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Mario Castro, MD, MPH, FCCP

Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Asthma
Lung Cancer

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917

Education

Education

Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri 1998
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1994
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1991
Medical Degree: University Of Missouri, Kansas City, Missouri 1988

Publication & Research

Publication & Research

FGFR2 risk SNPs confer breast cancer risk by augmenting estrogen responsiveness.
Campbell TM, Castro MA, de Santiago I, Fletcher MN, Halim S, Prathalingam R, Ponder BA, Meyer KB
Carcinogenesis. 2016 May 28; pii: bgw065.

PMID:
    27236187
    [PubMed - as supplied by publisher]
Related citations


Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma.
Trivedi A, Pavord ID, Castro M
Lancet Respir Med. 2016 May 23; pii: S2213-2600(16)30018-2. doi: 10.1016/S2213-2600(16)30018-2.

PMID:
    27230825
    [PubMed - as supplied by publisher]
Related citations


A versatile intensity-based 3D/2D rigid registration compatible with mobile C-arm for endovascular treatment of abdominal aortic aneurysm.
Duménil A, Kaladji A, Castro M, Göksu C, Lucas A, Haigron P
Int J Comput Assist Radiol Surg. 2016 May 26;

PMID:
    27230779
    [PubMed - as supplied by publisher]
Related citations


Condensation of Macrocyclic Polyketides Produced by Penicillium sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway.
de Castro MV, Ióca LP, Williams DE, Costa BZ, Mizuno CM, Santos MF, de Jesus K, Ferreira ÉL, Seleghim MH, Sette LD, Pereira Filho ER, Ferreira AG, Gonçalves NS, Santos RA, Patrick BO, Andersen RJ, Berlinck RG
J Nat Prod. 2016 May 26;

PMID:
    27227682
    [PubMed - as supplied by publisher]
Related citations


Marine Depsipeptides as Promising Pharmacotherapeutic Agents.
Rangel M, de Santana CJ, Pinheiro A, Dos Anjos L, Barth T, Pires Júnior OR, Fontes W, Castro MS
Curr Protein Pept Sci. 2016 May 26;

PMID:
    27226199
    [PubMed - as supplied by publisher]
Related citations


Neutrophil proteomic analysis reveals the participation of antioxidant enzymes, motility and ribosomal proteins in the prevention of ischemic effects by preconditioning.
Arshid S, Tahir M, Fontes B, Montero EF, Castro MS, Sidoli S, Schwämmle V, Roepstorff P, Fontes W
J Proteomics. 2016 May 18; pii: S1874-3919(16)30209-3. doi: 10.1016/j.jprot.2016.05.016.

PMID:
    27208787
    [PubMed - as supplied by publisher]
Related citations


Reduced Neurite Density in Neuronal Cell Cultures Exposed to Serum of Patients with Bipolar Disorder.
Wollenhaupt-Aguiar B, Pfaffenseller B, de Saraiva Chagas V, Castro MA, Passos IC, Kauer-Sant'Anna M, Kapczinski F, Klamt F
Int J Neuropsychopharmacol. 2016 May 13; pii: pyw051. doi: 10.1093/ijnp/pyw051.

PMID:
    27207915
    [PubMed - as supplied by publisher]
Related citations


Challenges for malaria elimination in Brazil.
Ferreira MU, Castro MC
Malar J. 2016 May 20; 15(1)284. doi: 10.1186/s12936-016-1335-1.

PMID:
    27206924
    [PubMed - in process]
Related citations


Electromyographic Analysis of the Lower Limb Muscles in Low- and High-Handicap Golfers.
Marta S, Silva L, Vaz JR, Castro MA, Reinaldo G, Pezarat-Correia P
Res Q Exerc Sport. 2016 May 19; 1-7.

PMID:
    27196665
    [PubMed - as supplied by publisher]
Related citations


A simple solution for antibody signal enhancement in immunofluorescence and triple immunogold assays.
Rosas-Arellano A, Villalobos-González JB, Palma-Tirado L, Beltrán FA, Cárabez-Trejo A, Missirlis F, Castro MA
Histochem Cell Biol. 2016 May 17;

PMID:
    27188756
    [PubMed - as supplied by publisher]
Related citations


IGF2 and IGF1R in pediatric adrenocortical tumors: roles in metastasis and steroidogenesis.
Lira R, Fedatto PF, Marco Antonio DS, Leal LF, Martinelli Junior CE, De Castro M, Tucci Junior S, Neder L, Ramalho LN, Seidinger AL, Cardinalli I, Mastellaro MJ, Yunes JA, Brandalise S, Tone LG, Antonini SR, Scrideli CA
Endocr Relat Cancer. 2016 May 16; pii: ERC-15-0426.

