Patient Portal

Matthew D. Smyth, MD

Appoline Blair Professor of Neurological Surgery and Pediatrics
Co-Director, Washington University Pediatric Epilepsy Center at St. Louis Children's Hospital
Director, Pediatric Radiosurgery Program

Specialty Areas

Pediatric Neurosurgery
Pediatric Epilepsy
Craniosynostosis
Gamma Knife
Minimally invasive laser ablation surgery
Robotic-assisted stereo EEG surgery

Board Certifications

American Board of Pediatric Neurological Surgery
American Board of Neurological Surgery

Hospital Affiliations

St. Louis Children's Hospital
Shriners Hospital for Children - St. Louis
Barnes-Jewish West County Hospital
St. John's Mercy Hospital - Consulting Staff
Barnes-Jewish Hospital

Areas of Clinical Interest

Pediatric neurosurgery, epilepsy, craniosynostosis, craniofacial surgery, brain tumors, neuro-endoscopy, chiari malformation, spina bifida, hydrocephalus, syringomyelia, spasticity, neurofibromatosis, tuberous sclerosis, cortical dysplasia.



More information on St. Louis Children's Hospital and craniosynostosis

  • Location(s)
  • Education
  • Publication & Research
  • Financial Disclosures

Location(s)

Location(s)

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Suite: E
Floor: 4
Office Phone: (314) 454-4454
Fax: (314) 454-2818

Education

Education

Fellowship: Pediatric Neurosurgery, Children's Hospital of Alabama at Birmingham, UAB, Birmingham, Alabama 2003
Chief Resident: Neurosurgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California 2002
Residency: Neurological Surgery, University of California, Irvine School of Medicine, Irvine, California 1997
Medical Degree: UC San Francisco School of Medicine, San Francisco, California 1996
B.A.: Neurobiology and Behavior, Cornell University, Ithaca, New York 1992

Publication & Research

Publication & Research

Evaluation of Direct Surgical Remodeling of Frontal Bossing in Patients With Sagittal Synostosis.
Yen DW, Nguyen DC, Skolnick GB, Naidoo S, Smyth MD, Patel KB, Woo AS
J Craniofac Surg. 2019 Nov-Dec; 30(8)2350-2354. doi: 10.1097/SCS.0000000000005786.

PMID:
    31633666
    [PubMed - in process]
Related citations


Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium.
Strahle JM, Taiwo R, Averill C, Torner J, Shannon CN, Bonfield CM, Tuite GF, Bethel-Anderson T, Rutlin J, Brockmeyer DL, Wellons JC, Leonard JR, Mangano FT, Johnston JM, Shah MN, Iskandar BJ, Tyler-Kabara EC, Daniels DJ, Jackson EM, Grant GA, Couture DE, Adelson PD, Alden TD, Aldana PR, Anderson RCE, Selden NR, Baird LC, Bierbrauer K, Chern JJ, Whitehead WE, Ellenbogen RG, Fuchs HE, Guillaume DJ, Hankinson TC, Iantosca MR, Oakes WJ, Keating RF, Khan NR, Muhlbauer MS, McComb JG, Menezes AH, Ragheb J, Smith JL, Maher CO, Greene S, Kelly M, O'Neill BR, Krieger MD, Tamber M, Durham SR, Olavarria G, Stone SSD, Kaufman BA, Heuer GG, Bauer DF, Albert G, Greenfield JP, Wait SD, Van Poppel MD, Eskandari R, Mapstone T, Shimony JS, Dacey RG, Smyth MD, Park TS, Limbrick DD
J Neurosurg Pediatr. 2019 Aug 16; 1-8. doi: 10.3171/2019.5.PEDS18527.

PMID:
    31419800
    [PubMed - as supplied by publisher]
Related citations


Feasibility of fast brain diffusion MRI to quantify white matter injury in pediatric hydrocephalus.
Isaacs AM, Shimony JS, Morales DM, Castaneyra-Ruiz L, Hartman A, Cook M, Smyser CD, Strahle J, Smyth MD, Yan Y, McAllister JP, McKinstry RC, Limbrick DD
J Neurosurg Pediatr. 2019 Jul 19; 1-8. doi: 10.3171/2019.5.PEDS18596.

