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Lukas D. Wartman, MD

Assistant Professor, Medicine
Division of Oncology
Section of Medical Oncology
Assistant Director, Cancer Genomics, The Genome Institute at Washington University

Specialty Areas

Medical Oncology
Oncology
Hematology

Board Certifications

Internal Medicine

Hospital Affiliations

Barnes-Jewish Hospital

Areas of Clinical Interest

Treatment of acute and chronic leukemia in adults,  blood cancer, bone marrow transplant, lymphoblastic leukemia, myelogenous leukemia, lymphocytic leukemia, 

  • Maps & Directions
  • Education
  • Publication & Research

Maps & Directions

Maps & Directions

Center for Advanced Medicine

4921 Parkview Place
St. Louis, MO 63110

Suite: B
Floor: 7
Office Phone: 314-454-8304
Fax: 314-454-7551

Education

Education

Residency: Internal Medicine, Barnes-Jewish Hospital, St. Louis MO 2007
Fellowship: Clinical Hematology/Oncology, Washington University School of Medicine, St. Louis MO 2008
B.S. (Molecular Biology): University of Wisconsin, Madison, WI 1998
Medical School: Washington University School of Medicine, St. Louis MO 2005
Fellowship (Research): Clinical Hematology/Oncology, Washington University School of Medicine, St. Louis MO 2011

Publication & Research

Publication & Research

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ
Cell. 2017 Feb 23; 168(5)801-816.e13. doi: 10.1016/j.cell.2017.01.021.

PMID:
    28215704
    [PubMed - in process]
Related citations


CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer.
Griffith M, Spies NC, Krysiak K, McMichael JF, Coffman AC, Danos AM, Ainscough BJ, Ramirez CA, Rieke DT, Kujan L, Barnell EK, Wagner AH, Skidmore ZL, Wollam A, Liu CJ, Jones MR, Bilski RL, Lesurf R, Feng YY, Shah NM, Bonakdar M, Trani L, Matlock M, Ramu A, Campbell KM, Spies GC, Graubert AP, Gangavarapu K, Eldred JM, Larson DE, Walker JR, Good BM, Wu C, Su AI, Dienstmann R, Margolin AA, Tamborero D, Lopez-Bigas N, Jones SJ, Bose R, Spencer DH, Wartman LD, Wilson RK, Mardis ER, Griffith OL
Nat Genet. 2017 Jan 31; 49(2)170-174. doi: 10.1038/ng.3774.

PMID:
    28138153
    [PubMed - in process]
Related citations


Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ, Welch JS
Blood. 2017 Mar 9; 129(10)1397-1401. doi: 10.1182/blood-2016-10-745273.

PMID:
    28082444
    [PubMed - in process]
Related citations


TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.
Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley TJ
N Engl J Med. 2016 Nov 24; 375(21)2023-2036.

PMID:
    27959731
    [PubMed - indexed for MEDLINE]
Related citations


A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia.
Lu C, Riedell P, Miller CA, Hagemann IS, Westervelt P, Ozenberger BA, O'Laughlin M, Magrini V, Demeter RT, Duncavage EJ, Griffith M, Griffith OL, Wartman LD
Cold Spring Harb Mol Case Stud. 2016 Jan; 2(1)a000687. doi: 10.1101/mcs.a000687.

PMID:
    27148581
    [PubMed]
Related citations


A case of me: clinical cancer sequencing and the future of precision medicine.
Wartman LD
Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1)a000349. doi: 10.1101/mcs.a000349.

PMID:
    27148564
    [PubMed]
Related citations


A genomic analysis of Philadelphia chromosome-negative AML arising in patients with CML.
Krysiak K, Christopher MJ, Skidmore ZL, Demeter RT, Magrini V, Kunisaki J, O'Laughlin M, Duncavage EJ, Miller CA, Ozenberger BA, Griffith M, Wartman LD, Griffith OL
Blood Cancer J. 2016 Apr 8; 6e413. doi: 10.1038/bcj.2016.18.

