Patient Portal

Mark E. Lowe, MD, PhD

Professor and Vice Chair, Pediatrics

Specialty Areas

Pediatric Gastroenterology

Board Certifications

Pediatric Gastroenterology

Hospital Affiliations

St. Louis Children's Hospital

Areas of Clinical Interest

Pancreatitis, general gastroenterology.

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

St. Louis Children's Specialty Care Center

13001 North Outer Forty
St. Louis, MO 63017

Suite: E
Floor: 2
Office Phone: 314-454-6173
Fax: 314-454-2412

Education

Education

Medical Degree: University of Miami, Miami, FL 1984
PhD, Biochemistry: University of Pennsylvania, Philadelphia, PA 1977
BA, Biology: Washington University, St. Louis, MO 1973

Publication & Research

Publication & Research

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis.
Németh BC, Pesei ZG, Hegyi E, Szücs Á, Szentesi A, Hegyi P, Lowe ME, Sahin-Tóth M
PLoS One. 2018; 13(11)e0206869. doi: 10.1371/journal.pone.0206869.

PMID:
    30408063
    [PubMed - in process]
Related citations


Pediatric Pancreatitis-Molecular Mechanisms and Management.
Abu-El-Haija M, Lowe ME
Gastroenterol Clin North Am. 2018 Dec; 47(4)741-753. doi: 10.1016/j.gtc.2018.07.003.

PMID:
    30337030
    [PubMed - in process]
Related citations


INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Uc A, Perito ER, Pohl JF, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery KM, Fishman DS, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes RW, Husain SZ, Maqbool A, Mascarenhas MR, McFerron BA, Morinville VD, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).
Pancreas. 2018 Nov/Dec; 47(10)1222-1228. doi: 10.1097/MPA.0000000000001172.

PMID:
    30325861
    [PubMed - in process]
Related citations


Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Fisher WE, Cruz-Monserrate Z, McElhany AL, Lesinski GB, Hart PA, Ghosh R, Van Buren G, Fishman DS, Rinaudo JAS, Serrano J, Srivastava S, Mace T, Topazian M, Feng Z, Yadav D, Pandol SJ, Hughes SJ, Liu RY, Lu E, Orr R, Whitcomb DC, Abouhamze AS, Steen H, Sellers ZM, Troendle DM, Uc A, Lowe ME, Conwell DL, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).
Pancreas. 2018 Nov/Dec; 47(10)1213-1221. doi: 10.1097/MPA.0000000000001171.

PMID:
    30325860
    [PubMed - in process]
Related citations


Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Lowe ME, Goodman MT, Coté GA, Glesby MJ, Haupt M, Schork NJ, Singh VK, Andersen DK, Pandol SJ, Uc A, Whitcomb DC
Pancreas. 2018 Nov/Dec; 47(10)1193-1199. doi: 10.1097/MPA.0000000000001164.

PMID:
    30325857
    [PubMed - in process]
Related citations


The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 <i>O-</i>glycans that can be modified by ABO blood group determinants.
El Jellas K, Johansson BB, Fjeld K, Antonopoulos A, Immervoll H, Choi MH, Hoem D, Lowe ME, Lombardo D, Njølstad PR, Dell A, Mas E, Haslam SM, Molven A
J Biol Chem. 2018 Dec 14; 293(50)19476-19491. doi: 10.1074/jbc.RA118.001934.

PMID:
    30315106
    [PubMed - in process]
Related citations


Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis.
Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Rhee S, Pohl JF, Perito ER, Palermo JJ, Ooi CY, Liu Q, Lin TK, Morinville VD, McFerron BA, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Lowe ME
Pancreas. 2018 Sep; 47(8)967-973. doi: 10.1097/MPA.0000000000001120.

PMID:
    30059474
    [PubMed - in process]
Related citations


Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE.
Lin TK, Abu-El-Haija M, Nathan JD, Palermo JP, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Liu Q, Maqbool A, Mascarenhas M, McFerron B, Morinville VD, Ooi CY, Perito E, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A
J Clin Gastroenterol. 2018 Jun 2; doi: 10.1097/MCG.0000000000001063.

