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Michael P. Whyte, MD

Professor, Medicine
Professor, Pediatrics
Professor, Genetics
Division of Bone and Mineral Diseases
Director, Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children

Specialty Areas

Endocrinology
Inherited Disorders of Bone and Mineral Metabolism
Pediatric Bone Disorders
Bone and Mineral Diseases
Osteoporosis

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Shriners Hospital for Children - St. Louis
St. Louis Children's Hospital

Areas of Clinical Interest

Diagnosis and treatment of heritable disorders of bone and mineral metabolism, bone disease in adults and children, mineral disease, osteogenesis imperfecta, rickets, osteopetrosis, hypophosphatasia, hypophosphatemia, genetics, vitamin D-resistant rickets, metabolic and dysplastic bone disease in children, chondrodysplasia, pseudohypoparathyroidism, juvenile osteoporosis

  • Location(s)
  • Education
  • Publication & Research

Location(s)

Location(s)

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-454-7775
Fax: 314-454-5047

Education

Education

Fellowship: Bone and Mineral Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Clinical Associate: National Institutes of Health, Bethesda, Maryland 1976
Residency: Internal Medicine, Bellevue Hospital, New York, New York 1974
Medical Degree: Downstate College of Medicine, State University Of New York, Brooklyn, New York 1972
B.A.: Chemistry, Washington Square College of Arts and Science, New York University, New York, New York 1968

Publication & Research

Publication & Research

Healing of vitamin D deficiency rickets complicating hypophosphatasia suggests a role beyond circulating mineral sufficiency for vitamin D in musculoskeletal health.
Lin EL, Gottesman GS, McAlister WH, Bijanki VN, Mack KE, Griffin DM, Mumm S, Whyte MP
Bone. 2020 Mar 18; 115322. doi: 10.1016/j.bone.2020.115322.

PMID:
    32200022
    [PubMed - as supplied by publisher]
Related citations


Genetics of Skeletal Disorders.
Hannan FM, Newey PJ, Whyte MP, Thakker RV
Handb Exp Pharmacol. 2020 Mar 13; doi: 10.1007/164_2020_350.

PMID:
    32166388
    [PubMed - as supplied by publisher]
Related citations


Hyperphosphatemia with low FGF7 and normal FGF23 and sFRP4 levels in the circulation characterizes pediatric hypophosphatasia.
Whyte MP, Zhang F, Wenkert D, Mumm S, Berndt TJ, Kumar R
Bone. 2020 May; 134115300. doi: 10.1016/j.bone.2020.115300.

PMID:
    32112990
    [PubMed - in process]
Related citations


ZNF687 Mutations in an Extended Cohort of Neoplastic Transformations in Paget's Disease of Bone: Implications for Clinical Pathology.
Scotto di Carlo F, Pazzaglia L, Mumm S, Benassi MS, De Chiara A, Franchi A, Parafioriti A, Righi A, Esposito T, Whyte MP, Gianfrancesco F
J Bone Miner Res. 2020 Feb 27; doi: 10.1002/jbmr.3993.

PMID:
    32106343
    [PubMed - as supplied by publisher]
Related citations


Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism.
Gaynor KU, Grigorieva IV, Mirczuk SM, Piret S, Kooblall KG, Stevenson M, Rizzoti K, Bowl MR, Nesbit MA, Christie PT, Fraser WD, Hough T, Whyte MP, Lovell-Badge R, Thakker R
Endocr Connect. 2020 Jan 1; pii: EC-19-0478.R1. doi: 10.1530/EC-19-0478.

PMID:
    31961795
    [PubMed - as supplied by publisher]
Related citations


Early-onset Paget's disease of bone in a Mexican family caused by a novel tandem duplication (77dup27) in TNFRSF11A that encodes RANK.
Iwamoto SJ, Rothman MS, Duan S, Baker JC, Mumm S, Whyte MP
Bone. 2020 Apr; 133115224. doi: 10.1016/j.bone.2020.115224.

PMID:
    31923705
    [PubMed - in process]
Related citations


X-Linked Hypophosphatemia: Uniquely Mild Disease Associated With PHEX 3'-UTR Mutation c.*231A>G (A Retrospective Case-Control Study).
Smith PS, Gottesman GS, Zhang F, Cook F, Ramirez B, Wenkert D, Wollberg V, Huskey M, Mumm S, Whyte MP
J Bone Miner Res. 2020 Jan 7; doi: 10.1002/jbmr.3955.

PMID:
    31910300
    [PubMed - as supplied by publisher]
Related citations


Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy?
Whyte MP, Amalnath SD, McAlister WH, McKee MD, Veis DJ, Huskey M, Duan S, Bijanki VN, Alur S, Mumm S
Bone. 2020 Mar; 132115190. doi: 10.1016/j.bone.2019.115190.

