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Mario Castro, MD, MPH, FCCP

Professor, Medicine and Pediatrics
Division of Pulmonary and Critical Care Medicine

Specialty Areas

Pulmonary Disease
Asthma
Lung Cancer

Board Certifications

Pulmonary Disease
Internal Medicine
Critical Care Medicine

Hospital Affiliations

Barnes-Jewish Hospital
Barnes-Jewish West County Hospital

Areas of Clinical Interest

Asthma and related allergic disease, COPD, emphysema, chronic bronchitis, interstital lung disease, idiopathic pulmonary fibrosis, sarcoidosis, chronic cough, unexplained shortness of breath, vasculitis, chronic lung infections, pulmonary hypertension, bronchiectasis.

  • Maps & Directions
  • Education
  • Publication & Research
  • Financial Disclosures

Maps & Directions

Maps & Directions

Center for Advanced Medicine
Lung Center

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 8
Office Phone: 314-454-8917

Education

Education

Graduate: Public Health, St. Louis University School of Public Health, St. Louis, Missouri 1998
Fellowship: Pulmonary/Critical Care, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1994
Residency: Internal Medicine, Mayo Clinic, Mayo Graduate School of Medicine, Rochester, Minnesota 1991
Medical Degree: University Of Missouri, Kansas City, Missouri 1988

Publication & Research

Publication & Research

Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes.
de Castro M, Bunt G, Wouters FS
Cell Death Discov. 2016; 216012. doi: 10.1038/cddiscovery.2016.12.

PMID:
    27551506
    [PubMed]
Related citations


The expression patterns of aquaporin 9, vacuolar H<sup>+</sup>-ATPase, and cytokeratin 5 in the epididymis of the common vampire bat.
Castro MM, Kim B, Hill E, Fialho MC, Puga LC, Freitas MB, Breton S, Machado-Neves M
Histochem Cell Biol. 2016 Aug 22;

PMID:
    27549752
    [PubMed - as supplied by publisher]
Related citations


Risk of Malignancy in Thyroid Nodules with Non-diagnostic Fine Needle Aspiration: A Retrospective Cohort Study.
Espinosa De Ycaza AE, Lowe KM, Dean DS, Castro MR, Fatourechi V, Ryder M, Morris JC 3rd, Stan MN
Thyroid. 2016 Aug 22;

PMID:
    27549368
    [PubMed - as supplied by publisher]
Related citations


Survival and proliferation of neural progenitor derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 autocrine positive feedback mechanism.
Calinescu AA, Yadav VN, Carballo E, Kadiyala P, Tran D, Zamler D, Doherty R, Srikanth M, Lowenstein PR, Castro MG
Clin Cancer Res. 2016 Aug 19; pii: clincanres.2888.2015.

PMID:
    27542769
    [PubMed - as supplied by publisher]
Related citations


Genome Sequence of a Multidrug-Resistant Strain of Bacillus pumilus, CB01, Isolated from the Feces of an American Crow, Corvus brachyrhynchos.
Nelson RL, Castro MA, Katti M, Eisen JA, Van Laar TA
Genome Announc. 2016 Aug 18; 4(4)pii: e00807-16. doi: 10.1128/genomeA.00807-16.

PMID:
    27540060
    [PubMed]
Related citations


Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W, NIH/NHLBI AsthmaNet
N Engl J Med. 2016 Aug 18; 375(7)619-30. doi: 10.1056/NEJMoa1515990.

PMID:
    27532828
    [PubMed - indexed for MEDLINE]
Related citations


Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.
Belo VA, Parente JM, Tanus-Santos JE, Castro MM
Biochem Pharmacol. 2016 Aug 13; pii: S0006-2952(16)30230-1. doi: 10.1016/j.bcp.2016.08.012.

PMID:
    27531060
    [PubMed - as supplied by publisher]
Related citations


Premature changes in neuronal excitability account for hippocampal network impairment and autistic-like behavior in neonatal BTBR T+tf/J mice.
Cellot G, Maggi L, Di Castro MA, Catalano M, Migliore R, Migliore M, Scattoni ML, Calamandrei G, Cherubini E
Sci Rep. 2016 Aug 16; 631696. doi: 10.1038/srep31696.

PMID:
    27526668
    [PubMed - in process]
Related citations


Noise Enhances Action Potential Generation in Mouse Sensory Neurons via Stochastic Resonance.
Onorato I, D'Alessandro G, Di Castro MA, Renzi M, Dobrowolny G, Musarò A, Salvetti M, Limatola C, Crisanti A, Grassi F
PLoS One. 2016; 11(8)e0160950. doi: 10.1371/journal.pone.0160950.

PMID:
    27525414
    [PubMed - in process]
Related citations


Multiple expressed endogenous glioma epitopes as novel vaccines for gliomas.
Lowenstein PR, Castro MG
Clin Cancer Res. 2016 Aug 12; pii: clincanres.1477.2016.

PMID:
    27521444
    [PubMed - as supplied by publisher]
Related citations


Physical exam in asymptomatic people drivers the detection of thyroid nodules undergoing ultrasound guided fine needle aspiration biopsy.
Singh Ospina N, Maraka S, Espinosa De Ycaza AE, Ahn HS, Castro MR, Morris JC, Montori VM, Brito JP
Endocrine. 2016 Aug 10;

PMID:
    27510173
    [PubMed - as supplied by publisher]
Related citations


Malaria Incidence Rates from Time Series of 2-Wave Panel Surveys.
Castro MC, Maheu-Giroux M, Chiyaka C, Singer BH
PLoS Comput Biol. 2016 Aug; 12(8)e1005065. doi: 10.1371/journal.pcbi.1005065.

