FollowMyHealth Patient Portal

Matthew J. Walter, MD

Professor, Medicine
Division of Medical Oncology
Section of Bone Marrow Transplant

Specialty Areas

Bone Marrow Transplant
Hematology
Hematologic Malignancies

Board Certifications

Internal Medicine
Medical Oncology
Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, oncology, bone marrow transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110
Phone: 314-747-7222

Suite: B
Floor: 7
Office Phone: 314-747-9270
Fax: 314-747-5178

Education

Education

Fellowship: Research Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 2004
Chief Med Resident: Chief of Service, Johns Hopkins Hospital, Baltimore, Maryland 2000
Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 1999
Residency: Medicine, Johns Hopkins Hospital, Baltimore, Maryland 1998
Medical Degree: St. Louis University School of Medicine, St. Louis, Missouri 1995
B.S.: American University, Washington, D.C. 1990

Publication & Research

Publication & Research

Magnesium isotope evidence that accretional vapour loss shapes planetary compositions.
Hin RC, Coath CD, Carter PJ, Nimmo F, Lai YJ, Pogge von Strandmann PAE, Willbold M, Leinhardt ZM, Walter MJ, Elliott T
Nature. 2017 Sep 27; 549(7673)511-515. doi: 10.1038/nature23899.

PMID:
    28959965
    [PubMed - in process]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - indexed for MEDLINE]
Related citations


What support is needed to self-manage a rheumatic disorder: a qualitative study.
Been-Dahmen JM, Walter MJ, Dwarswaard J, Hazes JM, van Staa A, Ista E
BMC Musculoskelet Disord. 2017 Feb 16; 18(1)84. doi: 10.1186/s12891-017-1440-5.

PMID:
    28209161
    [PubMed - in process]
Related citations


Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.
Liu T, Krysiak K, Shirai CL, Kim S, Shao J, Ndonwi M, Walter MJ
PLoS One. 2017; 12(2)e0170470. doi: 10.1371/journal.pone.0170470.

PMID:
    28178280
    [PubMed - indexed for MEDLINE]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - in process]
Related citations


Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, Graubert TA, Walter MJ
Nat Commun. 2017 Jan 9; 814060. doi: 10.1038/ncomms14060.

PMID:
    28067246
    [PubMed - in process]
Related citations


Antecedent CHIP in CML?
Walter MJ
Blood. 2017 Jan 5; 129(1)3-4. doi: 10.1182/blood-2016-11-746842.

PMID:
    28057668
    [PubMed - indexed for MEDLINE]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Splicing factor gene mutations in hematologic malignancies.
Saez B, Walter MJ, Graubert TA
Blood. 2017 Mar 9; 129(10)1260-1269. doi: 10.1182/blood-2016-10-692400.

PMID:
    27940478
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - indexed for MEDLINE]
Related citations


Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia. 2016 Dec; 30(12)2422-2426. doi: 10.1038/leu.2016.247.

PMID:
    27573557
    [PubMed - in process]
Related citations


Focus group interviews reveal reasons for differences in the perception of disease activity in rheumatoid arthritis.
Walter MJ, Van't Spijker A, Pasma A, Hazes JM, Luime JJ
Qual Life Res. 2017 Feb; 26(2)291-298. doi: 10.1007/s11136-016-1369-4.

PMID:
    27444780
    [PubMed - indexed for MEDLINE]
Related citations


'CHIP'ping away at clonal hematopoiesis.
Link DC, Walter MJ
Leukemia. 2016 Aug; 30(8)1633-5. doi: 10.1038/leu.2016.130.

PMID:
    27311932
    [PubMed - in process]
Related citations


Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, Larson DE, Heath SE, Fronick C, O'Laughlin S, Fulton RS, Magrini V, McGrath S, Smith SM, Miller CA, Maher CA, Payton JE, Walker JR, Eldred JM, Walter MJ, Link DC, Graubert TA, Westervelt P, Kulkarni S, DiPersio JF, Mardis ER, Wilson RK, Ley TJ
Exp Hematol. 2016 Jul; 44(7)603-13. doi: 10.1016/j.exphem.2016.04.011.

PMID:
    27181063
    [PubMed - indexed for MEDLINE]
Related citations


Slab melting as a barrier to deep carbon subduction.
Thomson AR, Walter MJ, Kohn SC, Brooker RA
Nature. 2016 Jan 7; 529(7584)76-9. doi: 10.1038/nature16174.

PMID:
    26738593
    [PubMed]
Related citations


Patterns and functional implications of rare germline variants across 12 cancer types.
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, Wilson RK, Goodfellow PJ, Raphael BJ, Chen F, Johnson KJ, Parvin JD, Ding L
Nat Commun. 2015 Dec 22; 610086. doi: 10.1038/ncomms10086.

PMID:
    26689913
    [PubMed - indexed for MEDLINE]
Related citations


Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.
Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, Wilson RK, Ley TJ, Link DC
Blood. 2016 Feb 18; 127(7)893-7. doi: 10.1182/blood-2015-10-677021.

PMID:
    26631115
    [PubMed - indexed for MEDLINE]
Related citations


Implications of Tumor Clonal Heterogeneity in the Era of Next-Generation Sequencing.
Jacoby MA, Duncavage EJ, Walter MJ
Trends Cancer. 2015 Dec; 1(4)231-241. doi: 10.1016/j.trecan.2015.10.006.

PMID:
    28741514
    [PubMed]
Related citations


Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA
Blood. 2015 Nov 26; 126(22)2484-90. doi: 10.1182/blood-2015-04-641100.

PMID:
    26492932
    [PubMed - indexed for MEDLINE]
Related citations


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
Related citations