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Mario Castro, MD, MPH, FCCP

Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Asthma
Lung Cancer

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917

Education

Education

Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri 1998
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1994
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1991
Medical Degree: University Of Missouri, Kansas City, Missouri 1988

Publication & Research

Publication & Research

Previous physical exercise alters hepatic profile of oxidative-inflammatory status and limits the secondary brain damage induced by severe TBI in rats.
de Castro MRT, Ferreira APO, Busanello GL, da Silva LRH, da Silveira Junior MEP, Fiorin F, Arrifano G, López MEC, Barcelos RP, Cuevas MJ, Bresciani G, González-Gallego J, Fighera MR, Royes LFF
J Physiol. 2017 Jul 20; doi: 10.1113/JP273933.

PMID:
    28726269
    [PubMed - as supplied by publisher]
Related citations


ALX receptor ligands define a biochemical endotype for severe asthma.
Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.
JCI Insight. 2017 Jul 20; 2(14)pii: 93534. doi: 10.1172/jci.insight.93534.

PMID:
    28724795
    [PubMed - as supplied by publisher]
Related citations


GridSample: an R package to generate household survey primary sampling units (PSUs) from gridded population data.
Thomson DR, Stevens FR, Ruktanonchai NW, Tatem AJ, Castro MC
Int J Health Geogr. 2017 Jul 19; 16(1)25. doi: 10.1186/s12942-017-0098-4.

PMID:
    28724433
    [PubMed - in process]
Related citations


Why Did Zika Not Explode in Cuba? The Role of Active Community Participation to Sustain Control of Vector-Borne Diseases.
Castro M, Perez D, Guzman MG, Barrington C
Am J Trop Med Hyg. 2017 Jun 19; doi: 10.4269/ajtmh.16-0906.

PMID:
    28722613
    [PubMed - as supplied by publisher]
Related citations


Evolutionary basis of a new approach for the treatment of malignant brain tumors: From mice to humans.
Lowenstein PR, Castro MG
Clin Immunol. 2017 Jul 15; pii: S1521-6616(17)30535-1. doi: 10.1016/j.clim.2017.07.006.

PMID:
    28720549
    [PubMed - as supplied by publisher]
Related citations


Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum.
Escudero-Martínez JM, Pérez-Pertejo Y, Reguera RM, Castro MÁ, Rojo MV, Santiago C, Abad A, García PA, López-Pérez JL, San Feliciano A, Balaña-Fouce R
Int J Parasitol Drugs Drug Resist. 2017 Jun 28; 7(3)272-285. doi: 10.1016/j.ijpddr.2017.06.003.

PMID:
    28719882
    [PubMed - as supplied by publisher]
Related citations


Combined training (strength plus aerobic) potentiates a reduction in body fat but only functional training reduced low-density lipoprotein cholesterol in postmenopausal women with a similar training load.
Rossi FE, Fortaleza ACS, Neves LM, Diniz TA, de Castro MR, Buonani C, Mota J, Freitas IF Junior
J Exerc Rehabil. 2017 Jun; 13(3)322-329. doi: 10.12965/jer.1734940.470.

PMID:
    28702444
    [PubMed]
Related citations


The Many "Buckets" of Severe Asthma: Moving Toward Personalized Management.
Moore WC, Castro M
J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4)936-937. doi: 10.1016/j.jaip.2017.05.017.

PMID:
    28689844
    [PubMed - in process]
Related citations


Nonpharmacologic Therapy for Severe Persistent Asthma.
Hall C, Nici L, Sood S, ZuWallack R, Castro M
J Allergy Clin Immunol Pract. 2017 Jul - Aug; 5(4)928-935. doi: 10.1016/j.jaip.2017.04.030.

PMID:
    28689843
    [PubMed - in process]
Related citations


Denatonium and Naringenin Promote SCA-9 Tumor Growth and Angiogenesis: Participation of Arginase.
Dmytrenko G, Castro ME, Sales ME
Nutr Cancer. 2017 Jul; 69(5)780-790. doi: 10.1080/01635581.2017.1328605.

PMID:
    28682138
    [PubMed - in process]
Related citations


Assessing medication adherence in inflammatory bowel diseases. A comparison between a self-administered scale and a pharmacy refill index.
de Castro ML, Sanromán L, Martín A, Figueira M, Martínez N, Hernández V, Del Campo V, Pineda JR, Martínez-Cadilla J, Pereira S, Rodríguez Prada JI
Rev Esp Enferm Dig. 2017 Jul 6; doi: 10.17235/reed.2017.5137/2017.