PMID:
    27509368
    [PubMed - in process]
Related citations


HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in Metabolic Syndrome.
Martins CS, Elias D, Colli LM, Couri CE, Souza MC, Moreira AC, Foss MC, Elias LL, de Castro M
Diabetes Metab Res Rev. 2016 Aug 9; doi: 10.1002/dmrr.2842.

PMID:
    27507764
    [PubMed - as supplied by publisher]
Related citations


Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men.
Navarro JA, de Gouveia LA, Rocha-Penha L, Cinegaglia N, Belo V, Castro MM, Sandrim VC
Clin Chim Acta. 2016 Aug 2; 461110-113. doi: 10.1016/j.cca.2016.08.002.

PMID:
    27496081
    [PubMed - as supplied by publisher]
Related citations


Hemispheric specialization of mood processing is abnormal in patients with schizophrenia.
Drucaroff LJ, Costanzo EY, Castro MN, Ortiz-Villafañe M, Wainsztein AE, Abulafia C, Duarte-Abritta B, Villarreal MF, Guinjoan SM
Schizophr Res. 2016 Aug 1; pii: S0920-9964(16)30350-4. doi: 10.1016/j.schres.2016.07.024.

PMID:
    27492755
    [PubMed - as supplied by publisher]
Related citations


Concurrent validity and reliability of using ground reaction force and center of pressure parameters in the determination of leg movement initiation during single leg lift.
Aldabe D, de Castro MP, Milosavljevic S, Bussey MD
Gait Posture. 2016 Jul 29; 49346-352. doi: 10.1016/j.gaitpost.2016.07.181.

PMID:
    27491051
    [PubMed - as supplied by publisher]
Related citations


Proposal for a New Predictive Scale for Recurrent Risk of Fall in a Cohort of Community-Dwelling Patients with Stroke.
Pinto EB, Nascimento C, Monteiro M, Castro M, Maso I, Campos A, Marinho C, Barreto-Neto NJ, Lopes AA, Jesus PA, Oliveira-Filho J
J Stroke Cerebrovasc Dis. 2016 Jul 27; pii: S1052-3057(16)30184-7. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.045.

PMID:
    27475520
    [PubMed - as supplied by publisher]
Related citations


[Breast cancer screening: On our way to the future].
Delaloge S, Bachelot T, Bidard FC, Espie M, Brain E, Bonnefoi H, Gligorov J, Dalenc F, Hardy-Bessard AC, Azria D, Jacquin JP, Lemonnier J, Jacot W, Goncalves A, Coutant C, Ganem G, Petit T, Penault-Lorca F, Debled M, Campone M, Levy C, Coudert B, Lortholary A, Venat-Bouvet L, Grenier J, Bourgeois H, Asselain B, Arvis J, Castro M, Tardivon A, Cox DG, Arveux P, Balleyguier C, André F, Rouzier R, Intergroupe national de recherche sur le cancer du sein Unicancer (UCBG)
Bull Cancer. 2016 Jul 26; pii: S0007-4551(16)30104-7. doi: 10.1016/j.bulcan.2016.06.005.

PMID:
    27473920
    [PubMed - as supplied by publisher]
Related citations


Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells.
Baker GJ, Chockley P, Zamler D, Castro MG, Lowenstein PR
Oncoimmunology. 2016 Jun; 5(6)e1163461. doi: 10.1080/2162402X.2016.1163461.

PMID:
    27471637
    [PubMed]
Related citations


Editorial (Thematic Issue: Toxins and Their Role as Therapeutic Agents).
Castro MS, Fontes W
Protein Pept Lett. 2016; 23(8)675.

PMID:
    27468833
    [PubMed - in process]
Related citations

Financial Disclosures

Financial Disclosures

Disclosure of Financial Interests with Industry

Washington University and its physicians are committed to ensuring integrity and objectivity in medical decision-making. Some of our physicians work collaboratively with pharmaceutical or medical device companies to develop innovative ideas and products that can improve health care delivery and clinical outcomes for patients. In some instances, our faculty physicians are paid by these commercial companies to provide advice on product design or to speak about the use of medications, devices, equipment or procedures. These payments may include: a) compensation for consulting and speaking engagements, b) equity, and/or c) royalties for products invented by our faculty. Any payments to Washington University physicians must be based on tangible services and may not exceed fair market value for their work. In addition to disclosure on this web site, physicians earning more than $10,000 per year must disclose their corporate financial relationship in writing to patients when prescribing or using that company's products.

This physician reported the following earned financial interests during calendar year 2015.

Company Name: Boehringer Ingelheim

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $10,001 - $25,000

Reporting Date: May 01, 2016


Company Name: Genentech

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016


Company Name: Sparo

Royalties:

Equity: Yes

Consulting/Advisory Board:

Speaker Fees:

Reporting Date: May 01, 2016


Company Name: Teva

Royalties:

Equity: No

Consulting/Advisory Board:

Speaker Fees: $25,001 - $50,000

Reporting Date: May 01, 2016