Michael Holtzman, MD

Michael J. Holtzman, MD

Selman and Herman Seldin Professor, Medicine
Director, Division of Pulmonary and Critical Care Medicine
Professor, Cell Biology and Physiology

Specialty Areas

Pulmonary Disease
Asthma

Board Certifications

Pulmonary Disease
Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Referral Information

Not Accepting New Patients

Areas of Clinical Interest

Pathogenesis and genetics of pulmonary diseases, asthma, bronchial hyperactivity, respiratory viral infections, COPD

Research areas include: molecular mechanisms of asthma, airway inflammation and immunity; the role of respiratory infections in childhood asthma; virus-induced gene expression; genetics of airway disease

Education
Publication & Research
Financial Disclosures

Education

Fellowship: Pumonary and Critical Care Medicine, University of California at San Francisco, California 1980
Residency: Internal Medicine, Duke University Medical School, Durham, North Carolina 1977
Medical Degree: Northwestern University, Chicago, Illinois 1975
B.A.: Northwestern University, Evanston, Illinois 1971

Publication & Research

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression.
Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD
Cell Host Microbe. 2016 Jul 13; 20(1)72-82. doi: 10.1016/j.chom.2016.06.006.

PMID:
27414498
[PubMed - in process]
Related citations

First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Yurtsever Z, Patel DA, Kober DL, Su A, Miller CA, Romero AG, Holtzman MJ, Brett TJ
Biochim Biophys Acta. 2016 Nov; 1860(11 Pt A)2335-44. doi: 10.1016/j.bbagen.2016.06.023.

PMID:
27369736
[PubMed - in process]
Related citations

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.
Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW
Cell Host Microbe. 2016 Jan 13; 19(1)102-13. doi: 10.1016/j.chom.2015.12.011.

PMID:
26764600
[PubMed - in process]
Related citations

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ
Nat Immunol. 2015 Dec; 16(12)1215-27. doi: 10.1038/ni.3279.

PMID:
26479788
[PubMed - indexed for MEDLINE]
Related citations

STAT1 modification improves therapeutic effects of interferons on lung cancer cells.
Chen J, Zhao J, Chen L, Dong N, Ying Z, Cai Z, Ji D, Zhang Y, Dong L, Li Y, Jiang L, Holtzman MJ, Chen C
J Transl Med. 2015 Sep 8; 13293. doi: 10.1186/s12967-015-0656-0.

PMID:
26351076
[PubMed - indexed for MEDLINE]
Related citations

An acoustofluidic sputum liquefier.
Huang PH, Ren L, Nama N, Li S, Li P, Yao X, Cuento RA, Wei CH, Chen Y, Xie Y, Nawaz AA, Alevy YG, Holtzman MJ, McCoy JP, Levine SJ, Huang TJ
Lab Chip. 2015 Aug 7; 15(15)3125-31. doi: 10.1039/c5lc00539f.

PMID:
26082346
[PubMed - indexed for MEDLINE]
Related citations

IL13 activates autophagy to regulate secretion in airway epithelial cells.
Dickinson JD, Alevy Y, Malvin NP, Patel KK, Gunsten SP, Holtzman MJ, Stappenbeck TS, Brody SL
Autophagy. 2016; 12(2)397-409. doi: 10.1080/15548627.2015.1056967.

PMID:
26062017
[PubMed - in process]
Related citations

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ
J Exp Med. 2015 May 4; 212(5)681-97. doi: 10.1084/jem.20141732.

PMID:
25897174
[PubMed - indexed for MEDLINE]
Related citations

The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ
Acta Crystallogr D Biol Crystallogr. 2015 Apr; 71(Pt 4)790-9. doi: 10.1107/S1399004715001212.

PMID:
25849390
[PubMed - indexed for MEDLINE]
Related citations

Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production.
Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK
J Neurosci. 2015 Mar 25; 35(12)4903-16. doi: 10.1523/JNEUROSCI.3081-14.2015.

PMID:
25810521
[PubMed - indexed for MEDLINE]
Related citations

The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa.
Kim HJ, Kim CH, Kim MJ, Ryu JH, Seong SY, Kim S, Lim SJ, Holtzman MJ, Yoon JH
Am J Respir Cell Mol Biol. 2015 Oct; 53(4)525-35. doi: 10.1165/rcmb.2014-0334OC.

PMID:
25751630
[PubMed - indexed for MEDLINE]
Related citations

OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes.
Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M
J Immunol. 2015 Apr 1; 194(7)3317-26. doi: 10.4049/jimmunol.1402289.

PMID:
25716998
[PubMed - indexed for MEDLINE]
Related citations

Linking acute infection to chronic lung disease. The role of IL-33-expressing epithelial progenitor cells.
Holtzman MJ, Byers DE, Brett JA, Patel AC, Agapov E, Jin X, Wu K
Ann Am Thorac Soc. 2014 Dec; 11 Suppl 5S287-91. doi: 10.1513/AnnalsATS.201402-056AW.

PMID:
25525734
[PubMed - indexed for MEDLINE]
Related citations

Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.
Gowdy KM, Martinu T, Nugent JL, Manzo ND, Zhang HL, Kelly FL, Holtzman MJ, Palmer SM
Transpl Immunol. 2015 Jan; 32(1)51-60. doi: 10.1016/j.trim.2014.10.005.

PMID:
25446809
[PubMed - indexed for MEDLINE]
Related citations

Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.
Morales DJ, Monte K, Sun L, Struckhoff JJ, Agapov E, Holtzman MJ, Stappenbeck TS, Lenschow DJ
J Virol. 2015 Jan; 89(1)337-49. doi: 10.1128/JVI.02110-14.

PMID:
25320315
[PubMed - indexed for MEDLINE]
Related citations

The role of airway epithelial cells and innate immune cells in chronic respiratory disease.
Holtzman MJ, Byers DE, Alexander-Brett J, Wang X
Nat Rev Immunol. 2014 Oct; 14(10)686-98. doi: 10.1038/nri3739.

PMID:
25234144
[PubMed - indexed for MEDLINE]
Related citations

Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma.
Patel DA, You Y, Huang G, Byers DE, Kim HJ, Agapov E, Moore ML, Peebles RS Jr, Castro M, Sumino K, Shifren A, Brody SL, Holtzman MJ
J Allergy Clin Immunol. 2014 Dec; 134(6)1402-1412.e7. doi: 10.1016/j.jaci.2014.07.013.

PMID:
25216987
[PubMed - indexed for MEDLINE]
Related citations

Myb permits multilineage airway epithelial cell differentiation.
Pan JH, Adair-Kirk TL, Patel AC, Huang T, Yozamp NS, Xu J, Reddy EP, Byers DE, Pierce RA, Holtzman MJ, Brody SL
Stem Cells. 2014 Dec; 32(12)3245-56. doi: 10.1002/stem.1814.

PMID:
25103188
[PubMed - indexed for MEDLINE]
Related citations

Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis.
Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible HG
Neurosci Lett. 2014 Jul 25; 57640-4. doi: 10.1016/j.neulet.2014.05.051.

PMID:
24905173
[PubMed - indexed for MEDLINE]
Related citations

Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.
Philippot Q, Deslée G, Adair-Kirk TL, Woods JC, Byers D, Conradi S, Dury S, Perotin JM, Lebargy F, Cassan C, Le Naour R, Holtzman MJ, Pierce RA
PLoS One. 2014; 9(5)e96285. doi: 10.1371/journal.pone.0096285.

PMID:
24789352
[PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2015.

Company Name: NuPeak

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016

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Washington University Physicians are the medical staff of Barnes-Jewish Hospital and St. Louis Children's Hospital