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Faculty Physicians

Marwan Shinawi, MD

Associate Professor, Pediatrics
Division of Genetics and Genomic Medicine

Specialty Areas

Genetics - Pediatric

Board Certifications

Clinical Genetics
Medical Biochemical Genetics

Languages

Hebrew

Areas of Clinical Interest

genetic counseling, birth defects, screening for newborns, inborn metabolic diseases, genetic syndromes, familial cancer syndromes, chromosomal abnormalities, autism spectrum disorders, cytogenetic abnormalities, microarray technology, and metabolic conditions, skeletal dysplasia

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children’s Hospital

1 Children’s Place
St. Louis, MO 63110

Office Phone: 314-454-6093
Fax: 314-454-2075

Education

Education

BS (Biology): The Hebrew University of Jerusalem, Israel, 1989
Residency: Pediatrics, Rambam Medical Center, Haifa, Israel, 2000
Residency: Clinical Genetics, Baylor College of Medicine, Houston, TX 2005
Medical School: Technion-Faculty of Medicine,Israel 1996
Fellowship: Genetics, Baylor College of Medicine, Houston, TX 2005

Publication & Research

Publication & Research

De novo mutations in SIK1 cause a spectrum of developmental epilepsies.
Hansen J, Snow C, Tuttle E, Ghoneim DH, Yang CS, Spencer A, Gunter SA, Smyser CD, Gurnett CA, Shinawi M, Dobyns WB, Wheless J, Halterman MW, Jansen LA, Paschal BM, Paciorkowski AR
Am J Hum Genet. 2015 Apr 2; 96(4)682-90. doi: 10.1016/j.ajhg.2015.02.013.

PMID:
    25839329
    [PubMed - indexed for MEDLINE]
Related citations


TBX6 null variants and a common hypomorphic allele in congenital scoliosis.
Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G, Zhang F
N Engl J Med. 2015 Jan 22; 372(4)341-50. doi: 10.1056/NEJMoa1406829.

PMID:
    25564734
    [PubMed - indexed for MEDLINE]
Related citations


A 5-month-old boy with delay in growth and development and decreased muscle tone.
Hucthagowder V, Shinawi M, Lockwood CM
Clin Chem. 2015 Jan; 61(1)50-4. doi: 10.1373/clinchem.2014.228486.

PMID:
    25550475
    [PubMed - indexed for MEDLINE]
Related citations


Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.
Carvalho CM, Vasanth S, Shinawi M, Russell C, Ramocki MB, Brown CW, Graakjaer J, Skytte AB, Vianna-Morgante AM, Krepischi AC, Patel GS, Immken L, Aleck K, Lim C, Cheung SW, Rosenberg C, Katsanis N, Lupski JR
Am J Hum Genet. 2014 Nov 6; 95(5)565-78. doi: 10.1016/j.ajhg.2014.10.006.

PMID:
    25439725
    [PubMed - indexed for MEDLINE]
Related citations


Positive lymph-node breast cancer patients – activation of NF-κB in tumor-associated leukocytes stimulates cytokine secretion that promotes metastasis via C-C chemokine receptor CCR7.
El-Ghonaimy EA, El-Shinawi M, Ibrahim SA, El-Ghazaly H, Abd-El-Tawab R, Nouh MA, El-Mamlouk T, Mohamed MM
FEBS J. 2015 Jan; 282(2)271-82. doi: 10.1111/febs.13124.

PMID:
    25327843
    [PubMed - indexed for MEDLINE]
Related citations


Brain MRI abnormalities and spectrum of neurological and clinical findings in three patients with proximal 16p11.2 microduplication.
Filges I, Sparagana S, Sargent M, Selby K, Schlade-Bartusiak K, Lueder GT, Robichaux-Viehoever A, Schlaggar BL, Shimony JS, Shinawi M
Am J Med Genet A. 2014 Aug; 164A(8)2003-12. doi: 10.1002/ajmg.a.36605.

PMID:
    24891046
    [PubMed - indexed for MEDLINE]
Related citations


Promoter hypermethylation and suppression of glutathione peroxidase 3 are associated with inflammatory breast carcinogenesis.
Mohamed MM, Sabet S, Peng DF, Nouh MA, El-Shinawi M, El-Rifai W
Oxid Med Cell Longev. 2014; 2014787195. doi: 10.1155/2014/787195.

PMID:
    24790704
    [PubMed - indexed for MEDLINE]
Related citations


Autosomal recessive posterior column ataxia with retinitis pigmentosa caused by novel mutations in the FLVCR1 gene.
Shaibani A, Wong LJ, Wei Zhang V, Lewis RA, Shinawi M
Int J Neurosci. 2015 Jan; 125(1)43-9. doi: 10.3109/00207454.2014.904858.

