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Matthew D. Smyth, MD

Appoline Blair Professor of Neurological Surgery and Pediatrics
Co-Director, Washington University Pediatric Epilepsy Center at St. Louis Children's Hospital
Director, Pediatric Radiosurgery Program

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Craniosynostosis
Gamma Knife
Minimally invasive laser ablation surgery
Robotic-assisted stereo EEG surgery

Board Certifications

American Board of Pediatric Neurological Surgery
American Board of Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Shriners Hospital for Children - St. Louis
Barnes-Jewish West County Hospital
St. John's Mercy Hospital - Consulting Staff
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy, craniosynostosis, craniofacial surgery, brain tumors, neuro-endoscopy, chiari malformation, spina bifida, hydrocephalus, syringomyelia, spasticity, neurofibromatosis, tuberous sclerosis, cortical dysplasia.



More information on St. Louis Children's Hospital and craniosynostosis

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: E
Floor: 4
Office Phone: (314) 454-4454
Fax: (314) 454-2818

Education

Education

Fellowship: Pediatric Neurosurgery, Children's Hospital of Alabama at Birmingham, UAB, Birmingham, Alabama 2003
Chief Resident: Neurosurgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, Irvine School of Medicine, Irvine, California 1997
Medical Degree: UC San Francisco School of Medicine, San Francisco, California 1996
B.A.: Neurobiology and Behavior, Cornell University, Ithaca, New York 1992

Publication & Research

Publication & Research

Resting state signal latency predicts laterality in pediatric medically refractory temporal lobe epilepsy.
Shah MN, Mitra A, Goyal MS, Snyder AZ, Zhang J, Shimony JS, Limbrick DD, Raichle ME, Smyth MD
Childs Nerv Syst. 2018 May; 34(5)901-910. doi: 10.1007/s00381-018-3770-5.

PMID:
    29511809
    [PubMed - in process]
Related citations


Resistance-promoting effects of ependymoma treatment revealed through genomic analysis of multiple recurrences in a single patient.
Miller CA, Dahiya S, Li T, Fulton RS, Smyth MD, Dunn GP, Rubin JB, Mardis ER
Cold Spring Harb Mol Case Stud. 2018 Apr; 4(2)pii: a002444. doi: 10.1101/mcs.a002444.

PMID:
    29440180
    [PubMed - in process]
Related citations


The Temporal Region in Unilateral Coronal Craniosynostosis: Fronto-orbital Advancement Versus Endoscopy-Assisted Strip Craniectomy.
Masserano B, Woo AS, Skolnick GB, Naidoo SD, Proctor MR, Smyth MD, Patel KB
Cleft Palate Craniofac J. 2018 Mar; 55(3)423-429. doi: 10.1177/1055665617739000.

PMID:
    29437517
    [PubMed - in process]
Related citations


MRI-Guided Interstitial Laser Ablation for Intracranial Lesions: A Large Single-Institution Experience of 133 Cases.
Kamath AA, Friedman DD, Hacker CD, Smyth MD, Limbrick DD Jr, Kim AH, Hawasli AH, Leuthardt EC
Stereotact Funct Neurosurg. 2017; 95(6)417-428. doi: 10.1159/000485387.

PMID:
    29339639
    [PubMed - in process]
Related citations


Editorial. Head shape at 36 months with and without helmeting.
Smyth MD
J Neurosurg Pediatr. 2018 Mar; 21(3)201-203. doi: 10.3171/2017.8.PEDS17419.

PMID:
    29303461
    [PubMed - in process]
Related citations


On the role of the corpus callosum in interhemispheric functional connectivity in humans.
Roland JL, Snyder AZ, Hacker CD, Mitra A, Shimony JS, Limbrick DD, Raichle ME, Smyth MD, Leuthardt EC
Proc Natl Acad Sci U S A. 2017 Dec 12; 114(50)13278-13283. doi: 10.1073/pnas.1707050114.

PMID:
    29183973
    [PubMed - in process]
Related citations


Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms.
Clarke CM, Fok VT, Gustafson JA, Smyth MD, Timms AE, Frazar CD, Smith JD, Birgfeld CB, Lee A, Ellenbogen RG, Gruss JS, Hopper RA, Cunningham ML
Am J Med Genet A. 2018 Feb; 176(2)290-300. doi: 10.1002/ajmg.a.38540.

PMID:
    29168297
    [PubMed - in process]
Related citations


Resting-state functional magnetic resonance imaging for surgical planning in pediatric patients: a preliminary experience.
Roland JL, Griffin N, Hacker CD, Vellimana AK, Akbari SH, Shimony JS, Smyth MD, Leuthardt EC, Limbrick DD Jr
J Neurosurg Pediatr. 2017 Dec; 20(6)583-590. doi: 10.3171/2017.6.PEDS1711.