PMID:
    31323624
    [PubMed - as supplied by publisher]
Related citations


Cleft and Craniofacial Multidisciplinary Team Clinic: A Look at Attrition Rates for Patients With Complete Cleft Lip and Palate and Nonsyndromic Single-Suture Craniosynostosis.
Cooper DC, Peterson EC, Grellner CG, Naidoo SD, Skolnick GB, Pfeifauf KD, Smyth MD, Snyder-Warwick AK, Patel KB
Cleft Palate Craniofac J. 2019 Nov; 56(10)1287-1294. doi: 10.1177/1055665619856245.

PMID:
    31195806
    [PubMed - in process]
Related citations


Long-Term Characterization of Cranial Defects After Surgical Correction for Single-Suture Craniosynostosis.
Skolnick GB, Murthy S, Patel KB, Huang Z, Naidoo SD, Ju T, Smyth MD, Woo AS
Ann Plast Surg. 2019 Jun; 82(6)679-685. doi: 10.1097/SAP.0000000000001906.

PMID:
    31082848
    [PubMed - in process]
Related citations


A comparison of resting state functional magnetic resonance imaging to invasive electrocortical stimulation for sensorimotor mapping in pediatric patients.
Roland JL, Hacker CD, Snyder AZ, Shimony JS, Zempel JM, Limbrick DD, Smyth MD, Leuthardt EC
Neuroimage Clin. 2019; 23101850. doi: 10.1016/j.nicl.2019.101850.

PMID:
    31077983
    [PubMed - in process]
Related citations


Evaluation of pediatric glioma outcomes using intraoperative MRI: a multicenter cohort study.
Karsy M, Akbari SH, Limbrick D, Leuthardt EC, Evans J, Smyth MD, Strahle J, Leonard J, Cheshier S, Brockmeyer DL, Bollo RJ, Kestle JR, Honeycutt J, Donahue DJ, Roberts RA, Hansen DR, Riva-Cambrin J, Sutherland G, Gallagher C, Hader W, Starreveld Y, Hamilton M, Duhaime AC, Jensen RL, Chicoine MR
J Neurooncol. 2019 Jun; 143(2)271-280. doi: 10.1007/s11060-019-03154-7.

PMID:
    30977059
    [PubMed - in process]
Related citations


Recent advances in the neurosurgical treatment of pediatric epilepsy: JNSPG 75th Anniversary Invited Review Article
Roland JL, Smyth MD
J Neurosurg Pediatr. 2019 Apr 5; 23(4)411-421. doi: 10.3171/2018.12.PEDS18350.

PMID:
    30970205
    [PubMed - indexed for MEDLINE]
Related citations


Evaluation of Endoscopic Strip Craniectomy and Orthotic Therapy for Bilateral Coronal Craniosynostosis.
Williams CT, Segar DJ, Naidoo SD, Skolnick GB, Proctor MR, Smyth MD, Patel KB
J Craniofac Surg. 2019 Mar/Apr; 30(2)453-457. doi: 10.1097/SCS.0000000000005118.

PMID:
    30640858
    [PubMed - indexed for MEDLINE]
Related citations


The number needed to treat and relevant between-trial comparisons of competing interventions.
Jansen JP, Khalid JM, Smyth MD, Patel H
Clinicoecon Outcomes Res. 2018; 10865-871. doi: 10.2147/CEOR.S180491.

PMID:
    30588048
    [PubMed]
Related citations


Single suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms. Am J Med Genet A. 2018 Feb;176(2):290-300.
Clarke CM, Fok VT, Gustafson JA, Smyth MD, Timms AE, Frazar CD, Smith JD, Birgfeld CB, Lee A, Ellenbogen RG, Gruss JS, Hopper RA, Cunningham ML
Am J Med Genet A. 2018 Nov; 176(11)2522. doi: 10.1002/ajmg.a.38846.

