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Matthew D. Smyth, MD

Appoline Blair Professor of Neurological Surgery and Pediatrics
Co-Director, Washington University Pediatric Epilepsy Center at St. Louis Children's Hospital
Director, Pediatric Radiosurgery Program

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Craniosynostosis
Gamma Knife
Minimally invasive laser ablation surgery
Robotic-assisted stereo EEG surgery

Board Certifications

American Board of Pediatric Neurological Surgery
American Board of Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Shriners Hospital for Children - St. Louis
Barnes-Jewish West County Hospital
St. John's Mercy Hospital - Consulting Staff
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy, craniosynostosis, craniofacial surgery, brain tumors, neuro-endoscopy, chiari malformation, spina bifida, hydrocephalus, syringomyelia, spasticity, neurofibromatosis, tuberous sclerosis, cortical dysplasia.



More information on St. Louis Children's Hospital and craniosynostosis

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: E
Floor: 4
Office Phone: (314) 454-4454
Fax: (314) 454-2818

Education

Education

Fellowship: Pediatric Neurosurgery, Children's Hospital of Alabama at Birmingham, UAB, Birmingham, Alabama 2003
Chief Resident: Neurosurgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, Irvine School of Medicine, Irvine, California 1997
Medical Degree: UC San Francisco School of Medicine, San Francisco, California 1996
B.A.: Neurobiology and Behavior, Cornell University, Ithaca, New York 1992

Publication & Research

Publication & Research

Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms. Am J Med Genet A. 2018 Feb;176(2):290-300.
Clarke CM, Fok VT, Gustafson JA, Smyth MD, Timms AE, Frazar CD, Smith JD, Birgfeld CB, Lee A, Ellenbogen RG, Gruss JS, Hopper RA, Cunningham ML
Am J Med Genet A. 2018 Nov; 176(11)2522. doi: 10.1002/ajmg.a.38846.

PMID:
    30537273
    [PubMed - in process]
Related citations


Postsurgical Changes in Osseous Dysmorphology of the Midface and Mandible in Unilateral Coronal Craniosynostosis.
Jo S, Skolnick GB, Naidoo SD, Smyth MD, Patel KB
J Craniofac Surg. 2018 Oct 29; doi: 10.1097/SCS.0000000000004877.

PMID:
    30376506
    [PubMed - as supplied by publisher]
Related citations


Role of resting state MRI temporal latency in refractory pediatric extratemporal epilepsy lateralization.
Shah MN, Nguyen RD, Pao LP, Zhu L, CreveCoeur TS, Mitra A, Smyth MD
J Magn Reson Imaging. 2018 Oct 22; doi: 10.1002/jmri.26320.

PMID:
    30350326
    [PubMed - as supplied by publisher]
Related citations


Enhancing contrast to noise ratio of hippocampi affected with mesial temporal sclerosis: A case-control study in children undergoing epilepsy surgeries.
Orlowski HLP, Smyth MD, Parsons MS, Dahiya S, Sharifai N, Hildebolt C, Sharma A
Clin Neurol Neurosurg. 2018 Nov; 174144-148. doi: 10.1016/j.clineuro.2018.09.005.

PMID:
    30241008
    [PubMed - in process]
Related citations


Variation in the management of isolated craniosynostosis: a survey of the Synostosis Research Group.
Kestle JRW, Lee A, Anderson RCE, Gociman B, Patel KB, Smyth MD, Birgfeld C, Pollack IF, Goldstein JA, Tamber M, Imahiyerobo T, Siddiqi FA, Synostosis Research Group.
J Neurosurg Pediatr. 2018 Sep 14; 1-5. doi: 10.3171/2018.7.PEDS18132.

PMID:
    30215587
    [PubMed - as supplied by publisher]
Related citations


Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate.
CreveCoeur TS, Salehi A, Miller BA, Austin MJ, Cross DT 3rd, Smyth MD
Childs Nerv Syst. 2018 Sep 10; doi: 10.1007/s00381-018-3968-6.

PMID:
    30203392
    [PubMed - as supplied by publisher]
Related citations


Editorial. Endoscopic synostosis surgery: case closed. Or open? Or in between?
Smyth MD
J Neurosurg Pediatr. 2018 Oct; 22(4)331-334. doi: 10.3171/2018.3.PEDS18122.

PMID:
    29979134
    [PubMed - in process]
Related citations


Focal traumatic rupture of a dermoid cyst in a pediatric patient: case report and literature review.
Akbari SHA, Somasundaram A, Ferguson CJ, Roland JL, Smyth MD, Strahle JM
Childs Nerv Syst. 2018 Dec; 34(12)2485-2490. doi: 10.1007/s00381-018-3879-6.

PMID:
    29961083
    [PubMed - in process]
Related citations


Assessing calvarial vault constriction associated with helmet therapy in deformational plagiocephaly.
Peterson EC, Patel KB, Skolnick GB, Pfeifauf KD, Davidson KN, Smyth MD, Naidoo SD
J Neurosurg Pediatr. 2018 Aug; 22(2)113-119. doi: 10.3171/2018.2.PEDS17634.