PMID:
    24628582
    [PubMed - indexed for MEDLINE]
Related citations


Scoliosis and vertebral anomalies: additional abnormal phenotypes associated with chromosome 16p11.2 rearrangement.
Al-Kateb H, Khanna G, Filges I, Hauser N, Grange DK, Shen J, Smyser CD, Kulkarni S, Shinawi M
Am J Med Genet A. 2014 May; 164A(5)1118-26. doi: 10.1002/ajmg.a.36401.

PMID:
    24458548
    [PubMed - indexed for MEDLINE]
Related citations


Two novel RAD21 mutations in patients with mild Cornelia de Lange syndrome-like presentation and report of the first familial case.
Minor A, Shinawi M, Hogue JS, Vineyard M, Hamlin DR, Tan C, Donato K, Wysinger L, Botes S, Das S, Del Gaudio D
Gene. 2014 Mar 10; 537(2)279-84. doi: 10.1016/j.gene.2013.12.045.

PMID:
    24378232
    [PubMed - indexed for MEDLINE]
Related citations


Cytokines secreted by macrophages isolated from tumor microenvironment of inflammatory breast cancer patients possess chemotactic properties.
Mohamed MM, El-Ghonaimy EA, Nouh MA, Schneider RJ, Sloane BF, El-Shinawi M
Int J Biochem Cell Biol. 2014 Jan; 46138-47. doi: 10.1016/j.biocel.2013.11.015.

PMID:
    24291763
    [PubMed - indexed for MEDLINE]
Related citations


Molecular and phenotypic characterization of atypical Williams-Beuren syndrome.
Euteneuer J, Carvalho CM, Kulkarni S, Vineyard M, Grady RM, Lupski JR, Shinawi M
Clin Genet. 2014 Nov; 86(5)487-91. doi: 10.1111/cge.12305.

PMID:
    24246242
    [PubMed - indexed for MEDLINE]
Related citations


Assessing the level of breast cancer awareness among recently diagnosed patients in Ain Shams University Hospital.
El-Shinawi M, Youssef A, Alsara M, Aly MK, Mostafa M, Yehia A, Hurlbert M, El-Tawab RA, Mohamed MM
Breast. 2013 Dec; 22(6)1210-4. doi: 10.1016/j.breast.2013.08.010.

PMID:
    24054904
    [PubMed - indexed for MEDLINE]
Related citations


Haploinsufficiency of ZNF238 is associated with corpus callosum abnormalities in 1q44 deletions.
Perlman SJ, Kulkarni S, Manwaring L, Shinawi M
Am J Med Genet A. 2013 Apr; 161A(4)711-6. doi: 10.1002/ajmg.a.35779.

PMID:
    23494996
    [PubMed - indexed for MEDLINE]
Related citations


Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients.
El-Shinawi M, Mohamed HT, El-Ghonaimy EA, Tantawy M, Younis A, Schneider RJ, Mohamed MM
PLoS One. 2013; 8(2)e55755. doi: 10.1371/journal.pone.0055755.

PMID:
    23418456
    [PubMed - indexed for MEDLINE]
Related citations


NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay.
Al-Kateb H, Shimony JS, Vineyard M, Manwaring L, Kulkarni S, Shinawi M
Am J Med Genet A. 2013 Feb; 161A(2)377-81. doi: 10.1002/ajmg.a.35650.

PMID:
    23300014
    [PubMed - indexed for MEDLINE]
Related citations


Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome.
Mills KI, Anderson J, Levy PT, Cole FS, Silva JN, Kulkarni S, Shinawi M
Am J Med Genet A. 2013 Jan; 161A(1)137-44. doi: 10.1002/ajmg.a.35701.

PMID:
    23239491
    [PubMed - indexed for MEDLINE]
Related citations


Duplication of OCRL and adjacent genes associated with autism but not Lowe syndrome.
Schroer RJ, Beaudet AL, Shinawi M, Sahoo T, Patel A, Sun Q, Skinner C, Stevenson RE
Am J Med Genet A. 2012 Oct; 158A(10)2602-5. doi: 10.1002/ajmg.a.35566.

PMID:
    22965764
    [PubMed - indexed for MEDLINE]
Related citations


ADULT syndrome due to an R243W mutation in TP63.
Berk DR, Armstrong NL, Shinawi M, Whelan AJ
Int J Dermatol. 2012 Jun; 51(6)693-6. doi: 10.1111/j.1365-4632.2011.05375.x.

PMID:
    22607287
    [PubMed - indexed for MEDLINE]
Related citations


A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.
Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH Jr, Goin-Kochel RP, Vaz FM, Beaudet AL
Proc Natl Acad Sci U S A. 2012 May 22; 109(21)7974-81. doi: 10.1073/pnas.1120210109.

PMID:
    22566635
    [PubMed - indexed for MEDLINE]
Related citations