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Faculty Physicians

Marwan Shinawi, MD

Associate Professor, Pediatrics
Division of Genetics and Genomic Medicine

Specialty Areas

Genetics - Pediatric

Board Certifications

Clinical Genetics
Medical Biochemical Genetics

Hospital Affiliations

St. Louis Children's Hospital

Languages

Hebrew

Areas of Clinical Interest

genetic counseling, birth defects, screening for newborns, inborn metabolic diseases, genetic syndromes, familial cancer syndromes, chromosomal abnormalities, autism spectrum disorders, cytogenetic abnormalities, microarray technology, and metabolic conditions, skeletal dysplasia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6093
Fax: 314-454-2075

Education

Education

BS (Biology): The Hebrew University of Jerusalem, Israel, 1989
Residency: Pediatrics, Rambam Medical Center, Haifa, Israel, 2000
Residency: Clinical Genetics, Baylor College of Medicine, Houston, TX 2005
Medical School: Technion-Faculty of Medicine,Israel 1996
Fellowship: Genetics, Baylor College of Medicine, Houston, TX 2005

Publication & Research

Publication & Research

A recurrent de novo CTBP1 mutation is associated with developmental delay, hypotonia, ataxia, and tooth enamel defects.
Beck DB, Cho MT, Millan F, Yates C, Hannibal M, O'Connor B, Shinawi M, Connolly AM, Waggoner D, Halbach S, Angle B, Sanders V, Shen Y, Retterer K, Begtrup A, Bai R, Chung WK
Neurogenetics. 2016 Apr 19;

PMID:
    27094857
    [PubMed - as supplied by publisher]
Related citations


The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype-phenotype correlations.
Chen CA, Bosch DG, Cho MT, Rosenfeld JA, Shinawi M, Lewis RA, Mann J, Jayakar P, Payne K, Walsh L, Moss T, Schreiber A, Schoonveld C, Monaghan KG, Elmslie F, Douglas G, Boonstra FN, Millan F, Cremers FP, McKnight D, Richard G, Juusola J, Kendall F, Ramsey K, Anyane-Yeboa K, Malkin E, Chung WK, Niyazov D, Pascual JM, Walkiewicz M, Veluchamy V, Li C, Hisama FM, de Vries BB, Schaaf C
Genet Med. 2016 Mar 17; doi: 10.1038/gim.2016.18.

PMID:
    26986877
    [PubMed - as supplied by publisher]
Related citations


STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy.
Stamberger H, Nikanorova M, Willemsen MH, Accorsi P, Angriman M, Baier H, Benkel-Herrenbrueck I, Benoit V, Budetta M, Caliebe A, Cantalupo G, Capovilla G, Casara G, Courage C, Deprez M, Destrée A, Dilena R, Erasmus CE, Fannemel M, Fjær R, Giordano L, Helbig KL, Heyne HO, Klepper J, Kluger GJ, Lederer D, Lodi M, Maier O, Merkenschlager A, Michelberger N, Minetti C, Muhle H, Phalin J, Ramsey K, Romeo A, Schallner J, Schanze I, Shinawi M, Sleegers K, Sterbova K, Syrbe S, Traverso M, Tzschach A, Uldall P, Van Coster R, Verhelst H, Viri M, Winter S, Wolff M, Zenker M, Zoccante L, De Jonghe P, Helbig I, Striano P, Lemke JR, Møller RS, Weckhuysen S
Neurology. 2016 Mar 8; 86(10)954-62. doi: 10.1212/WNL.0000000000002457.

PMID:
    26865513
    [PubMed - in process]
Related citations


Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations.
Lalani SR, Liu P, Rosenfeld JA, Watkin LB, Chiang T, Leduc MS, Zhu W, Ding Y, Pan S, Vetrini F, Miyake CY, Shinawi M, Gambin T, Eldomery MK, Akdemir ZH, Emrick L, Wilnai Y, Schelley S, Koenig MK, Memon N, Farach LS, Coe BP, Azamian M, Hernandez P, Zapata G, Jhangiani SN, Muzny DM, Lotze T, Clark G, Wilfong A, Northrup H, Adesina A, Bacino CA, Scaglia F, Bonnen PE, Crosson J, Duis J, Maegawa GH, Coman D, Inwood A, McGill J, Boerwinkle E, Graham B, Beaudet A, Eng CM, Hanchard NA, Xia F, Orange JS, Gibbs RA, Lupski JR, Yang Y
Am J Hum Genet. 2016 Feb 4; 98(2)347-57. doi: 10.1016/j.ajhg.2015.12.008.

PMID:
    26805781
    [PubMed - in process]
Related citations


Assessing the Awareness of Egyptian Medical Students about Responsible Conduct of Research and Research Ethics: Impact of an Educational Campaign.
El-Shinawi M, Mohamed KO, Fouad YA, Fahmy YM, Asar HA, Khalil MG, Anestidou L, El-Kamary SS, Mohamed MM
Account Res. 2016; 23(4)199-218. doi: 10.1080/08989621.2015.1127762.

PMID:
    26647065
    [PubMed - in process]
Related citations


Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE
Am J Med Genet A. 2016 Mar; 170(3)583-93. doi: 10.1002/ajmg.a.37445.

PMID:
    26601658
    [PubMed - in process]
Related citations


Inflammatory and Non-inflammatory Breast Cancer: A Potential Role for Detection of Multiple Viral DNAs in Disease Progression.
El-Shinawi M, Mohamed HT, Abdel-Fattah HH, Ibrahim SA, El-Halawany MS, Nouh MA, Schneider RJ, Mohamed MM
Ann Surg Oncol. 2016 Feb; 23(2)494-502. doi: 10.1245/s10434-015-4888-2.

