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Michael P. Whyte, MD

Professor, Medicine
Professor, Pediatrics
Professor, Genetics
Division of Bone and Mineral Diseases
Director, Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children

Specialty Areas

Endocrinology
Inherited Disorders of Bone and Mineral Metabolism
Pediatric Bone Disorders
Bone and Mineral Diseases
Osteoporosis

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Shriners Hospital for Children - St. Louis
St. Louis Children's Hospital

Areas of Clinical Interest

Diagnosis and treatment of heritable disorders of bone and mineral metabolism, bone disease in adults and children, mineral disease, osteogenesis imperfecta, rickets, osteopetrosis, hypophosphatasia, hypophosphatemia, genetics, vitamin D-resistant rickets, metabolic and dysplastic bone disease in children, chondrodysplasia, pseudohypoparathyroidism, juvenile osteoporosis

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-454-7775
Fax: 314-454-5047

Education

Education

Fellowship: Bone and Mineral Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Clinical Associate: National Institutes of Health, Bethesda, Maryland 1976
Residency: Internal Medicine, Bellevue Hospital, New York, New York 1974
Medical Degree: Downstate College of Medicine, State University Of New York, Brooklyn, New York 1972
B.A.: Chemistry, Washington Square College of Arts and Science, New York University, New York, New York 1968

Publication & Research

Publication & Research

Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
Mumm S, Gottesman GS, Wenkert D, Campeau PM, Nenninger A, Huskey M, Bijanki VN, Veis DJ, Barnes AM, Marini JC, Stolina M, Zhang F, McAlister WH, Whyte MP
Bone. 2019 Aug 28; 130115047. doi: 10.1016/j.bone.2019.115047.

PMID:
    31472299
    [PubMed - as supplied by publisher]
Related citations


Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial.
Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA
Lancet. 2019 Jun 15; 393(10189)2416-2427. doi: 10.1016/S0140-6736(19)30654-3.

PMID:
    31104833
    [PubMed - indexed for MEDLINE]
Related citations


New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6.
Whyte MP, McAlister WH, Zhang F, Bijanki VN, Nenninger A, Gottesman GS, Lin EL, Huskey M, Duan S, Dahir K, Mumm S
Bone. 2019 Oct; 127228-243. doi: 10.1016/j.bone.2019.05.003.

PMID:
    31085352
    [PubMed - in process]
Related citations


Natural History of Perinatal and Infantile Hypophosphatasia: A Retrospective Study.
Whyte MP, Leung E, Wilcox WR, Liese J, Argente J, Martos-Moreno GÁ, Reeves A, Fujita KP, Moseley S, Hofmann C, Study 011-10 Investigators.
J Pediatr. 2019 Jun; 209116-124.e4. doi: 10.1016/j.jpeds.2019.01.049.

PMID:
    30979546
    [PubMed - in process]
Related citations


No vascular calcification on cardiac computed tomography spanning asfotase alfa treatment for an elderly woman with hypophosphatasia.
Whyte MP, McAlister WH, Mumm S, Bierhals AJ
Bone. 2019 May; 122231-236. doi: 10.1016/j.bone.2019.02.025.

PMID:
    30825650
    [PubMed - in process]
Related citations


Skeletal fluorosis in a resettled refugee from Kakuma refugee camp.
Fabreau GE, Bauman P, Coakley AL, Johnston K, Kennel KA, Gifford JL, Sadrzadeh HM, Whitford GM, Whyte MP, Kline GA
Lancet. 2019 Jan 19; 393(10168)223-225. doi: 10.1016/S0140-6736(18)32842-3.

PMID:
    30663587
    [PubMed - indexed for MEDLINE]
Related citations


Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study.
Frost M, Tencerova M, Andreasen CM, Andersen TL, Ejersted C, Svaneby D, Qui W, Kassem M, Zarei A, McAlister WH, Veis DJ, Whyte MP, Frederiksen AL
Bone. 2019 Apr; 121243-254. doi: 10.1016/j.bone.2019.01.014.

PMID:
    30659980
    [PubMed - in process]
Related citations


Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial.
Whyte MP, Carpenter TO, Gottesman GS, Mao M, Skrinar A, San Martin J, Imel EA
Lancet Diabetes Endocrinol. 2019 Mar; 7(3)189-199. doi: 10.1016/S2213-8587(18)30338-3.

