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Mario Castro, MD, MPH, FCCP

Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Asthma
Lung Cancer

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917

Education

Education

Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri 1998
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1994
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1991
Medical Degree: University Of Missouri, Kansas City, Missouri 1988

Publication & Research

Publication & Research

Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer.
Moreno Ayala MA, Gottardo MF, Gori MS, Nicola Candia AJ, Caruso C, De Laurentiis A, Imsen M, Klein S, Bal de Kier Joffé E, Salamone G, Castro MG, Seilicovich A, Candolfi M
J Cancer Res Clin Oncol. 2017 Apr 21; doi: 10.1007/s00432-017-2421-7.

PMID:
    28432455
    [PubMed - as supplied by publisher]
Related citations


Design of the magnetic homonuclear bonds boron nitride nanosheets using DFT methods.
Anota EC, Hernández AB, Morales AE, Castro M
J Mol Graph Model. 2017 Mar 30; 74135-142. doi: 10.1016/j.jmgm.2017.03.019.

PMID:
    28414977
    [PubMed - as supplied by publisher]
Related citations


Sustained low peritoneal effluent CCL18 levels are associated with preservation of peritoneal membrane function in peritoneal dialysis.
Ossorio M, Bajo MA, Del Peso G, Martínez V, Fernández M, Castro MJ, Rodríguez-Sanz A, Madero R, Bellón T, Selgas R
PLoS One. 2017; 12(4)e0175835. doi: 10.1371/journal.pone.0175835.

PMID:
    28414753
    [PubMed - in process]
Related citations


Electronic and vibrational second hyperpolarizabilities of (MgO)<sub>n</sub> clusters.
Feitoza L, Castro MA, Leão SA, Fonseca TL
J Chem Phys. 2017 Apr 14; 146(14)144309. doi: 10.1063/1.4979910.

PMID:
    28411612
    [PubMed - in process]
Related citations


BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes.
Ehlers A, Xie W, Agapov E, Brown S, Steinberg D, Tidwell R, Sajol G, Schutz R, Weaver R, Yu H, Castro M, Bacharier LB, Wang X, Holtzman MJ, Haspel JA
Mucosal Immunol. 2017 Apr 12; doi: 10.1038/mi.2017.24.

PMID:
    28401936
    [PubMed - as supplied by publisher]
Related citations


Effect of intranasal corticosteroids on allergic airway disease in asthma.
Dixon AE, Castro M, Gerald LB, Holbrook JT, Henderson RJ, Casale TB, Irvin CG, Black K, Wise RA, Sugar EA, American Lung Association Airways Clinical Research Centers' Writing Committee.
J Allergy Clin Immunol Pract. 2017 Apr 7; pii: S2213-2198(17)30167-8. doi: 10.1016/j.jaip.2017.02.022.

PMID:
    28396113
    [PubMed - as supplied by publisher]
Related citations


Genes Involved in the Enamel Development Are Associated with Calcium and Phosphorus Level in Saliva.
Küchler EC, Pecharki GD, Castro ML, Ramos J, Barbosa F Jr, Brancher JA, Vieira AR, Gerlach RF, Trevilatto PC
Caries Res. 2017 Apr 11; 51(3)225-230. doi: 10.1159/000450764.

PMID:
    28395292
    [PubMed - as supplied by publisher]
Related citations


Anxiety in Cancer Patients during <sup>18</sup>F-FDG PET/CT Low Dose: A Comparison of Anxiety Levels before and after Imaging Studies.
Grilo A, Vieira L, Carolino E, Oliveira C, Pacheco C, Castro M, Alonso J
Nurs Res Pract. 2017; 20173057495. doi: 10.1155/2017/3057495.

PMID:
    28392942
    [PubMed - in process]
Related citations


Impact of distance education on academic performance in a pharmaceutical care course.
Gossenheimer AN, Bem T, Carneiro ML, de Castro MS
PLoS One. 2017; 12(4)e0175117. doi: 10.1371/journal.pone.0175117.

PMID:
    28384362
    [PubMed - in process]
Related citations


Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.
Berger BA, Cossio A, Saravia NG, Castro MD, Prada S, Bartlett AH, Pho MT
PLoS Negl Trop Dis. 2017 Apr 6; 11(4)e0005459. doi: 10.1371/journal.pntd.0005459.

