Patient Portal

Mario Castro, MD, MPH, FCCP

Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Asthma
Lung Cancer

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917

Education

Education

Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri 1998
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1994
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1991
Medical Degree: University Of Missouri, Kansas City, Missouri 1988

Publication & Research

Publication & Research

Variations in Tissue Mercury Contents in Three Species of Adult Salamanders in Streams in Western Maryland.
Castro MS, Kaumeyer M, Hilderbrand RH
Arch Environ Contam Toxicol. 2019 Feb 18; doi: 10.1007/s00244-019-00606-z.

PMID:
    30778626
    [PubMed - as supplied by publisher]
Related citations


Corrigendum to "Biochemical and structural characterization of a protein complex containing a hyaluronidase and a CRISP-like protein isolated from the venom of the spider Acanthoscurria natalensis" [J. Proteome 192. (2019) 102-113].
Barth T, Mandacaru SC, Charneau S, de Sousa MV, Ricart CAO, Noronha EF, Souza AA, de Freitas SM, Roepstorff P, Fontes W, Castro MS, Júnior ORP
J Proteomics. 2019 Feb 15; pii: S1874-3919(19)30010-7. doi: 10.1016/j.jprot.2019.01.002.

PMID:
    30777676
    [PubMed - as supplied by publisher]
Related citations


A biocompatible redox MRI probe based on a Mn(ii)/Mn(iii) porphyrin.
Pinto SMA, Calvete MJF, Ghica ME, Soler S, Gallardo I, Pallier A, Laranjo MB, Cardoso AMS, Castro MMCA, Brett CMA, Pereira MM, Tóth É, Geraldes CFGC
Dalton Trans. 2019 Feb 18; doi: 10.1039/c8dt04775h.

PMID:
    30776044
    [PubMed - as supplied by publisher]
Related citations


Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.
Cortegiani A, Gregoretti C, Neto AS, Hemmes SNT, Ball L, Canet J, Hiesmayr M, Hollmann MW, Mills GH, Melo MFV, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Schultz MJ, Pelosi P, LAS VEGAS Investigators, the PROVE Network, and the Clinical Trial Network of the European Society of Anaesthesiology.
Br J Anaesth. 2019 Mar; 122(3)361-369. doi: 10.1016/j.bja.2018.10.063.

PMID:
    30770054
    [PubMed - in process]
Related citations


IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, Ljungman M, Qin T, Sartor MA, Tagett R, Venneti S, Brosnan-Cashman J, Meeker A, Gorbunova V, Zhao L, Kremer DM, Zhang L, Lyssiotis CA, Jones L, Herting CJ, Ross JL, Hambardzumyan D, Hervey-Jumper S, Figueroa ME, Lowenstein PR, Castro MG
Sci Transl Med. 2019 Feb 13; 11(479)pii: eaaq1427. doi: 10.1126/scitranslmed.aaq1427.

PMID:
    30760578
    [PubMed - in process]
Related citations


The Effect of Plasma Nitriding on the Fatigue Behavior of the Ti-6Al-4V Alloy.
de Castro MCB, Couto AA, Almeida GFC, Massi M, de Lima NB, da Silva Sobrinho A, Castagnet M, Xavier GL, Oliveira RR
Materials (Basel). 2019 Feb 9; 12(3)pii: E520. doi: 10.3390/ma12030520.

PMID:
    30744088
    [PubMed]
Related citations


Determination of macromineral requirements for preweaned dairy calves in tropical conditions.
Castro MMD, Silva AL, Costa E Silva LF, Rotta PP, Engle TE, Marcondes MI
J Dairy Sci. 2019 Feb 6; pii: S0022-0302(19)30116-X. doi: 10.3168/jds.2018-15166.

PMID:
    30738689
    [PubMed - as supplied by publisher]
Related citations


Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort.
Agier L, Basagaña X, Maitre L, Granum B, Bird PK, Casas M, Oftedal B, Wright J, Andrusaityte S, de Castro M, Cequier E, Chatzi L, Donaire-Gonzalez D, Grazuleviciene R, Haug LS, Sakhi AK, Leventakou V, McEachan R, Nieuwenhuijsen M, Petraviciene I, Robinson O, Roumeliotaki T, Sunyer J, Tamayo-Uria I, Thomsen C, Urquiza J, Valentin A, Slama R, Vrijheid M, Siroux V
Lancet Planet Health. 2019 Feb 5; pii: S2542-5196(19)30010-5. doi: 10.1016/S2542-5196(19)30010-5.

PMID:
    30737192
    [PubMed - as supplied by publisher]
Related citations


CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
Castro M, Laviña B, Ando K, Álvarez-Aznar A, Abu Taha A, Brakebusch C, Dejana E, Betsholtz C, Gaengel KB
Circ Res. 2019 Feb 8; doi: 10.1161/CIRCRESAHA.118.314300.