PMID:
    28679280
    [PubMed - as supplied by publisher]
Related citations


Long-Term Efficacy and Safety of Cyclosporine in a Cohort of Steroid-Refractory Acute Severe Ulcerative Colitis Patients from the ENEIDA Registry (1989-2013): A Nationwide Multicenter Study.
Ordás I, Domènech E, Mañosa M, García-Sánchez V, Iglesias-Flores E, Peñalva M, Cañas-Ventura A, Merino O, Fernández-Bañares F, Gomollón F, Vera M, Gutiérrez A, Garcia-Planella E, Chaparro M, Aguas M, Gento E, Muñoz F, Aguirresarobe M, Muñoz C, Fernández L, Calvet X, Jiménez CE, Montoro MA, Mir A, De Castro ML, García-Sepulcre MF, Bermejo F, Panés J, Esteve M
Am J Gastroenterol. 2017 Jul 4; doi: 10.1038/ajg.2017.180.

PMID:
    28675163
    [PubMed - as supplied by publisher]
Related citations


Repetition priming in mild cognitive impairment and mild dementia: Impact of educational attainment.
O'Shea DM, De Wit L, Yutsis M, Castro M, Smith GE
J Clin Exp Neuropsychol. 2017 Jul 3; 1-9. doi: 10.1080/13803395.2017.1347253.

PMID:
    28671486
    [PubMed - as supplied by publisher]
Related citations


HCT-CI Predicts Morbidity and Mortality in Autologous Stem Cell Transplantation.
Berro M, Arbelbide JA, Rivas MM, Basquiera AL, Ferini G, Vitriu A, Foncuberta C, Escobar NF, Requejo A, Milovic V, Yantorno S, Szelagoswki M, Rolon JM, Bentolila G, Garcia JJ, Garcia P, Caeiro G, Castro M, Jaimovich G, Palmer S, Trucco JI, Bet LA, Shaw BE, Kusminsky GD
Biol Blood Marrow Transplant. 2017 Jun 29; pii: S1083-8791(17)30523-2. doi: 10.1016/j.bbmt.2017.06.014.

PMID:
    28669923
    [PubMed - as supplied by publisher]
Related citations


The genome sequence of Condylorrhiza vestigialis NPV, a novel baculovirus for the control of the Alamo moth on Populus spp. in Brazil.
Castro MEB, Melo FL, Tagliari M, Inglis PW, Craveiro SR, Ribeiro ZMA, Ribeiro BM, Báo SN
J Invertebr Pathol. 2017 Jun 29; 148152-161. doi: 10.1016/j.jip.2017.06.013.

PMID:
    28669710
    [PubMed - as supplied by publisher]
Related citations


Dendropsophin 1, a novel antimicrobial peptide from the skin secretion of the endemic Colombian frog Dendropsophus columbianus.
Triana-Vidal LE, Castro MS, Pires Júnior OR, Álvares ACM, de Freitas SM, Fontes W, Vargas JAG, Zúñiga-Baos JA, Correia Batista IF, Grellier P, Charneau S
Nat Prod Res. 2017 Jun 29; 1-7. doi: 10.1080/14786419.2017.1346646.

PMID:
    28659061
    [PubMed - as supplied by publisher]
Related citations


SparkBLAST: scalable BLAST processing using in-memory operations.
de Castro MR, Tostes CDS, Dávila AMR, Senger H, da Silva FAB
BMC Bioinformatics. 2017 Jun 27; 18(1)318. doi: 10.1186/s12859-017-1723-8.

PMID:
    28655296
    [PubMed - in process]
Related citations


Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis.
Pardo E, Cárcamo C, Uribe-San Martín R, Ciampi E, Segovia-Miranda F, Curkovic-Peña C, Montecino F, Holmes C, Tichauer JE, Acuña E, Osorio-Barrios F, Castro M, Cortes P, Oyanadel C, Valenzuela DM, Pacheco R, Naves R, Soza A, González A
PLoS One. 2017; 12(6)e0177472. doi: 10.1371/journal.pone.0177472.

PMID:
    28650992
    [PubMed - in process]
Related citations


Highly fluorescent and superparamagnetic nanosystem for biomedical applications.
Cabrera MP, Filho PEC, Silva CMCM, Oliveira RM, Geraldes CFGC, Castro MMCA, Costa BFO, Henriques MSC, Paixão JA, Carvalho LB, Santos BS, Hallwass F, Fontes A, Pereira GAL
Nanotechnology. 2017 Jul 14; 28(28)285704. doi: 10.1088/1361-6528/aa752a.

PMID:
    28643695
    [PubMed - in process]
Related citations


Long-Term Excessive Selenium Supplementation Induces Hypertension in Rats.
Grotto D, Carneiro MFH, de Castro MM, Garcia SC, Barbosa Junior F
Biol Trace Elem Res. 2017 Jun 20; doi: 10.1007/s12011-017-1076-1.

PMID:
    28634813
    [PubMed - as supplied by publisher]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2016.

Company Name: Genentech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2017


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $50,001 - $100,000

Reporting Date: May 01, 2017