PMID:
    30537273
    [PubMed]
Related citations


Regression of cephalic index following endoscopic repair of sagittal synostosis.
Pickersgill NA, Skolnick GB, Naidoo SD, Smyth MD, Patel KB
J Neurosurg Pediatr. 2018 Oct 5; 23(1)54-60. doi: 10.3171/2018.7.PEDS18195.

PMID:
    30497205
    [PubMed - indexed for MEDLINE]
Related citations


Editorial. Mapping at rest: translating resting-state functional MRI to clinical practice.
Roland JL, Smyth MD
J Neurosurg. 2018 Oct 26; 131(3)759-761. doi: 10.3171/2018.5.JNS181057.

PMID:
    30497193
    [PubMed - indexed for MEDLINE]
Related citations


Postsurgical Changes in Osseous Dysmorphology of the Midface and Mandible in Unilateral Coronal Craniosynostosis.
Jo S, Skolnick GB, Naidoo SD, Smyth MD, Patel KB
J Craniofac Surg. 2019 Jan; 30(1)127-132. doi: 10.1097/SCS.0000000000004877.

PMID:
    30376506
    [PubMed - indexed for MEDLINE]
Related citations


Role of resting state MRI temporal latency in refractory pediatric extratemporal epilepsy lateralization.
Shah MN, Nguyen RD, Pao LP, Zhu L, CreveCoeur TS, Mitra A, Smyth MD
J Magn Reson Imaging. 2019 May; 49(5)1347-1355. doi: 10.1002/jmri.26320.

PMID:
    30350326
    [PubMed - in process]
Related citations


Enhancing contrast to noise ratio of hippocampi affected with mesial temporal sclerosis: A case-control study in children undergoing epilepsy surgeries.
Orlowski HLP, Smyth MD, Parsons MS, Dahiya S, Sharifai N, Hildebolt C, Sharma A
Clin Neurol Neurosurg. 2018 Nov; 174144-148. doi: 10.1016/j.clineuro.2018.09.005.

PMID:
    30241008
    [PubMed - in process]
Related citations


Variation in the management of isolated craniosynostosis: a survey of the Synostosis Research Group.
Kestle JRW, Lee A, Anderson RCE, Gociman B, Patel KB, Smyth MD, Birgfeld C, Pollack IF, Goldstein JA, Tamber M, Imahiyerobo T, Siddiqi FA, Synostosis Research Group.
J Neurosurg Pediatr. 2018 Dec 1; 22(6)627-631. doi: 10.3171/2018.7.PEDS18132.

PMID:
    30215587
    [PubMed - indexed for MEDLINE]
Related citations


Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate.
CreveCoeur TS, Salehi A, Miller BA, Austin MJ, Cross DT 3rd, Smyth MD
Childs Nerv Syst. 2019 Feb; 35(2)373-378. doi: 10.1007/s00381-018-3968-6.

PMID:
    30203392
    [PubMed - in process]
Related citations


Editorial. Endoscopic synostosis surgery: case closed. Or open? Or in between?
Smyth MD
J Neurosurg Pediatr. 2018 Oct; 22(4)331-334. doi: 10.3171/2018.3.PEDS18122.

PMID:
    29979134
    [PubMed - indexed for MEDLINE]
Related citations


Focal traumatic rupture of a dermoid cyst in a pediatric patient: case report and literature review.
Akbari SHA, Somasundaram A, Ferguson CJ, Roland JL, Smyth MD, Strahle JM
Childs Nerv Syst. 2018 Dec; 34(12)2485-2490. doi: 10.1007/s00381-018-3879-6.

PMID:
    29961083
    [PubMed - indexed for MEDLINE]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2018:

Company Name: Therma Neurosciences

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2019

Areas of Research Interest

Cortical dysplasia, animal models of epilepsy, cortical cooling for epilepsy, deep brain stimulation for epilepsy, genetic correlates of craniosynostosis