PMID:
    30732528
    [PubMed - as supplied by publisher]
Related citations


Unmet Needs in Severe Asthma Subtyping and Precision Medicine Trials: Bridging Clinical and Patient Perspectives.
Siddiqui S, Denlinger LC, Fowler SJ, Akuthota P, Shaw DE, Heaney LG, Brown L, Castro M, Winders TA, Kraft M, Wagers S, Peters MC, Pavord ID, Walker S, Jarjour NN
Am J Respir Crit Care Med. 2019 Feb 6; doi: 10.1164/rccm.201809-1817PP.

PMID:
    30726120
    [PubMed - as supplied by publisher]
Related citations


High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme.
Kadiyala P, Li D, Nuñez FM, Altshuler D, Doherty R, Kuai R, Yu M, Kamran N, Edwards M, Moon JJ, Lowenstein PR, Castro MG, Schwendeman A
ACS Nano. 2019 Feb 11; doi: 10.1021/acsnano.8b06842.

PMID:
    30721028
    [PubMed - as supplied by publisher]
Related citations


Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.
Alkhouli MF, Hung J, Squire M, Anderson M, Castro M, Babu JR, Al-Nakkash L, Broderick TL, Plochocki JH
BMC Complement Altern Med. 2019 Feb 4; 19(1)39. doi: 10.1186/s12906-019-2451-6.

PMID:
    30717730
    [PubMed - in process]
Related citations


Ticks and Rickettsia on anteaters from Southeast and Central-West Brazil.
Szabó MPJ, Pascoal JO, Martins MM, Ramos VDN, Osava CF, Santos ALQ, Yokosawa J, Rezende LM, Tolesano-Pascoli GV, Torga K, de Castro MB, Suzin A, Barbieri ARM, Werther K, Silva JMM, Labruna MB
Ticks Tick Borne Dis. 2019 Jan 24; pii: S1877-959X(18)30240-1. doi: 10.1016/j.ttbdis.2019.01.008.

PMID:
    30709660
    [PubMed - as supplied by publisher]
Related citations


Use of open mobile mapping tool to assess human mobility traceability in rural offline populations with contrasting malaria dynamics.
Carrasco-Escobar G, Castro MC, Barboza JL, Ruiz-Cabrejos J, Llanos-Cuentas A, Vinetz JM, Gamboa D
PeerJ. 2019; 7e6298. doi: 10.7717/peerj.6298.

PMID:
    30697487
    [PubMed]
Related citations


Leptin-deficient mice have altered three-dimensional growth plate histomorphometry.
Hung J, Al-Nakkash L, Broderick TL, Castro M, Plochocki JH
Diabetol Metab Syndr. 2019; 118. doi: 10.1186/s13098-019-0402-5.

PMID:
    30697359
    [PubMed]
Related citations


Bronchial Thermoplasty.
Mainardi AS, Castro M, Chupp G
Clin Chest Med. 2019 Mar; 40(1)193-207. doi: 10.1016/j.ccm.2018.10.015.

PMID:
    30691712
    [PubMed - in process]
Related citations


Histatin-1 counteracts the cytotoxic and anti-migratory effects of zoledronic acid in endothelial and osteoblast-like cells.
Castro M, Torres P, Solano L, Córdova LA, Torres VA
J Periodontol. 2019 Jan 28; doi: 10.1002/JPER.18-0644.

PMID:
    30690743
    [PubMed - as supplied by publisher]
Related citations


Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures.
Núñez FJ, Mendez FM, Garcia-Fabiani MB, Pardo J, Edwards M, Lowenstein PR, Castro MG
J Vis Exp. 2019 Jan 9; (143)doi: 10.3791/58931.

PMID:
    30688315
    [PubMed - in process]
Related citations


Gastroesophageal reflux disease in a patient with BMI 30kg/m<sup>2</sup> and previous endoscopic vertical gastroplasty: Indication for a one anastomosis gastric bypass.
Ruiz-Tovar J, Carbajo MA, Jimenez JM, Ortiz-de-Solorzano J, Castro MJ
Cir Esp. 2019 Jan 22; pii: S0009-739X(18)30361-0. doi: 10.1016/j.ciresp.2018.12.005.

PMID:
    30683273
    [PubMed - as supplied by publisher]
Related citations


Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma.
Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE
Am J Respir Crit Care Med. 2019 Jan 25; doi: 10.1164/rccm.201808-1543OC.

PMID:
    30682261
    [PubMed - as supplied by publisher]
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Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians and health professionals are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians and health professionals work collaboratively with pharmaceutical, medical device or other medical care related companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our physicians and health professionals have an ownership or potential ownership interest in a commercial company; and/or are paid by a commercial company to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians or health professionals must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this website, physicians and health professionals earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following financial interests during calendar year 2017:

Company Name: Genentech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,000 - $19,999

Reporting Date: May 01, 2018


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $100,000 - $149,999

Reporting Date: May 01, 2018


Company Name: Astrazenica

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $20,000 - $39,999

Reporting Date: May 01, 2018