Patient Portal

Michael P. Whyte, MD

Professor, Medicine
Professor, Pediatrics
Professor, Genetics
Division of Bone and Mineral Diseases
Director, Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children

Specialty Areas

Endocrinology
Inherited Disorders of Bone and Mineral Metabolism
Pediatric Bone Disorders
Bone and Mineral Diseases

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Shriners Hospital for Children - St. Louis
St. Louis Children's Hospital

Areas of Clinical Interest

Diagnosis and treatment of heritable disorders of bone and mineral metabolism, bone disease in adults and children, mineral disease, osteogenesis imperfecta, rickets, osteopetrosis, hypophosphatasia, hypophosphatemia, genetics, vitamin D-resistant rickets, metabolic and dysplastic bone disease in children, chondrodysplasia, pseudohypoparathyroidism, juvenile osteoporosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-454-7775
Fax: 314-454-5047

Education

Education

Fellowship: Bone and Mineral Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Clinical Associate: National Institutes of Health, Bethesda, Maryland 1976
Residency: Internal Medicine, Bellevue Hospital, New York, New York 1974
Medical Degree: Downstate College of Medicine, State University Of New York, Brooklyn, New York 1972
B.A.: Chemistry, Washington Square College of Arts and Science, New York University, New York, New York 1968

Publication & Research

Publication & Research

Sclerosteosis: Report of type 1 or 2 in three Indian Tamil families and literature review.
Whyte MP, Deepak Amalnath S, McAlister WH, Pedapati R, Muthupillai V, Duan S, Huskey M, Bijanki VN, Mumm S
Bone. 2018 Aug 2; 116321-332. doi: 10.1016/j.bone.2018.07.022.

PMID:
    30077757
    [PubMed - as supplied by publisher]
Related citations


Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis.
Whyte MP, Lim E, McAlister WH, Gottesman GS, Trinh L, Veis DJ, Bijanki VN, Boden MG, Nenninger A, Mumm S, Buchbinder D
J Bone Miner Res. 2018 Jun 22; doi: 10.1002/jbmr.3532.

PMID:
    29933504
    [PubMed - as supplied by publisher]
Related citations


Burosumab Therapy in Children with X-Linked Hypophosphatemia.
Carpenter TO, Whyte MP, Imel EA, Boot AM, Högler W, Linglart A, Padidela R, Van't Hoff W, Mao M, Chen CY, Skrinar A, Kakkis E, San Martin J, Portale AA
N Engl J Med. 2018 May 24; 378(21)1987-1998. doi: 10.1056/NEJMoa1714641.

PMID:
    29791829
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Whyte MP
Clin Chem. 2018 Apr; 64(4)643-644. doi: 10.1373/clinchem.2017.280784.

PMID:
    29592907
    [PubMed - in process]
Related citations


AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV
Cell Rep. 2018 Jan 23; 22(4)1054-1066. doi: 10.1016/j.celrep.2017.12.089.

PMID:
    29420171
    [PubMed - in process]
Related citations


Hypophosphatasia: Biochemical hallmarks validate the expanded pediatric clinical nosology.
Whyte MP, Coburn SP, Ryan LM, Ericson KL, Zhang F
Bone. 2018 May; 11096-106. doi: 10.1016/j.bone.2018.01.022.

PMID:
    29360619
    [PubMed - in process]
Related citations


Validation of a Novel Scoring System for Changes in Skeletal Manifestations of Hypophosphatasia in Newborns, Infants, and Children: The Radiographic Global Impression of Change Scale.
Whyte MP, Fujita KP, Moseley S, Thompson DD, McAlister WH
J Bone Miner Res. 2018 May; 33(5)868-874. doi: 10.1002/jbmr.3377.

PMID:
    29297597
    [PubMed - in process]
Related citations


Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5).
Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Veis DV, Stolina M, Woo AS, Katsonis P, Lichtarge O, Zhang F, Shinawi M
Bone. 2018 Feb; 107161-171. doi: 10.1016/j.bone.2017.11.012.

