Publication & Research
Epithelial-Immune Cell Interactions for Drug Discovery in Chronic Obstructive Pulmonary Disease.
Keeler SP, Gerovac BJ, Wu K, Wang X, Chartock JR, Byers DE, Romero AG, Holtzman MJ
Ann Am Thorac Soc. 2018 Dec; 15(Supplement_4)S260-S265. doi: 10.1513/AnnalsATS.201808-531MG.
PMID:
30759005
[PubMed - in process]
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Influenza A Virus Infection Causes Chronic Lung Disease Linked to Sites of Active Viral RNA Remnants.
Keeler SP, Agapov EV, Hinojosa ME, Letvin AN, Wu K, Holtzman MJ
J Immunol. 2018 Oct 15; 201(8)2354-2368. doi: 10.4049/jimmunol.1800671.
PMID:
30209189
[PubMed - in process]
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Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.
Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS
J Clin Invest. 2018 Nov 1; 128(11)5110-5122. doi: 10.1172/JCI120453.
PMID:
30137026
[PubMed - in process]
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The choroid plexus is an important circadian clock component.
Myung J, Schmal C, Hong S, Tsukizawa Y, Rose P, Zhang Y, Holtzman MJ, De Schutter E, Herzel H, Bordyugov G, Takumi T
Nat Commun. 2018 Mar 14; 9(1)1062. doi: 10.1038/s41467-018-03507-2.
PMID:
29540683
[PubMed - indexed for MEDLINE]
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Recurrent wheezing in children following human metapneumovirus infection.
Coverstone AM, Wilson B, Burgdorf D, Schechtman KB, Storch GA, Holtzman MJ, Castro M, Bacharier LB, Sumino K
J Allergy Clin Immunol. 2018 Jul; 142(1)297-301.e2. doi: 10.1016/j.jaci.2018.02.008.
PMID:
29481834
[PubMed - in process]
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Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.
Siller SS, Sharma H, Li S, Yang J, Zhang Y, Holtzman MJ, Winuthayanon W, Colognato H, Holdener BC, Li FQ, Takemaru KI
PLoS Genet. 2017 Dec; 13(12)e1007128. doi: 10.1371/journal.pgen.1007128.
PMID:
29244804
[PubMed - indexed for MEDLINE]
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Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity in COPD.
Byers DE, Wu K, Dang-Vu G, Jin X, Agapov E, Zhang X, Battaile JT, Schechtman K, Yusen R, Pierce RA, Holtzman MJ
Chest. 2018 Jan; 153(1)77-86. doi: 10.1016/j.chest.2017.09.044.
PMID:
29017955
[PubMed - in process]
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Epithelial Chloride Transport by CFTR Requires TMEM16A.
Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K
Sci Rep. 2017 Sep 29; 7(1)12397. doi: 10.1038/s41598-017-10910-0.
PMID:
28963502
[PubMed - in process]
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The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS
Science. 2017 Aug 4; 357(6350)498-502. doi: 10.1126/science.aam5336.
PMID:
28774928
[PubMed - indexed for MEDLINE]
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Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.
Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, Amarasinghe GK, Leung DW
Nat Microbiol. 2017 Jun 30; 217101. doi: 10.1038/nmicrobiol.2017.101.
PMID:
28665409
[PubMed - indexed for MEDLINE]
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American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.
Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA
Am J Respir Crit Care Med. 2017 Aug 1; 196(3)375-381. doi: 10.1164/rccm.201705-0973WS.
PMID:
28636425
[PubMed - indexed for MEDLINE]
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BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Mucosal Immunol. 2018 Jan; 11(1)97-111. doi: 10.1038/mi.2017.24.
PMID:
28401936
[PubMed - indexed for MEDLINE]
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Estrogen receptor α is required for oviductal transport of embryos.
Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W
FASEB J. 2017 Apr; 31(4)1595-1607. doi: 10.1096/fj.201601128R.
PMID:
28082352
[PubMed - indexed for MEDLINE]
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PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.
Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL
Radiology. 2017 Jun; 283(3)758-768. doi: 10.1148/radiol.2016161409.
PMID:
28045644
[PubMed - indexed for MEDLINE]
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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ
Elife. 2016 Dec 20; 5pii: e20391. doi: 10.7554/eLife.20391.
PMID:
27995897
[PubMed - indexed for MEDLINE]
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Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.
Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA
Mol Cell Neurosci. 2016 Dec; 7747-52. doi: 10.1016/j.mcn.2016.10.004.
PMID:
27751903
[PubMed - indexed for MEDLINE]
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Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression.
Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD
Cell Host Microbe. 2016 Jul 13; 20(1)72-82. doi: 10.1016/j.chom.2016.06.006.
PMID:
27414498
[PubMed - indexed for MEDLINE]
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First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ
Biochim Biophys Acta. 2016 Nov; 1860(11 Pt A)2335-2344. doi: 10.1016/j.bbagen.2016.06.023.
PMID:
27369736
[PubMed - indexed for MEDLINE]
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Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.
Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW
Cell Host Microbe. 2016 Jan 13; 19(1)102-13. doi: 10.1016/j.chom.2015.12.011.
PMID:
26764600
[PubMed - indexed for MEDLINE]
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PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ
Nat Immunol. 2015 Dec; 16(12)1215-27. doi: 10.1038/ni.3279.
PMID:
26479788
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