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Michael P. Whyte, MD

Professor, Medicine
Professor, Pediatrics
Professor, Genetics
Division of Bone and Mineral Diseases
Director, Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children

Specialty Areas

Endocrinology
Inherited Disorders of Bone and Mineral Metabolism
Pediatric Bone Disorders
Bone and Mineral Diseases

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Shriners Hospital for Children - St. Louis
St. Louis Children's Hospital

Areas of Clinical Interest

Diagnosis and treatment of heritable disorders of bone and mineral metabolism, bone disease in adults and children, mineral disease, osteogenesis imperfecta, rickets, osteopetrosis, hypophosphatasia, hypophosphatemia, genetics, vitamin D-resistant rickets, metabolic and dysplastic bone disease in children, chondrodysplasia, pseudohypoparathyroidism, juvenile osteoporosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Medicine Multispecialty Center

4921 Parkview Place
St. Louis, MO 63110

Suite: C
Floor: 5
Office Phone: 314-454-7775
Fax: 314-454-5047

Education

Education

Fellowship: Bone and Mineral Metabolism, Washington University School of Medicine, St. Louis, Missouri 1979
Clinical Associate: National Institutes of Health, Bethesda, Maryland 1976
Residency: Internal Medicine, Bellevue Hospital, New York, New York 1974
Medical Degree: Downstate College of Medicine, State University Of New York, Brooklyn, New York 1972
B.A.: Chemistry, Washington Square College of Arts and Science, New York University, New York, New York 1968

Publication & Research

Publication & Research

Hypophosphatasia: Natural history study of 101 affected children investigated at one research center.
Whyte MP, Wenkert D, Zhang F
Bone. 2016 Aug 26; pii: S8756-3282(16)30239-3. doi: 10.1016/j.bone.2016.08.019.

PMID:
    27576207
    [PubMed - as supplied by publisher]
Related citations


Skeletal Fluorosis Due to Inhalation Abuse of a Difluoroethane-Containing Computer Cleaner.
Tucci JR, Whitford GM, McAlister WH, Novack D, Mumm S, Keaveny TM, Whyte MP
J Bone Miner Res. 2016 Jul 23; doi: 10.1002/jbmr.2923.

PMID:
    27449958
    [PubMed - as supplied by publisher]
Related citations


Commentary.
Whyte MP
Clin Chem. 2016 May; 62(5)688. doi: 10.1373/clinchem.2015.248765.

PMID:
    27127243
    [PubMed - in process]
Related citations


ADULT HYPOPHOSPHATASIA TREATED WITH TERIPARATIDE: REPORT OF 2 PATIENTS AND REVIEW OF THE LITERATURE.
Camacho PM, Mazhari AM, Wilczynski C, Kadanoff R, Mumm S, Whyte MP
Endocr Pract. 2016 Aug; 22(8)941-50. doi: 10.4158/EP15890.OR.

PMID:
    27042741
    [PubMed - in process]
Related citations


Idiopathic Acquired Osteosclerosis in a Middle-Aged Woman With Systemic Lupus Erythematosus.
Guañabens N, Mumm S, Gifre L, Ruiz-Gaspà S, Demertzis JL, Stolina M, Novack DV, Whyte MP
J Bone Miner Res. 2016 Sep; 31(9)1774-82. doi: 10.1002/jbmr.2842.

PMID:
    27005479
    [PubMed - in process]
Related citations


Hypophosphatasia - aetiology, nosology, pathogenesis, diagnosis and treatment.
Whyte MP
Nat Rev Endocrinol. 2016 Apr; 12(4)233-46. doi: 10.1038/nrendo.2016.14.

PMID:
    26893260
    [PubMed - indexed for MEDLINE]
Related citations


Auricular ossification: A newly recognized feature of osteoprotegerin-deficiency juvenile Paget disease.
Gottesman GS, Madson KL, McAlister WH, Nenninger A, Wenkert D, Mumm S, Whyte MP
Am J Med Genet A. 2016 Apr; 170A(4)978-85. doi: 10.1002/ajmg.a.37536.

PMID:
    26762549
    [PubMed - in process]
Related citations


Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9.
Phatarakijnirund V, Mumm S, McAlister WH, Novack DV, Wenkert D, Clements KL, Whyte MP
Bone. 2016 Mar; 84289-98. doi: 10.1016/j.bone.2015.11.022.

PMID:
    26746779
    [PubMed - in process]
Related citations


Alkaline Phosphatase and Hypophosphatasia.
Millán JL, Whyte MP
Calcif Tissue Int. 2016 Apr; 98(4)398-416. doi: 10.1007/s00223-015-0079-1.

PMID:
    26590809
    [PubMed - in process]
Related citations


Asfotase Alfa Treatment Improves Survival for Perinatal and Infantile Hypophosphatasia.
Whyte MP, Rockman-Greenberg C, Ozono K, Riese R, Moseley S, Melian A, Thompson DD, Bishop N, Hofmann C
J Clin Endocrinol Metab. 2016 Jan; 101(1)334-42. doi: 10.1210/jc.2015-3462.

