Patient Portal

Luqi Chi, MD, MSCE, FACP

Associate Professor, Neurology

Specialty Areas

Sleep Medicine
Internal Medicine

Board Certifications

Internal Medicine
Sleep Medicine

Hospital Affiliations

Barnes-Jewish Hospital



Areas of Clinical Interest

Outpatient consultation and hospital sleep medicine, obstructive sleep apnea, central sleep apnea, treatment adherence issues associated with positive airway pressure therapy, sleep related hypoventilation, obesity hypoventilation syndrome, circadian rhythm disorders, insomnia, hypersomnia, narcolepsy, restless leg syndrome, periodic limb movement disorder, and parasomnias (sleep walking, sleep-related eating disorder, REM behavior disorder, etc). 

In addition to treating sleep disorders, Dr. Chi also has expertise in treating patients with chronic respiratory failure/insufficiency caused by neuromuscular disease (such as ALS), chest wall deformity, lung disease and congestive heart failure using noninvasive ventilation (NIV) delivered through a variety of ventilatory modes. 

  • Location(s)
  • Education
  • Publication & Research



Center 40 Building

1600 S. Brentwood Blvd.
Suite 600
St. Louis, MO 63144

Office Phone: (314) 362-4342
Fax: (314) 747-3813



Fellowship: Sleep Medicine, University of Pennsylvania School of Medicine, Philadelphia 2008
Master of Science: Clinical Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 2008
Residency: Internal Medicine, Rochester General Hospital, Rochester, New York 2006
Master of Science: Cardiopulmonary Pathophysiology, Military Postgraduate Medical School (General Hospital of PLA), Beijing, China 1997
Fellowship: Critical Care Medicine, Peking Medical University 1st Hospital 1991
Fellowship: Pulmonary Medicine, Kailuan General Hospital, Tanshan, China 1990
Residency: Internal Medicine, Kailuan General Hospital, Tanshan, China 1987
Medical Degree: Huabei Medical College for Coal Industry, Tangshan, Hebei, China 1984

Publication & Research

Publication & Research

Web-based access to positive airway pressure usage with or without an initial financial incentive improves treatment use in patients with obstructive sleep apneaKuna S.T., Shuttleworth D.,Chi, L.,Schutte-Rodin, S., Friedman, E.,   Guo H., Dhand, S.,   Yang, L., Zhu, J., Bellamy, S.L., Volpp, K.G., Asch, D.A.  Sleep. 2015; 38(8):1229-36
PMID: 25581921 

Heritability of Craniofacial Structures in Normal Subjects and Patients with Obstructive Sleep ApneaChi, L.,Comyn, F., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I., Schwab, R.J. Sleep. 2014 Oct 1;37(10):1689-98
PMID: 25197806 

Identification of Craniofacial Risk Factors for Obstructive Sleep Apnea Using Three-Dimensional MRI. Chi, L., Comyn, F., Mitra, N., Reilly, M.P., Wan, F., Maislin, G., Chmiewski, L., Thorne-FitzGerald, M.D., Victor, U.N., Pack, A.I., Schwab, R.J. Eur  Resp J. 2011; 38:348-58
PMID: 21233264 

Interleukin-6 Production by endothelial cells via protease-activated receptor stimulation is synergized by endotoxin and tumor necrosis factor-alpha. Chi, L., Li, Y., Stehno-Bittle, L., Stechschulte, D.J., Dileepan, K.N. Journal of Interferon and Cytokine Research. 2001; 21:231-240 
PMID: 11359654 

Signal transduction pathways in mast cell granule-mediated endothelial cell activation. Chi, L., Stehno-Bittel, L., Smirnova., I., Stechschulte, D.J., Dileepan, K.N.Mediators Inflamm. 2003; 12:79-87
PMID: 12775357  

Histamine-induced production of IL-6 and IL-8 by human coronary artery endothelial cells is enhanced by endotoxin and TNF-alpha. Li, Y.,Chi, L., Stechschulte, D.J., Dileepan, K.N. Microvascular Research 2001; 61:253-262
PMID: 11336536 

Areas of Research Interest

Dr. Chi is a principle investigator and co-investigator of the following clinical trials:
1. Differential upper airway anatomic risk factors between Chinese and Caucasian apneics
2. The effect of CPAP on cardiac function in hospitalized patients with obstructive sleep apnea and heart failure
3. Reducing heart failure re-admissions by enhancing CPAP adherence