Michael Holtzman, MD

Michael J. Holtzman, MD

Selman and Herman Seldin Professor, Medicine
Director, Division of Pulmonary and Critical Care Medicine
Professor, Cell Biology and Physiology

Specialty Areas

Pulmonary Disease
Asthma

Board Certifications

Pulmonary Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Pathogenesis and genetics of pulmonary diseases, asthma, bronchial hyperactivity, respiratory viral infections, COPD

Education
Publication & Research
Financial Disclosures

Education

Fellowship: Pumonary and Critical Care Medicine, University of California at San Francisco, California 1980
Residency: Internal Medicine, Duke University Medical School, Durham, North Carolina 1977
Medical Degree: Northwestern University, Chicago, Illinois 1975
B.A.: Northwestern University, Evanston, Illinois 1971

Publication & Research

Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost.
Zhang Y, Mao D, Keeler SP, Wang X, Wu K, Gerovac BJ, Shornick LL, Agapov EV, Holtzman MJ
J Immunol. 2019 Apr 15; 202(8)2332-2347. doi: 10.4049/jimmunol.1801491.

PMID:
30804041
[PubMed - in process]
Related citations

Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease.
Keeler SP, Gerovac BJ, Wu K, Wang X, Chartock JR, Byers DE, Romero AG, Holtzman MJ
Ann Am Thorac Soc. 2018 Dec; 15(Supplement_4)S260-S265. doi: 10.1513/AnnalsATS.201808-531MG.

PMID:
30759005
[PubMed - in process]
Related citations

Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.
Keeler SP, Agapov EV, Hinojosa ME, Letvin AN, Wu K, Holtzman MJ
J Immunol. 2018 Oct 15; 201(8)2354-2368. doi: 10.4049/jimmunol.1800671.

PMID:
30209189
[PubMed - indexed for MEDLINE]
Related citations

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.
Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS
J Clin Invest. 2018 Nov 1; 128(11)5110-5122. doi: 10.1172/JCI120453.

PMID:
30137026
[PubMed - in process]
Related citations

The choroid plexus is an important circadian clock component.
Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T
Nat Commun. 2018 Mar 14; 9(1)1062. doi: 10.1038/s41467-018-03507-2.

PMID:
29540683
[PubMed - indexed for MEDLINE]
Related citations

Recurrent wheezing in children following human metapneumovirus infection.
Coverstone AM, Wilson B, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K
J Allergy Clin Immunol. 2018 Jul; 142(1)297-301.e2. doi: 10.1016/j.jaci.2018.02.008.

PMID:
29481834
[PubMed - in process]
Related citations

Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.
Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI
PLoS Genet. 2017 Dec; 13(12)e1007128. doi: 10.1371/journal.pgen.1007128.

PMID:
29244804
[PubMed - indexed for MEDLINE]
Related citations

Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity in COPD.
Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ
Chest. 2018 Jan; 153(1)77-86. doi: 10.1016/j.chest.2017.09.044.

PMID:
29017955
[PubMed - indexed for MEDLINE]
Related citations

Epithelial Chloride Transport by CFTR Requires TMEM16A.
Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K
Sci Rep. 2017 Sep 29; 7(1)12397. doi: 10.1038/s41598-017-10910-0.

PMID:
28963502
[PubMed - indexed for MEDLINE]
Related citations

The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS
Science. 2017 Aug 4; 357(6350)498-502. doi: 10.1126/science.aam5336.

PMID:
28774928
[PubMed - indexed for MEDLINE]
Related citations

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.
Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW
Nat Microbiol. 2017 Jun 30; 217101. doi: 10.1038/nmicrobiol.2017.101.

PMID:
28665409
[PubMed - indexed for MEDLINE]
Related citations

American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.
Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA
Am J Respir Crit Care Med. 2017 Aug 1; 196(3)375-381. doi: 10.1164/rccm.201705-0973WS.

PMID:
28636425
[PubMed - indexed for MEDLINE]
Related citations

BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Mucosal Immunol. 2018 Jan; 11(1)97-111. doi: 10.1038/mi.2017.24.

PMID:
28401936
[PubMed - indexed for MEDLINE]
Related citations

Estrogen receptor α is required for oviductal transport of embryos.
Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W
FASEB J. 2017 Apr; 31(4)1595-1607. doi: 10.1096/fj.201601128R.

PMID:
28082352
[PubMed - indexed for MEDLINE]
Related citations

PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.
Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL
Radiology. 2017 Jun; 283(3)758-768. doi: 10.1148/radiol.2016161409.

PMID:
28045644
[PubMed - indexed for MEDLINE]
Related citations

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ
Elife. 2016 Dec 20; 5pii: e20391. doi: 10.7554/eLife.20391.

PMID:
27995897
[PubMed - indexed for MEDLINE]
Related citations

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.
Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA
Mol Cell Neurosci. 2016 Dec; 7747-52. doi: 10.1016/j.mcn.2016.10.004.

PMID:
27751903
[PubMed - indexed for MEDLINE]
Related citations

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression.
Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD
Cell Host Microbe. 2016 Jul 13; 20(1)72-82. doi: 10.1016/j.chom.2016.06.006.

PMID:
27414498
[PubMed - indexed for MEDLINE]
Related citations

First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ
Biochim Biophys Acta. 2016 Nov; 1860(11 Pt A)2335-2344. doi: 10.1016/j.bbagen.2016.06.023.

PMID:
27369736
[PubMed - indexed for MEDLINE]
Related citations

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.
Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW
Cell Host Microbe. 2016 Jan 13; 19(1)102-13. doi: 10.1016/j.chom.2015.12.011.

PMID:
26764600
[PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: NuPeak

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2019

Areas of Research Interest

Molecular mechanisms of asthma, airway inflammation and immunity; the role of respiratory infections in childhood asthma; virus-induced gene expression; genetics of airway disease

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