PMID:
    28960172
    [PubMed - indexed for MEDLINE]
Related citations


One hundred consecutive endoscopic repairs of sagittal craniosynostosis: an evolution in care.
Nguyen DC, Farber SJ, Skolnick GB, Naidoo SD, Smyth MD, Kane AA, Patel KB, Woo AS
J Neurosurg Pediatr. 2017 Nov; 20(5)410-418. doi: 10.3171/2017.5.PEDS16674.

PMID:
    28841109
    [PubMed - indexed for MEDLINE]
Related citations


Applications of a robotic stereotactic arm for pediatric epilepsy and neurooncology surgery.
Miller BA, Salehi A, Limbrick DD Jr, Smyth MD
J Neurosurg Pediatr. 2017 Oct; 20(4)364-370. doi: 10.3171/2017.5.PEDS1782.

PMID:
    28777037
    [PubMed - indexed for MEDLINE]
Related citations


Hydrocephalus presenting as idiopathic aqueductal stenosis with subsequent development of obstructive tumor: report of 2 cases demonstrating the importance of serial imaging.
Roland JL, Price RL, Kamath AA, Akbari SH, Leuthardt EC, Miller BA, Smyth MD
J Neurosurg Pediatr. 2017 Oct; 20(4)329-333. doi: 10.3171/2017.5.PEDS1779.

PMID:
    28777035
    [PubMed - indexed for MEDLINE]
Related citations


Anthropometric Outcome Measures in Patients With Metopic Craniosynostosis.
Farber SJ, Nguyen DC, Skolnick GB, Naidoo SD, Smyth MD, Patel KB
J Craniofac Surg. 2017 May; 28(3)713-716. doi: 10.1097/SCS.0000000000003495.

PMID:
    28468154
    [PubMed - indexed for MEDLINE]
Related citations


Electrophysiological Sequelae of Hemispherotomy in Ipsilateral Human Cortex.
Hawasli AH, Chacko R, Szrama NP, Bundy DT, Pahwa M, Yarbrough CK, Dlouhy BJ, Limbrick DD, Barbour DL, Smyth MD, Leuthardt EC
Front Hum Neurosci. 2017; 11149. doi: 10.3389/fnhum.2017.00149.

PMID:
    28424599
    [PubMed]
Related citations


Corpus callosotomy-Open and endoscopic surgical techniques.
Smyth MD, Vellimana AK, Asano E, Sood S
Epilepsia. 2017 Apr; 58 Suppl 173-79. doi: 10.1111/epi.13681.

PMID:
    28386923
    [PubMed - indexed for MEDLINE]
Related citations


The use of hippocampal volumetric measurements to improve diagnostic accuracy in pediatric patients with mesial temporal sclerosis.
Guzmán Pérez-Carrillo GJ, Owen C, Schwetye KE, McFarlane S, Vellimana AK, Mar S, Miller-Thomas MM, Shimony JS, Smyth MD, Benzinger TLS
J Neurosurg Pediatr. 2017 Jun; 19(6)720-728. doi: 10.3171/2016.12.PEDS16335.

PMID:
    28338446
    [PubMed - in process]
Related citations


Hemispherotomy in children with electrical status epilepticus of sleep.
Jeong A, Strahle J, Vellimana AK, Limbrick DD Jr, Smyth MD, Bertrand M
J Neurosurg Pediatr. 2017 Jan; 19(1)56-62. doi: 10.3171/2016.8.PEDS16319.

PMID:
    27791702
    [PubMed - indexed for MEDLINE]
Related citations


Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series.
Dadey DY, Kamath AA, Smyth MD, Chicoine MR, Leuthardt EC, Kim AH
Neurosurg Focus. 2016 Oct; 41(4)E4.

PMID:
    27690652
    [PubMed - indexed for MEDLINE]
Related citations


Laser interstitial thermal therapy for subependymal giant cell astrocytoma: technical case report.
Dadey DY, Kamath AA, Leuthardt EC, Smyth MD
Neurosurg Focus. 2016 Oct; 41(4)E9.

PMID:
    27690646
    [PubMed - indexed for MEDLINE]
Related citations


Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy.
Dlouhy BJ, Nguyen DC, Patel KB, Hoben GM, Skolnick GB, Naidoo SD, Woo AS, Smyth MD
J Neurosurg Pediatr. 2016 Dec; 25(6)674-678.

PMID:
    27611899
    [PubMed - indexed for MEDLINE]
Related citations


Comparison of the accuracy and proximal shunt failure rate of freehand placement versus intraoperative guidance in parietooccipital ventricular catheter placement.
Wilson TJ, McCoy KE, Al-Holou WN, Molina SL, Smyth MD, Sullivan SE
Neurosurg Focus. 2016 Sep; 41(3)E10. doi: 10.3171/2016.5.FOCUS16159.

PMID:
    27581306
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Cortical dysplasia, animal models of epilepsy, cortical cooling for epilepsy, deep brain stimulation for epilepsy, genetic correlates of craniosynostosis