PMID:
    29864067
    [PubMed - as supplied by publisher]
Related citations


Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study.
Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kumar S, Lowe ME, Morinville VD, Ooi CY, Palermo J, Pohl JF, Schwarzenberg SJ, Werlin S, Wilschanski M, Zimmerman MB, Uc A
Pancreas. 2017 Jul; 46(6)764-769. doi: 10.1097/MPA.0000000000000848.

PMID:
    28609364
    [PubMed - indexed for MEDLINE]
Related citations


Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
Giefer MJ, Lowe ME, Werlin SL, Zimmerman B, Wilschanski M, Troendle D, Schwarzenberg SJ, Pohl JF, Palermo J, Ooi CY, Morinville VD, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Uc A
J Pediatr. 2017 Jul; 18695-100. doi: 10.1016/j.jpeds.2017.03.063.

PMID:
    28502372
    [PubMed - indexed for MEDLINE]
Related citations


A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosis.
Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME
J Biol Chem. 2017 May 12; 292(19)7744. doi: 10.1074/jbc.A116.734384.

PMID:
    28500240
    [PubMed]
Related citations


Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.
Oparaji JA, Rose F, Okafor D, Howard A, Turner RL, Orabi AI, Byersdorfer C, Mi Q, Ritchey K, Lowe ME, Husain SZ
J Clin Gastroenterol. 2017 Nov/Dec; 51(10)907-913. doi: 10.1097/MCG.0000000000000827.

PMID:
    28375864
    [PubMed - indexed for MEDLINE]
Related citations


A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.
Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME
J Biol Chem. 2016 Oct 28; 291(44)23224-23236.

PMID:
    27650499
    [PubMed - indexed for MEDLINE]
Related citations


Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.
Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Schwarzenberg SJ, Troendle DM, Yen E, Uc A
J Pediatr Gastroenterol Nutr. 2017 Jan; 64(1)95-103. doi: 10.1097/MPG.0000000000001446.

PMID:
    27782962
    [PubMed - indexed for MEDLINE]
Related citations


Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Uc A, Andersen DK, Bellin MD, Bruce JI, Drewes AM, Engelhardt JF, Forsmark CE, Lerch MM, Lowe ME, Neuschwander-Tetri BA, OʼKeefe SJ, Palermo TM, Pasricha P, Saluja AK, Singh VK, Szigethy EM, Whitcomb DC, Yadav D, Conwell DL
Pancreas. 2016 Nov; 45(10)1365-1375.

PMID:
    27748719
    [PubMed - indexed for MEDLINE]
Related citations


A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.
Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T
J Pediatr Surg Case Rep. 2015 May; 3(5)223-226.

PMID:
    27182490
    [PubMed]
Related citations


Lipase Genetic Variants in Chronic Pancreatitis: When the End Is Wrong, All's Not Well.
Molven A, Fjeld K, Lowe ME
Gastroenterology. 2016 Jun; 150(7)1515-1518. doi: 10.1053/j.gastro.2016.04.019.

PMID:
    27133394
    [PubMed - indexed for MEDLINE]
Related citations


Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE.
Kumar S, Ooi CY, Werlin S, Abu-El-Haija M, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Lin TK, Lowe ME, Morinville V, Palermo JJ, Pohl JF, Schwarzenberg SJ, Troendle D, Wilschanski M, Zimmerman MB, Uc A
JAMA Pediatr. 2016 Jun 1; 170(6)562-9. doi: 10.1001/jamapediatrics.2015.4955.

PMID:
    27064572
    [PubMed - indexed for MEDLINE]
Related citations


Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry.
Ting J, Wilson L, Schwarzenberg SJ, Himes R, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Husain SZ, Kumar S, Morinville VD, Lowe ME, Ooi CY, Pohl JF, Troendle D, Usatin D, Werlin SL, Wilschanski M, Heyman MB, Uc A
J Pediatr Gastroenterol Nutr. 2016 Mar; 62(3)443-9. doi: 10.1097/MPG.0000000000001057.

PMID:
    26704866
    [PubMed - indexed for MEDLINE]
Related citations


Next Generation of Pancreatic Enzyme Replacement Therapy: Recombinant Microbial Enzymes and Finding the Perfect Lipase.
Lowe ME, Whitcomb DC
Gastroenterology. 2015 Dec; 149(7)1678-81. doi: 10.1053/j.gastro.2015.10.025.

PMID:
    26505819
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dietary fat digestion and mechanisims of chronic pancreatitis.