PMID:
    27058228
    [PubMed - indexed for MEDLINE]
Related citations


A phase I study of carfilzomib for relapsed or refractory acute myeloid and acute lymphoblastic leukemia.
Wartman LD, Fiala MA, Fletcher T, Hawkins ER, Cashen A, DiPersio JF, Jacoby MA, Stockerl-Goldstein KE, Pusic I, Uy GL, Westervelt P, Vij R
Leuk Lymphoma. 2016; 57(3)728-30. doi: 10.3109/10428194.2015.1076930.

PMID:
    26674111
    [PubMed - indexed for MEDLINE]
Related citations


Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.
Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, Chang GS, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Larson DE, Kulkarni S, Ozenberger BA, Welch JS, Walter MJ, Graubert TA, Westervelt P, Radich JP, Link DC, Mardis ER, DiPersio JF, Wilson RK, Ley TJ
JAMA. 2015 Aug 25; 314(8)811-22. doi: 10.1001/jama.2015.9643.

PMID:
    26305651
    [PubMed - indexed for MEDLINE]
Related citations


Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
Cancer Genome Atlas Research Network.
N Engl J Med. 2013 May 30; 368(22)2059-74. doi: 10.1056/NEJMoa1301689.

PMID:
    23634996
    [PubMed - indexed for MEDLINE]
Related citations


Notch signaling in acute promyelocytic leukemia.
Grieselhuber NR, Klco JM, Verdoni AM, Lamprecht T, Sarkaria SM, Wartman LD, Ley TJ
Leukemia. 2013 Jul; 27(7)1548-57. doi: 10.1038/leu.2013.68.

PMID:
    23455394
    [PubMed - indexed for MEDLINE]
Related citations


Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.
Wartman LD, Welch JS, Uy GL, Klco JM, Lamprecht T, Varghese N, Nagarajan R, Ley TJ
PLoS One. 2012; 7(10)e46529. doi: 10.1371/journal.pone.0046529.

PMID:
    23056333
    [PubMed - indexed for MEDLINE]
Related citations


The origin and evolution of mutations in acute myeloid leukemia.
Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, Chen K, Harris CC, Schmidt HK, Kalicki-Veizer JM, Lu C, Zhang Q, Lin L, O'Laughlin MD, McMichael JF, Delehaunty KD, Fulton LA, Magrini VJ, McGrath SD, Demeter RT, Vickery TL, Hundal J, Cook LL, Swift GW, Reed JP, Alldredge PA, Wylie TN, Walker JR, Watson MA, Heath SE, Shannon WD, Varghese N, Nagarajan R, Payton JE, Baty JD, Kulkarni S, Klco JM, Tomasson MH, Westervelt P, Walter MJ, Graubert TA, DiPersio JF, Ding L, Mardis ER, Wilson RK
Cell. 2012 Jul 20; 150(2)264-78. doi: 10.1016/j.cell.2012.06.023.

PMID:
    22817890
    [PubMed - indexed for MEDLINE]
Related citations


Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
Wartman LD, Larson DE, Xiang Z, Ding L, Chen K, Lin L, Cahan P, Klco JM, Welch JS, Li C, Payton JE, Uy GL, Varghese N, Ries RE, Hoock M, Koboldt DC, McLellan MD, Schmidt H, Fulton RS, Abbott RM, Cook L, McGrath SD, Fan X, Dukes AF, Vickery T, Kalicki J, Lamprecht TL, Graubert TA, Tomasson MH, Mardis ER, Wilson RK, Ley TJ
J Clin Invest. 2011 Apr; 121(4)1445-55. doi: 10.1172/JCI45284.

PMID:
    21436584
    [PubMed - indexed for MEDLINE]
Related citations

Areas of Research Interest

Dr Wartman studies leukemogenesis, acute promeylocytic leukemia, cancer genomics and epigenetics