PMID:
    29175271
    [PubMed - in process]
Related citations


Alkaline Phosphatase: Discovery and Naming of Our Favorite Enzyme.
Siller AF, Whyte MP
J Bone Miner Res. 2018 Feb; 33(2)362-364. doi: 10.1002/jbmr.3225.

PMID:
    28727174
    [PubMed - in process]
Related citations


Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS.
Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER
Bone. 2017 Aug; 101145-155. doi: 10.1016/j.bone.2017.04.010.

PMID:
    28434888
    [PubMed - indexed for MEDLINE]
Related citations


Hypophosphatasia: An overview For 2017.
Whyte MP
Bone. 2017 Sep; 10215-25. doi: 10.1016/j.bone.2017.02.011.

PMID:
    28238808
    [PubMed - indexed for MEDLINE]
Related citations


Hypophosphatasia: Enzyme Replacement Therapy Brings New Opportunities and New Challenges.
Whyte MP
J Bone Miner Res. 2017 Apr; 32(4)667-675. doi: 10.1002/jbmr.3075.

PMID:
    28084648
    [PubMed - indexed for MEDLINE]
Related citations


Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia.
Boukpessi T, Hoac B, Coyac BR, Leger T, Garcia C, Wicart P, Whyte MP, Glorieux FH, Linglart A, Chaussain C, McKee MD
Bone. 2017 Feb; 95151-161. doi: 10.1016/j.bone.2016.11.019.

PMID:
    27884786
    [PubMed - indexed for MEDLINE]
Related citations


Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660).
Whyte MP, McAlister WH, Fallon MD, Pierpont ME, Bijanki VN, Duan S, Otaify GA, Sly WS, Mumm S
J Bone Miner Res. 2017 Apr; 32(4)757-769. doi: 10.1002/jbmr.3034.

PMID:
    27862258
    [PubMed - indexed for MEDLINE]
Related citations


Hypophosphatasia: Natural history study of 101 affected children investigated at one research center.
Whyte MP, Wenkert D, Zhang F
Bone. 2016 Dec; 93125-138. doi: 10.1016/j.bone.2016.08.019.

PMID:
    27576207
    [PubMed - indexed for MEDLINE]
Related citations


Asfotase alfa therapy for children with hypophosphatasia.
Whyte MP, Madson KL, Phillips D, Reeves AL, McAlister WH, Yakimoski A, Mack KE, Hamilton K, Kagan K, Fujita KP, Thompson DD, Moseley S, Odrljin T, Rockman-Greenberg C
JCI Insight. 2016 Jun 16; 1(9)e85971.

PMID:
    27699270
    [PubMed - in process]
Related citations


Skeletal Fluorosis Due To Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.
Tucci JR, Whitford GM, McAlister WH, Novack DV, Mumm S, Keaveny TM, Whyte MP
J Bone Miner Res. 2017 Jan; 32(1)188-195. doi: 10.1002/jbmr.2923.

PMID:
    27449958
    [PubMed - indexed for MEDLINE]
Related citations


Commentary.
Whyte MP
Clin Chem. 2016 May; 62(5)688. doi: 10.1373/clinchem.2015.248765.

PMID:
    27127243
    [PubMed - in process]
Related citations


ADULT HYPOPHOSPHATASIA TREATED WITH TERIPARATIDE: REPORT OF 2 PATIENTS AND REVIEW OF THE LITERATURE.
Camacho PM, Mazhari AM, Wilczynski C, Kadanoff R, Mumm S, Whyte MP
Endocr Pract. 2016 Aug; 22(8)941-50. doi: 10.4158/EP15890.OR.

PMID:
    27042741
    [PubMed - indexed for MEDLINE]
Related citations


Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus.
Guañabens N, Mumm S, Gifre L, Ruiz-Gaspà S, Demertzis JL, Stolina M, Novack DV, Whyte MP
J Bone Miner Res. 2016 Sep; 31(9)1774-82. doi: 10.1002/jbmr.2842.

PMID:
    27005479
    [PubMed - indexed for MEDLINE]
Related citations