PMID:
    26529632
    [PubMed - indexed for MEDLINE]
Related citations


Reply: Response to: Rapid Skeletal Turnover in a Radiographic Mimic of Osteopetrosis Might Be Secondary to Systemic Mastocytosis.
Whyte MP, Madson KL, McAlister WH, Mumm S, Novack DV, Blair JC, Shaw NJ
J Bone Miner Res. 2015 Aug; 30(8)1537. doi: 10.1002/jbmr.2561.

PMID:
    26183677
    [PubMed]
Related citations


Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).
Frederiksen AL, Larsen MJ, Brusgaard K, Novack DV, Knudsen PJ, Schrøder HD, Qiu W, Eckhardt C, McAlister WH, Kassem M, Mumm S, Frost M, Whyte MP
J Bone Miner Res. 2016 Jan; 31(1)163-72. doi: 10.1002/jbmr.2590.

PMID:
    26178921
    [PubMed - in process]
Related citations


Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects.
Hannan FM, Howles SA, Rogers A, Cranston T, Gorvin CM, Babinsky VN, Reed AA, Thakker CE, Bockenhauer D, Brown RS, Connell JM, Cook J, Darzy K, Ehtisham S, Graham U, Hulse T, Hunter SJ, Izatt L, Kumar D, McKenna MJ, McKnight JA, Morrison PJ, Mughal MZ, O'Halloran D, Pearce SH, Porteous ME, Rahman M, Richardson T, Robinson R, Scheers I, Siddique H, Van't Hoff WG, Wang T, Whyte MP, Nesbit MA, Thakker RV
Hum Mol Genet. 2015 Sep 15; 24(18)5079-92. doi: 10.1093/hmg/ddv226.

PMID:
    26082470
    [PubMed - indexed for MEDLINE]
Related citations


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G
Nat Genet. 2015 Jul; 47(7)717-26. doi: 10.1038/ng.3304.

PMID:
    25985138
    [PubMed - indexed for MEDLINE]
Related citations


Hypophosphatasia: validation and expansion of the clinical nosology for children from 25 years experience with 173 pediatric patients.
Whyte MP, Zhang F, Wenkert D, McAlister WH, Mack KE, Benigno MC, Coburn SP, Wagy S, Griffin DM, Ericson KL, Mumm S
Bone. 2015 Jun; 75229-39. doi: 10.1016/j.bone.2015.02.022.

PMID:
    25731960
    [PubMed - indexed for MEDLINE]
Related citations


Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia.
Foster BL, Sheen CR, Hatch NE, Liu J, Cory E, Narisawa S, Kiffer-Moreira T, Sah RL, Whyte MP, Somerman MJ, Millán JL
J Dent Res. 2015 May; 94(5)706-14. doi: 10.1177/0022034515573273.

PMID:
    25716980
    [PubMed - indexed for MEDLINE]
Related citations


Response to: A rapid skeletal turnover in radiographic mimic of osteopetrosis might be secondary to systemic mastocytosis.
Whyte MP, Madson KL, McAlister WH, Mumm S, Novack DV, Blair JC, Shaw NJ
J Bone Miner Res. 2015 May; 30(5)946. doi: 10.1002/jbmr.2455.

PMID:
    25588359
    [PubMed - indexed for MEDLINE]
Related citations


Lenz-Majewski hyperostotic dwarfism with hyperphosphoserinuria from a novel mutation in PTDSS1 encoding phosphatidylserine synthase 1.
Whyte MP, Blythe A, McAlister WH, Nenninger AR, Bijanki VN, Mumm S
J Bone Miner Res. 2015 Apr; 30(4)606-14. doi: 10.1002/jbmr.2398.

PMID:
    25363158
    [PubMed - indexed for MEDLINE]
Related citations


Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANK.
Whyte MP, Tau C, McAlister WH, Zhang X, Novack DV, Preliasco V, Santini-Araujo E, Mumm S
Bone. 2014 Nov; 68153-61. doi: 10.1016/j.bone.2014.07.019.

PMID:
    25063546
    [PubMed - indexed for MEDLINE]
Related citations


PHEX 3'-UTR c.*231A>G near the polyadenylation signal is a relatively common, mild, American mutation that masquerades as sporadic or X-linked recessive hypophosphatemic rickets.
Mumm S, Huskey M, Cajic A, Wollberg V, Zhang F, Madson KL, Wenkert D, McAlister WH, Gottesman GS, Whyte MP
J Bone Miner Res. 2015 Jan; 30(1)137-43. doi: 10.1002/jbmr.2307.

PMID:
    25042154
    [PubMed - indexed for MEDLINE]
Related citations