PMID:
    28384261
    [PubMed - as supplied by publisher]
Related citations


Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas.
de Araújo LJ, Lerario AM, de Castro M, Martins CS, Bronstein MD, Machado MC, Trarbach EB, Villares Fragoso MC
Front Endocrinol (Lausanne). 2017; 855. doi: 10.3389/fendo.2017.00055.

PMID:
    28382019
    [PubMed - in process]
Related citations


Response of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox status.
Casós K, Ferrer-Curriu G, Soler-Ferrer P, Pérez ML, Permanyer E, Blasco-Lucas A, Gracia-Baena JM, Castro MA, Sureda C, Barquinero J, Galiñanes M
PLoS One. 2017; 12(4)e0174588. doi: 10.1371/journal.pone.0174588.

PMID:
    28380047
    [PubMed - in process]
Related citations


Risk factors for therapeutic failure to meglumine antimoniate and miltefosine in adults and children with cutaneous leishmaniasis in Colombia: A cohort study.
Castro MDM, Cossio A, Velasco C, Osorio L
PLoS Negl Trop Dis. 2017 Apr; 11(4)e0005515. doi: 10.1371/journal.pntd.0005515.

PMID:
    28379954
    [PubMed - in process]
Related citations


Front microrheology of the non-Newtonian behaviour of blood: scaling theory of erythrocyte aggregation by aging.
Trejo-Soto C, Costa-Miracle E, Rodriguez-Villarreal I, Cid J, Castro M, Alarcon T, Hernandez-Machado A
Soft Matter. 2017 Apr 19; 13(16)3042-3047. doi: 10.1039/c6sm02412b.

PMID:
    28375423
    [PubMed - in process]
Related citations


Matrix Metalloproteinase (MMP)-2 Activity is Associated with Divergent Regulation of Calponin-1 in Conductance and Resistance Arteries in Hypertension-Induced Early Vascular Dysfunction and Remodelling.
Parente JM, Pereira CA, Oliveira-Paula GH, Tanus-Santos JE, Tostes RC, Castro MM
Basic Clin Pharmacol Toxicol. 2017 Apr 4; doi: 10.1111/bcpt.12787.

PMID:
    28374979
    [PubMed - as supplied by publisher]
Related citations


Validation of self-reported diabetes in a representative sample of São Paulo city.
Fontanelli MM, Teixeira JA, Sales CH, Castro MA, Cesar CL, Alves MC, Goldbaum M, Marchioni DM, Fisberg RM
Rev Saude Publica. 2017; 5120. doi: 10.1590/s1518-8787.2017051006378.

PMID:
    28355348
    [PubMed - in process]
Related citations


Changes in plasma concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D during pregnancy: a Brazilian cohort.
Figueiredo AC, Cocate PG, Adegboye AR, Franco-Sena AB, Farias DR, de Castro MB, Brito A, Allen LH, Mokhtar RR, Holick MF, Kac G
Eur J Nutr. 2017 Mar 28; doi: 10.1007/s00394-017-1389-z.

PMID:
    28353072
    [PubMed - as supplied by publisher]
Related citations


Outbreak of group A streptococcal pharyngitis at a national sports competition in Montevideo, Uruguay.
Gabarrot GG, Debat ET, Rodriguez G, Castro M, Gagliano G, Camou T
Rev Argent Microbiol. 2017 Mar 23; pii: S0325-7541(17)30011-1. doi: 10.1016/j.ram.2016.11.003.

PMID:
    28343855
    [PubMed - as supplied by publisher]
Related citations


Importance of major histocompatibility complex of class I (MHC-I) expression for astroglial reactivity and stability of neural circuits in vitro.
Bombeiro AL, Hell RC, Simões GF, Castro MV, Oliveira AL
Neurosci Lett. 2017 Apr 24; 64797-103. doi: 10.1016/j.neulet.2017.03.038.

PMID:
    28341478
    [PubMed - in process]
Related citations


The potential of stimulating nitric oxide formation in the treatment of hypertension.
Pinheiro LC, Tanus-Santos JE, Castro MM
Expert Opin Ther Targets. 2017 May; 21(5)543-556. doi: 10.1080/14728222.2017.1310840.

PMID:
    28338370
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2015.

Company Name: Boehringer Ingelheim

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2016


Company Name: Genentech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016


Company Name: Sparo

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016