PMID:
    26508152
    [PubMed - in process]
Related citations


WAC loss-of-function mutations cause a recognisable syndrome characterised by dysmorphic features, developmental delay and hypotonia and recapitulate 10p11.23 microdeletion syndrome.
DeSanto C, D'Aco K, Araujo GC, Shannon N, DDD Study, Vernon H, Rahrig A, Monaghan KG, Niu Z, Vitazka P, Dodd J, Tang S, Manwaring L, Martir-Negron A, Schnur RE, Juusola J, Schroeder A, Pan V, Helbig KL, Friedman B, Shinawi M
J Med Genet. 2015 Nov; 52(11)754-61. doi: 10.1136/jmedgenet-2015-103069.

PMID:
    26264232
    [PubMed - in process]
Related citations


Digynic triploidy: utility and challenges of noninvasive prenatal testing.
Fleischer J, Shenoy A, Goetzinger K, Cottrell CE, Baldridge D, White FV, Shinawi M
Clin Case Rep. 2015 Jun; 3(6)406-10. doi: 10.1002/ccr3.247.

PMID:
    26185638
    [PubMed]
Related citations


Mutations in COQ4, an essential component of coenzyme Q biosynthesis, cause lethal neonatal mitochondrial encephalomyopathy.
Chung WK, Martin K, Jalas C, Braddock SR, Juusola J, Monaghan KG, Warner B, Franks S, Yudkoff M, Lulis L, Rhodes RH, Prasad V, Torti E, Cho MT, Shinawi M
J Med Genet. 2015 Sep; 52(9)627-35. doi: 10.1136/jmedgenet-2015-103140.

PMID:
    26185144
    [PubMed - in process]
Related citations


A Novel Mutation in Isoform 3 of the Plasma Membrane Ca2+ Pump Impairs Cellular Ca2+ Homeostasis in a Patient with Cerebellar Ataxia and Laminin Subunit 1α Mutations.
Calì T, Lopreiato R, Shimony J, Vineyard M, Frizzarin M, Zanni G, Zanotti G, Brini M, Shinawi M, Carafoli E
J Biol Chem. 2015 Jun 26; 290(26)16132-41. doi: 10.1074/jbc.M115.656496.

PMID:
    25953895
    [PubMed - indexed for MEDLINE]
Related citations


De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


Multi-systemic involvement in NGLY1-related disorder caused by two novel mutations.
Heeley J, Shinawi M
Am J Med Genet A. 2015 Apr; 167A(4)816-20. doi: 10.1002/ajmg.a.36889.

PMID:
    25707956
    [PubMed - indexed for MEDLINE]
Related citations


Inflammatory breast cancer: New factors contribute to disease etiology: A review.
Mohamed MM, Al-Raawi D, Sabet SF, El-Shinawi M
J Adv Res. 2014 Sep; 5(5)525-36. doi: 10.1016/j.jare.2013.06.004.

PMID:
    25685520
    [PubMed]
Related citations


Developing sustainable trauma care education in Egypt: sequential trauma education program, steps to success.
El-Shinawi M, McCunn M, Sisley AC, El-Setouhy M, Hirshon JM
J Surg Educ. 2015 Jul-Aug; 72(4)e29-32. doi: 10.1016/j.jsurg.2014.12.001.

PMID:
    25600355
    [PubMed - indexed for MEDLINE]
Related citations


TBX6 null variants and a common hypomorphic allele in congenital scoliosis.
Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G, Zhang F
N Engl J Med. 2015 Jan 22; 372(4)341-50. doi: 10.1056/NEJMoa1406829.

PMID:
    25564734
    [PubMed - indexed for MEDLINE]
Related citations


A 5-month-old boy with delay in growth and development and decreased muscle tone.
Hucthagowder V, Shinawi M, Lockwood CM
Clin Chem. 2015 Jan; 61(1)50-4. doi: 10.1373/clinchem.2014.228486.

PMID:
    25550475
    [PubMed - indexed for MEDLINE]
Related citations


Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.
Carvalho CM, Vasanth S, Shinawi M, Russell C, Ramocki MB, Brown CW, Graakjaer J, Skytte AB, Vianna-Morgante AM, Krepischi AC, Patel GS, Immken L, Aleck K, Lim C, Cheung SW, Rosenberg C, Katsanis N, Lupski JR
Am J Hum Genet. 2014 Nov 6; 95(5)565-78. doi: 10.1016/j.ajhg.2014.10.006.

PMID:
    25439725
    [PubMed - indexed for MEDLINE]
Related citations


Positive lymph-node breast cancer patients – activation of NF-κB in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7.
El-Ghonaimy EA, El-Shinawi M, Ibrahim SA, El-Ghazaly H, Abd-El-Tawab R, Nouh MA, El-Mamlouk T, Mohamed MM
FEBS J. 2015 Jan; 282(2)271-82. doi: 10.1111/febs.13124.

PMID:
    25327843
    [PubMed - indexed for MEDLINE]
Related citations


Inflammatory breast cancer: high incidence of detection of mixed human cytomegalovirus genotypes associated with disease pathogenesis.
Mohamed HT, El-Shinawi M, Nouh MA, Bashtar AR, Elsayed ET, Schneider RJ, Mohamed MM
Front Oncol. 2014; 4246. doi: 10.3389/fonc.2014.00246.

PMID:
    25309872
    [PubMed]
Related citations