PMID:
    30638856
    [PubMed - in process]
Related citations


Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone. 2019 Apr; 121149-162. doi: 10.1016/j.bone.2018.12.011.

PMID:
    30576866
    [PubMed - in process]
Related citations


Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial.
Whyte MP, Simmons JH, Moseley S, Fujita KP, Bishop N, Salman NJ, Taylor J, Phillips D, McGinn M, McAlister WH
Lancet Diabetes Endocrinol. 2019 Feb; 7(2)93-105. doi: 10.1016/S2213-8587(18)30307-3.

PMID:
    30558909
    [PubMed - in process]
Related citations


Genetic approaches to metabolic bone diseases.
Hannan FM, Newey PJ, Whyte MP, Thakker RV
Br J Clin Pharmacol. 2019 Jun; 85(6)1147-1160. doi: 10.1111/bcp.13803.

PMID:
    30357886
    [PubMed - in process]
Related citations


Sclerosteosis: Report of type 1 or 2 in three Indian Tamil families and literature review.
Whyte MP, Deepak Amalnath S, McAlister WH, Pedapati R, Muthupillai V, Duan S, Huskey M, Bijanki VN, Mumm S
Bone. 2018 Nov; 116321-332. doi: 10.1016/j.bone.2018.07.022.

PMID:
    30077757
    [PubMed - indexed for MEDLINE]
Related citations


Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis.
Whyte MP, Lim E, McAlister WH, Gottesman GS, Trinh L, Veis DJ, Bijanki VN, Boden MG, Nenninger A, Mumm S, Buchbinder D
J Bone Miner Res. 2018 Nov; 33(11)2071-2080. doi: 10.1002/jbmr.3532.

PMID:
    29933504
    [PubMed - indexed for MEDLINE]
Related citations


Burosumab Therapy in Children with X-Linked Hypophosphatemia.
Carpenter TO, Whyte MP, Imel EA, Boot AM, Högler W, Linglart A, Padidela R, Van't Hoff W, Mao M, Chen CY, Skrinar A, Kakkis E, San Martin J, Portale AA
N Engl J Med. 2018 May 24; 378(21)1987-1998. doi: 10.1056/NEJMoa1714641.

PMID:
    29791829
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Whyte MP
Clin Chem. 2018 Apr; 64(4)643-644. doi: 10.1373/clinchem.2017.280784.

PMID:
    29592907
    [PubMed - indexed for MEDLINE]
Related citations


AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV
Cell Rep. 2018 Jan 23; 22(4)1054-1066. doi: 10.1016/j.celrep.2017.12.089.

PMID:
    29420171
    [PubMed - indexed for MEDLINE]
Related citations


Hypophosphatasia: Biochemical hallmarks validate the expanded pediatric clinical nosology.
Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F
Bone. 2018 May; 11096-106. doi: 10.1016/j.bone.2018.01.022.

PMID:
    29360619
    [PubMed - indexed for MEDLINE]
Related citations


Validation of a Novel Scoring System for Changes in Skeletal Manifestations of Hypophosphatasia in Newborns, Infants, and Children: The Radiographic Global Impression of Change Scale.
Whyte MP, Fujita KP, Moseley S, Thompson DD, McAlister WH
J Bone Miner Res. 2018 May; 33(5)868-874. doi: 10.1002/jbmr.3377.

PMID:
    29297597
    [PubMed - indexed for MEDLINE]
Related citations


Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5).
Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Veis DV, Stolina M, Woo AS, Katsonis P, Lichtarge O, Zhang F, Shinawi M
Bone. 2018 Feb; 107161-171. doi: 10.1016/j.bone.2017.11.012.

PMID:
    29175271
    [PubMed - indexed for MEDLINE]
Related citations


Alkaline Phosphatase: Discovery and Naming of Our Favorite Enzyme.
Siller AF, Whyte MP
J Bone Miner Res. 2018 Feb; 33(2)362-364. doi: 10.1002/jbmr.3225.

PMID:
    28727174
    [PubMed - indexed for MEDLINE]
Related citations