PMID:
    31843680
    [PubMed - in process]
Related citations


Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
Mumm S, Gottesman GS, Wenkert D, Campeau PM, Nenninger A, Huskey M, Bijanki VN, Veis DJ, Barnes AM, Marini JC, Stolina M, Zhang F, McAlister WH, Whyte MP
Bone. 2020 Jan; 130115047. doi: 10.1016/j.bone.2019.115047.

PMID:
    31472299
    [PubMed - in process]
Related citations


Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial.
Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA
Lancet. 2019 Jun 15; 393(10189)2416-2427. doi: 10.1016/S0140-6736(19)30654-3.

PMID:
    31104833
    [PubMed - indexed for MEDLINE]
Related citations


New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6.
Whyte MP, McAlister WH, Zhang F, Bijanki VN, Nenninger A, Gottesman GS, Lin EL, Huskey M, Duan S, Dahir K, Mumm S
Bone. 2019 Oct; 127228-243. doi: 10.1016/j.bone.2019.05.003.

PMID:
    31085352
    [PubMed - in process]
Related citations


Natural History of Perinatal and Infantile Hypophosphatasia: A Retrospective Study.
Whyte MP, Leung E, Wilcox WR, Liese J, Argente J, Martos-Moreno GÁ, Reeves A, Fujita KP, Moseley S, Hofmann C, Study 011-10 Investigators.
J Pediatr. 2019 Jun; 209116-124.e4. doi: 10.1016/j.jpeds.2019.01.049.

PMID:
    30979546
    [PubMed - in process]
Related citations


No vascular calcification on cardiac computed tomography spanning asfotase alfa treatment for an elderly woman with hypophosphatasia.
Whyte MP, McAlister WH, Mumm S, Bierhals AJ
Bone. 2019 May; 122231-236. doi: 10.1016/j.bone.2019.02.025.

PMID:
    30825650
    [PubMed - in process]
Related citations


Skeletal fluorosis in a resettled refugee from Kakuma refugee camp.
Fabreau GE, Bauman P, Coakley AL, Johnston K, Kennel KA, Gifford JL, Sadrzadeh HM, Whitford GM, Whyte MP, Kline GA
Lancet. 2019 Jan 19; 393(10168)223-225. doi: 10.1016/S0140-6736(18)32842-3.

PMID:
    30663587
    [PubMed - indexed for MEDLINE]
Related citations


Absence of an osteopetrosis phenotype in IKBKG (NEMO) mutation-positive women: A case-control study.
Frost M, Tencerova M, Andreasen CM, Andersen TL, Ejersted C, Svaneby D, Qui W, Kassem M, Zarei A, McAlister WH, Veis DJ, Whyte MP, Frederiksen AL
Bone. 2019 Apr; 121243-254. doi: 10.1016/j.bone.2019.01.014.

PMID:
    30659980
    [PubMed - in process]
Related citations


Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial.
Whyte MP, Carpenter TO, Gottesman GS, Mao M, Skrinar A, San Martin J, Imel EA
Lancet Diabetes Endocrinol. 2019 Mar; 7(3)189-199. doi: 10.1016/S2213-8587(18)30338-3.

PMID:
    30638856
    [PubMed - in process]
Related citations


Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia.
Kishnani PS, Rockman-Greenberg C, Rauch F, Bhatti MT, Moseley S, Denker AE, Watsky E, Whyte MP
Bone. 2019 Apr; 121149-162. doi: 10.1016/j.bone.2018.12.011.

PMID:
    30576866
    [PubMed - in process]
Related citations


Asfotase alfa for infants and young children with hypophosphatasia: 7 year outcomes of a single-arm, open-label, phase 2 extension trial.
Whyte MP, Simmons JH, Moseley S, Fujita KP, Bishop N, Salman NJ, Taylor J, Phillips D, McGinn M, McAlister WH
Lancet Diabetes Endocrinol. 2019 Feb; 7(2)93-105. doi: 10.1016/S2213-8587(18)30307-3.

PMID:
    30558909
    [PubMed - in process]
Related citations


Genetic approaches to metabolic bone diseases.
Hannan FM, Newey PJ, Whyte MP, Thakker RV
Br J Clin Pharmacol. 2019 Jun; 85(6)1147-1160. doi: 10.1111/bcp.13803.

PMID:
    30357886
    [PubMed - in process]
Related citations


Sclerosteosis: Report of type 1 or 2 in three Indian Tamil families and literature review.
Whyte MP, Deepak Amalnath S, McAlister WH, Pedapati R, Muthupillai V, Duan S, Huskey M, Bijanki VN, Mumm S
Bone. 2018 Nov; 116321-332. doi: 10.1016/j.bone.2018.07.022.

PMID:
    30077757
    [PubMed - indexed for MEDLINE]
Related citations