467-018-05458-0.

PMID:
    30072692
    [PubMed - in process]
Related citations


Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice.
Frei JC, Wirchnianski AS, Govero J, Vergnolle O, Dowd KA, Pierson TC, Kielian M, Girvin ME, Diamond MS, Lai JR
J Virol. 2018 Sep 15; 92(18)pii: e01023-18. doi: 10.1128/JVI.01023-18.

PMID:
    29976679
    [PubMed - indexed for MEDLINE]
Related citations


Mxra8 is a receptor for multiple arthritogenic alphaviruses.
Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS
Nature. 2018 May; 557(7706)570-574. doi: 10.1038/s41586-018-0121-3.

PMID:
    29769725
    [PubMed - in process]
Related citations


Zika virus vaccines: immune response, current status, and future challenges.
Richner JM, Diamond MS
Curr Opin Immunol. 2018 Aug; 53130-136. doi: 10.1016/j.coi.2018.04.024.

PMID:
    29753210
    [PubMed - in process]
Related citations


An Immunocompetent Mouse Model of Zika Virus Infection.
Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH 3rd, Rückert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A, Diamond MS
Cell Host Microbe. 2018 May 9; 23(5)672-685.e6. doi: 10.1016/j.chom.2018.04.003.

PMID:
    29746837
    [PubMed - in process]
Related citations


Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections.
Thackray LB, Handley SA, Gorman MJ, Poddar S, Bagadia P, Briseño CG, Theisen DJ, Tan Q, Hykes BL Jr, Lin H, Lucas TM, Desai C, Gordon JI, Murphy KM, Virgin HW, Diamond MS
Cell Rep. 2018 Mar 27; 22(13)3440-3453.e6. doi: 10.1016/j.celrep.2018.03.001.

PMID:
    29590614
    [PubMed - in process]
Related citations


Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.
Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK
Immunity. 2018 Mar 20; 48(3)487-499.e5. doi: 10.1016/j.immuni.2018.01.014.

PMID:
    29525521
    [PubMed - in process]
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<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infection.
Nair S, Huynh JP, Lampropoulou V, Loginicheva E, Esaulova E, Gounder AP, Boon ACM, Schwarzkopf EA, Bradstreet TR, Edelson BT, Artyomov MN, Stallings CL, Diamond MS
J Exp Med. 2018 Apr 2; 215(4)1035-1045. doi: 10.1084/jem.20180118.

PMID:
    29511063
    [PubMed - in process]
Related citations


Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.
Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE Jr, Diamond MS
MBio. 2018 Feb 27; 9(1)pii: e00008-18. doi: 10.1128/mBio.00008-18.

PMID:
    29487230
    [PubMed - in process]
Related citations


Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.
Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ
Sci Transl Med. 2018 Jan 31; 10(426)pii: eaao7090. doi: 10.1126/scitranslmed.aao7090.

PMID:
    29386359
    [PubMed - in process]
Related citations


Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.
Poonsiri T, Wright GSA, Diamond MS, Turtle L, Solomon T, Antonyuk SV
J Virol. 2018 Apr 1; 92(7)pii: e01868-17. doi: 10.1128/JVI.01868-17.

PMID:
    29343583
    [PubMed - indexed for MEDLINE]
Related citations


Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.
Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H
J Virol. 2018 Jan 17; pii: JVI.00038-18. doi: 10.1128/JVI.00038-18.

PMID:
    29343577
    [PubMed - as supplied by publisher]
Related citations


Vaccines in 2017: Closing in on a Zika virus vaccine.
Diamond MS, Coyne CB
Nat Rev Immunol. 2018 Feb; 18(2)89-90. doi: 10.1038/nri.2017.132.

PMID:
    29199280
    [PubMed - in process]
Related citations


Protection of mice deficient in mature B cells from West Nile virus infection by passive and active immunization.
Giordano D, Draves KE, Young LB, Roe K, Bryan MA, Dresch C, Richner JM, Diamond MS, Gale M Jr, Clark EA
PLoS Pathog. 2017 Nov; 13(11)e1006743. doi: 10.1371/journal.ppat.1006743.

PMID:
    29176765
    [PubMed - indexed for MEDLINE]
Related citations


Dengue virus-reactive CD8<sup>+</sup> T cells mediate cross-protection against subsequent Zika virus challenge.
Wen J, Elong Ngono A, Regla-Nava JA, Kim K, Gorman MJ, Diamond MS, Shresta S
Nat Commun. 2017 Nov 13; 8(1)1459. doi: 10.1038/s41467-017-01669-z.

PMID:
    29129917
    [PubMed - indexed for MEDLINE]
Related citations


An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses.
Carlin AF, Plummer EM, Vizcarra EA, Sheets N, Joo Y, Tang W, Day J, Greenbaum J, Glass CK, Diamond MS, Shresta S
Cell Rep. 2017 Nov 7; 21(6)1600-1612. doi: 10.1016/j.celrep.2017.10.054.

PMID:
    29117564
    [PubMed - indexed for MEDLINE]
Related citations


Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA
PLoS Pathog. 2017 Sep; 13(9)e1006635. doi: 10.1371/journal.ppat.1006635.

PMID:
    28953980
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

West Nile virus, Dengue virus, Chikungunya virus, antibody immunity, interferon immunity