Patient Portal

Matthew J. Walter, MD

Professor, Medicine
Division of Medical Oncology
Section of Bone Marrow Transplant

Specialty Areas

Bone Marrow Transplant
Hematology
Hematologic Malignancies

Board Certifications

Internal Medicine
Medical Oncology
Hematology

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Hematology, oncology, bone marrow transplant

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Siteman Cancer Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-747-9270
Fax: 314-747-5178

Education

Education

Fellowship: Research Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 2004
Chief Med Resident: Chief of Service, Johns Hopkins Hospital, Baltimore, Maryland 2000
Fellowship: Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri 1999
Residency: Medicine, Johns Hopkins Hospital, Baltimore, Maryland 1998
Medical Degree: St. Louis University School of Medicine, St. Louis, Missouri 1995
B.S.: American University, Washington, D.C. 1990

Publication & Research

Publication & Research

Mutation Clearance after Transplantation for Myelodysplastic Syndrome.
Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, Wartman LD, Christopher MJ, Pusic I, Welch JS, Uy GL, Link DC, DiPersio JF, Westervelt P, Ley TJ, Trinkaus K, Graubert TA, Walter MJ
N Engl J Med. 2018 Sep 13; 379(11)1028-1041. doi: 10.1056/NEJMoa1804714.

PMID:
    30207916
    [PubMed - in process]
Related citations


Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
Nguyen HD, Leong WY, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, Graubert TA
Cancer Res. 2018 Sep 15; 78(18)5363-5374. doi: 10.1158/0008-5472.CAN-17-3970.

PMID:
    30054334
    [PubMed - in process]
Related citations


Fatigue in early, intensively treated and tight-controlled rheumatoid arthritis patients is frequent and persistent: a prospective study.
Walter MJM, Kuijper TM, Hazes JMW, Weel AE, Luime JJ
Rheumatol Int. 2018 Sep; 38(9)1643-1650. doi: 10.1007/s00296-018-4102-5.

PMID:
    30014260
    [PubMed - in process]
Related citations


Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS.
Alberti MO, Srivatsan SN, Shao J, McNulty SN, Chang GS, Miller CA, Dunlap JB, Yang F, Press RD, Gao Q, Ding L, Heusel JW, Duncavage EJ, Walter MJ
Leukemia. 2018 Aug; 32(8)1874-1878. doi: 10.1038/s41375-018-0193-y.

PMID:
    29959414
    [PubMed - in process]
Related citations


Germ line tissues for optimal detection of somatic variants in myelodysplastic syndromes.
Padron E, Ball MC, Teer JK, Painter JS, Yoder SJ, Zhang C, Zhang L, Moscinski LC, Rollison DE, Gore SD, Bejar R, Walter MJ, Sekeres MA, Komrokji RS, Epling-Burnette PK
Blood. 2018 May 24; 131(21)2402-2405. doi: 10.1182/blood-2018-01-827881.

PMID:
    29661788
    [PubMed - in process]
Related citations


Systematic Analysis of Splice-Site-Creating Mutations in Cancer.
Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-González H, Chai S, Wang F, Varghese R, Huang M, Liang WW, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyö D, Miner JH, Walter MJ, Cancer Genome Atlas Research Network., Vincent B, Eyras E, Chen K, Shmulevich I, Chen F, Ding L
Cell Rep. 2018 Apr 3; 23(1)270-281.e3. doi: 10.1016/j.celrep.2018.03.052.

PMID:
    29617666
    [PubMed - in process]
Related citations


Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.
Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ
JCI Insight. 2018 Mar 8; 3(5)pii: 98962. doi: 10.1172/jci.insight.98962.

PMID:
    29515031
    [PubMed - as supplied by publisher]
Related citations


Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.
Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, Vij R, DiPersio JF, Welch JS, Graubert TA, Walter MJ, Ley TJ, Link DC
Nat Commun. 2018 Jan 31; 9(1)455. doi: 10.1038/s41467-018-02858-0.

PMID:
    29386642
    [PubMed - indexed for MEDLINE]
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Loss of Toll-like receptor 2 results in accelerated leukemogenesis in the <i>NUP98-HOXD13</i> mouse model of MDS.
Monlish DA, Bhatt ST, Duncavage EJ, Greenberg ZJ, Keller JL, Romine MP, Yang W, Aplan PD, Walter MJ, Schuettpelz LG
Blood. 2018 Mar 1; 131(9)1032-1035. doi: 10.1182/blood-2017-08-801944.

PMID:
    29358180
    [PubMed - in process]
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Magnesium isotope evidence that accretional vapour loss shapes planetary compositions.
Hin RC, Coath CD, Carter PJ, Nimmo F, Lai YJ, Pogge von Strandmann PAE, Willbold M, Leinhardt ZM, Walter MJ, Elliott T
Nature. 2017 Sep 27; 549(7673)511-515. doi: 10.1038/nature23899.

PMID:
    28959965
    [PubMed]
Related citations


CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - indexed for MEDLINE]
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What support is needed to self-manage a rheumatic disorder: a qualitative study.
Been-Dahmen JM, Walter MJ, Dwarswaard J, Hazes JM, van Staa A, Ista E
BMC Musculoskelet Disord. 2017 Feb 16; 18(1)84. doi: 10.1186/s12891-017-1440-5.

PMID:
    28209161
    [PubMed - indexed for MEDLINE]
Related citations


Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.
Liu T, Krysiak K, Shirai CL, Kim S, Shao J, Ndonwi M, Walter MJ
PLoS One. 2017; 12(2)e0170470. doi: 10.1371/journal.pone.0170470.

PMID:
    28178280
    [PubMed - indexed for MEDLINE]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - indexed for MEDLINE]
Related citations


Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, Graubert TA, Walter MJ
Nat Commun. 2017 Jan 9; 814060. doi: 10.1038/ncomms14060.

PMID:
    28067246
    [PubMed - in process]
Related citations


Antecedent CHIP in CML?
Walter MJ
Blood. 2017 Jan 5; 129(1)3-4. doi: 10.1182/blood-2016-11-746842.

PMID:
    28057668
    [PubMed - indexed for MEDLINE]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036. doi: 10.1056/NEJMoa1605949.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


Splicing factor gene mutations in hematologic malignancies.
Saez B, Walter MJ, Graubert TA
Blood. 2017 Mar 9; 129(10)1260-1269. doi: 10.1182/blood-2016-10-692400.

PMID:
    27940478
    [PubMed - indexed for MEDLINE]
Related citations


Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.
Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reineck T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, Welch JS, Ley TJ, Graubert TA, Westervelt P, Walter MJ
Leukemia. 2017 Apr; 31(4)872-881. doi: 10.1038/leu.2016.282.

PMID:
    27740633
    [PubMed - indexed for MEDLINE]
Related citations


Targeted sequencing informs the evaluation of normal karyotype cytopenic patients for low-grade myelodysplastic syndrome.
Duncavage EJ, O'Brien J, Vij K, Miller CA, Chang GS, Shao J, Jacoby MA, Heath S, Janke MR, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Westervelt P, Ley TJ, Wilson RK, Walter MJ
Leukemia. 2016 Dec; 30(12)2422-2426. doi: 10.1038/leu.2016.247.

PMID:
    27573557
    [PubMed - indexed for MEDLINE]
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