PMID:
    29749885
    [PubMed - in process]
Related citations


Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.
Shah MN, Mitra A, Goyal MS, Snyder AZ, Zhang J, Shimony JS, Limbrick DD, Raichle ME, Smyth MD
Childs Nerv Syst. 2018 May; 34(5)901-910. doi: 10.1007/s00381-018-3770-5.

PMID:
    29511809
    [PubMed - in process]
Related citations


Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient.
Miller CA, Dahiya S, Li T, Fulton RS, Smyth MD, Dunn GP, Rubin JB, Mardis ER
Cold Spring Harb Mol Case Stud. 2018 Apr; 4(2)pii: a002444. doi: 10.1101/mcs.a002444.

PMID:
    29440180
    [PubMed - in process]
Related citations


The Temporal Region in Unilateral Coronal Craniosynostosis: Fronto-orbital Advancement Versus Endoscopy-Assisted Strip Craniectomy.
Masserano B, Woo AS, Skolnick GB, Naidoo SD, Proctor MR, Smyth MD, Patel KB
Cleft Palate Craniofac J. 2018 Mar; 55(3)423-429. doi: 10.1177/1055665617739000.

PMID:
    29437517
    [PubMed - in process]
Related citations


MRI-Guided Interstitial Laser Ablation for Intracranial Lesions: A Large Single-Institution Experience of 133 Cases.
Kamath AA, Friedman DD, Hacker CD, Smyth MD, Limbrick DD Jr, Kim AH, Hawasli AH, Leuthardt EC
Stereotact Funct Neurosurg. 2017; 95(6)417-428. doi: 10.1159/000485387.

PMID:
    29339639
    [PubMed - in process]
Related citations


Editorial. Head shape at 36 months with and without helmeting.
Smyth MD
J Neurosurg Pediatr. 2018 Mar; 21(3)201-203. doi: 10.3171/2017.8.PEDS17419.

PMID:
    29303461
    [PubMed - in process]
Related citations


On the role of the corpus callosum in interhemispheric functional connectivity in humans.
Roland JL, Snyder AZ, Hacker CD, Mitra A, Shimony JS, Limbrick DD, Raichle ME, Smyth MD, Leuthardt EC
Proc Natl Acad Sci U S A. 2017 Dec 12; 114(50)13278-13283. doi: 10.1073/pnas.1707050114.

PMID:
    29183973
    [PubMed - indexed for MEDLINE]
Related citations


Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms.
Clarke CM, Fok VT, Gustafson JA, Smyth MD, Timms AE, Frazar CD, Smith JD, Birgfeld CB, Lee A, Ellenbogen RG, Gruss JS, Hopper RA, Cunningham ML
Am J Med Genet A. 2018 Feb; 176(2)290-300. doi: 10.1002/ajmg.a.38540.

PMID:
    29168297
    [PubMed - in process]
Related citations


Resting-state functional magnetic resonance imaging for surgical planning in pediatric patients: a preliminary experience.
Roland JL, Griffin N, Hacker CD, Vellimana AK, Akbari SH, Shimony JS, Smyth MD, Leuthardt EC, Limbrick DD Jr
J Neurosurg Pediatr. 2017 Dec; 20(6)583-590. doi: 10.3171/2017.6.PEDS1711.

PMID:
    28960172
    [PubMed - indexed for MEDLINE]
Related citations


One hundred consecutive endoscopic repairs of sagittal craniosynostosis: an evolution in care.
Nguyen DC, Farber SJ, Skolnick GB, Naidoo SD, Smyth MD, Kane AA, Patel KB, Woo AS
J Neurosurg Pediatr. 2017 Nov; 20(5)410-418. doi: 10.3171/2017.5.PEDS16674.

PMID:
    28841109
    [PubMed - indexed for MEDLINE]
Related citations


Applications of a robotic stereotactic arm for pediatric epilepsy and neurooncology surgery.
Miller BA, Salehi A, Limbrick DD Jr, Smyth MD
J Neurosurg Pediatr. 2017 Oct; 20(4)364-370. doi: 10.3171/2017.5.PEDS1782.

PMID:
    28777037
    [PubMed - indexed for MEDLINE]
Related citations


Hydrocephalus presenting as idiopathic aqueductal stenosis with subsequent development of obstructive tumor: report of 2 cases demonstrating the importance of serial imaging.
Roland JL, Price RL, Kamath AA, Akbari SH, Leuthardt EC, Miller BA, Smyth MD
J Neurosurg Pediatr. 2017 Oct; 20(4)329-333. doi: 10.3171/2017.5.PEDS1779.

PMID:
    28777035
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Therma Neurosciences

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2018

Areas of Research Interest

Cortical dysplasia, animal models of epilepsy, cortical cooling for epilepsy, deep brain stimulation for epilepsy, genetic correlates of craniosynostosis