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Michael Justin Noetzel, MD

Professor, Neurology
Professor, Pediatrics
Director, Division of Pediatric and Developmental Neurology
Neurologist-in-Chief and Medical Director, Clinical and Diagnostic Neuroscience Services at St Louis Children's Hospital

Specialty Areas

Pediatric Neurology
Cerebral Palsy
Neurological Rehabilitation
Pediatric Stroke

Board Certifications

Pediatrics
Child Neurology
Neuro-Rehabilitation

Hospital Affiliations

Barnes-Jewish Hospital
St. Louis Children's Hospital

Areas of Clinical Interest

Pediatric neurological assessment, neurology, neurological disorders, neurological diseases, seizures, nervous system disorders, CNS malformations, birth-related brachial plexus palsy injury, cerebral palsy, neuro rehabilitation therapy, spasticity, metabolic disorders, abnormal development.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: 2nd Floor, Suite C/D
Office Phone: 314-454-6120
Fax: 314-454-2523
Email: noetzelm@neuro.wustl.edu

Education

Education

Fellowship: Child Neurology, St. Louis Children's Hospital, St. Louis, Missouri 1982
Residency: Neurology, Barnes Hospital, St. Louis, Missouri 1980
Residency: Pediatrics, St. Louis Children's Hospital, St. Louis, Missouri 1979
Medical Degree: University Of Virginia 1977
B.A.: History, Yale University, New Haven, Connecticutt 1973

Publication & Research

Publication & Research

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2016 Sep 1; 26(17)4282-6. doi: 10.1016/j.bmcl.2016.07.042.

PMID:
    27476142
    [PubMed - in process]
Related citations


Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
Wood MR, Noetzel MJ, Engers JL, Bollinger KA, Melancon BJ, Tarr JC, Han C, West M, Gregro AR, Lamsal A, Chang S, Ajmera S, Smith E, Chase P, Hodder PS, Bubser M, Jones CK, Hopkins CR, Emmitte KA, Niswender CM, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW
Bioorg Med Chem Lett. 2016 Jul 1; 26(13)3029-33. doi: 10.1016/j.bmcl.2016.05.010.

PMID:
    27185330
    [PubMed - in process]
Related citations


State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.
Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, Lindsley CW, Conn PJ, Jones CK
Neuropharmacology. 2016 Mar; 102244-53. doi: 10.1016/j.neuropharm.2015.11.016.

PMID:
    26617071
    [PubMed - in process]
Related citations


Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.
Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Nov 15; 25(22)5115-20. doi: 10.1016/j.bmcl.2015.10.009.

PMID:
    26475522
    [PubMed - indexed for MEDLINE]
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Pediatric Hemorrhagic Brainstem Encephalitis Associated With HHV-7 Infection.
Fay AJ, Noetzel MJ, Mar SS
Pediatr Neurol. 2015 Dec; 53(6)523-6. doi: 10.1016/j.pediatrneurol.2015.06.016.

PMID:
    26255752
    [PubMed - in process]
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Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Ghoshal A, Rook JM, Dickerson JW, Roop GN, Morrison RD, Jalan-Sakrikar N, Lamsal A, Noetzel MJ, Poslusney MS, Wood MR, Melancon BJ, Stauffer SR, Xiang Z, Daniels JS, Niswender CM, Jones CK, Lindsley CW, Conn PJ
Neuropsychopharmacology. 2016 Jan; 41(2)598-610. doi: 10.1038/npp.2015.189.

PMID:
    26108886
    [PubMed - in process]
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Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).
Smith E, Chase P, Niswender CM, Utley TJ, Sheffler DJ, Noetzel MJ, Lamsal A, Wood MR, Conn PJ, Lindsley CW, Madoux F, Acosta M, Scampavia L, Spicer T, Hodder P
J Biomol Screen. 2015 Aug; 20(7)858-68. doi: 10.1177/1087057115581770.

PMID:
    25877150
    [PubMed - indexed for MEDLINE]
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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Martín-Martín ML, Bartolomé-Nebreda JM, Conde-Ceide S, Alonso de Diego SA, López S, Martínez-Viturro CM, Tong HM, Lavreysen H, Macdonald GJ, Steckler T, Mackie C, Bridges TM, Daniels JS, Niswender CM, Noetzel MJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Mar 15; 25(6)1310-7. doi: 10.1016/j.bmcl.2015.01.038.

PMID:
    25683622
    [PubMed - indexed for MEDLINE]
Related citations


Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.
Han C, Chatterjee A, Noetzel MJ, Panarese JD, Smith E, Chase P, Hodder P, Niswender C, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2015 Jan 15; 25(2)384-8. doi: 10.1016/j.bmcl.2014.11.011.

PMID:
    25435150
    [PubMed - indexed for MEDLINE]
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Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).
Gentry PR, Kokubo M, Bridges TM, Noetzel MJ, Cho HP, Lamsal A, Smith E, Chase P, Hodder PS, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Wood MR
J Med Chem. 2014 Sep 25; 57(18)7804-10. doi: 10.1021/jm500995y.