PMID:
    27185872
    [PubMed - as supplied by publisher]
Related citations


Frequency of histopathological changes in Howler monkeys ( Alouatta sp.) naturally infected with yellow fever virus in Brazil.
Leal SG, Romano AP, Monteiro RV, Melo CB, Vasconcelos PF, Castro MB
Rev Soc Bras Med Trop. 2016 Feb; 49(1)29-33. doi: 10.1590/0037-8682-0363-2015.

PMID:
    27163561
    [PubMed - in process]
Related citations


Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3.
Pfaffenseller B, da Silva Magalhães PV, De Bastiani MA, Castro MA, Gallitano AL, Kapczinski F, Klamt F
Transl Psychiatry. 2016 May 10; 6e805. doi: 10.1038/tp.2016.78.

PMID:
    27163206
    [PubMed - in process]
Related citations


Long-Term Remission of Acromegaly after Octreotide withdrawal is an Uncommon and Frequently Unsustainable Event.
Casagrande A, Bronstein MD, Jallad RS, Moraes AB, Elias PC, Castro M, Czepielewski MA, Boschi A, Ribeiro-Oliveira A Jr, Schweizer JR, Vilar L, Nazato DM, Gadelha MR, Abucham J, Boguszewski CL, Jatene EM, Leães CG, Miranda PA, Mota JI, Nunes VS, Tabet A, Tavares AB
Neuroendocrinology. 2016 May 5;

PMID:
    27161443
    [PubMed - as supplied by publisher]
Related citations


Type 2 Diabetes Mellitus Trajectories and Associated Risks.
Oh W, Kim E, Castro MR, Caraballo PJ, Kumar V, Steinbach MS, Simon GJ
Big Data. 2016 Mar 1; 4(1)25-30.

PMID:
    27158565
    [PubMed]
Related citations


Absence of TERT promoter mutations in pituitary adenomas.
Martins CS, de Castro M, Calado RT
J Endocrinol Invest. 2016 May 6;

PMID:
    27153849
    [PubMed - as supplied by publisher]
Related citations


Prognosis of patients with benign thyroid nodules: a population-based study.
Singh Ospina N, Maraka S, Espinosa de Ycaza AE, Brito JP, Castro MR, Morris JC, Montori VM
Endocrine. 2016 May 3;

PMID:
    27142412
    [PubMed - as supplied by publisher]
Related citations


The Presence of Pretransplant Antiphospholipid Antibodies IgA Anti-β-2-Glycoprotein I as a Predictor of Graft Thrombosis After Renal Transplantation.
Morales JM, Serrano M, Martínez-Flores JA, Pérez D, Castro MJ, Sánchez E, García F, Rodríguez-Antolín A, Alonso M, Gutierrez E, Morales E, Praga M, González E, Andrés A, Paz-Artal E, Martínez MA, Serrano A
Transplantation. 2016 May 2;

PMID:
    27140515
    [PubMed - as supplied by publisher]
Related citations


1st Workshop on Upper-Extremity Assistive Technology for People with Duchenne: State of the art, emerging avenues, and challenges: April 27th 2015, London, United Kingdom.
Bergsma A, Lobo-Prat J, Vroom E, Furlong P, Herder JL, Workshop Participants
Neuromuscul Disord. 2016 Jun; 26(6)386-93. doi: 10.1016/j.nmd.2016.04.005.

PMID:
    27133663
    [PubMed - in process]
Related citations


Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β<sub>2</sub> agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial.
Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, Eckert L, Graham NM, Stahl N, Yancopoulos GD, Louis-Tisserand M, Teper A
Lancet. 2016 Apr 26; pii: S0140-6736(16)30307-5. doi: 10.1016/S0140-6736(16)30307-5.

PMID:
    27130691
    [PubMed - as supplied by publisher]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2015.

Company Name: Boehringer Ingelheim

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2016


Company Name: Genentech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016


Company Name: Sparo

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016