PMID:
    25147929
    [PubMed - indexed for MEDLINE]
Related citations


Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.
DeBaun MR, Gordon M, McKinstry RC, Noetzel MJ, White DA, Sarnaik SA, Meier ER, Howard TH, Majumdar S, Inusa BP, Telfer PT, Kirby-Allen M, McCavit TL, Kamdem A, Airewele G, Woods GM, Berman B, Panepinto JA, Fuh BR, Kwiatkowski JL, King AA, Fixler JM, Rhodes MM, Thompson AA, Heiny ME, Redding-Lallinger RC, Kirkham FJ, Dixon N, Gonzalez CE, Kalinyak KA, Quinn CT, Strouse JJ, Miller JP, Lehmann H, Kraut MA, Ball WS Jr, Hirtz D, Casella JF
N Engl J Med. 2014 Aug 21; 371(8)699-710. doi: 10.1056/NEJMoa1401731.

PMID:
    25140956
    [PubMed - indexed for MEDLINE]
Related citations


Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK
ACS Chem Neurosci. 2014 Oct 15; 5(10)920-42. doi: 10.1021/cn500128b.

PMID:
    25137629
    [PubMed - indexed for MEDLINE]
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Silent cerebral infarction, income, and grade retention among students with sickle cell anemia.
King AA, Rodeghier MJ, Panepinto JA, Strouse JJ, Casella JF, Quinn CT, Dowling MM, Sarnaik SA, Thompson AA, Woods GM, Minniti CP, Redding-Lallinger RC, Kirby-Allen M, Kirkham FJ, McKinstry R, Noetzel MJ, White DA, Kwiatkowski JK, Howard TH, Kalinyak KA, Inusa B, Rhodes MM, Heiny ME, Fuh B, Fixler JM, Gordon MO, DeBaun MR
Am J Hematol. 2014 Oct; 89(10)E188-92. doi: 10.1002/ajh.23805.

PMID:
    25042018
    [PubMed - indexed for MEDLINE]
Related citations


Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.
Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR
Bioorg Med Chem Lett. 2014 Aug 1; 24(15)3641-6. doi: 10.1016/j.bmcl.2014.04.087.

PMID:
    24961642
    [PubMed - indexed for MEDLINE]
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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).
Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR
J Med Chem. 2014 Jul 10; 57(13)5620-37. doi: 10.1021/jm500259z.

PMID:
    24914612
    [PubMed - indexed for MEDLINE]
Related citations


Headache and migraine in children with sickle cell disease are associated with lower hemoglobin and higher pain event rates but not silent cerebral infarction.
Dowling MM, Noetzel MJ, Rodeghier MJ, Quinn CT, Hirtz DG, Ichord RN, Kwiatkowski JL, Roach ES, Kirkham FJ, Casella JF, DeBaun MR
J Pediatr. 2014 May; 164(5)1175-1180.e1. doi: 10.1016/j.jpeds.2014.01.001.

PMID:
    24529619
    [PubMed - indexed for MEDLINE]
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Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.
Gregory KJ, Nguyen ED, Malosh C, Mendenhall JL, Zic JZ, Bates BS, Noetzel MJ, Squire EF, Turner EM, Rook JM, Emmitte KA, Stauffer SR, Lindsley CW, Meiler J, Conn PJ
ACS Chem Neurosci. 2014 Apr 16; 5(4)282-95. doi: 10.1021/cn400225x.

PMID:
    24528109
    [PubMed - indexed for MEDLINE]
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Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Yin S, Noetzel MJ, Johnson KA, Zamorano R, Jalan-Sakrikar N, Gregory KJ, Conn PJ, Niswender CM
J Neurosci. 2014 Jan 1; 34(1)79-94. doi: 10.1523/JNEUROSCI.1129-13.2014.

PMID:
    24381270
    [PubMed - indexed for MEDLINE]
Related citations


Parent education and biologic factors influence on cognition in sickle cell anemia.
King AA, Strouse JJ, Rodeghier MJ, Compas BE, Casella JF, McKinstry RC, Noetzel MJ, Quinn CT, Ichord R, Dowling MM, Miller JP, Debaun MR
Am J Hematol. 2014 Feb; 89(2)162-7. doi: 10.1002/ajh.23604.

PMID:
    24123128
    [PubMed - indexed for MEDLINE]
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Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
Turlington M, Noetzel MJ, Chun A, Zhou Y, Gogliotti RD, Nguyen ED, Gregory KJ, Vinson PN, Rook JM, Gogi KK, Xiang Z, Bridges TM, Daniels JS, Jones C, Niswender CM, Meiler J, Conn PJ, Lindsley CW, Stauffer SR
J Med Chem. 2013 Oct 24; 56(20)7976-96. doi: 10.1021/jm401028t.

PMID:
    24050755
    [PubMed - indexed for MEDLINE]
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